Electrical Specifications .................... 21 Rating Plate ........................ 21 Introduction............................ 23 Siting Considerations ...................... 24 5.1.1 Environmental Considerations .................. 24 Installation of the minispec mq20 Toothpaste Analyzer............ 26 5.2.1 Unpacking the System ...................... 26 5.2.2 Electronic Control and the Magnet Unit Connections ............ 28 Interpretation of the LEDs .................... 29 5.3.1...
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Contents mq20 Toothpaste Analyzer On Temperature.............. 33 Running minispec Plus Software .................. 33 7.2.1 Daily Check........................ 34 Calibrations ........................ 35 Measurements of Unknown Samples ................ 41 7.4.1 Result Handling......................... 43 Administration Details ....................... 44 More Details........................ 46 minispec.exe Software for Diagnostic and Service Purposes ............. 47 Configuration of minispec.exe................... 47 8.1.1 Wake-up State of the minispec.exe Software .............. 47 8.1.2...
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Contents Index .............................. 83 E1400912_1_001...
Options and accessories may or may not be illustrated in each figure. Policy Statement It is the policy of Bruker to improve products as new techniques and components become available. Bruker reserves the right to change specifications at any time.
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About This Manual WARNING WARNING indicates a hazardous situation, which, if not avoided, could result in death or serious injury. This is the consequence of not following the warning. 1. This is the safety condition. u This is the safety instruction. CAUTION CAUTION indicates a hazardous situation, which, if not avoided, may result in minor or moderate injury or severe material or property damage.
Correct Usage This device and its components may only be used in the way discussed with a BRUKER specialist and in connection with devices or components from other manufacturers which have been approved or recommended by BRUKER.
Note: No other components within the spectrometer should be touched (even with the power off) without first contacting a Bruker service representative to obtain all necessary instructions, to ensure user and spectrometer safety. E1400912_1_001...
Safety Lifting Safety The magnet unit weighs about 85 kg, to ensure safety the follow safety instructions must be followed: CAUTION Risk of injury from lifting heavy objects. The unit is very heavy and may lead to injury when lifting. u Do not attempt to lift the unit over the edge of the carton, remove the carton first.
Safety Figure 2.1: Magnet Stray Field Plot For the mq20 Toothpaste Analyzer the following distances of the 5 Gauss line from the housing of the system apply (refer to figure above): • System front and back panels: 5 Gauss line goes 5 cm out of the box. •...
Safety 2.6.2 Safety When Working with Glassware WARNING Danger of injury from glassware or ceramics breakage! Broken glassware or ceramics may cause minor injuries or material damage, but may also result in a life threatening situation if hazardous substances are used. u If glassware or ceramics breaks, refer to the corresponding precautions and cleaning/ disinfection instructions.
Installation, initial commissioning, retrofitting, repairs, adjustments or dismantling of the device must only be carried out by Bruker Service or personnel authorized by Bruker. Damage due to servicing that is not authorized by Bruker is not covered by your warranty. Symbols on the Packaging The following symbols are affixed to the packaging material.
Transport, Packaging and Storage Do not Damage Air-tight The packaging is air-tight. Damage to the Packaging barrier layer may render the contents unusable. Do not pierce. Do not use sharp objects to open. Component Sensitive to The packaging contains components which Electrostatic Charge are sensitive to an electrostatic charge.
It is recommended to store the packaging for later use in the event that you need to return the unit to Bruker. Handling Packaging Materials Dispose of packaging material in accordance with the relevant applicable legal requirements...
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Transport, Packaging and Storage E1400912_1_001...
Technical Data Technical Data General Information Series Type Weight Length Width Heigth (kg) (cm) (cm) (cm) mq20 Toothpaste Analyzer Table 4.1: Technical Data: General Information All specifications above are without a PC. Weights and dimensions apply to the instruments, not to the packaged systems. Connection Values Grounding is vital for the safe operation of the instrument.
• Pollution degree 2. • Protection class IP20. minispec Software CD Description Manual Bruker Part Number minispec Software CD-ROM The minispec Pre-Installation manual E1405378 (Windows 7/Office 2013). is available as a PDF document on the CD-ROM/memory stick. Table 4.4: Bruker minispec Software-CD E1400912_1_001...
