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Pharmacokinetic models in Alaris® PK Syringe Pump and their parameters
Drug: Diprivan
Model: Marsh (weight adjusted)
Age Limit: 16 years upwards
Unit of Plasma Concentration: μg/ml
Max. Plasma Concentration: 15 μg/ml
Vc = 0.228 x mass
(litres x kg
-1
k
= 0.119 min
10
-1
k
= 0.112 min
12
-1
k
= 0.0419 min
13
-1
k
= 0.055 min
21
-1
k
= 0.0033 min
31
-1
K
= 0.26 min
eo
Reference from the literature: Marsh et al.: Brit J Anaesth 1991, 67, 41-48
Drug : Remifentanil
Model: Minto
Age Limit: 12 years upwards
Unit of Plasma Concentration: ng/ml
Max. Plasma concentration: 20 ng/ml
Vc = 5.1 - 0.0201 x (age-40) + 0.072 x (lbm-55)
V2 = 9.82 - 0.0811 x (age-40) + 0.108 x (lbm-55)
V3 = 5.42
CL
= 2.6 - 0.0162 x (age - 40) + 0.0191 x (lbm - 55)
1
CL
= 2.05 - 0.0301 x (age - 40)
2
CL
= 0.076 - 0.00113 x (age - 40)
3
k
= Cl1 / Vc
10
k
= Cl2 / Vc
12
k
= Cl3 / Vc
13
k
= Cl2 / V2
21
k
= Cl3 / V3
31
k
= 0.595 - 0.007 x (age - 40)
eo
Reference from the literature : Minto et al.: Anesthesiology 1997, 86, 10 - 33
Drug : Sufentanil
Model: Gepts (not weight adjusted)
Age Limit: 12 years upwards
Unit of Plasma Concentration: ng/ml
Max. Plasma concentration: 2 ng/ml
Vc = 14.3 l
-1
k
= 0.0645 min
10
-1
k
= 0.1086 min
12
-1
k
= 0.0229 min
13
-1
k
= 0.0245 min
21
-1
k
= 0.0013 min
31
Reference from the literature : Gepts et al.: Anesthesiology 1995, 83, 1194-1204
Additional : k
calculated with time to peak effect 5.6 min (k
eo
63)
TCI Overview (continued)
-1
)
1000DF00005 Iss. 2
-1
= 0.17559 min
) (reference: Shafer et al Anesthesiology. 1991 Jan;74(1):53-
eo
5/44
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