Weighing Portion Of The Formulation; The Mixing Process - Gako UNGUATOR Q Operatng Instructons And Producton Recomendatons

First, the UNGUATOR® jar cap (small white screw cap) of the UNGUATOR® Jar and then
the UNGUATOR® Jar lid (large red or white screw cap) must be unscrewed from the
UNGUATOR® Jar.
Second, the UNGUATOR® MB is inserted into the UNGUATOR® Jar housing, sliding the
UNGUATOR® Jar down. The UNGUATOR® Jar lid is then slid onto the UNGUATOR® MB
standing in the UNGUATOR® Jar housing and pressed down firmly using both thumbs.
Ensure that the sealing lip of the UNGUATOR® Jar lid opening is not damaged by the
bayonet noses because the ointment may otherwise rise on the UNGUATOR® MB shaft
during the mixing process.
Third, the UNGUATOR® MB is carefully removed from the UNGUATOR® Jar and the
UNGUATOR® Jar lid will be moved all the way in the direction of the Blade. Both parts, i.
e. the UNGUATOR® MB and the UNGUATOR® Jar lid are put down or possibly tarde on the
balance together with the UNGUATOR® Jar.

6.2 Weighing portion of the formulation

Generally, oily, greasy, aqueous and pulverized ingredients can be weighed out into the
UNGUATOR® Jar all at the same time. It is however advantageous to consider certain
general procedures to optimize the mixing results. Generally, know-how gained from the
traditional preparation of ointments is very helpful when using the UNGUATOR® Mixing
System. As already mentioned at the beginning of the operating instructions, true to the
motto:
learning by doing
Listed below are the seven different general procedures used to produce the routine
standard formulations in pharmaceutical preparation of ointments: EMULSION, EMULSION
+, NORMAL, SUSPENSION <2%, SUSPENSION >2% as well as GEL and SUPPOSITORIES.
Due to the rapid heat generation, powder mixtures should be processed only at very low
speed. In the following, these standard formulations will be defined and the recommended
procedure on weighing described. This will produce a code of practice for orientation. This
does not exclude other possible methods for optimization.
For mixtures with high liquid content, ensure that the ointment base on the UNGUATOR®
Jar Bottom is first carefully placed around the sealing lip. This enhances the leak tightness
of the UNGUATOR® Jar when it is filled. For UNGUATOR® Jars of 200ml and up an active
ingredient proportion of less than 5%, of the active ingredient can be filled alternating
with the foundation ointment over two or more levels to speed up vertical intermixture.
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