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Promega Maxwell RSC 48 Operating Manual

Rapid sample concentrator
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Maxwell
RSC 48 Instrument
®
Operating Manual
Instructions for Use of Catalog Number AS8500
TM510 | RevISed 10/24

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Summary of Contents for Promega Maxwell RSC 48

  • Page 1 Maxwell RSC 48 Instrument ® Operating Manual Instructions for Use of Catalog Number AS8500 TM510 | RevISed 10/24...

  • Page 2: Table Of Contents

    Table of Contents Introduction ....................5 Maxwell RSC 48 Instrument Extraction Procedure  ......... 5 ® Product Use  ...................... 6 Product Use Limitations  ................. 6 Maxwell RSC 48 Instrument Features  ............6 ® Maxwell RSC 48 Instrument Specifications  ..........7 ® Product Components ...
  • Page 3 Maxwell RSC 48 User Interface ............21 ® ‘Home’ Screen  ....................21 User Interface Settings  .................23 Administrator Settings  ..................29 Operating the Maxwell RSC 48 Instrument .........45 ® Preprogrammed Methods  ................45 Starting a Method  ..................45 Clean Up ......................61 Quantitating with Optional Quantus™ Fluorometer  .........62 Reports ......................66 Running Reports ...
  • Page 4 Technical Manual. e-mail Promega Technical Services if you have questions on use of this system: techserv@promega.com Maxwell® RSC 48 Instrument | TM510 | Revised 10/24...

  • Page 5: Introduction

    Introduction Maxwell RSC 48 Instrument extraction Procedure ® The Maxwell Rapid Sample Concentrator 48 (RSC 48) Instrument provides automated ® nucleic acid extraction for a range of research sample types. The Maxwell RSC 48 Instrument ® is designed for use by laboratory professionals. The extraction methods use sample lysis and binding to paramagnetic particles as the primary separation principle.

  • Page 6: Product Use

    Introduction Product Use The Maxwell RSC 48 Instrument is exclusively designed to be used with Maxwell ® ® reagent kits to perform automated isolation of nucleic acids. The Maxwell RSC 48 Instrument is for research use only. ® Product Use Limitations The Maxwell RSC 48 Instrument is not intended for use with reagent kits other than ®...

  • Page 7: Maxwell ® Rsc 48 Instrument Specifications

    Introduction Maxwell RSC 48 Instrument Specifications ® Processing Time 30–70 minutes (depending on sample type and method) Number of Samples Up to 48 Weight <60lb (<27kg) dimensions (W × d × H) 21 × 21 × 14 inches (533.4 × 533.4 × 355.6mm) Power Requirements 100–240vAC, 50/60Hz, 4A Fuse...

  • Page 8: Inspection

    RSC 48 Instrument, please inspect the package carefully to ® make sure all components are present and that the instrument has not been damaged in shipping. If any item is damaged, contact Promega Technical Services (e-mail: techserv@promega.com). Included components are shown in Figure 1. Figure 1. Maxwell RSC 48 Instrument.

  • Page 9: Precautions

    • do not reuse cartridges, plungers or elution tubes. • If the equipment is used in a manner other than that specified by Promega, the protection provided by the equipment may be impaired. • Keep hands clear of instrument platform as it moves in and out of the instrument.

  • Page 10: Safety Symbols And Markings

    Introduction Safety Symbols and Markings Important Safety Instructions. Save these instructions. Safety Symbols and Markings danger. Hazardous voltage. Risk of danger. Tension dangereuse. Risque electrical shock. de choc électrique. Avertissement. Risque de préjudice Warning. Risk of personal injury to corporel pour l’opérateur ou risque the operator or a safety hazard to the de danger pour l’appareil ou la zone 5294MA.eps...
  • Page 11 It is important to understand and follow all laws regarding the Made in z, 1.0A safe and proper disposal of electrical instrumentation. Please 0V, 2.5A consult your local Promega representative regarding instrument g, 5x20mm 249469 disposal. 050-9800 Rev. D Ce Compliance Marked...

  • Page 12: Environmental Requirements

    Introduction 1.10 environmental Requirements (Operating, Shipping and Storage Conditions) Power Requirements: 100–240vAC, 50/60Hz, 4A Temperature: 4–50°C (shipping/storage), 15–25°C (operation) Humidity: Up to 80% relative humidity, non-condensing Operating Altitude: <2000 meters The Maxwell RSC 48 Instrument is intended for indoor use only. Wipe up spills immediately. ®...

  • Page 13: Hardware Overview

    Hardware Overview Figure 2. Front of the Maxwell RSC 48 Instrument. ® Figure 3. Side and Rear views of the Maxwell RSC 48 Instrument. Panel A. The side of the instrument showing ® the On/Off switch and the three-port USB hub for accessories such as the Bar Code Reader. Panel B. The rear of the instrument showing the power cable connector and USB communication port for the Tablet PC.
  • Page 14 Hardware Overview Figure 4. Magnetic assembly components and platform. The hardware components inside the Maxwell RSC 48 ® Instrument. The magnet and plunger bars, which are used for sample processing, and the platform, which holds the deck trays, are evident. Maxwell®...

