3DHISTECH Pannoramic 1000 User Manual
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3DHISTECH Pannoramic 1000 User Manual

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Pannoramic 1000
3.0.2
User's Guide
2020/ Sep 9/
Rev. 1
P1000-302-UG-Rev1

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Summary of Contents for 3DHISTECH Pannoramic 1000

  • Page 1 Pannoramic 1000 3.0.2 User’s Guide 2020/ Sep 9/ Rev. 1 P1000-302-UG-Rev1...

  • Page 2: Table Of Contents

    Pannoramic 1000 3.0.2 – User’s Guide Contents Disclaimer........................4 Declaration Of Conformity....................6 Character Formats and Symbols..................7 Notes Regarding Operational Safety................8 Notes on Warranty......................11 Terms and Abbreviations....................12 About this User's Guide....................13 1 Product Description....................14 1.1 Product Overview........................14 1.1.1 Intended Use..............................14...
  • Page 3 Pannoramic 1000 3.0.2 – User’s Guide 5.4 Maintenance tasks........................61 5.4.1 Preventive maintenance..........................61 5.4.2 Refilling the pipetting unit..........................61 5.4.3 Replacing fuses of the main power switch....................63 6 Troubleshooting......................65 6.1 Removing a slide........................66 6.2 Removing a slide/slides from the safety container..............68 7 Transporting Pannoramic®...

  • Page 4: Disclaimer

    IP are the sole properties of the 3DHISTECH Ltd. 3DHISTECH Ltd. is not liable for damage of whatever nature (including, but not limited to, general or specific damage, indirect damage, consequential damage or incidental damage, including the...
  • Page 5 Pannoramic 1000 3.0.2 – User’s Guide Company Address: 3 Öv street 1141 Budapest – HUNGARY Sep 9, 2020 – Rev. 1 3DHISTECH Ltd. 5(74)

  • Page 6: Declaration Of Conformity

    Pannoramic 1000 3.0.2 – User’s Guide Declaration Of Conformity 3DHISTECH Ltd. declares that the product Pannoramic 1000 digital scanner is designed and produced ® with consideration of specified requirements according to the ISO13485 Medical devices. Quality management systems. Requirements for regulatory purposes (ISO 13485:2016).

  • Page 7: Character Formats And Symbols

    Pannoramic 1000 3.0.2 – User’s Guide Character Formats and Symbols Example Words or characters that appear on the screen. These include field names, screen and window titles, push-button and menu names, paths or options. Keys on the keyboard. For example, function keys (such as F11) or the Ctrl+M key combination.

  • Page 8: Notes Regarding Operational Safety

    Pannoramic 1000 3.0.2 – User’s Guide Notes Regarding Operational Safety The below section of this User’s Guide contains information and warnings of a kind that must be followed by owner/operator personnel. Warning and advisory symbols which are used on the base unit of the Pannoramic® 1000 and in the...
  • Page 9 Pannoramic 1000 3.0.2 – User’s Guide Remember to unplug the power cord before you open the Pannoramic® 1000 Disconnect plug! device. Only connect external devices that are safety extra low voltage rated to the Warning! instrument to avoid the risk of electrical shock.
  • Page 10 Pannoramic 1000 3.0.2 – User’s Guide The product is not equipped with protection against hazardous materials (infectious, toxic, radioactive, corrosive substances or other effects damaging to health). Decontaminate infectious materials after use. Dust, specks and humidity may decrease or harm the operating capability of the device. Protect it with dust cover when not in use.

  • Page 11: Notes On Warranty

    Pannoramic 1000 3.0.2 – User’s Guide Notes on Warranty 3DHISTECH Ltd. – as the Product Manufacturer – warrants the Pannoramic® 1000 to be free from faults in material and workmanship at the moment of installation. Defects must be notified immediately on identification and maximum efforts must be undertaken in order to the amount of damage as small as possible.

  • Page 12: Terms And Abbreviations

    Pannoramic 1000 3.0.2 – User’s Guide Terms and Abbreviations Comma Separated Value Field of View Numerical Aperture Virtual Slide / Slide A digital image of a thin glass plate on which specimens are mounted for microscopic study: a dynamic, interactive image that you can manage, save, magnify, zoom, name, evaluate, annotate, mark and comment, send to a colleague electronically for co- operation or advice, and so on.

  • Page 13: About This User's Guide

    Pannoramic 1000 3.0.2 – User’s Guide About this User's Guide About this User's Guide The purpose of this manual is to assist the user in the safe and reliable operation of the product described. Before operating the device, you must carefully read this instruction manual, and adhere...

