ThermoFisher Scientific thermoscientific Vanquish HPLC Pre-Installation Manual
  1. Manuals
  2. Brands
  3. ThermoFisher Scientific Manuals
  4. Laboratory Equipment
  5. thermoscientific Vanquish HPLC
  6. Pre-installation manual

ThermoFisher Scientific thermoscientific Vanquish HPLC Pre-Installation Manual

Hide thumbs
Table of Contents

Advertisement

Quick Links

Download this manual
thermoscientific
Vanquish
HPLC & UHPLC
Systems
Pre-installation Requirements Guide
Revision 3.0
•
September 2021

Advertisement

Table of Contents
loading
Need help?

Need help?

Do you have a question about the thermoscientific Vanquish HPLC and is the answer not in the manual?

Questions and answers

Related Manuals for ThermoFisher Scientific thermoscientific Vanquish HPLC

Summary of Contents for ThermoFisher Scientific thermoscientific Vanquish HPLC

  • Page 1 thermoscientific Vanquish HPLC & UHPLC Systems Pre-installation Requirements Guide Revision 3.0 • September 2021...
  • Page 2 Copyright © 2021 Thermo Fisher Scientific Inc. All rights reserved. Trademarks The following are registered trademarks in the United States and other countries: Dranetz is a registered trademark of Dranetz Technologies Inc. ionBench is a trademark of ionBench Corporation. PEEK is a trademark of Victrex PLC. Styrofoam is a registered trademark of Dow Chemical Company.
  • Page 3 Contacting Us Contacting Us There are several ways to contact us: Ordering Information For ordering information or sales support for HPLC products, contact your local Thermo Fisher Scientific sales organization. For contact information, go to Contact Us on http://www.thermofisher.com. Technical Assistance For technical support for HPLC products, contact your local Thermo Fisher Scientific support organization.

  • Page 4: Table Of Contents

    Contents Contents 1 Using this Manual ................7 About this Manual....................8 Conventions ......................9 1.2.1 Safety Messages ..................9 1.2.2 Special Notices and Informational Notes ...........9 1.2.3 Typographical Conventions ..............10 Reference Documentation ................... 11 2 Safety ..................... 12 Safety Symbols and Signal Words ................ 13 2.1.1 Safety Symbols and Signal Words in This Manual ........
  • Page 5 Contents 5 Line Power ..................45 Quality of Power ....................46 Power Monitoring Devices..................47 Power Conditioning Devices ................. 48 Available Outlets ....................49 Connecting to Power Sockets ................52 Uninterruptible Power Supply ................55 Technical Assistance ..................... 55 6 Waste and Ventilation ..............56 General........................
  • Page 6 Contents Page 6 Vanquish Manual - Template Operating Manual...

  • Page 7: Using This Manual

    • Using this Manual 1 Using this Manual This chapter provides information about this manual, the conventions used throughout the manual, and the reference documentation that is available in addition to this manual. Vanquish Manual - Template Operating Manual Page 7...

  • Page 8: About This Manual

    • Using this Manual About this Manual NOTICE This Vanquish (U)HPLC System Pre-installation Requirements Guide document contains information specific to stand-alone Vanquish (U)HPLC Systems. A typical stand-alone system consists of a Vanquish system base with solvent rack, a pump, an autosampler, a column compartment, and a detector.

  • Page 9: Conventions

    • Using this Manual Conventions This section describes the conventions that are used throughout this manual. 1.2.1 Safety Messages The safety messages and precautionary statements in this manual appear as follows: • Safety messages or precautionary statements that apply to the entire manual and all procedures in this manual are grouped in the Safety chapter.

  • Page 10: Typographical Conventions

    • Using this Manual 1.2.3 Typographical Conventions These typographical conventions apply to the descriptions in this manual: Data Input and Output The following appears in bold type: • ♦ Input that you enter via keyboard or select with the mouse Buttons that you click on the screen ♦...

