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Miltenyi Biotec MACSima User Manual

Imaging system
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MACSima™ Imaging System
Hardware user manual

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Summary of Contents for Miltenyi Biotec MACSima

  • Page 1 MACSima™ Imaging System Hardware user manual...
  • Page 2 MACSima™ Imaging System may make copies solely for purposes of training personnel in the use and servicing of the unit within their business or organization. Maximal care has been taken by Miltenyi Biotec in the preparation of this user manual.
  • Page 3 MACSima™ Imaging System User manual Original instructions Issued: 2022-04 140-005-904.02 Miltenyi Biotec B.V. & Co. KG Friedrich-Ebert-Straße 68 51429 Bergisch Gladbach Germany Phone +49 2204 8306-0 Fax +49 2204 85197 macsde@miltenyi.com www.miltenyibiotec.com...
  • Page 4 Before using the MACSima Imaging System, read the chapter Important safety information and all other information contained in this user manual including any safety and operating instructions. Pay special attention to all warnings displayed on the instrument. Failure to read and follow these guidelines could lead to improper or incorrect usage and result in damage to the instrument.

  • Page 5: Table Of Contents

    Content 1 Important safety information 2 Introduction 2.1 Introduction 2.2 Intended use 3 Installation 3.1 Components 3.1.1 Components included in the delivery 3.1.2 Consumables 3.2 Unpacking and installation 4 Switching on and off 4.1 Switching on the instrument 4.2 Switching off the instrument 4.3 Long-term storage 5 Monitoring the instrument 5.1 LED signals...
  • Page 6 7.2.2 Emptying the waste bottle 8 Technical data and specifications 8.1 Technical data and specifications 8.2 EC/EU Declaration of Conformity 8.3 UK Declaration of Conformity 9 Technical support 10 Legal notes 10.1 Limited warranty 10.2 Trademarks...

  • Page 7: Important Safety Information

    • In case of severe accidents, damages to the instrument, or if smoke or flames appear, cut the power supply immediately. • Do not use the instrument if it has been dropped or is damaged. Contact Miltenyi Biotec Technical Support immediately.
  • Page 8 Hazard levels Signal words are used to warn against hazardous situations and property damages. The following signal words are used in this user manual. or WARNING! indicates a hazardous situation that, if not avoided, could result in death or serious injury.
  • Page 9 • Inspect the safety labels and safety markings regularly and replace them if they are not legible or identifiable from a safe viewing distance. • Contact Miltenyi Biotec for replacement labels. Figure 1.1: Hazard areas and safety symbols on the front side of the instrument. The symbol "optical radiation" applies to service...
  • Page 10 Figure 1.2: Hazard areas and safety symbols on the rear side of the instrument. Figure 1.3: Safety symbols in the sample chamber. The symbol "optical radiation" applies to service personnel only.
  • Page 11 • Operate the instrument only from a power source that meets the electrical specifications mentioned on the marking plate. If you have questions about the type of power source to use, contact the Miltenyi Biotec Technical Support or your local electricity supplier.
  • Page 12 • Clean up spilled liquids immediately. • Use only small amounts of cleaning agents on a soft cloth to wipe the instrument. Do not spray or pour liquid cleaning agents onto or into the instrument. Humid and dusty environments A change in the environmental temperature may cause condensation inside the instrument. Humidity, condensation, or dust inside the instrument can cause short circuits.
  • Page 13 • If hazardous or potentially infectious material has been spilled or leaked from the system, decontaminate the affected area. • Do not continue to use contaminated accessories or parts of the instrument. Contact Miltenyi Biotec Technical Support immediately. • Aerosols might leak from the system. Protect mouth and nose if processing hazardous or potentially infectious material that can be transmitted through the air.
  • Page 14 • Do not remove the bottle holders. Thermal hazards HOT SURFACE Hot surfaces can cause burns. Sample container Wrong sample container may become hot if exposed to the LEDs. • Use only MACSwell disposables approved by Miltenyi Biotec for processing samples with the instrument.
  • Page 15 • Only use tables or laboratory benches that support a weight of 200 kg. • Do not install the instrument yourself. • Only trained Miltenyi Biotec personnel or personnel authorized by Miltenyi Biotec is allowed to install the instrument. ERGONOMIC HAZARD Risk of tearing or straining muscles.
  • Page 16 Disposal WASTE OF ELECTRICAL AND ELECTRONIC EQUIPMENT (WEEE) CUSTOMER INFORMATION Dispose of your end-of-life Miltenyi Biotec products in accordance with the applicable WEEE and hazardous waste disposal legislation, which may differ by country or region. Electrical equipment may contain hazardous substances that may have a serious detrimental effect on the environment and/or human health.

  • Page 17: Introduction

    One single sample can be stained with several fluorescence markers in each cycle and sequentially with up to several hundred fluorescence markers. The MACSima Imaging System is for research use only in laboratory environment. It is to be used by laboratory professional users only.
  • Page 18 Figure 2.2: The MACSima Imaging System, rear side.

  • Page 19: Installation

    Components included in the delivery Component MACSima Imaging System 1 × bottle closure for MACSima System Buffer and empty bottle 1 × bottle closure for MACSima Running Buffer and empty bottle 1 × bottle closure for MACSQuant/MACSima Storage Solution and empty bottle 1 ×...

