Section Eprinciples Of Operation - Hologic Genius Operator's Manual

Special Precautions
There are conditions that might result in a slide not being successfully imaged. Some conditions may
be prevented or corrected by following these guidelines.
• The coverslip media is dry. (Wet media could cause equipment malfunction.)
• The slides are clean (no fingerprints, dust, debris, bubbles). Handle the slides by the edges.
• The coverslip does not extend beyond the surface of the slide.
• The label is applied smoothly, without overhang. (Lifted edges may stick during handling,
causing broken slides or instrument malfunction.)
• The slide is appropriately labeled for use with the Digital Imager. Refer to "Slide Labeling"
on page 4.7.
• Stain - for staining Gyn slides, do not substitute solutions for the ThinPrep Stain solutions.
Follow the stain protocols exactly as they are written. Refer to the ThinPrep Stain User's
Manual.
• ThinPrep microscope slides appropriate for the sample type must be used. On ThinPrep
Imaging System microscope slides, the fiducial marks should not be scratched or marred.
Specimen handling
Please refer to your laboratory guidelines for specimen handling.
SECTION
E
PRINCIPLES OF OPERATION
The Genius Digital Imager consists of a slide handling system, a slide carrier deck, scanning and
imaging modules, and electronics and cabling. Sensors on the slide handling arm detect the location
of microscope slides loaded into the instrument by the operator.
The Digital Imager is controlled by the Digital Imager computer. The Digital Imager computer also
performs image compression and analysis, and it provides the communication to and from the Image
Management Server.
Each slide imaging sequence is optimized for the biological characteristics of the various cytological
specimens.
For Gyn samples, the Digital Imager computer uses the Genius™ Cervical AI to assist in primary
cervical cancer screening of ThinPrep
microscope slides and imaged on the Genius Digital Diagnostics System for the presence of atypical
cells, cervical neoplasia, including its precursor lesions (Low Grade Squamous Intraepithelial
Lesions, High Grade Squamous Intraepithelial Lesions), and carcinoma as well as all other
®
Pap tests. Samples are prepared on ThinPrep Imaging System
Genius™ Digital Imager Operator's Manual
I
NTRODUCTION
1
1.11