  • Page 11: Reference Documentation

    • Using this Manual Reference Documentation In addition to this guide, Thermo Fisher Scientific provides the following documents as PDF files or printed booklets for the Vanquish (U)HPLC Systems: • Thermo Scientific Vanquish UHPLC System Operating Manual • Thermo Scientific Vanquish Neo (VN-A10, VN-C10, VN-P10, VN-S10) Operating Manual •...

  • Page 12: Safety

    • Safety 2 Safety This chapter provides general and specific safety information and informs on the intended use of the system. Page 12 Vanquish Manual - Template Operating Manual...

  • Page 13: Safety Symbols And Signal Words

    • Safety Safety Symbols and Signal Words 2.1.1 Safety Symbols and Signal Words in This Manual This manual contains safety messages to prevent injury of the persons using the system. The safety symbols and signal words in this manual include the following: Always be aware of the safety information.

  • Page 14: Observing This Manual

    • Safety 2.1.2 Observing this Manual Observe the following: Before installing or operating the system, read this manual carefully • to be familiar with the system and this manual. The manual contains important information regarding user safety as well as use and care of the system.
  • Page 15 • Safety Symbol Description Surface becomes hot during operation—La surface devient chaude lors du fonctionnement. Puncture hazard—To avoid injury during autosampler operation, keep your hands away from the syringe. Risque de pincement—Pour éviter des blessures pendant l'opération du passeur d'échantillon, tenez vos mains à distance de la seringue. Pinch point hazard—Risque de pincement Refer to the Operating Manual to prevent risk of harm to the operator and to protect the instrument against damage.

  • Page 16: Intended Use

    • Safety Intended Use The devices are designed to be operated only by qualified and authorized personnel. All users must know the hazards presented by the device and the used substances. The Vanquish (U)HPLC systems are designed for laboratory research use only in ultra-high-performance liquid chromatography ((U)HPLC) applications.

  • Page 17: Safety Precautions

    • Safety Safety Precautions 2.3.1 General Safety Information When working with analytical instrumentation, you should know the potential hazards of using chemical solvents. TIP Before initial operation of the instruments, make sure that you are familiar with the contents of this Pre-installation Requirements Guide and the Operating Manuals of the respective module.
  • Page 18 • Safety The toxicological properties of many samples may not be well • known. If you have any doubt about a sample, treat it as if it contains a potentially harmful substance. • Wear goggles when handling mobile phases or operating the instrument.

  • Page 19: Consignes Générales De Sécurité

    • Safety 2.3.2 Consignes Générales de Sécurité Veuillez noter Avant de commencer à utiliser l'instrument, assurez-vous que vous vous êtes familiarisés avec le contenu de ce manuel. Observez des étiquettes d'avertissement sur l'appareil et référez-vous aux sections correspondantes dans ce mode d'emploi. Lors de l’utilisation des instruments analytiques, il faut connaître les dangers potentiels liés aux solvents chimiques.
  • Page 20 • Safety De nombreux solvants organiques et solutions salines sont toxiques. • Informez-vous des propriétés toxicologiques de toutes les phases mobiles que vous utilisez. Les propriétés toxicologiques de nombreux échantillons peuvent • être mal connues. Au moindre doute concernant un échantillon, traitez-le comme s'il contenait une substance potentiellement dangereuse.
  • Page 21 • Safety La fluidique des quelques instruments et accessoires Vanquish est • conçu exclusivement pour le système capillaire Viper™. En ce cas, n’utilisez que des capillaires Viper pour installer les connexions fluidiques. L'utilisation de non-Viper capillaires produira des fuites et des risques de dommages mécaniques aux orifices des valves.

  • Page 22: Federal Communications Commission (Fcc) Note

    • Safety Federal Communications Commission (FCC) Note The Vanquish (U)HPLC systems have been tested and found to comply with the limits of Class A digital devices, pursuant to part 15 of the U.S. FCC Rules. These limits are designed to provide reasonable protection against harmful interferences when the equipment is operated in a commercial environment.

