Cleaning And Storage - GE BioProcess LPLC Operating Instructions Manual

6.4

Cleaning and storage

Introduction
This section provides information about cleaning and storing BioProcess LPLC and MPLC
columns when not in use.
Cleaning frequency
It is the responsibility of the user to establish cleaning intervalls and routines in accor-
dance with local regulations, frequency and type of use.
Cleaning of the column should be aimed at prevention rather than cleaning due to
growth or contamination.
Cleaning exterior surfaces
BioProcess LPLC and MPLC columns are designed to be operated in a clean environment.
The external surfaces should not normally accumulate any substantial amount of dust
or dirt.
GE Healthcare recommends using 20% ethanol to clean surface residues from the outside
of the column as required, but particularly after unpacking or performing maintenance
procedures.
Cleaning-in-place (CIP)
The appropriate cleaning-in-place methods for packed BioProcess LPLC and MPLC
columns are determined by the specific chromatography media used.
Please refer to the Chemical Resistance Chart in Chapter 8 Reference information, on
page 94 for information about specific solutions. Avoid any solution that may compromise
the quality of the chromatography media.
LPLC and MPLC Columns Operating Instructions 28-9638-66 AC
6 Maintenance
6.4 Cleaning and storage
89