Bruker Fourier 80 User Manual
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Bruker Fourier 80 User Manual

Bruker Fourier 80 User Manual

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ITEM OPPORTUNITY SYNOPSIS
2024-098
Nuclear Magnetic Resonance (NMR) Spectrometer
North Carolina
Commercially available benchtop nuclear magnetic resonance (NMR)
spectrometer
All standard manufacturing processes required to produce a nuclear
magnetic resonance (NMR) spectrometer scientific instrument capable of
autonomous NMR measurement, data processing, and data extraction.
Manufacturing capabilities may include but are not limited to: injection
molding, metal casting, electronic manufacture and assembly, precise set
up of sensitive analytical equipment, software development accompanying
the extraction of NMR data, and IT construction and development for use
of the instrument and extraction of data.
NMR must be able to fit compactly on a standard-sized scientific
benchtop/workspace. Please see attached product brochure for
commercial specifications. Please see attached specifications document for
required salient characteristics.
Product is a complex scientific instrument intended for the identification,
determination and/ or confirmation of chemical structures, from small and
simple molecules to larger and more complex species, including
possibilities of monitoring reactions and kinetic. The instrument is
controlled via software installed on a computer. Many materials and
processes would be required to replicate the instrument, please see
attached product brochure for more information and image of equipment.
All certifications for laboratory equipment to be utilized in the United
States are applicable.
All regulations for laboratory equipment to be utilized in the United States
are applicable.
All standards and requirements for laboratory equipment to be utilized in
the United States are applicable.
Must be commercially available and fit the salient characteristics
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  • Page 1 ITEM OPPORTUNITY SYNOPSIS Scouting Number: 2024-098 Name of the item to be scouted: Nuclear Magnetic Resonance (NMR) Spectrometer State item to be used in: North Carolina Contract Manufacturer Commercially available benchtop nuclear magnetic resonance (NMR) Please describe the item application/the end use of the item. spectrometer Supplier Information: Type of Supplier Being Sought (select from the list below):...
  • Page 2 US EPA has been quoted $149,568.26 for the supply, initial setup, and 12 month warranty of one (1) Fourier 80 NMR spectrometer manufactured Estimated Target Price/Unit Cost Information: and sold by the Bruker Corporation.
  • Page 3 Fourier 80 ● Spectrometer User Manual Version 003 Innovation with Integrity...
  • Page 4 Product names used are trademarks or registered trademarks of their re- spective holders. © August 12, 2020 Bruker Corporation Document Number: 10000062515 P/N: H172348...

  • Page 5: Table Of Contents

    Contents Contents Introduction............................. Intended Use........................Policy Statement ......................Limitation of Liability......................Warranty Terms ......................Customer Service ......................Product Safety and Electromagnetic Compatibility ............Safety............................... General ........................... Symbols and Conventions ....................System Owner's Responsibility..................Personnel Requirements ....................2.4.1 Qualifications ........................2.4.2 Unauthorized Persons ....................
  • Page 6 Contents Benchtop Installation....................... 25 Connecting to a PC......................29 Connecting to the Mains Supply ..................30 Operation............................31 Starting the Fourier 80 ....................31 Setting Up the Fourier 80....................32 6.2.1 Sample Insertion ......................32 6.2.2 Temperature Stabilization and First Shimming of the System ........34 6.2.3...

  • Page 7: Introduction

    Introduction Introduction This document describes the basic operation of the Bruker NMR spectrometer Fourier 80. In this context, the acronym NMR means Nuclear Magnetic Resonance. The spectrometer is controlled almost entirely via user software, which includes defined workflows for an easy and fast experiment setup.

  • Page 8: Limitation Of Liability

    Introduction Limitation of Liability All specifications and instructions in this manual have been compiled taking into account ap- plicable standards and regulations, the current state of technology and the experience and in- sights we have gained over the years. The manufacturer accepts no liability for damage due to: •...