  • Page 23: Compliance Information

    • Safety Compliance Information Thermo Fisher Scientific performs complete testing and evaluation of its products to ensure full compliance with applicable domestic and international regulations. When the system is delivered to you, it meets all pertinent electromagnetic compatibility (EMC) and safety standards as described in the next section or sections by product name.
  • Page 24 • Safety Thermo Fisher Scientific herewith declares conformity of the above products with the respective requirements of the following regulations: Low-Voltage Directive 2014/35/EU • • EMC Directive 2014/30/EU The electrical safety of the products was evaluated based on the following standard: DIN EN 61010-1: 2010 •...

  • Page 25: Site Preparation

    • Site Preparation 3 Site Preparation This chapter introduces you to the system space and load. Vanquish Manual - Template Operating Manual Page 25...

  • Page 26: Shipping Containers

    • Site Preparation Shipping Containers NOTICE It is important that you prepare the site before your field service engineer can install the system. Please review the space and load requirements provided in this chapter and ensure that the laboratory workbenches are large enough and strong enough to support the data system hardware and the LC system.
  • Page 27 • Site Preparation Component Height Width Depth Weight Vanquish Column Compartment H/C (VH-C10-A-03, VC-C10-A- Vanquish Column Compartment N (VN-C10-A-01) Optical Detectors (VWD, DAD, MWD, FLD) Vanquish Charged Aerosol Detectors (VH-D20-A, VF-D20-A) Vanquish Neo System (VN- S10-A-01) Table 1: Shipping container dimensions and weight NOTICE The Vanquish System Base contains base, solvent rack, reservoirs, and the Ship Kit.

  • Page 28: Space And Load Requirements

    • Site Preparation Space and Load Requirements Prepare a bench top for the Vanquish (U)HPLC system in a clean, well- ventilated area. Please make sure that the required bench-top space is available to install all system components and the data system properly. Figure 1 shows the recommended layout for a stand-alone Vanquish (U)HPLC System with a Vanquish detector, column compartment,...
  • Page 29 • Site Preparation Figure 2 shows the recommended layout for a stand-alone Vanquish (U)HPLC System with a Vanquish detector, column compartment, autosampler, pump, system base with solvent rack, and additionally a charger module. Allow at least 210 cm (83 in) for the installation of the shown setup, including the data system and printer.
  • Page 30 • Site Preparation Figure 3 shows the recommended layout for a stand-alone Vanquish Duo (U)HPLC System with two Vanquish optical detectors, column compartment, autosampler, pump, system base with solvent rack, and additionally a charger module. Allow at least 160 cm (63 in) for the installation of the shown setup, including the data system and printer.
  • Page 31 • Site Preparation Figure 4 shows the recommended layout for a stand-alone Vanquish Duo (U)HPLC System with Vanquish charged aerosol detector, optical detector, column compartment, autosampler, pump, system base with solvent rack, and additionally a charger module. Allow at least 160 cm (63 in.) for the installation of the shown setup, including the data system and printer.
  • Page 32 • Site Preparation Figure 5 shows the typical layout for a stand-alone Vanquish Duo (U)HPLC System with a Vanquish detector, column compartment, autosampler, pump, and system base with solvent rack using the ionBench Liftable Table for system mobility. For further information, refer to the supplier’s Operating Manuals.
  • Page 33 • Site Preparation Extended tower Vanquish (U)HPLC systems with, for example, two optical detectors or the optical/charged aerosol combination and two pumps, require stabilizing options. This is accomplished via the stack stabilizer kit or by securing the system on the ionBench. The ionBench mounting brackets do not extend the footprint beyond the top surface of the ionBench.
  • Page 34 • Site Preparation System Configuration Example Vanquish Solvent Rack Vanquish Pumps Split Samplers HT/FT/CT/C Dual Split Samplers HT/FT Column Compartment H/C Diode Array Detector HL or any other Vanquish optical detector Diode Array Detector HL or any other Vanquish optical detector Charged Aerosol Detector...
  • Page 35 • Site Preparation NOTICE This height provision will allow sufficient access to the 1-liter solvent bottles in the solvent platform. If you plan to use larger solvent containers, allow more vertical space. Please note that it is not allowed to stack more than 4 Vanquish modules (e.g. 1x Pump, 1x Sampler, and 2x Detectors).
  • Page 36 • Site Preparation Component Height Width Depth Weight Split Sampler CT 11.4 16.6 24.4 52.9 Split Sampler C 11.4 16.6 24.4 48.5 Dual Split Sampler HT/FT 11.4 16.6 24.4 63.9 Split Sampler NT 11.4 16.6 24.4 57.3 Charger Module 29.5 33.9 13.4 24.2...

