CareFusion Alaris PK Plus MK4 8005PK201 Directions For Use Manual page 7

Pharmacokinetic models in Alaris PK Plus Syringe Pump and their parameters
Drug: Diprivan Model: Marsh (weight adjusted)
Age Limit: 16 years upwards
Unit of Plasma Concentration: µg/ml
Max. Plasma Concentration: 15 µg/ml
-1
Vc = 0.228 x mass (litres x kg
-1
k = 0.119 minutes
10
-1
k = 0.112 minutes
12
-1
k = 0.0419 minutes
13
-1
k = 0.055 minutes
21
-1
k = 0.0033 minutes
31
-1
k = 0.26 minutes
eo
Reference from the literature: Marsh et al.: Brit J Anaesth 1991, 67, 41-48
Drug : Remifentanil Model: Minto
Age Limit: 12 years upwards
Unit of Plasma Concentration: ng/ml
Max. Plasma concentration: 20 ng/ml
Vc = 5.1 - 0.0201 x (age-40) + 0.072 x (lbm-55)
V2 = 9.82 - 0.0811 x (age-40) + 0.108 x (lbm-55)
V3 = 5.42
cl1 = 2.6 - 0.0162 x (age - 40) + 0.0191 x (lbm - 55)
cl2 = 2.05 - 0.0301 x (age - 40)
cl3 = 0.076 - 0.00113 x (age - 40)
k = cl1 / Vc
10
k = cl2 / Vc
12
k = cl3 / Vc
13
k = cl2 / V2
21
k = cl3 / V3
31
k = 0.595 - 0.007 x (age - 40)
eo
Reference from the literature : Minto et al.: Anesthesiology 1997, 86, 10 - 33
Drug : Sufentanil Model: Gepts (not weight adjusted)
Age Limit: 12 years upwards
Unit of Plasma Concentration: ng/ml
Max. Plasma concentration: 2 ng/ml
Vc = 14.3 l
-1
k = 0.0645 minutes
10
-1
k = 0.1086 minutes
12
-1
k = 0.0229 minutes
13
-1
k = 0.0245 minutes
21
-1
k = 0.0013 minutes
31
Reference from the literature : Gepts et al.: Anesthesiology 1995, 83, 1194-1204
Additional :
k calculated with time to peak effect 5.6 minutes (k
eo
63)
)
= 0.17559 minutes
eo
1000DF00741 Issue 5
Alaris™ PK Plus Syringe Pump
-1
) (reference: Shafer et al Anesthesiology. 1991 Jan;74(1):53-
6/52
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