Gako UNGUATOR Q Operatng Instructons And Producton Recomendatons page 29

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overheating of the formulation.
In case the basis should not contain any water, the components that are to be melted may
be softened directly in the UNGUATOR® jar on a water bath.
To support cooling off during the mixing process, attaching a cooling jacket/pad on the
outside of the jar for smaller jar sizes or repeating the mixing process for larger jar sizes
might be applicable.
Normal (soft in soft)
The "Normal" and/or "soft-in-soft" (S/S) program may be applied to mix semi-solid
substances in the range of low-viscosity to pasty, e.g. incorporation of formulation
concenrates in bases or mixing two bases.
To ensure a homogeneous processing, you may use UNGUATOR® standard- or disposable
mixing blades.
You may first start with 50% of ointment base and weigh the required substance on top.
Afterwards cover the substance with the remaining base. At a jar size 200ml or greater,
you may also implement multiple layering in order to ensure a faster mixing of the final
formulation.
Suspension <2%
After a pregrinding process has been completet, the "Suspension <2%" program gives you
the opportunity to finalize the formulation with ointment base.
Suspension >2%
Selecting the "Suspension >2%" program you may incorporate solids with a content >2%
homogeneously in an ointment base, e.g. incorporation of zinc oxide,. salicylic acid or
bismuth gallate in ointment base.
To ensure a homogeneous processing we recommend applying a standard mixing blades.
For suspensions with an active ingredient content of more than 2% a pregrinding process
is not required.
You may initially load the jar with approx. 50% of the required ointment base, embedding
the micronized solids afterwards. You may now add the remaining base covering the
active ingredients in order to avoid powder residue sticking on the blade.
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