  • Page 15: Unpacking The Maxwell ® Rsc 48 Instrument

    Unpacking the Maxwell RSC 48 ® Instrument Allow 10 minutes to unpack and set up the instrument. Choose a location with sufficient space to be able to see the components and screen. 1. Cut off the straps from shipping box. 2.

  • Page 16: Setting Up The Maxwell ® Rsc 48 Instrument

    Unpacking the Maxwell RSC 48 Instrument ® Setting Up the Maxwell RSC 48 Instrument ® 1. Manually open the instrument door and carefully remove the foam piece from the inside front of the instrument (Figure 7, Panel A). The Maxwell RSC 48 Instrument door is ®...

  • Page 17: Preparing The Maxwell ® Rsc 48 Instrument For Use

    Preparing the Maxwell RSC 48 ® Instrument for Use Setting Up the Tablet PC 1. Remove the Tablet PC from the accessories box. 2. Raise the tablet holder as shown in Figure 9. Figure 9. Tablet PC Holder. 3. Using the 2.5mm Hex Wrench, remove the Tablet Mount Attachment Piece from the top of the tablet holder.
  • Page 18 Preparing the Maxwell RSC 48 Instrument for Use ® 5. Connect the USB Cable to the Tablet PC and plug the other end of the USB Cable to the back of the Maxwell RSC 48 Instrument (Figure 10). ® Figure 10. Connecting the Tablet PC to the back of the Maxwell RSC 48 Instrument.

  • Page 19: Switching On The Maxwell ® Rsc 48 Instrument

    Preparing the Maxwell RSC 48 Instrument for Use ® Switching On the Maxwell RSC 48 Instrument ® Following the unpacking and installation described in Section 4.1, you can connect the Maxwell RSC 48 Instrument to a power outlet. The instrument has two power switches: a ®...

  • Page 20: Shutting Down The Maxwell ® Rsc 48 Instrument

    Preparing the Maxwell RSC 48 Instrument for Use ® Shutting down the Maxwell RSC 48 Instrument ® 4.3.1 Shutting Down the Instrument 1. Shut down the software by pressing the X in the upper left corner of the ‘Home’ screen. From any other screen in the software, touch the Home button at the upper left corner of the screen to return to the ‘Home’...

  • Page 21: Maxwell ® Rsc 48 User Interface

    Maxwell RSC 48 User Interface ® ‘Home’ Screen The ‘Home’ screen is the main launching pad for interaction with the functionalities built into the Maxwell RSC 48 User Interface. The ‘Home’ screen (Figure 13) contains four buttons: ® Pressing the Start button on the Maxwell RSC 48 ‘Home’...
  • Page 22 Maxwell RSC 48 User Interface ® Figure 13. Maxwell RSC 48 software ‘Home’ screen. The Instrument name appears in the title bar of the user ® interface. The following navigation and informational buttons are displayed in the title bar at the top of the user interface screen: Home From any screen other than the ‘Home’...

  • Page 23: User Interface Settings

    Maxwell RSC 48 User Interface ® Portal Error When visible, the Portal icon with a red circle containing an exclamation point indicates that the connection to the Portal software has been lost. Results from the last run will be exported to the Portal software when the connection is restored.

  • Page 24: Instrument Info

    Maxwell RSC 48 User Interface ® Figure 14. Maxwell RSC 48 ‘Settings’ screen. From this screen, various instrument-specific functions can be ® accessed. The Administrator button will be displayed only for Windows user accounts with administrator-level access ® to the Maxwell RSC 48 software.
  • Page 25 Maxwell RSC 48 User Interface ® • Plunger Calibration Value: the calibration value for the plunger bar axis on the Maxwell ® RSC 48 Instrument • Magnet Calibration Value: the calibration value for the magnet bar axis on the Maxwell ®...
  • Page 26 Maxwell RSC 48 User Interface ® 5.2.2 Self Test You can perform a check of instrument functions by touching the Self Test button from the Maxwell RSC 48 ‘Settings’ screen (Figure 16). On touching the Self Test button, the ® Maxwell RSC 48 Instrument will perform a routine test to confirm that instrument functions ®...
  • Page 27 ® process and will generate and display the system report from the Clean Up process. If plungers are not ejected after several cleanup attempts, the operator should contact Promega Technical Services (techserv@promega.com; 1-800-356-9526) to determine the appropriate next steps. Figure 17. Maxwell RSC 48 ‘Settings’...

  • Page 28: Export Logs

    Instrument logs will be exported as a zip file to the path that was specified by the operator. The zip file of the logs should be retrieved from the specified location and sent to a Promega Technical Services representative for further troubleshooting.