Technical Data Specifications mq20 Toothpaste Analyzer 4.5.1 Weights and Dimensions Electronic Control Unit Magnet Unit Dimensions (W x H x D) in cm 23 x 31 x 60 47 x 31 x 60 Weight (kg) Table 4.5: Weights and Dimensions for mq20 Toothpaste Analyzer 4.5.2 Electrical Specifications minispec mq-Series systems (wideline versions / see corresponding label on back of the unit):...
Introduction Introduction The minispec mq20 Toothpaste Analyzer is a benchtop Nuclear Magnetic Resonance (NMR) analyzer for detection of fluorine ( This manual provides instructions on proper installation of the minispec and an introduction to the use of the minispec hardware and software. Topics covered include: •...
Introduction Siting Considerations Place the units on a strong, level, non-magnetic benchtop surface, capable of supporting their weight (refer to Weights and Dimensions). A minimum distance of 10 cm should be allowed between the back of the Electronic Control Unit and adjacent objects in order to ensure sufficient air-cooling.
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Introduction WARNING Risk to life due to high magnetic fields A magnetic field of more than 0.5 mT (5 Gauss) is life-threatening for people with pacemakers or active metal implants. Exposure to more than 8 T can cause damage to health. Duration of exposure (8 h/day) above the limit of 200 mT can cause damage to health.
Introduction Installation of the minispec mq20 Toothpaste Analyzer The minispec mq-Series consists of 2 units plus a control PC: • Magnet Unit, containing the magnet system and the probe assembly • Electronic Control Unit with the NMR electronics • Standard PC user interface for measurement control, data processing, etc.
Introduction CAUTION Risk of injury from lifting heavy objects. The unit is very heavy and may lead to injury when lifting. u Do not attempt to lift the unit over the edge of the carton, remove the carton first. u Do not attempt to lift the unit on your own or without necessary precaution against injury.
8. Remove and retain the clear plastic dust covers from each component of the minispec and inspect them for damage. 9. If either unit appears to be damaged, contact your BRUKER representative immediately. Due to accessories, consumables or optional units packaging may vary. Bruker will make every effort to deliver the instrument damage free.
Introduction Interpretation of the LEDs Users receive continuous indication of the status of the different units in the form of light emitting diodes (LEDs), which are built into the front panel of the units. 5.3.1 LEDs for the mq20 Toothpaste Analyzer Electronic Control Unit Right LED, connection status indicator: •...
Introduction WARNING Danger of injury due to falling lid The hinged lids may close unexpectedly during probe exchange causing injury to hands or fingers. u Ensure that the gas spring on the outer lid is operating correctly. u The blue inner hinged lid does not have a gas spring, use extreme care when exchanging the probe assembly.
Plus can be opened without first opening the minispec.exe software. However in some cases (like when the system was not shipped from Bruker directly) it might be useful to first run the minispec.exe software to make sure there is a proper network connection from PC to the minispec, then afterwards switch to the minispec Plus program.
2. Connect the PC to the minispec using the blue crossed-wire UTP-cable, which is delivered with the minispec (10-Base-T with RJ45 connectors, see the figures in the section Installation of the minispec mq20 Toothpaste Analyzer [} 26]). 3. Power ON the instrument and computer.
The PC that has been started will pause at the Windows log-in window. When configured by Bruker, no password has been entered and the user may proceed by pressing Enter. The PC will then finish the boot-up process and show the minispec Plus icon on the desktop. Besides the software icon, a link to the “minispec documentation”...
Running the minispec mq20 Toothpaste Analyzer You will now be transferred to the main menu of minispec Plus. Figure 7.2: The minispec Plus Main Menu 7.2.1 Daily Check As a first action, chose to run the Daily Check function to validate the mq20 Toothpaste Analyzer system.
Running the minispec mq20 Toothpaste Analyzer During Daily Check, the system runs a number of tests, all following one after the other. If all the tests passed, the software will indicate this accordingly. The corresponding message will also be displayed in the main menu.
