Waters Xevo TQ-S IVD Manuals

Manuals and User Guides for Waters Xevo TQ-S IVD. We have 1 Waters Xevo TQ-S IVD manual available for free PDF download: Overview And Maintenance Manual

Waters Xevo TQ-S IVD Overview And Maintenance Manual (159 pages)

Brand: Waters | Category: Laboratory Equipment | Size: 5 MB

General Information
2
Copyright Notice
2
Trademarks
2
Contacting Waters
3
Safety Considerations
3
Safety Hazard Symbol Notice
3
Considerations Specific to the Device
4
Bottle Placement Prohibition
4
Electrical Power Safety Notice
6
Equipment Misuse Notice
6
Safety Advisories
7
Safe Disposal
7
Operating the Device
7
Applicable Symbols
7
Audience and Purpose
9
Intended Use of the Xevo TQ-S IVD
9
Calibrating
9
Quality Control for LC-MS/MS Systems
9
EMC Considerations
10
FCC Radiation Emissions Notice
10
Canada Spectrum Management Emissions Notice
11
ISM Classification: ISM Group 1 Class a
11
EMC Emissions
11
Manufacturing Information
11
Australian Sponsor Information
12
Table of Contents
13
Xevo TQ-S IVD Overview
18
Waters Xevo TQ-S IVD
18
Intellistart Technology
19
ACQUITY UPLC/MS Xevo TQ-S IVD Systems
19
ACQUITY UPLC IVD System
19
ACQUITY UPLC I-Class IVD System
19
Software and Data System
21
Instrument Console Software
21
Electrospray Ionization (ESI)
22
Intellistart Fluidics System
22
Overview
22
System Components
23
System Operation
23
Ion Optics
23
MS Operating Modes
24
MS/MS Operating Modes
25
Product (Daughter) Ion Mode
26
Typical Applications
26
Precursor (Parent) Ion Mode
26
Multiple Reaction Monitoring Mode
27
Constant Neutral Loss Mode
27
Scanwave Daughter Scan Mode
28
Leak Sensors
29
Vacuum System
29
Rear Panel
29
Preparing the Mass Spectrometer for Operation
31
Starting the Mass Spectrometer
31
Verifying the Instrument's State of Readiness
32
Monitoring the Mass Spectrometer Leds
33
Tuning and Calibration Information
33
Running the Mass Spectrometer at High Flow Rates
33
Preparing the Intellistart Fluidics System
33
Installing the Reservoir Bottles
34
Required Materials
34
Adjusting the Solvent Delivery Tube Positions
35
Purging the Infusion Pump
36
Rebooting the Mass Spectrometer
36
Leaving the Mass Spectrometer Ready for Operation
37
Emergency Shutdown of the Mass Spectrometer
38
ESI Operation
39
Electrospray Ionization
39
Installing the ESI Probe
39
Removing the ESI Probe
42
Maintenance Procedures
44
Maintenance Schedule
44
Spare Parts
45
Safety and Handling
46
Preparing the Instrument for Working on the Source
46
Using Masslynx Software to Prepare the Instrument for Operations on or Inside Its Source
47
Removing and Refitting the Source Enclosure
47
Removing the Source Enclosure from the Instrument
47
Fitting the Source Enclosure to the Instrument
49
Operating the Source Isolation Valve
49
Closing the Source Isolation Valve before Starting a Maintenance Procedure
50
Opening the Source Isolation Valve after Completing a Maintenance Procedure
51
Removing O-Rings and Seals
51
Cleaning the Instrument Case
52
Emptying the Nitrogen Exhaust Trap Bottle
52
Maintaining the Oerlikon Leybold Oil-Filled Roughing Pumps
54
Gas Ballasting the Oil-Filled Roughing Pump
55
Inspecting the Roughing Pump Oil Levels
56
Adding Oil to the Roughing Pump
56
Replacing the Roughing Pump's Oil and Oil Demister Elements
58
Fitting the New Oil Demister Element
63
Preparing for Operation after Changing the Roughing Pump's Oil and Oil Demister Element
64
Gas Ballasting the Edwards Xds35I Oil-Free Roughing Pump
64
Use of the Gas Ballast Control
65
Cleaning the Source Components
65
Cleaning the Sampling Cone Assembly
66
Removing the Sampling Cone Assembly from the Source
66
Disassembling the Sampling Cone Assembly
67
Cleaning the Sample Cone and Cone Gas Nozzle
70
Assembling the Sampling Cone Assembly
71
Fitting the Sampling Cone Assembly to the Source
72
Cleaning the Ion Block Assembly
73
Removing the Ion Block Assembly from the Source Assembly
74
Disassembling the Source Ion Block Assembly
76
Cleaning the Ion Block Components
80
Assembling the Source Ion Block Assembly
82
Fitting the Ion Block Assembly to the Source Assembly
83
Cleaning the Stepwave Ion Guide Assembly
84
Handling the Stepwave Ion Guide Assembly
84
Removing the Ion Block Support from the Source Assembly
84
Disassembling the Stepwave Ion Guide Assembly
85
Cleaning the Stepwave Ion Guide Assembly
88
Assembling the Stepwave Ion Guide Assembly
91
Fitting the Stepwave Assembly to the Source Assembly
93
Fitting the Ion Block Support to the Source
96
Replacing the ESI Probe Tip and Gasket
96
Replacing the Probe Tip and Gasket
97
Fitting the Low-Flow ESI Probe Tip and Gasket
98
Replacing the ESI Probe Sample Capillary
99
Removing the Existing Capillary
99
Installing the New Capillary
103
Replacing the Ion Block Source Heater
107
Replacing the Source Assembly Seals
110
Removing the Probe Adjuster Assembly Probe and Source Enclosure Seals
111
Fitting the New Source Enclosure and Probe Adjuster Assembly Probe Seals
113
Replacing the Air Filter Inside the Front Door
114
A Safety Advisories
116
Safety Advisories
116
Warning Symbols
116
Specific Warnings
117
Notices
119
Bottles Prohibited Symbol
119
Required Protection
120
Warnings that Apply to All Waters Instruments and Devices
120
Warnings that Address the Replacement of Fuses
124
Electrical Symbols
125
Handling Symbols
126
B External Connections
128
External Wiring and Vacuum Connections
128
Connecting the Oerlikon Leybold Oil-Filled Roughing Pumps
130
Required Materials
130
Connecting the Edwards Oil-Free Roughing Pumps
135
Making the Roughing Pump Connections to the Xevo TQ-S IVD
141
Connecting to the Nitrogen Gas Supply
142
Connecting to the Collision Cell Gas Supply
143
Connecting the Nitrogen Exhaust Line
143
Connecting Liquid Waste Lines
145
Connecting to the Workstation
147
Connecting Ethernet Cables (Systems with ACQUITY LC)
148
Input/Output Signal Connectors
148
Making Signal Connections
150
Connecting to the Electricity Source
153
C Materials of Construction and Compatible Solvents
154
Preventing Contamination
154
Items Exposed to Solvent
154
Solvents Used to Prepare Mobile Phases
155
D Plumbing the Intellistart Fluidics System
157
Preventing Contamination
157
Plumbing Schematic
157
Tubing Specifications
158

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Waters Xevo TQ-S IVD Overview And Maintenance Manual (159 pages)

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