  • Page 9: Safety

    Safety Safety This section provides an overview of all the main safety aspects involved in ensuring optimal personnel protection, as well as safe and smooth operation. Non-compliance with the action guidelines and safety instructions contained in this manual may result in serious hazards. General There are no user-serviceable parts inside the Fourier spectrometer.
  • Page 10 Safety In this regard, the following requirements should be particularly observed: • The system owner must obtain information about the applicable occupational safety regu- lations, and - in the context of risk assessment - must determine any additional dangers resulting from the specific working conditions at the usage location of the device. The system owner must then implement this information in a set of operating instructions gov- erning operation of the device.

  • Page 11: Personnel Requirements

    Safety Personnel Requirements Only trained Bruker personnel are allowed to mount, retrofit, repair, adjust and dismantle the unit! 2.4.1 Qualifications This manual specifies the personnel qualifications required for the different areas of work, listed below: Laboratory Personnel Laboratory personnel are professionals, technicians, and assistants staffing a research or in- dustrial facility where specimens are synthesized, tested, or evaluated and the results of such measurements are recorded.

  • Page 12: Basic Dangers

    Safety Basic Dangers The following section specifies residual risks which may result from using the device and have been established by means of a risk assessment. In order to minimize health hazards and avoid dangerous situations, follow the safety instruc- tions specified here as well as in the following chapters of this manual.

  • Page 13: Non-Ionizing Radiation

    Safety CAUTION Risk of injury and/or property damage due to the static magnet field! The significant hazard potential within a static magnet field comes from metallic and ferromagnetic objects. They are attracted and can damage the spectrometer, if they attain the magnet bore.

  • Page 14: Hot Materials

    Safety 2.5.5 Hot Materials CAUTION Risk of injury due to hot materials! Some components, accessories (e.g. temperature unit) and/or substances become very hot during operation and, therefore, can cause burns (also irreversible). u Do not touch these components and/or substances during operation! u Handle such components, accessories or substances with utmost caution.

  • Page 15: Emergency Shutoff

    Emergency Shutoff The mains switch on the back of the Fourier 80 consoles serve as an EMERGENCY OFF. If the main switch is not easily accessible due to the placing of the instrument, please pull the power cable from the power plug in case of an emergency.
  • Page 16 Safety 14 / 64 H172348_3_003...

  • Page 17: Packaging, Storage And Transportation

    Installation, initial commissioning, retrofitting, repairs, adjustments or dismantling of the device must only be carried out by Bruker Service or personnel authorized by Bruker. Damage due to servicing that is not authorized by Bruker is not covered by warranty. Symbols on the Packaging The following symbols are affixed to the packaging material.

  • Page 18: Inspection At Delivery

    Packaging, Storage and Transportation Do not Damage Air-tight The packaging is air-tight. Damage to the bar- Packaging rier layer may render the contents unusable. Do not pierce. Do not use sharp objects to open. Component Sensitive to The packaging contains components which Electrostatic Discharge are sensitive to an electrostatic discharge.

  • Page 19: Storage & Transportation

    Packaging, Storage and Transportation Storage & Transportation Climatic Conditions for Storage & Transportation • Store the packages according to the climatic conditions defined in IEC 60721-3-1, classi- fication level 1K21. • For the transportation, it is recommended to comply with the climatic conditions defined in IEC 60721-3-2, classification level 2K11.
  • Page 20 Packaging, Storage and Transportation 18 / 64 H172348_3_003...

  • Page 21: Design And Function

    Design and Function Design and Function This chapter describes the function of the Fourier 80 spectrometer and its components. The spectrometer can be equipped with optional accessories, which enlarge its range of func- tions but also making it look slightly different.

  • Page 22: Pc Hardware

    Design and Function 4.2.1 PC Hardware The Fourier 80 spectrometer is delivered as default with the following workstation • HP MS-Windows PC Mini • HP monitor with touchscreen (23’’) • At least 1920 x 1080 at 60 Hz • At least Windows 10, Intel® Core™ i3 Processor, 16 GB SDRAM; 256 GB SSD Connections 4.3.1...