  • Page 29: Administrator Settings

    Maxwell RSC 48 User Interface ® Administrator Settings Software settings for the Maxwell RSC 48 software can be accessed by Windows ® ® user accounts with administrator-level access to the Maxwell RSC 48 software using ® the Administrator button on the ‘Settings’ screen. From the ‘Settings’ screen touch the Administrator button to open the ‘Administrator Page’...
  • Page 30 Maxwell RSC 48 User Interface ® Note: If the Administrator button is not visible, log out of the Windows ® operating system with this user and log in with user credentials that have administrator access rights within the Maxwell RSC 48 ®...
  • Page 31 Maxwell RSC 48 User Interface ® 5.3.1 Sample Entry Maxwell RSC 48 has two modes for sample tracking: Portal sample tracking and local sample ® tracking. In Portal mode (see Section 5.3.5, Preferences), all sample tracking information is reported locally in individual run reports in the software, and to the Portal software for tracking of samples between instrument modules.
  • Page 32 Maxwell RSC 48 User Interface ® Figure 23. Maxwell RSC 48 ‘Sample Entry’ screen. Use this screen to configure the bar code information that must ® be entered for each sample prior to performing an extraction method. When Portal software is enabled, Sample ID is a required bar code entry field.
  • Page 33 Maxwell RSC 48 User Interface ® 3. Touch the text box next to “default sanitization duration:” to open the on-screen number pad. enter the number of minutes to be used for Uv sanitization when the Sanitization button on the ‘Home’ screen is touched. Touch the OK button on the on-screen number pad to accept the duration value or touch the Cancel button on the on-screen number pad to discard changes.
  • Page 34 Import new methods using the Select Import Package button. 5.3.4 Importing and Deleting Methods As Promega provides new nucleic acid purification kits for use with the Maxwell ® 48 instrument, new extraction methods can be added to the Maxwell RSC 48 software.
  • Page 35 Maxwell RSC 48 User Interface ® Methods are provided as files with a .package extension. Follow the instructions below to import a method into the Maxwell RSC 48 software. ® 1. Save the method (.package) file on the Tablet PC attached to the Maxwell RSC 48.
  • Page 36 Maxwell RSC 48 User Interface ® ‘Common Settings’ Tab Figure 26. ‘Common Settings’ tab on the ‘Preferences’ screen. From the ‘Common Settings’ tab, the administrator can specify software and export behaviors as well as use of the Vision system camera. Additionally, you can set the approvals required to make changes to sample deck tray layouts retrieved from the Portal software or the Sample Data Import function.
  • Page 37 Maxwell RSC 48 User Interface ® • Auto Export: Report files can be automatically exported to an administrator-defined location at the end of instrument runs. Check the “Auto export” box to enable this function, and then touch the text box below this option to specify the path to which exported results files should be saved.
  • Page 38 Maxwell RSC 48 User Interface ® ‘Alarm Settings’ Tab Figure 27. ‘Alarm Settings’ tab on the ‘Preferences’ screen. From the ‘Alarm Settings’ tab, the administrator can specify whether audible alarms should be played on completion of an extraction run or on error. The ‘Alarm Settings’...
  • Page 39 Maxwell RSC 48 User Interface ® ‘E-mail Settings’ Tab Figure 28. ‘E-mail Settings’ tab on the ‘Preferences’ screen. From the ‘E-mail Settings’ tab, the administrator can specify e-mail server settings, under what conditions e-mail notifications should be sent, and the distribution list to which e-mails should be sent.
  • Page 40 Maxwell RSC 48 User Interface ® On the right side of the screen the administrator can specify under what conditions and to whom e-mail notifications will be sent. Options include: • Send mail when extraction is completed: Check this box to have e-mails automatically sent to the specified e-mail addresses when an extraction run has been completed.
  • Page 41 Portal software and define the server information necessary to connect to the Portal software. Modifications to sample Note: Contact Promega tracking information retrieved from the Portal software (additions or removals of samples to be Technical Services processed) can be set to require User or Administrator approvals in the ‘Common Settings’...

  • Page 42: Audit Records

    Maxwell RSC 48 User Interface ® Once the software-specific information has been entered, touch the Test Connection button to determine whether the Maxwell RSC 48 software can successfully connect to the Portal ® software using the information supplied. A message will be displayed indicating whether the connection was successful.
  • Page 43 Maxwel RSC 48 User Interface l® 1. Touch the Export button on the ‘Audit Records’ screen. 2. Using the Yellow and Red rectangle buttons you can select the folder location (Figure 31) where the method run reports will be saved. The current path is indicated by the yellow rectangles at the top of the ‘export Folder’...

  • Page 44: Instrument Name

    Maxwell RSC 48 User Interface ® 5.3.7 Instrument Name You can define a unique identifying name for the Maxwell RSC 48 Instrument. This name will ® be shown on the title bar of the Maxwell RSC 48 software ‘Home’ screen and will be recorded ®...