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Running the minispec mq20 Toothpaste Analyzer The user may choose the Calibrate button and proceed to the Calibration menu. Create a new calibration and select a corresponding name. Choose the corresponding Bruker pre-defined method and double-check the number of scans. E1400912_1_001...
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Running the minispec mq20 Toothpaste Analyzer The user may also define a reference sample / standard that can be measured periodically by the instrument. Moreover for the Fluorine in Toothpaste applications the number of scans (NS) and the recycle delay (RD) time may differ in the calibration and in the measurement part. Per default the same numbers are applied.
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Running the minispec mq20 Toothpaste Analyzer Start the calibration and tune the gain with the sample that has the highest NMR signal (typically the sample with the highest mass/highest concentration). After Gain Adjustment one calibration sample after the other is analyzed. Depending on the application one or two parameters are calibrated.
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Running the minispec mq20 Toothpaste Analyzer After the first sample is done, go on with further calibration samples. By default the software requests a minimum of 3 samples per calibration parameter. However often the calibration can be improved by including further samples, for example 5 or 6.
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Running the minispec mq20 Toothpaste Analyzer You might add samples or delete some, depending upon the needs and results of the calibration. As the very last step and when the calibration fulfills the requirements, the calibration is signed. From then on it cannot be modified any further.
Running the minispec mq20 Toothpaste Analyzer Afterwards switch back to the main menu of minispec Plus to start running measurements of unknown samples. Measurements of Unknown Samples When the calibration(s) is(are) finished, one may switch to the “Measurement” section. Here unknown samples are analyzed and measured according to the calibration curve selected by the user.
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Running the minispec mq20 Toothpaste Analyzer • Insert the sample into the NMR as instructed by the software and see the measurement progress. • Once the measurement has completed, the result will be indicated and displayed on the screen in large letters and also on the results list.
Running the minispec mq20 Toothpaste Analyzer 7.4.1 Result Handling As unknown samples have been measured, the results are archived into the minispec Plus data base. Going to “Results” the data can be sorted / selected according to criteria such as time span, user etc.
Running the minispec mq20 Toothpaste Analyzer Exporting to MS-Excel templates are used so that the data is presented in the most clearly arranged way. Administration Details minispec Plus comprises an extensive Administration section. Also for this part counts: the most prominent features for your application should already be factory set and for most of the customers there will be no reason to access this part of minispec Plus.
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Running the minispec mq20 Toothpaste Analyzer Moreover the minispec can be configured, please see the next screenshot. The minispec serial number as well as software installation path can be set. However – if the software runs for instance the Daily Check successfully, then there is no need to do any modification on those settings.
Running the minispec mq20 Toothpaste Analyzer Finally application settings can be defined in minispec Plus – we recommend to approach this only in case your designated application cannot be selected within the calibration section of minispec Plus. More Details For further details on the calibration procedures, measurements, results archiving, administration please refer to the dedicated minispec Plus manuals dealing with those matters in much more detail.
minispec.exe Software for Diagnostic and Service Purposes minispec.exe Software for Diagnostic and Service Purposes The software minispec.exe described in this chapter is typically not used by mq20 Toothpaste Analyzer users. For these users the software minispec.exe is mostly applied only for diagnostic and service purposes.
minispec.exe Software for Diagnostic and Service Purposes Figure 8.1: The Welcome Box Several symbols, entries and buttons are displayed in the Welcome Box: • Applications to be loaded (path and file name in the white field). • Serial number of the minispec to be connected to (here: NE3449). •...
minispec.exe Software for Diagnostic and Service Purposes 8.1.2.2 Changing Analyzer Type and Calibration Permission Use the Customize button in the configuration level (see Selecting Applications and Connections) to open a dialog box. In this window the analyzer type and the calibration permission can be selected by checking the corresponding select box with a mouse click.
minispec.exe Software for Diagnostic and Service Purposes minispec.exe Standard Windows The minispec user interface provides access to all menu functions, parameters, application programs, NMR signal display, and measurement results. In order to provide ready access to commonly needed views of the software operations, the screen is divided into different parts. To facilitate measurement handling and provide easy access to command commands, icon bars have been integrated into the user interface, and windows are available for the control of the measured signal (Signal Window) and the results (Result Window, Statistics Box).