  • Page 14: Product Description

    Pannoramic 1000 3.0.2 – User’s Guide 1 Product Description 1 Product Description 1.1 Product Overview 1.1.1 Intended Use Pannoramic® 1000 is designed to digitize histology slides using high-numerical aperture objectives through illumination of transmitted light (Brightfield illumination). The target users of the product can work for example, in education, research, industrial, or medical sectors.

  • Page 15: Features And Benefits

    Pannoramic 1000 3.0.2 – User’s Guide 1.1.2 Features and Benefits 1.1.2 Features and Benefits The Pannoramic® 1000 offers world-class brightfield whole slide scanning. An outstanding 0.12 µm/pixel resolution in Brightfield mode is achieved with the 40×/0.95 NA (equivalent to 80×...
  • Page 16 Pannoramic 1000 3.0.2 – User’s Guide 1.1.2 Features and Benefits Software Pannoramic® 1000 Scanner Control software developed for Pannoramic® 1000 • New, flexible, Touch Mode ready[TH1], easy-to-use software user interface • Direct scanning to CaseCenter server • Advanced scanning profile features: •...

  • Page 17: Warning And Information Labels

    Pannoramic 1000 3.0.2 – User’s Guide 1.1.3 Warning and Information Labels 1.1.3 Warning and Information Labels The following figure contains the labels used on the Pannoramic® 1000 main unit. Figure 1 – Warning and information labels NOTE: The symbol refers to the possibility of exposure to biological hazards whenever handling slides.

  • Page 18: Main Parts Of The Device

    Pannoramic 1000 3.0.2 – User’s Guide 1.1.4 Main Parts of the Device 1.1.4 Main Parts of the Device The following figure shows the main outer parts of the base unit. Figure 2 – Main outer parts of the base unit 1.
  • Page 19 Pannoramic 1000 3.0.2 – User’s Guide 1.1.4 Main Parts of the Device The below image shows the main inner components of the base unit. Figure 3 – Main inner components of the base unit 1. Magazine compartment 2. Slide loader/grabber 3.
  • Page 20 Pannoramic 1000 3.0.2 – User’s Guide 1.1.4 Main Parts of the Device Figure 4 – Illumination component of the Pannoramic® 1000 11. PAX 10 FLASH illumination unit Sep 9, 2020 – Rev. 1 3DHISTECH Ltd. 20(74)

  • Page 21: Connector Panel

    Pannoramic 1000 3.0.2 – User’s Guide 1.1.5 Connector panel 1.1.5 Connector panel The following figure details the sub-assemblies of the connector panel. Figure 5 – Sub-assemblies of the connector panel 1. Outlet for controller PC, camera, HUB, and USB cables 2.

  • Page 22: Hardware Options

    Pannoramic 1000 3.0.2 – User’s Guide 1.2.2 Hardware Options 1.2.2 Hardware Options The configuration of the control computer and monitor can vary depending on the product order. Camera Adimec QUARTZ Q-12A180 1 CMOS camera for high-quality Brightfield applications allowing fast scanning Camera adapter 1.6×...

  • Page 23: Control Software

    Pannoramic 1000 3.0.2 – User’s Guide 1.2.2 Hardware Options Objectives Plan-Apochromat 20× / NA 0.8 • Plan-Apochromat 40× Corr / NA 0.95 • C-Apochromat 40× Corr / NA 1.2 (optional) • Warning! Do not change correction collar settings on 40×/NA objectives, if you need it to be set, contact customer service.

  • Page 24: Installation

    Pannoramic 1000 3.0.2 – User’s Guide 2 Installation 2 Installation Warning! The installation of Pannoramic® 1000 must be carried out by a trained professional! In any other case the warranty will be automatically voided. The supplier or distributor is not liable for any damages caused by an installation carried out by an unauthorized person.

  • Page 25: Connectors And Cables

    Pannoramic 1000 3.0.2 – User’s Guide 2 Installation 3. Audio in/out (3.5mm Jack ports) 4. Power on/off button 5. Power supply connector 6. 6× USB port 7. Network ports 8. Dedicated USB-card for CAN communication and preview camera 9. Monitor port 10.

  • Page 26: Preparing Slides And Magazines

    Pannoramic 1000 3.0.2 – User’s Guide 3 Preparing Slides and Magazines 3 Preparing Slides and Magazines You can use both standard and large slides and cover slips that meet the following specifications: Slides Cover slips Length 75.0 to 76.0 mm max.