  • Page 45: Operating The Maxwell ® Rsc 48 Instrument

    Operating the Maxwell RSC 48 ® Instrument Preprogrammed Methods The preprogrammed methods available for the Maxwell RSC 48 Instrument can be used ® to perform extractions for a variety of sample types. The sample type and type of molecule extracted are determined by the Maxwell RSC or Maxwell FSC reagent kit used.
  • Page 46 Operating the Maxwell RSC 48 Instrument ® Figure 33. Maxwell RSC 48 ‘Home’ screen. Selecting the Start button begins the process of running an extraction ® method on the Maxwell RSC 48 Instrument. ® 6.2.1 Portal Mode If the instrument is in Portal mode, the ‘Scan Trays’ screen will be displayed (Figure 34, Panel A). Touch the appropriate text box and scan the bar code on the top of the specified deck tray.

  • Page 47: Local Mode

    Operating the Maxwell RSC 48 Instrument ® When starting a new method follow the instructions below for Local Mode to select a method. All kit lot and sample tracking information will have to be entered on the ‘Cartridge Setup’ screen for this run. Figure 34.
  • Page 48 Operating the Maxwell RSC 48 Instrument ® Figure 35. Kit label indicating bar code to scan. Scan the bar code, shown in the upper right of the kit label inside the blue box, to start an extraction run. Figure 36. Selecting a method. Pressing the method line selects the extraction method on the Maxwell RSC 48 ®...
  • Page 49 Upon touching the OK button on the user prompt, the software will return to the ‘Home’ screen. Please contact Promega Technical Services (techserv@promega.com) to get the most up-to-date information on the available methods.
  • Page 50 Operating the Maxwell RSC 48 Instrument ® 3. After selecting an extraction method, you will be presented with the ‘Cartridge Setup’ screen (Figure 38) on which you specify the positions on the Maxwell RSC 48 deck trays ® that will be occupied by cartridges and enter sample tracking information for each sample. each deck tray of 24 samples will be displayed on a separate screen for sample entry.
  • Page 51 Operating the Maxwell RSC 48 Instrument ® Option 2: Sample Import a. To import sample bar code information from an external file, touch the Import button. This will bring up the ‘File’ tab of the ‘Sample data Import’ screen (Figure 39, Panel A). b.
  • Page 52 Operating the Maxwell RSC 48 Instrument ® If sample bar code information is required by the Administrator, but was not present in the imported file, a red exclamation point will be displayed at the top of the cartridge positions missing the required bar code information. The missing information can be entered manually or by importing from an external file containing all of the required sample bar code information.
  • Page 53 Operating the Maxwell RSC 48 Instrument ® Figure 39. Sample Data Import. Panel A. The ‘File’ tab is displayed after touching the Import button. Select the file filter and navigate to the file location where the sample import file is located. Touch the desired blue box file and touch the Open button to open up the ‘Data’...
  • Page 54 Operating the Maxwell RSC 48 Instrument ® 4. After all required information has been entered, touch the Proceed button to display the ‘door’ prompt. Touch the OK button to open the Maxwell RSC 48 Instrument door. ® 5. You will be presented with an ‘Extraction Checklist’ screen (Figure 41). Confirm that the deck trays and instrument have been prepared as indicated on the ‘extraction Checklist’...
  • Page 55 Operating the Maxwell RSC 48 Instrument ® • Completely remove seals from all cartridges. • Place elution tubes at the selected positions in the deck trays. • Add the appropriate volume of elution buffer to each elution tube (see the Maxwell RSC or ®...
  • Page 56 Operating the Maxwell RSC 48 Instrument ® 6. If the vision system is active on your system, when the deck tray is retracted after touching Start, the Vision system will scan the deck trays to confirm deck tray setup. The Vision system will check that cartridges are present at all active cartridge positions, plungers are present at well #8 in the cartridges, elution tubes are present and open for every cartridge Important: The...
  • Page 57 Operating the Maxwell RSC 48 Instrument ® Figure 44. Method ‘Running’ screen. The method ‘Running’ screen is displayed during an extraction method run. This screen indicates what method is currently being run at the top of the screen. Also indicated on this screen are the user who started the run, an approximate indication of when the run will end, a description of the current method step and a progress bar showing the percent completion of the method.
  • Page 58 Operating the Maxwell RSC 48 Instrument ® Figure 45. ‘Protocol Running’ screen after method completion. Upon completion of the currently running extraction method, the progress bar will show 100% completion. The Current Step changes to Completed after a run is finished. After a method is completed you can touch the Open Door button to open the door of the Maxwell RSC 48 Instrument ®...
  • Page 59 Operating the Maxwell RSC 48 Instrument ® Figure 47. Removing the elution tubes and deck trays. After the door is opened, the ‘Report view’ screen (Figure 48) will be presented. If the administrator has required that Uv sanitization be performed after an extraction run, the user will be prompted to confirm that no samples or eluates are present in the instrument prior to the Uv sanitization (see Section 6.7, Sanitizing).
  • Page 60 Contact Promega Technical Services before attempting to repurify samples. Figure 49. ‘Protocol Running’ screen after abort by the user. If a method is aborted by the user, the ‘Protocol Running’...