minispec.exe Software for Diagnostic and Service Purposes 8.2.3 The Spreadsheet Window Spreadsheets have a number of functions in the minispec software: • They allow a clear data input for the preparation of a measurement series. • They give a listed view of the measurement results. •...
minispec.exe Software for Diagnostic and Service Purposes minispec.exe Menu Functions The minispec software provides many opportunities for data display, data saving, and measurement handling. This chapter describes all functions that are available when the software is configured as NMR-Analyzer. When the minispec is used only for specialized applications (Fluorine, etc.) many of these functions are unnecessary.
minispec.exe Software for Diagnostic and Service Purposes 8.3.2 The File Menu The list of items in the Menu Bar depends on the active window. If the Signal Window is active, and an application is loaded, all entries are visible. The functions of the menu can be activated by a mouse click, or alternatively, using a keyboard shortcut (Alt + underlined letter).
minispec.exe Software for Diagnostic and Service Purposes The Save command (Save As, Save Copy As) Use the Save command to save the active document to its current name and directory. When you save a document for the first time, the minispec software displays the Save Copy As dialog box for input of a name.
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minispec.exe Software for Diagnostic and Service Purposes You can modify the default data saving behavior using Measured Data Backup every..To include an output of the instrument and acquisition parameter settings, select Settings Print Out in Results Header. These settings are dependent on the minispec applications. The Print Command Use this command to print a document.
minispec.exe Software for Diagnostic and Service Purposes 8.3.3 The Edit Menu The list of commands in the Edit pull-down menu depends on the active window (see figure below). In the following description all commands are included to ensure a complete documentation.
The minispec serial number, which is the host name of the minispec, is used to identify the BRUKER minispec, controlled by the minispec software that is running on a PC in a TCP/IP network. It is recommended to add the IP address of the minispec and its corresponding Serial Number to the Windows ‘hosts‘...
minispec.exe Software for Diagnostic and Service Purposes The Instrument Settings Command Minispec instrument settings (see the figure below) are instrument dependent values such as the pulse lengths and the magnetic field at NMR resonance. Instrument settings differ from minispec to minispec, and must be tuned the first time a minispec is connected. You can use this command to change the settings of the instrument with manual input.
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minispec.exe Software for Diagnostic and Service Purposes An update of the instrument settings can be done periodically to check the instrument validity. An update may be necessary after the system has been relocated or the probe assembly has been changed. An instrument settings update is also recommended if the Daily Check fails. The Update Settings routine is faster than the Tune Settings routine, as it starts from pre- adjusted settings (listed in the current instrument setting table).
After a successful license procedure, the menu entry is checked and grayed. Have ready the minispec instrument's system number (see Status Bar ) and contact BRUKER for information or license numbers. 8.3.5 The Measurement Menu All commands concerning the execution of measurements are concentrated in this menu item (see the figure below).
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minispec.exe Software for Diagnostic and Service Purposes The command Continue is used to leave an intermediate process in order to continue running the minispec application (e.g. during a waiting time, a data acquisition or a fit display). Shortcuts: Standard Tool Bar: Measurement Tool Bar: Keys: ESC The Calibrate Command...
minispec.exe Software for Diagnostic and Service Purposes The Detect raw Signal Command In some cases, for example to adjust the acquisition parameters, it might be helpful to detect the signal without data processing. This command was implemented to execute only the pulse sequence and acquisition without data processing or result output.
minispec.exe Software for Diagnostic and Service Purposes Experiment parameters that can be edited through the Acquisition Parameters menu: Figure 8.11: The Acquisition Parameter Table Scans (1 – 32000) Scans is used to set the number of times the NMR experiment should be repeated for signal averaging before the result is evaluated.
minispec.exe Software for Diagnostic and Service Purposes Mag Cycle Steps (0 - 2048 Steps) The Mag Cycle Steps provides a method of improving the performance of the detection system for multi-scan measurements. Instead of accumulating all scans on resonance, the magnetic field is cycled symmetrically about the resonance in steps, their size depending on the field cycling range and the number of scans.
