Adjusting Compressibility - Agilent Technologies 1100 Series User Manual

Table 1
Using the Pump

Adjusting Compressibility

Adjusting Compressibility
Liquid chromatographic solvents are compressible under pressure. This solvent
compressibility produces a change in flow rate as the pressure changes. To
compensate for this effect, you can use the pump compressibility setting to maintain
a uniform and accurate flow regardless of the system pressure. The compressibility
setting can be accessed by using the Pump Settings button [F1] in the Analysis
screen.
Table 1 lists compressibility values for common solvents used in LC.
Compressibility Values for Common LC Solvents
Solvent Compressibility (10
Acetone 126
Acetonitrile 115
Benzene 95
Carbon tetrachloride 110
Chloroform 100
Cyclohexane 118
Ethanol 114
Ethyl acetate 104
Heptane 120
Hexane 150
Isobutanol 100
Isopropanol 100
Methanol 120
1-Propanol 100
Toluene 87
Water 46
66
-6
per bar)