  • Page 61: Clean Up

    After the Clean Up is successful, you can press the Open Door button and remove the deck tray. If the plunger Clean Up fails, you should contact Promega Technical Services for further assistance. Maxwell® RSC 48 Instrument | TM510 | Revised 10/24...

  • Page 62: Quantitating With Optional Quantus™ Fluorometer

    Operating the Maxwell RSC 48 Instrument ® Quantitating with Optional Quantus™ Fluorometer If an optional Quantus™ Fluorometer is attached to the instrument, results from the Quantus™ Fluorometer can be appended to completed run reports on the Maxwell RSC 48 Instrument. ®...
  • Page 63 Operating the Maxwell RSC 48 Instrument ® 1. Upon completing a Maxwell RSC 48 run, the run report will be displayed (Figure 52). To ® append quantitation data to an existing Maxwell RSC 48 run report, select Results from ® the ‘Home’...
  • Page 64 Operating the Maxwell RSC 48 Instrument ® Figure 53. Optional Quantus measurement. From this screen, select the sample position (black square below the cartridge) for which you would like to quantitate the sample with an optional Quantus™ Fluorometer. Toggle between front and back deck trays using the Front and Back buttons in the lower left corner of the screen.
  • Page 65 Operating the Maxwell RSC 48 Instrument ® Figure 54. ‘Quantus Measurement’ screen. After making a quantitation measurement with the Quantus™ Fluorometer, the quantitation value is displayed to the right of the sample identifier. 8. Press down on the lower right corner of the Quantus™ Fluorometer lid to open the Quantus™...

  • Page 66: Reports

    Operating the Maxwell RSC 48 Instrument ® Figure 55. ‘Quantitation Parameters’ screen. Enter the name of the kit used to quantitate the sample and a description of the standard used for calibration. Reports The ‘Report view’ screen is displayed after the Open Door button is pressed (Figure 56). Run reports can be accessed later by selecting the Results button on the Maxwell RSC 48 ‘Home’...
  • Page 67 Operating the Maxwell RSC 48 Instrument ® Figure 56. ‘Report View’ screen. The ‘Report View’ screen displays the sample tracking and method-specific information for the current instrument run. Included in this report are the sample tracking information recorded prior to starting the method, the final status of the method (Completed or Aborted), the time the method run was started, the length of time the method took to process, the operator ID and additional instrument information.
  • Page 68 Operating the Maxwell RSC 48 Instrument ® Figure 57. Quantitation report tab. The quantitation report tab shows sample quantitation data gathered using the Quantus™ Fluorometer. Using the buttons on the left side of the ‘Report view’ screen, you can: Print reports to a printer that can be accessed by the Tablet PC. Export reports in tab-delimited text file format as well as Microsoft Excel format and/or ®...
  • Page 69 Operating the Maxwell RSC 48 Instrument ® Figure 58. ‘Export Folder’ screen. When the Export button is touched, the user will be asked to navigate to the file location where report files should be saved. Touch the Export button to navigate to the folder location where the report should be exported, and then touch the Save button.

  • Page 70: Running Reports

    Operating the Maxwell RSC 48 Instrument ® Figure 59. Example of an exported text file in the tab-separated format. Running Reports From the ‘Home’ screen (Figure 60) of the user interface, it is possible to view sample tracking reports and service reports on the instrument by pressing the Results button. The ‘Results’ screen displays a listing of the extraction reports for the methods that have been run (Figure 61).
  • Page 71 Operating the Maxwell RSC 48 Instrument ® Figure 60. Maxwell RSC 48 ‘Home’ screen. Selecting Results opens the Maxwell RSC 48 ‘Results’ screen from ® ® which extraction reports from all method runs can be viewed. Figure 61. ‘Results’ screen. The ‘Results’ screen lists the reports from all of the methods that have been run. Touch any report listing to see a detailed view of the report data from that method run.
  • Page 72 Operating the Maxwell RSC 48 Instrument ® Figure 62. Extraction report. An example of the sample tracking information present in an extraction report. Maxwell® RSC 48 Instrument | TM510 | Revised 10/24...

  • Page 73: Sanitizing

    Operating the Maxwell RSC 48 Instrument ® Sanitizing Touch the Sanitize button on the ‘Home’ screen (Figure 63) to perform a Uv sanitization of the instrument. Make sure all samples have been removed from the instrument prior to initiating the Uv sanitization protocol. You will be presented with a sanitization checklist (Figure 64) that informs you on how long the UV sanitization will take.
  • Page 74 Performing Maintenance After Sanitization is completed, you will see one of the following icons in the title bar: Sanitization completed successfully. Touch the icon to view the Sanitization report (Figure 64). An error occurred during sanitization. Touch the icon to view the Sanitization report.