  • Page 23: Side Panel

    Figure 4.3: Optional Accessories Port Status LED The spectrometer has a status LED located on the front, which can have the following listed color states. Figure 4.4: Location of the Status LED on the Fourier 80 Color Status Description Blue Ready for operation.
  • Page 24 Design and Function The GoScan user software also contains a status indicator. Figure 4.5: Status Indicator in GoScan In TopSpin “Spectrometer running” appears in the status bar and during experiments there is an acquisition status indicator if this is selected in the preferences. Refer to the online help in TopSpin for more information.

  • Page 25: Installation

    Avoid installation in the vicinity of large electromagnetic fields such as overhead lines of a railway line. The Fourier 80 produces only a very small magnetic stray field outside of its housing (< 2 G or 0.2 mT). Therefore, it has no considerable influence on magnetizable material in the vicin- ity of the system.
  • Page 26 Electrical Power Requirements The Fourier 80 needs about 200 W of electrical power from a standard power outlet. Its inter- nal wide-range power supply accepts 110-240 V, 50-60 Hz AC. In case of instabilities of the provision of electricity, an uninterruptable power supply UPS is recommended in order to have a steady temperature regulation of the Fourier 80 magnet.

  • Page 27: Benchtop Installation

    H176415 ple holder, etc. Fourier 80 User Man- Printed Fourier 80 User Manual H172348 Table 5.1: Fourier 80 Standard Benchtop System Components Optional components • Lift truck. CAUTION Risk of injury from lifting heavy objects. The unit is very heavy and may lead to injury when lifting.
  • Page 28 Installation • Use a lift truck to pick up the pallet and raise it to the table height using the foot pump. Note that some lift trucks have a hydraulic system valve, which prevents oil from leaking the lift truck during transportation •...
  • Page 29 Installation Carefully slide the spectrometer onto the table using the handles located on the bottom of the spectrome- ter. Unscrew the handles using an Allen key and remove them from the spectrometer. Tools: 1 x Allen key. 1 x combination wrench P/N H138346. Transport plates.
  • Page 30 Installation The device can now be moved to the desired loca- tion. Turn the adjustable feet counterclockwise down- wards, using an open-end wrench, until the spec- trometer rests level and firmly on the stand. Slide the transport rails out of contact with the table. Clamp the decorative trim on the spectrometer.

  • Page 31: Connecting To A Pc

    Installation Connecting to a PC Connect the network cable to the PC and the Ethernet port labeled SPEC located on the rear side of the spectrometer. On the PC, configure the network interface so that it obtains the configuration from a DHCP server. For details concerning the spectrometer interfaces, ports and/or connectors see section Con- nections...

  • Page 32: Connecting To The Mains Supply

    Installation Figure 5.2: Spectrometer Ethernet Port Connecting to the Mains Supply The spectrometer’s power connector is located on the rear side of the device. • Connect the spectrometer to the mains supply using the delivered power supply cable. For detailed specifications for the power supply see Specifications [} 58].

  • Page 33: Operation

    It is best to wait for the system to stabi- lize overnight. The LED on the front will indicate that the Fourier 80 is ready to be used by turning from orange to blue.

  • Page 34: Setting Up The Fourier 80

    TopSpin is not connected to a spectrometer hardware and, therefore, configures as a data station. In this case, check the LAN or WLAN connection from the PC to the Fourier 80 and the settings of the respective Ethernet adapters of the PC. If the problem is resolved, restart TopSpin.
  • Page 35 Operation Insert the sample until it is submerged in the sample holder. Continue to gently pull the sample down until a slight resistance is felt. Do not go too far, as this may push the cap out so that it hangs in the spinner. Note: Make sure your hands are clean and dry, and grasp the sample tube above the sample level to prevent contamination of the tube.

  • Page 36: Temperature Stabilization And First Shimming Of The System

    Operation Guide the sample holder to the stop in the sample gauge, the sample should now be resting on the bot- tom of the sample gauge. Note that the sample should be filled at least to the to graduation mark. Note on labels: 7 in.