  • Page 27: Affixing Barcode Stickers To Slides

    Pannoramic 1000 3.0.2 – User’s Guide 3 Preparing Slides and Magazines Caution! Do NOT scratch any circular marker onto the glass surface of a slide, use a soft tip pen instead for marking area of interest. 3.1 Affixing Barcode Stickers to Slides This section describes how to affix barcode stickers to slides.

  • Page 28: Preparing Magazines

    Pannoramic 1000 3.0.2 – User’s Guide 3.1 Affixing Barcode Stickers to Slides The label area (1) is recorded by the preview camera, and can be displayed by the control and viewer software. To affix barcode stickers to slides, do the following: 1.
  • Page 29 Pannoramic 1000 3.0.2 – User’s Guide 3.2 Preparing Magazines Figure 8 – Inserting a standard slide into a magazine Figure 9 – Inserting a large slide into a magazine Warning! Make sure that placing the magazine by reading UP SIDE at the top when inserting standard, or at the left of the magazine when inserting large slides.
  • Page 30 Pannoramic 1000 3.0.2 – User’s Guide 3.2 Preparing Magazines Insert magazines into the device Note: Magazines can be loaded into the device once the control software has been launched. 1. If the door opening button (1) pulsates in green, the door can be opened freely. If the door needs to opened during a running scanning process (while the button is pulsating in purple) or if no process is running at the moment (the button lights in purple), press the button once.
  • Page 31 Pannoramic 1000 3.0.2 – User’s Guide 3.2 Preparing Magazines 4. Once you have inserted all the required magazines, close the door (1) by sliding it to the right. Note: If you are using the Scanner in Wet mode, after closing the door, the system always checks the amount of water remaining in the pipette.

  • Page 32: Software And Workflow

    Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow 4 Software and Workflow Launch control software Run scanner software by double-clicking the icon on the desktop, and the Home View window is opened. Figure 10 – Home View Global settings Click to open Global settings window.
  • Page 33 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow Trigger action to solve parsing-based error – Whenever barcode-based parsing action cannot • be performed because the barcode is missing (or due to barcode reading/identification error), the further slide management operation/task can be set here.
  • Page 34 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow This panel includes the following: In the E-mail host setup section, a SMTP server must be dedicated through which the ◦ software sends mails to the selected recipients. 1. Click to set parameters of the dedicated SMTP server displayed in the Host field.
  • Page 35 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow The Notification options panel serves for managing recipients (users). ◦ Figure 13 – Notification options The Users field lists the users added as recipients. User controls – Click to add a new user to the recipient list, then enter Display name and Address of the recipient.
  • Page 36 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow – External application call setup • Figure 15 – External application call setup This window serves for opening external applications (.exe or .bat) triggered by the selected event (for example, CaseViewer software can be opened after scanning is finished). These calls can run only the following scripts: ◦...
  • Page 37 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow Window mode – The following window modes can be set: – Hidden • – Normal • – Minimized • – Maximized • If you select a parameter in the Pass parameters section, it will be passed on to the software when called.
  • Page 38 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow II. Insert magazines On how to prepare and insert magazines into the device, please read chapter 3 Preparing Slides and Magazines. If the magazines are inserted properly, the LED above/at the side of the slot is lit in white. The status of the corresponding magazine position that is checked is indicated also in the Home View window –...
  • Page 39 CaseCenter. IV. Select Scanning mode There are two scanning modes available for you to select from, if the Pannoramic 1000 device you are using is capable of performing immersion scanning: – Dry •...
  • Page 40 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow – In Wet mode, the level of immersion water available in the pipette is detected by the sensors during initialization, and the measured level is displayed by the software on the pipette icon.
  • Page 41 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow V. Assign Settings cards and Profiles First, select a magazine or multiple magazines with the mouse, then assign a card from the Settings panel and a profile from the Profiles panel to the selected magazine(s). Both panels include general and temporary items.
  • Page 42 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow It is advised to generate several different profiles in advance to create an inventory list from which you can select the matching profile for your slides. After assigning a profile to a selected magazine, click or double click the profile to activate for processing.
  • Page 43 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow VI. Manage slide properties Once you navigated to the Magazine View, the slides of the selected magazine and the set parameters are listed on this panel. Figure 17 – Magazine View Magazine number is displayed on the tab of the Magazine View.
  • Page 44 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow Figure 19 – Editor for Settings card At the Parsing section of the editor panel parsing options of naming, profile, and the • destination folder can be set. Note: A tooltip is displayed when moving the cursor over any of the fields in the Parsing section of the editor, in which an aid is visible for parsing the barcode string.
  • Page 45 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow ▪ ▪ There are four predefined Compression quality types, and a custom settings option on the list: Medium (60%) ◦ Good (80%) ◦ Fine (90%) ◦ Excellent (95%) ◦ Custom by which the quality can be adjusted with the Quality value slider. Greater ◦...
  • Page 46 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow 3. Preview status – Preview is not yet recorded ◦ – Preview image is in the queue ◦ – Preview image is recorded and available ◦ 4. Label area image / Barcode reading status –...
  • Page 47 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow Progress bar that can be expanded and is scrollable, lists detailed process and scanning progress information. Figure 21 – Progress panel VII. Set scanning parameters In Slide View the selected profiles can be parameterized and saved as well if needed.
  • Page 48 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow The barcode and name of the slide are displayed over the preview image. Slide name can be edited here as well if required. If barcode is not read, upon clicking the button the label area will be recorded and the barcode will be identified if barcode reading function is enabled.
  • Page 49 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow If you set 5 for example, one current, two focus levels above and below FOVs are captured. Therefore, it is advised to choose an odd number for the focus levels.
  • Page 50 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow Important! Make sure that the result of detection is acceptable for you. Otherwise set the threshold value manually or append missing areas with the help of Scanned area / Preview tool function located at the preview toolbar.
  • Page 51 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow Preview Areas – The preview image shows the area to be digitized with a light coral colored • mask. Coverslip Detection – Turn On/Off ◦ Figure 25 – Preview Areas Selection Area –...
  • Page 52 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow Custom Areas – Enable manual selection options. If several objects are laid on each ◦ other, the layer order can be modified if necessary by clicking the up or down arrow buttons.
  • Page 53 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow ICC Profile – Select an applicable preset color profile to be used for Brightfield scanning from the drop-down menu. Settings according to the profile has effect on the color set, color temperature, and gamma value of the scanned image.
  • Page 54 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow VIII. Follow-up scanning progress Progress View displays the actual progress in details. Scanning queue is listed where the performed actions can be seen. Figure 27 – Progress View with preview IX.
  • Page 55 Pannoramic 1000 3.0.2 – User’s Guide 4 Software and Workflow The following views are available to select by clicking the buttons at the bottom left corner of the panel: – All events • – Scanned successfully • – Different from planned (non-erroneous event has occurred) •...