  • Page 75: Cleaning And Maintenance

    Cleaning and Maintenance The Maxwell RSC 48 Instrument has no user-serviceable parts and is designed to require ® minimal maintenance. However, it is important to clean the instrument after every use. If samples or reagents have been spilled, immediately clean the instrument to avoid damage or sample contamination.

  • Page 76: Cleaning The Hardware

    The damp cloth may be wrapped around a magnet to facilitate removal of magnetic particles. 7. If the magnetic rod assemblies cannot be cleaned, please contact Promega Technical Services for assistance. 8. After cleaning the magnetic rod assemblies, replace the front magnetic rod by angling the magnetic rod assembly into the front magnet bar and reattaching the three knob screws.

  • Page 77: Dealing With Spills

    Cleaning and Maintenance dealing with Spills Wipe up any spills immediately. If any material spills in the instrument, wipe up the material using a cloth dampened with 70% ethanol. Note that the reagents contain hazardous materials; therefore dispose of the cleaning materials according to your institutional guidelines. Wipe well once visible material is removed.

  • Page 78: Troubleshooting

    Troubleshooting For questions not addressed here, please contact your local Promega Branch Office or distributor. Contact information available at: www.promega.com. e-mail: techserv@promega.com Symptoms Causes and Comments Clean Up function If plungers are still engaged on the plunger bars, perform the following steps: does not unload the •...
  • Page 79 Open door was detected during operation. The run will be aborted and operation samples will be lost. If error persists, contact Promega Technical Services. Protocol: Aborted By User User aborted the method. An aborted run (due to power failure or other unexpected error) may result in the loss of all the samples.

  • Page 80: Use Of A Usb Flash Drive

    Troubleshooting Use of a USB Flash drive • When using a USB flash drive, insert it before running any method and do not remove it until the method is finished. • Do not insert or remove a USB flash drive while instrument is running. •...

  • Page 81: Instrument Service

    Promega representative for support. visit the Promega website at www.promega.com for the contact information for the Promega branch or distributor nearest you. If further action is required, repair options will be presented and a return authorization number assigned if necessary.

  • Page 82: Repacking The Maxwell ® Rsc 48 Instrument

    RSC 48 Instrument ® Note: If you do not have the original Maxwell RSC 48 Instrument packaging, please contact ® Promega Technical Services or your local Promega representative to order Maxwell RSC 48 ® Instrument packaging. Ship the Maxwell RSC 48 Instrument only with Promega packaging to avoid any damages.
  • Page 83 Instrument Service 4. Place the upper die-cut foam as shown in Figure 68. Figure 68. Placement of upper die-cut foam. 5. Manually move the plunger bar and magnet bar (Figure 69) up to attach the shipping screws. Figure 69. Placement of plastic stoppers. Move the magnet and plunger bars up, and secure the four shipping screws on both sides of the magnet and plunger bars.
  • Page 84 Instrument Service Troubleshooting 7. Insert the front die cut foam into the instrument so that the serrated edge covers the magnet rods (Figure 70). Figure 70. Insert the front die-cut foam. Make sure the serrated edge covers the magnet rods. 8.

  • Page 85: Instrument Disposal

    ® 12. Close the flaps on the shipping container top, and secure them with packing tape. 13. Write the return authorization number provided to you by Promega or your local Promega representative on the outside of the shipping box. Instrument disposal Contact your local Promega Representative for disposal of the instrument.

  • Page 86: Warranties, Service Agreements And Related Products

    Warranties, Service Agreements and Related Products 10.1 Warranty Upon purchase of the Maxwell RSC 48 Instrument, the instrument will be covered by a ® one-year Standard Warranty. The Standard Warranty covers all parts, labor and shipping to and from our depot repair location as well as your choice of a loaner (where available). We will repair your instrument and return it to you performing to original factory specifications.
  • Page 87 ® Maxwell RSC 48 Preventive Maintenance Cat.# SA1356 ® In order to keep the system operation at peak performance, Promega recommends that Maxwell RSC 48 instruments receive a Preventive Maintenance check after 12 months of use. ® During this procedure, our qualified service personnel test the instrument, check parts for wear and replace them as needed.
  • Page 88 This service product must be delivered by a Promega representative who is certified to perform the Installation Qualification. The service product involves a site visit to perform: •...

  • Page 89: Out Of Warranty Service

    (where available) to be used during your instrument’s repair. The instrument is to be safely packed and shipped to Promega at Promega’s expense. Promega will return the repaired or replaced unit to you at Promega’s expense within 3 business days after the repair is complete.

  • Page 90: Certificate Of Decontamination

    Certificate of Decontamination disinfection and decontamination are required prior to shipping the instrument and accessories for repair. Returned Instruments must be accompanied by a signed and dated Certificate of Decontamination, which must be attached to the accessories box inside the instrument packaging.