  • Page 20: Consumables

    Before installation, ensure that your site is properly prepared. The instrument must be installed on the MACSima Table or a standard laboratory tables that can carry a weight of at least 200 kg and is certified by Miltenyi Biotec. Allow a minimum of 15 cm free space to the rear side and both sides of the instrument. Allow a minimum of 100 cm free space in front of the instrument.

  • Page 21: Switching On And Off

    Switching on and off Switching on the instrument 1 Switch on the instrument. The power switch is located on the rear right side of the instrument when viewed from the front. 2 Tap the screen to boot the instrument and start the MACS iQ View Control Software. Switching off the instrument Under normal circumstances it is unnecessary to switch off the instrument.

  • Page 23: Monitoring The Instrument

    Monitoring the instrument LED signals LED color Description Instrument is switched off Instrument is in standby mode Green Instrument is turned on or booting Table 5.1: Signals of the LED lamp on the monitor. Door handle illumination Illumination color and pattern Description White, continuous Door is fully open...

  • Page 25: Preparing The Instrument

    2 Align the rear side of the frame with the rack position and press the front side down until you hear a click sound. Figure 6.1: The MACSima Imaging System, top side. Inserting a MACSwell 24 Imaging Plate 1 Insert the samples by placing a MACSwell 24 Imaging Plate onto the right and/or the left imaging stage rack positions (Figure 6.1) as defined in the MACS iQ View Control Software.

  • Page 26: Inserting A Reascreen Plate

    3 Make sure the plate is securely in place. Inserting the vials 1 Remove the lid of the MACSima Mixing Vials and the reagent vials. 2 Insert the vials between the antibody stage rack postions as defined in the MACS iQ View Control Software.

  • Page 27: Maintenance

    Maintenance Service the instrument every 6 months. Contact Miltenyi Biotec for support. Cleaning the instrument ELECTRICAL HAZARD Electric shock, short circuit, overheating, fire, and explosion may lead to death or serious injury. Unplug the instrument before cleaning it. Use only small amounts of cleaning agents on a soft cloth to wipe the instrument.

  • Page 28: Emptying The Waste Bottle

    Figure 7.1: The MACSima Imaging System, side view. 7.2.2 Emptying the waste bottle BIOLOGICAL HAZARD Contamination or infection may lead to death or serious injury, depending on the material used. All liquid and solid waste must be considered hazardous. Follow local regulations regarding waste disposal.

  • Page 29: Technical Data And Specifications

    Technical data and specifications Technical data and specifications The MACSima™ Imaging System is labeled as a protection class I device and must be plugged into a grounded power outlet. The instrument is suitable for rated pollution degree 2. This equipment has been tested and found to comply with the limits for a Class A digital device, pursuant to Part 15 of the FCC Rules.
  • Page 30 20% – 80% relative humidity, non-condensing Storage conditions Temperature 5–40 °C Humidity max. 5% – 85% relative humidity, non-condensing Transport conditions Temperature -25–50 °C Humidity max. 85% relative humidity, non-condensing Table 8.1: Technical specifications of the MACSima Imaging System.

  • Page 31: Ec/Eu Declaration Of Conformity

    EC/EU Declaration of Conformity This declaration of conformity is issued under the sole responsibility of the manufacturer: Miltenyi Biotec B.V. & Co. KG Friedrich-Ebert-Straße 68 51429 Bergisch Gladbach Germany This declaration relates exclusively to the machinery in the state in which it was placed on the market, and excludes components which are added and/or operations carried out subsequently by the final user.

  • Page 32: Uk Declaration Of Conformity

    UK Declaration of Conformity This declaration of conformity is issued under the sole responsibility of the manufacturer: Miltenyi Biotec B.V. & Co. KG Friedrich-Ebert-Straße 68 51429 Bergisch Gladbach Germany This declaration relates exclusively to the machinery in the state in which it was placed on the market, and excludes components which are added and/or operations carried out subsequently by the final user.

  • Page 33: Technical Support

    Technical support For technical support, contact your local Miltenyi Biotec representative or Miltenyi Biotec Technical Support at Miltenyi Biotec headquarters: Miltenyi Biotec B.V. & Co. KG Friedrich-Ebert-Straße 68 51429 Bergisch Gladbach Germany Phone: +49 2204 8306 3803 Email: technicalsupport@miltenyi.com Visit www.miltenyibiotec.com for local Miltenyi Biotec Technical Support contact information.

  • Page 35: Legal Notes

    Miltenyi Biotec group which supplied the product in effect at the date of purchase. Those terms and conditions of sale may vary by country and region. Nothing in this document should be construed as constituting an additional warranty.

  • Page 36: Trademarks

    Miltenyi Biotec’s warranty does not cover products sold AS IS or WITH ALL FAULTS, or which had its serial number defaced, altered, or removed, or any consumables or parts identified as being supplied by a third party. Miltenyi Biotec must be informed promptly if a claim is made under this limited warranty. If a material or...
  • Page 38 Unless otherwise specifically indicated, Miltenyi Biotec products and services are for research use only and not for therapeutic or diagnostic use. MACS, MACSima, MACSQuant, MACSwell, REAscreen and the Miltenyi Biotec logo are registered trademarks or trademarks of Miltenyi Biotec and/or its affiliates in various countries worldwide. All other trademarks mentioned in this publication are the property of their respective owners and are used for identification purposes only.

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