minispec.exe Software for Diagnostic and Service Purposes 8.3.6.4 The Repetitive Measurement Settings Command Repetitive measurements require several control parameters. When this command is selected, a table appears where the following parameters can be specified: the waiting time in seconds before a repetitive minispec measurement begins, the delay between two successive repetitions, and the maximum number of repetitive measurements.
minispec.exe Software for Diagnostic and Service Purposes – Transmitter power status. – Heater power status. – Electronic Control Unit temperature status (grayed if Control Unit temperature detection is set OFF. – External Gradient Unit status. – Possibility of attenuated and shaped pulses. The entries are marked with a checkmark ( ) when the corresponding item status is OK.
minispec.exe Software for Diagnostic and Service Purposes 4. Fit Info: You can display a window containing all information of a current fit. An active Fit Window is marked with a check mark. The Display Modes Command Different display modes are available for the measurement signal. Possible modes are: Figure 8.14: Display Modes You can activate the desired display mode with a mouse click.
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Note: Zooming, data, distance and marker cursors can only be used exclusively. The Welcome Box Command On the BRUKER minispec program start, the software wakes up with the Welcome Box (see also section Configuration of the Software, the Welcome Box). The Welcome Box offers the possibility of adapting some software settings to the user’s purposes (e.g.
minispec.exe Software for Diagnostic and Service Purposes Some of the functions described might only be available in certain minispec.exe software versions. 8.3.8 The Process Menu The Process item is only displayed when a Signal Window is active. Different commands for data processing are summarized in this pull-down menu: Figure 8.15: The Process Pull-Down Menu Within the context not all commands may be reasonable, in which case they will be grayed.
minispec.exe Software for Diagnostic and Service Purposes 8.3.9 The Window Menu Figure 8.16: The Window Pull-Down Menu Default, Cascade, Tile Horizontal and Tile Vertical Commands You can arrange the windows (see figure) as Cascade in an overlapping fashion, or you may arrange multiple open windows Horizontally or Vertically side by side.
minispec.exe Software for Diagnostic and Service Purposes 8.3.10 The Help Menu For a user friendly handling the minispec software includes a detailed help function. You have the choice of different entries to receive help on your questions (see figure). Green entries in the help text are cross references to related topics.
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minispec.exe Software for Diagnostic and Service Purposes E1400912_1_001...
Basic NMR Principles Basic NMR Principles NMR (Nuclear Magnetic Resonance) is made possible by the properties possessed by some atoms that cause their nuclei (part of every atom) to have a magnetic moment. The atom most commonly investigated by NMR is hydrogen ( H), the nucleus of which is composed of a single proton.
(SFC) measurements. As a consequence such materials as foodstuff, cosmetics, chemical products and much more can be investigated. For a more detailed description refer to the application descriptions available from Bruker. Furthermore, the intensity of the NMR signal is a function of the number of atomic moments contributing to the macroscopic magnetization.
Maintenance 10 Maintenance 10.1 Cleaning Before Cleaning Disconnect the mains cable from the unit before cleaning. Cleaning the Main Unit Use a clean damp cloth to wipe off any residue from the outside of the unit. Wipe off excess moisture immediately with a dry cloth. For non water soluble marks, wipe using a cloth with a few drops of isopropyl alcohol.
Dismantling and Disposal 11 Dismantling and Disposal Following the end of its operational life, the unit can be returned to Bruker for safe disposal. If this is impractical, the unit should be disposed of safely as prescribed by local environmental regulations.
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Dismantling and Disposal E1400912_1_001...
WEEE DE43181702 Bruker BioSpin Hotlines Contact our Bruker BioSpin service centers. Bruker BioSpin provides dedicated hotlines and service centers, so that our specialists can respond as quickly as possible to all your service requests, applications questions, software or technical needs.
Magnet Stray Field Plot ....................Figure 4.1: The minispec MQ-Series Rating Plate................Figure 5.1: The minispec mq20 Toothpaste Analyzer ..............Figure 5.2: The minispec Magnet Unit (left) and Electronic Control Unit (right)......Figure 5.3: Handles on the Side of the Magnet Unit ...............