MOTU 828mkII User Manual page 52

MOTU FireWire Control Panel setting that you
wish to change is grayed out, simply quit all
828mkII-compatible audio programs (which may
include Sound Manager-compatible programs,
too, if you are using the 828mkII with Sound
Manager). Once you have quite all applications, all
MOTU FireWire Control Panel settings will be
available (not grayed out).
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M O T U F I R E W I R E C O N T R O L P A N E L ( M A C O S 9 )