  • Page 91: Appendix: Configuring The Tablet Pc

    Appendix: Configuring the Tablet PC For use with Windows 10 Tablet PC ® 12.1 Maxwell RSC 48 Instrument and Tablet PC ® The Maxwell RSC 48 Instrument is controlled by Maxwell RSC 48 software on a touch ® ® screen Tablet PC that is provided with the system. This document describes the setup and configuration options for the Tablet PC provided with the Maxwell RSC 48 System.

  • Page 92: Glossary

    Appendix: Configuring the Tablet PC 12.2 Glossary For users who are unfamiliar with the Windows 10 Operating System, this section describes ® terms and actions common to this operating system. ‘Lock’ Screen: Once local Windows user accounts with password protection or network ®...
  • Page 93 Appendix: Configuring the Tablet PC Figure 74. The ‘Desktop’ Screen. At the bottom of the ‘Desktop’ screen is the task bar. Access to the options and settings referenced in this document is provided by the Windows Start, Search, Speaker, Wi-Fi and Keyboard buttons ®...

  • Page 94: Adjusting Volume Settings

    Appendix: Configuring the Tablet PC Accounts Settings Power Figure 75. The Windows Start menu. The left side of the start menu displays buttons for Accounts, Settings and ® Power. 12.3 Adjusting volume Settings volume settings on the Tablet PC can be adjusted through one of two means. 1.

  • Page 95: Configuring Date And Time Settings

    Appendix: Configuring the Tablet PC 12.4 Configuring Date and Time Settings The date and time set on the Tablet PC are used for instrument reports and the instrument run log to indicate when a function was performed on the Maxwell RSC 48 Instrument.

  • Page 96: Setting Date And Time

    Appendix: Configuring the Tablet PC 3. Touch the Time & language button on the ‘Windows Settings’ screen to open the ‘Time & ® language’ screen (Figure 77). Figure 77. ‘Time & language’ screen. Settings for date and time can be modified from this screen. 4.

  • Page 97: Managing Local Windows ® User Accounts

    Operator credentials and access levels for the Maxwell RSC 48 software are controlled ® through assigning accounts in the Windows operating system to one of two Promega access- Note: If the tablet level groups. The sections below detail the process of adding and removing local Windows ®...
  • Page 98 Appendix: Configuring the Tablet PC 12.5.1 Creating Local Windows User Accounts If the Maxwell RSC 48 system is run as a stand-alone device (i.e., not connected to your ® site domain), you can create local Windows user accounts on the Tablet PC for each user of the system.
  • Page 99 Appendix: Configuring the Tablet PC 3. Touch the Accounts button on the ‘Windows Settings’ screen to open the ‘Accounts’ ® screen (Figure 80). Figure 80. ‘Accounts’ screen. Settings related to Windows user accounts can be managed from the ‘Accounts’ ® screen.
  • Page 100 Appendix: Configuring the Tablet PC 4. From the list on the left side of the screen, touch the Family & Other People button to display account settings for this PC (Figure 81). Figure 81. Managing accounts. Windows user accounts can be created, removed and managed from the ‘Family & ®...
  • Page 101 Appendix: Configuring the Tablet PC 6. On the ‘Create an account for this PC’ screen enter the username, password and password hint for the new local user account where indicated. Then touch Next to create the new user account and return to the ‘Accounts’ screen. Note: Touch the Keyboard icon at the bottom right side of the screen to open the on-screen keyboard for typing information into text boxes.
  • Page 102 Tablet PC will not have access to run the Maxwell RSC 48 software unless ® level access in the they have been added to one of the Promega access groups. do not use these instructions to Windows operating ®...
  • Page 103 Appendix: Configuring the Tablet PC Note: Make sure the local Windows user account to be deleted is signed out of the Tablet PC ® (see Section 12.7). 1. Close the Maxwell RSC 48 software if it is open. If not at the ‘Home’ screen, touch the ®...
  • Page 104 Appendix: Configuring the Tablet PC 4. After signing out, sign back into an account with administrator-level access in Windows. 5. From the ‘desktop’ screen, touch the Windows Start button on the left side of the task bar. ® Choose the Settings icon to open the ‘Windows Settings’ screen (Figure 86). Figure 86.
  • Page 105 Appendix: Configuring the Tablet PC 6. Touch the Accounts button on the ‘Windows Settings’ screen to open the ‘Accounts’ screen (Figure 87). Figure 87. ‘Accounts’ screen. Settings related to Windows user accounts can be managed from the ‘Accounts’ ® screen. 7.
  • Page 106 Appendix: Configuring the Tablet PC 8. Under the Other people heading, touch the user account you wish to remove under the Other people heading to open options for that user (Figure 87). Figure 88. Removing an account. Touch any of the listed Windows user accounts to access the ability to remove an ®...
  • Page 107 ® ® folder shown in the list of installed items on the Tablet PC. Touch and hold the Maxwell RSC 48 icon to open the options popup. Panel B. After touching Pin to Start the Maxwell RSC 48 icon will appear to the right of the installed ®...