  • Page 37: Telephone

    • Site Preparation Telephone Install a telephone in your laboratory near the instrument so that, if necessary, you can conveniently operate the system while you speak with Technical Support for Thermo Scientific products by telephone. Place the voice telephone outlet within 2 m (6 ft.) of your system. IMPORTANT Your instrument is designed to work in a controlled electromagnetic environment.

  • Page 38: Operation Environment

    • Operation Environment 4 Operation Environment This chapter provides information for operating the system under the prescribed environmental conditions. Page 38 Vanquish Manual - Template Operating Manual...

  • Page 39: Temperature

    • Operation Environment Temperature NOTICE Attention to the operating environment will ensure continued high performance of your Vanquish (U)HPLC System. Any investment in air conditioning is offset by increased sample throughput and/or reduced repair costs. IMPORTANT You are responsible for providing the operating environment necessary for proper operation of the Vanquish (U)HPLC System.
  • Page 40 • Operation Environment TIP The heat output is specified for typical operation mode. The heat output might differ from these values depending on the actual operation (e.g. heating, cooling, etc.). The heat output might deviate from given values if additional features are installed. Heat output Heat output Components...

  • Page 41: Humidity

    • Operation Environment Humidity Maintain the relative humidity of the operating environment with no condensation between 5% and 80%. Operating a Vanquish (U)HPLC System in an environment with very low humidity can cause static electricity to accumulate and discharge, which can shorten the life of the electronic components.

  • Page 42: Electrostatic Discharge

    • Operation Environment Electrostatic Discharge Electrostatic discharge (ESD) can damage the electronic components of your Vanquish (U)HPLC System. The discharge of static electricity is not perceptible to humans until the potential is at least 4000 V. However, a discharge of electrostatic potential as small as 50 V can damage many electronic components.
  • Page 43 • Operation Environment Because of ESD, Thermo Fisher Scientific recommends the following precautions, especially when operating your system at the lower end of the relative humidity specification: Use a static-dissipating floor covering (such as tile or conductive • linoleum) in the room that houses your instrument. •...

  • Page 44: Gas Supply

    • Operation Environment Gas Supply For the operation of Vanquish Charged Aerosol Detectors, nitrogen is required that is dry (no water vapor), clean, and free of micro-particles (< 0.1 µm). Nitrogen gas from a liquid nitrogen source (medical grade) is satisfactory.

  • Page 45: Line Power

    • Line Power 5 Line Power This chapter specifies the requirements for the line power to achieve optimal instrument performance. Vanquish Manual - Template Operating Manual Page 45...

  • Page 46: Quality Of Power

    • Line Power Quality of Power The quality of line power delivered to your system can affect its performance and lifetime. To ensure that your instrument performs optimally and is not damaged by power line fluctuations, verify that your laboratory electrical supply complies with all power quality requirements.