  • Page 37: Re-Shimming The Magnet

    Re-Configuring a Fourier 80 In case, the configuration of a Fourier 80 needs to be updated, cf must be run from the TopSpin command line. This is only needed in case the magnet frequency doesn’t fit the sys- tem any longer.

  • Page 38: Shimming The Sample In Daily Use

    In order to speed up the shim routine, it is recommended to use the shim sample which is provided with the Fourier 80 system. This sample (5% H2O in D2O) gives a single resonance line with a good S/N ratio and has a reasonable fast relaxation time.

  • Page 39: Locking The System

    Operation Locking the System The Fourier 80 uses an external lock sample. This has several beneficial implications. First, no deuterated solvent is needed in the sample. Second, once the system is locked, it is al- ways locked even when no sample is inserted. It also doesn’t need to be re-locked when in- serting a new sample, making the workflow easier and faster.

  • Page 40: Monitoring The Magnet And Shim Temperature

    The system comes with a cleaning kit which allows the user to remove a broken sample tube and spilled out sample from the probe. In case of doubt or if help is needed, contact the Bruker Service. 38 / 64...

  • Page 41: First Proton Spectrum

    Shim Sample using the Fourier parameter set PROTON_f. This experiment can be also be used to check the basic function of a newly installed Fourier 80 spectrometer. For the first Proton spectrum on the Fourier, the shim sample which is delivered with the sys- tem can be used.
  • Page 42 Operation • In the Create New Dataset window, enter or select: NAME = Proton_exp (this is just an example name, you can use any name) EXPNO = 1 Directory = e.g. C:\Data Figure 6.6: Create a New Dataset Directory, NAME and EXPNO define where the new experiment dataset will be stored on the computer: Directory/NAME/EXPNO/ In the example: C:\Data\proton_exp\1 Directory can be selected in the drop-down list, or a new location can be typed in the text...
  • Page 43 Operation • In the Parameters group click Read parameterset and Select to open the rpar window. Figure 6.7: Parameter Sets - rpar • Ensure that the source directory is <Topspin>\exp\stan\nmr\par and not <Topspin>\exp\stan\nmr\par\user • In the table select PROTON_f as experiment and click Set selected item in editor. •...

  • Page 44: Acquisition

    Choose the solvent The Fourier 80 system uses a permanently installed external lock sample. Therefore, the sys- tem stays locked in normal operating conditions. No lock command is required. But the information about the solvent is written into the dataset for reference. If not done al- ready when creating the data set, it can be done at any time using the Solvent tab.

  • Page 45: Processing

    Operation 6.7.1.3 Processing • When the acquisition has finished, click Process on the menu bar. • On the Proc Spectrum button, click the drop-down arrow to see more options. • In the list, select Configure Standard Processing (proc1d). • In the proc1d window, enable the following options: –...

  • Page 46: Turning The Spectrometer Off

    Operation Turning the Spectrometer Off The power switch is located on the back panel of the spectrometer. Pressing the switch turns the spectrometer off. The status LED on the front turns off indicating that the system has been shut down. IN S Figure 6.11: Location of the Power Switch 44 / 64...

  • Page 47: Maintenance

    Maintenance Maintenance The Fourier 80 is a low-maintenance spectrometer. Only perform maintenance procedures described in this section. Maintenance procedures not described herein may only be per- formed by authorized personal and/or the Bruker Service. Bruker does not incur any liability in case of infringements! WARNING Exposure and other health hazards to maintenance personnel.
  • Page 48 Maintenance Remove the filter grill. Remove the old filter. Insert a new filter P/N H176516. Tighten the four screws using a TX20 Torx key. 46 / 64 H172348_3_003...

  • Page 49: Replacing The Bottom Filter

    Maintenance Replacing the Bottom Filter Bottom Filter Housing (P/N H176414) with filter drawer on the bottom front electronic unit. Loosen the screw using a TX10 Torx key. Remove the filter drawer. H172348_3_003 47 / 64...
  • Page 50 Maintenance Pull the metal filter out of the guide. Clean the metal filter with compressed air or replace it with a new one (H176405 F80 HOUSING WIRE FILTER MATTE). Insert the filter and drawer in the unit. Secure the drawer with the screw. 48 / 64 H172348_3_003...