  • Page 56: Cleaning And Maintenance

    Warning! If during the operation a possible defect or malfunction of the Scanner is suspected, the user must immediately contact 3DHISTECH Support for service, and the Scanner must be switched off and cannot be further operated.

  • Page 57: Removing The Protective Cover

    Pannoramic 1000 3.0.2 – User’s Guide 5.1 Opening the service door Figure 30 – Service door is opened 5.2 Removing the protective cover Caution! Only instructed persons or service technicians can remove/reattach the cover of the device! 1. Release the four latches at the top of the two cover plates at the back of the device.

  • Page 58: Cleaning Tasks

    Pannoramic 1000 3.0.2 – User’s Guide 5.3 Cleaning tasks 5.3 Cleaning tasks Warning! Dust, specks and humidity may decrease or harm the operating capability of the device. Protect it with dust cover when not in use. Switch the power off before covering it.

  • Page 59: Cleaning The Covers

    Pannoramic 1000 3.0.2 – User’s Guide 5.3.1 Cleaning the covers 5.3.1 Cleaning the covers Before cleaning, switch off the device and pull the plug out. • To clean liquid from the device, use a lint-free cotton cloth. You can moisten the cloth with •...

  • Page 60: Cleaning The Condenser

    Pannoramic 1000 3.0.2 – User’s Guide 5.3.2 Cleaning the stage and the objectives 7. Push the stage back once the cleaning procedure is completed. 8. Use the rubber dust blower pump to blow off dust from the surface of the granite slab.

  • Page 61: Removing Splinters

    Pannoramic 1000 3.0.2 – User’s Guide 5.3.4 Removing splinters 5.3.4 Removing splinters Tools you will need: Tweezers • Soft brush • Follow these steps to clean the Scanner from the splinters: 1. Remove bigger pieces of shattered glass slide with the tweezers.
  • Page 62 Pannoramic 1000 3.0.2 – User’s Guide 5.4.2 Refilling the pipetting unit Figure 34 – B.Braun Omnifix 50 ml syringe 3. Firmly grab the syringe at the top, then pull/tilt it outwards from its seating. Warning! Do NOT turn the syringe upside down, and make sure to hold it so that its tip points downwards during the whole process of emptying and refilling.