  • Page 108: Managing Maxwell ® Rsc 48 Access Levels For A Windows ® User Account

    The instructions below detail the steps involved in adding a Windows user account (whether ® local or domain) to one of the Promega access-level groups on the Tablet PC. All Windows ® user accounts that will have access to the Maxwell RSC 48 software must be added to either ®...
  • Page 109 Appendix: Configuring the Tablet PC Figure 90. Accessing Users and Groups. Panel A. Touch the Search button in the task bar and enter lusrmgr.msc into the search text box to bring up the lusrmgr.msc item. Panel B. Touching the lusrmgr.msc item from the search list opens the ‘Local Users and Groups (Local)’...
  • Page 110 Touch the X in the upper right corner of the on-screen keyboard to close the keyboard. Figure 92. Adding users to a Promega group. Panel A. The ‘PromegaAdministrators Properties’ or ‘PromegaUsers Properties’ screen lists the Windows user accounts currently assigned to the specified group.
  • Page 111 Appendix: Configuring the Tablet PC 11. The username(s) that you have assigned to the specified group should now be capable of running the Maxwell RSC 48 software with the specified access level. ® 12. Restart the tablet for new account access levels to take effect. To do this, touch the Windows Start button in the lower left corner of the screen, and then touch the Power ®...
  • Page 112 RSC 48 software are controlled by assigning a Windows ® ® user account to a Promega access-level group. The instructions below detail the steps involved in removing a Windows user account from one of the Promega access-level groups. Once ®...
  • Page 113 Appendix: Configuring the Tablet PC Figure 95. Accessing Users and Groups. Panel A. Touch the Search button in the task bar and enter “lusrmgr.msc” into the search text box to bring up the lusrmgr.msc item. Panel B. Touching the lusrmgr.msc item from the search list opens the ‘Local Users and Groups (Local)’...
  • Page 114 ® ® account you wish to remove from the selected Promega access-level group, and then touch the Remove button. 8. Touch the Remove button to remove this user from this Promega access group. 9. Touch OK on the ‘Properties’ screen to accept the changes, or touch Cancel to discard the changes.

  • Page 115: Managing The Current Active Account

    Appendix: Configuring the Tablet PC Figure 98. Power options popup. Touching the Power button from the ‘Windows Start’ menu opens the Power ® options popup. This popup presents options for managing the Tablet PC power state. 12.7 Managing the Current Active Account To correctly annotate functions in the Maxwell RSC 48 software with the user that performed ®...
  • Page 116 Appendix: Configuring the Tablet PC Figure 99. Account information popup. Accessed from the ‘Windows Start’ menu, the Account information popup ® displays the Windows user accounts on the Tablet PC and enables the current user to Sign out of the Windows ®...

  • Page 117: Shutting Down And Restarting

    Appendix: Configuring the Tablet PC 12.8 Shutting down and Restarting Occasionally you will need to shut down or restart the Tablet PC. The instructions below detail the process of shutting down or restarting the Tablet PC. 1. Close the Maxwell RSC 48 software if it is open.

  • Page 118: Connecting To A Network

    Appendix: Configuring the Tablet PC 12.9 Connecting to a Network The Maxwell RSC 48 Tablet PC can connect to local networks through a Wi-Fi connection. ® If it is desired to connect the Tablet PC to a site network, follow the instructions below. Alternatively, an ethernet Adapter (Cat.# AS8403) is available to directly connect to an ethernet port for access to a network.

  • Page 119: Adding A Network Printer

    Appendix: Configuring the Tablet PC 12.10 Adding a Network Printer From the Maxwell RSC 48 software, you can print reports using a network printer. The printer ® you wish to use with the Maxwell RSC 48 software needs to be located on your network and ®...
  • Page 120 Appendix: Configuring the Tablet PC 4. Touch the Devices button on the ‘Windows Settings’ screen to open the ‘devices’ screen (Figure 103). Figure 103. ‘Devices’ screen. Connecting to a network printer can be performed from the ‘Devices’ screen. The Tablet PC must be connected to a network to access network printers.

  • Page 121: Summary Of Changes

    Products may be covered by pending or issued patents or may have certain limitations. Please visit our Web site for more information. All prices and specifications are subject to change without prior notice. Product claims are subject to change. Please contact Promega Technical Services or access the Promega online catalog for the most up-to-date information on Promega products.
  • Page 122 PROMEGA CORPORATION 2800 WOODS HOLLOW ROAD MADISON, WI 53711-5399 USA TELEPHONE 608-274-4330 • • • www.promega.com • • • • • © 2024 PROMEGA CORPORATION ALL RIGHTS RESERVED PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE TM510 REVISED 10/24...

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