Chemical Resistance - GE Biacore X100 Operating Instructions Manual

8.2

Chemical resistance

This section gives some general guidelines concerning chemical resistance for
Biacore X100 components. Regarding exposure to solutions not covered by these
guidelines, contact your GE representative for recommendations.
The flow system and sensor chip are the only parts of Biacore X100 that come into
contact with solutions. The guidelines in this section relate to tubing and connectors,
selector valves, connector block, IFC and sensor chip. In most analysis situations, the
ligand attached to the sensor surface limits the chemical resistance of the system as a
whole.
In general, the flow system components withstand long-term exposure to common
aqueous buffer solutions used in biochemical laboratories. The table below lists compat-
ibility with other common substances.
Concentrated organic solvents as well as long-term exposure to extremes of pH (<3 and
>11) should be avoided. For solutions with short-term compatibility, do not use as running
buffer or for injections longer than 10 minutes. Solutions classed as long-term compatible
may be used as running buffer.
Solution
Acetonitrile
Dimethyl formamide (DMF)
Dimethyl sulfoxide (DMSO)
Ethanol
Ethylene glycol
Formic acid
Formamide
Biacore X100 Operating Instructions 28961142 AD
Concentration Compatibility
50% Short term
50% Short term
50% Short term
10% Long term
70% Short term
10% Long term
100% Short term
70% Short term
40% Long term
8 Reference information
8.2 Chemical resistance
87