Toyota Sienna 2010 Owner's Manual page 194

2-4. Using other driving systems
Automatic cruise control cancellation
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The set speed is automatically canceled in any of the following situations.
Actual vehicle speed falls more than 10 mph (16 km/h) below the preset
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vehicle speed.
At this time, the memorized set speed is not retained.
Actual vehicle speed is below 25 mph (40 km/h).
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VSC is activated.
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If the cruise control indicator light flashes
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Turn the "ON-OFF" button off once, and then reactivate the system.
If the cruise control speed cannot be set or if the cruise control cancels
immediately after being activated, there may be a malfunction in the cruise
control system. Have the vehicle inspected by your Toyota dealer.
CAUTION
To avoid operating the cruise control by mistake
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Keep the "ON-OFF" button off when not in use.
Situations unsuitable for cruise control
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Do not use cruise control in any of the following situations.
Doing so may result in control of the vehicle being lost and could cause an
accident resulting in death or serious injury.
In heavy traffic
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On roads with sharp bends
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On winding roads
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On slippery roads, such as those covered with rain, ice or snow
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On steep hills
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