  • Page 51: Troubleshooting

    This chapter describes possible problems relating to the system’s hardware components, their potential causes and recommended solutions. If the recommended solutions do not solve the problem, contact the Bruker Service Hotline. For problems relating to the user software refer to the corresponding help of your software application.
  • Page 52 Troubleshooting 50 / 64 H172348_3_003...

  • Page 53: Replacement Of Parts

    Fourier 80 Cleaning Kit Table 9.1: Spare Parts Replacing the Fuse The Fourier 80 uses a 5 x 20 mm 6.3 A T fuse (P/N 180717). WARNING Risk to life from electrical shock A life-threatening shock may result when the housing is open during operation.
  • Page 54 Replacement of Parts Set mains switch to zero, then unplug the power cord. Pull out the middle slot. Take the fuses out of the holder. Replacement fuses P/N 1801717. 52 / 64 H172348_3_003...
  • Page 55 Replacement of Parts Insert fuse in the slot. Slide the drawer back into the middle bay provided for this purpose. Insert until it is flush again. Reconnect the mains plug and set the mains switch back to position 1. H172348_3_003 53 / 64...

  • Page 56: Returning The Unit For Repair

    Replacement of Parts Returning the Unit for Repair If the Bruker Hotline diagnoses an instrument failure that requires a part to be returned for re- pair, please follow the procedure listed here: 1. Contact your local Bruker office to start the repair process (see Contact). Repair is always handled by your local Bruker office.

  • Page 57: 10 Dismantling And Disposal

    Installation, initial commissioning, retrofitting, repairs, adjustments or dismantling of the device must only be carried out by Bruker Service or personnel authorized by Bruker. Damage due to servicing that is not authorized by Bruker is not covered by warranty. 10.1...

  • Page 58: Disposal In Usa And Other (Non-Eu) Countries

    European directive WEEE 2012/19/EU. Bruker BioSpin offers to take back the equipment (only for deliveries after 23.03.2006) after termination of use at the customer site upon request by the customer. Additional costs for dis- mantling and transport service will apply! Only 100% pre-decontaminated equipment can and will be accepted by Bruker BioSpin.

  • Page 59: 11 Technical Data

    Technical Data 11 Technical Data 11.1 Drawings Figure 11.1: Drawing — Front View (all dimensions in mm) Figure 11.2: Drawing — Top View (all dimensions in mm) H172348_3_003 57 / 64...

  • Page 60: Specifications

    Technical Data 11.2 Specifications In this chapter only hardware-related specifications are listed. For further information con- cerning the user software refer to the corresponding Online Help of the software application used by you. 11.2.1 General Parameter Value/Definition Dimension (L x W x H) 59 x 70 x 51 cm Weight 94 - 96 kg...

  • Page 61: Rating Plate

    Technical Data 11.3 Rating Plate The system’s rating plate is located on its rear side. Figure 11.3: Rating Plate Sample Registration number of WEEE Product number (PN) guideline (Waste of Electrical and Elec- tronic Equipment) Voltage and apparent power con- Serial number (SN) sumption Specifications for the fuses used Engineering Change Level (ECL)
  • Page 62 Technical Data 60 / 64 H172348_3_003...

  • Page 63: 12 Contact

    WEEE DE43181702 Bruker BioSpin Hotlines Contact our Bruker BioSpin service centers. Bruker BioSpin provides dedicated hotlines and service centers, so that our specialists can respond as quickly as possible to all your service requests, applications questions, software or technical needs.
  • Page 66 ● Bruker Corporation info@bruker.com www.bruker.com Order No: H172348...
  • Page 67 Specifications for benchtop NMR 1.0 Background and Justification The US EPA’s Office of Research and Development (ORD) through the National Research Programs has the responsibility of developing and applying state-of-the-art methods, measurements, models, and tools to complex environmental issues. The need to quickly and accurately identify the toxicity from emerging contaminants is a major requirement of many EPA research programs.

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