  • Page 47: Power Monitoring Devices

    • Line Power Power Monitoring Devices Monitor the quality of your line power with a power-line disturbance analyzer. This type of device provides a continuous record of line performance by analyzing and printing out information on three types of voltage disturbances: slow average, sag and surge, and transient. The Dranetz™...

  • Page 48: Power Conditioning Devices

    • Line Power Power Conditioning Devices You can correct a line voltage problem using various line voltage conditioning devices. If you have good regulation but the power line disturbance analyzer shows transient voltages, then an isolation/noise- suppression transformer can resolve the problem. If there are both transient and regulation problems, consider power conditioners that can control these problems.

  • Page 49: Available Outlets

    • Line Power Available Outlets All Vanquish modules are equipped with auto-ranging power modules and can operate within the range of 100 V to 240 V, 50/60 Hz. The minimum and maximum voltage tolerances are in accordance with EN60950-1:2001, as follows: “If the equipment is intended for direct connection to the AC main supply, the tolerances on rated voltage shall be taken as +6% and -10% unless the rated voltage is 230 V single phase or 400 V three-phase, in...
  • Page 50 • Line Power IMPORTANT Any Vanquish (U)HPLC System, including the data system hardware, must have a common ground. The interconnected power outlets for the Vanquish (U)HPLC System must have a common point to one ground connector. Connecting the modules of the Vanquish (U)HPLC System to external grounds at different potentials can create a ground loop that causes noise and interference.
  • Page 51 • Line Power Before you install a Vanquish (U)HPLC System, plan your power system. Refer to Table 9 for an example of the number of outlets that your laboratory might require to properly supply power to your Vanquish (U)HPLC System. Item Outlets HPLC System...

  • Page 52: Connecting To Power Sockets

    • Line Power Connecting to Power Sockets CAUTION Never connect a mass spectrometer and a Vanquish (U)HPLC System to the same electrical power socket circuit. TIP The power specifications for the modules in your system might vary from those in this guide. Item Module Outlet 115 V AC Maximum current drawn...
  • Page 53 • Line Power Item Module Outlet 230 V AC Maximum current drawn Binary Pump H Binary Pump F/C Quaternary Pump F/C/CN Binary Pump N Split Sampler HT/FT/CT/C Dual Split Sampler HT/FT Split Sampler N Column Compartment H/C Column Compartment N Diode Array Detector HL Diode Array Detector FG/CG Multi-Wavelength Detector CG...
  • Page 54 • Line Power Destination Plug type Voltage rating Current rating CEE 7/7 250 V AC 10 A 6000.1000 United States NEMA 5-15P 125 V AC 10 A 6000.1001 and Canada United BS 1363 250 V AC 6000.1020 Kingdom Switzerland SEV 1011 250 V AC 10 A 6000.1030...

  • Page 55: Uninterruptible Power Supply

    • Line Power Uninterruptible Power Supply If your local area is susceptible to corrupted power or power disruptions, install an Uninterruptible Power Supply (UPS) in your laboratory. CAUTION For compliance and safety, your uninterruptible power supply (UPS) devices must be certified by recognized domestic and international organizations (for example, UL, CSA, TUV, and VDE).

  • Page 56: Waste And Ventilation

    • Waste and Ventilation 6 Waste and Ventilation This chapter describes the waste and exhaust arrangements for your system. Page 56 Vanquish Manual - Template Operating Manual...

  • Page 57: General

    • Waste and Ventilation General The waste and exhaust arrangements for your Vanquish (U)HPLC System can affect the proper performance of the system. Solvent wastes must be collected and disposed properly. IMPORTANT It is in your responsibility to provide the proper waste and ventilation systems that are required to operate your LC system.
  • Page 58 • Waste and Ventilation Model Vanquish Split Sampler Needle wash and condensation waste HT/FT/CT/C All modules Drain liquid in case of leakage or spilling Table 12: Number of liquid waste lines and possible maximum flow rates for the various Vanquish (U)HPLC modules IMPORTANT Thermo Fisher Scientific recommends that the waste container is placed in a secondary containment vessel large enough to hold 110% the volume of the waste container itself.

