Multimode Ionization (Mmi) Source - Agilent Technologies 6475 User Manual

2 Hardware Overview

Multimode Ionization (MMI) source

Multimode Ionization (MMI) source
The Multimode source for LC/MS can simultaneously do ESI and APCI ionization.
The Multimode source can operate in ESI mode only, in APCI mode only, or in
mixed ESI/APCI mode. This technology significantly improves the speed,
accuracy and productivity of high-throughput screening in drug discovery and
other research applications.
High-throughput screening is used to analyze large numbers of chemical
compounds rapidly and with high sensitivity. In order to be analyzed by mass
spectrometry, all compounds must be converted into ions. Since not all
molecules respond to the same mode of ionization, multiple ionization sources
were developed to facilitate high-throughput screening.
Figure 7. MMI cover, ion source, and spray shield
Simultaneous ESI and APCI capability and high LC flow rate compatibility (up to 2
mL/min) means more compounds can be detected in less time with the Agilent
Multimode source.
Agilent 6475 Triple Quad LC/MS System User Guide 26