  • Page 63: Replacing Fuses Of The Main Power Switch

    Pannoramic 1000 3.0.2 – User’s Guide 5.4.2 Refilling the pipetting unit 4. Empty the syringe entirely. 5. Pump up same type and necessary amount (max. 50 ml) of distilled water by pulling the „knob” of the syringe outwards. 6. Place the syringe back to its seating by placing the nib to its stand first then tilt back the syringe’s neck.
  • Page 64 Pannoramic 1000 3.0.2 – User’s Guide 5.4.3 Replacing fuses of the main power switch 4. Remove insert from the compartment. Figure 38 – Removing the fuse insert 5. Replace fuses, put the insert back into its seating, and push it inwards until you hear a snap, so the lever locks.

  • Page 65: Troubleshooting

    Pannoramic 1000 3.0.2 – User’s Guide 6 Troubleshooting 6 Troubleshooting This section describes the most common troubleshooting solutions for the Pannoramic® products. If any problem arises that does not have solution in this manual, contact the service personnel. The product does not start Power supply is interrupted •...

  • Page 66: Removing A Slide

    Pannoramic 1000 3.0.2 – User’s Guide 6 Troubleshooting Slide status is marked with gray because the slide is moved into the safety container Slide cannot be placed back to its position in the magazine for some reason • If more than 10 slides are moved into safety container, the following error message is •...
  • Page 67 Pannoramic 1000 3.0.2 – User’s Guide 6.1 Removing a slide 3. Open magazine compartment door or service door depending on the position of the slide during the digitization process. 4. First, locate then remove the slide. Warning! If the slide is broken, make sure to remove all pieces completely from the device.

  • Page 68: Removing A Slide/Slides From The Safety Container

    Pannoramic 1000 3.0.2 – User’s Guide 6.2 Removing a slide/slides from the safety container 6.2 Removing a slide/slides from the safety container The safety container serves for storing slides that could not be processed during operation, and were selected not to be placed back to their original positions in the magazines. The container has a capacity of storing a maximum of 10 slides (a sensor detects the amount of slides in the container), and if the container is full, the following message is displayed by the software: “There is too much...

  • Page 69: Transporting Pannoramic® 1000

    Pannoramic 1000 3.0.2 – User’s Guide 7 Transporting Pannoramic® 1000 7 Transporting Pannoramic® 1000 The below sequence of steps demonstrate how to move Pannoramic® 1000 to another location within a building: Caution! The base unit does not have carrying handles for transporting. At least 4 or 6 persons can carry the base unit by holding it by its base plate.

  • Page 70: Using Profiles

    Pannoramic 1000 3.0.2 - User’s Guide 8 Using Profiles 8 Using Profiles Note: Saved profile settings cannot be applied if using a different type of Pannoramic® scanner. The following scan settings are saved in a profile: Multilayer ∙ Output resolution ∙...

  • Page 71: Technical Data

    Pannoramic 1000 3.0.2 – User’s Guide 9 Technical Data 9 Technical Data Dimensions (width × depth × height) Base unit Approx. 1540×902×1004 mm Weight Base unit Approx. 270 kg Ambient conditions Transportation / shipment (packed) Permissible ambient temperature -40 °C to +70 °C...
  • Page 72 Pannoramic 1000 3.0.2 – User’s Guide 9 Technical Data Operating data Intended site closed room facilities Electrical protection class Internal protection degree IP 20 Electrical safety in compliance with EN61010-1:2010, EN61010-2-081:2015, EN61010-2-101:2017 Over-voltage category Electromagnetic compatibility in compliance with EN61326-2-6:2013...
  • Page 73 Pannoramic 1000 3.0.2 – User’s Guide 9 Technical Data Control computer, minimum system requirements Operating System Microsoft Windows 10 64-bit EN Intel Xeon Gold 5120 14C 2.2 GHz 12×8 GB (96 GB) DDR4-2666 rg ECC Hard disk 1+2 TB / 1 TB SSD...

  • Page 74: Index

    Pannoramic 1000 3.0.2 – User’s Guide Index Index Adimec QUARTZ Q-12A180......................22, 72 Barcode..........................23, 27, 28 Brightfield..........................15, 22, 72 CaseCenter............................23 Control software........................23, 59, 66 Focus............................48, 49 Marker............................50, 70 Pannoramic® 1000....................15, 17, 22, 24, 28, 69 Pannoramic® Viewer.........................23 Preview........................25, 28, 49, 50, 51 Scan........................15, 49, 50, 51, 65, 72...

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