  • Page 59: Vanquish Charged Aerosol Detectors

    • Waste and Ventilation Vanquish Charged Aerosol Detectors 6.2.1 Ventilation Requirements Exhaust gases (including carrier gas, vaporized eluent and solute micro particles) exit from the instrument through an external vent. This gas outlet is located on the rear panel of the instrument. It must be connected to a fume hood or a similar venting device with the plastic tubing (20 mm diameter) included in the accessories kit.

  • Page 60: Solvents

    • Solvents 7 Solvents This chapter describes the recommendations for your solvent purity. Page 60 Vanquish Manual - Template Operating Manual...
  • Page 61 • Solvents IMPORTANT You are responsible for providing the high-purity solvents that are required to operate the Vanquish (U)HPLC System. We recommend the use of (U)HPLC- or LC/MS-grade solvents and additives only. The installation of a Vanquish (U)HPLC System requires HPLC-grade methanol and water.

  • Page 62: Installation

    • Installation 8 Installation This chapter provides an overview of the installation requirements. Page 62 Vanquish Manual - Template Operating Manual...

  • Page 63: Installation Kits

    • Installation Installation Kits NOTICE Prior to installation of the Vanquish (U)HPLC System, make sure to complete all preparations described in the previous chapters. After you have completed your laboratory site preparation, (e)mailed or faxed the Vanquish (U)HPLC system Installation Request (at the beginning of this guide) to your local office for Thermo Scientific products, and received the system, call your Thermo Fisher Scientific office to set an installation date.

  • Page 64: Installation

    • Installation Installation When your new Vanquish (U)HPLC System is on site and it is ready for installation, a field service engineer will install it. TIP You are responsible for replacing any consumables used during the installation. Check with your Sales contact that the required column is available at installation.

  • Page 65: Preventive Maintenance

    • Installation Preventive Maintenance IMPORTANT You are responsible for the routine and preventive maintenance of the Vanquish (U)HPLC System and the data system computer. Regular preventive maintenance is essential. It increases the lifetime of the system, maximizes the uptime of your system, and provides you with optimum system performance.

  • Page 66: Instrument Shipments

    • Instrument Shipments 9 Instrument Shipments This chapter provides information of shipments from the factory. Page 66 Vanquish Manual - Template Operating Manual...
  • Page 67 • Instrument Shipments All electrical and mechanical components of the system are carefully tested before the instruments are shipped from the factory. Forwarding companies specialized in the handling of electronic equipment and delicate machinery ship the Vanquish (U)HPLC System to your site.
  • Page 68 • Instrument Shipments Most systems are shipped EXW Germering, and any damage incurred in shipment is the responsibility of the purchaser and the carrier. However, Thermo Fisher Scientific will assist with claims filing and (billable) repairs if necessary. If the system is shipped CIF or CFR destination and is damaged, Thermo Fisher Scientific files a claim against the carrier.

  • Page 69: Index

    • Index 10 Index Vanquish Manual - Template Operating Manual Page 69...
  • Page 70 • Index accessories ........... 18, 57, 59 lighting ..............41 ship kit ..............28 line power ........... 45, 47, 55 air-conditioning load ..........39 liquid waste ............. 57 Audit Trail messages ..........64, 65 available outlets ............49 messages ............64, 65 minimum vertical height .........
  • Page 71 • Index safety precautions ........... 17 safety symbols ............13 uninterruptible power supply ......... 55 shipments ..............66 shipping containers ..........26 signal words ............13 site preparation ............25 ventilation requirements ........59 solvents ..........19, 17, 60, 63 vibration ..............
  • Page 72 www.thermofisher.com Thermo Fisher Scientific Inc. 168 Third Avenue Waltham Massachusetts 02451...

This manual is also suitable for:

Thermoscientific vanquish uhplc

Table of Contents