Freeze Dry Rates - Labconco FreeZone Plus Manual

Chapter 1: Introduction
2
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Freeze drying is a process whereby water is removed
from frozen materials by converting the frozen water
directly into its vapor without the intermediate
formation of liquid water. The basis for this
sublimation process involves the absorption of heat by
the frozen sample in order to vaporize the water; the use
of a vacuum pump to enhance the removal of water
vapor from the surface of the sample; the transfer and
deposit of water vapor onto a collector; and the removal
of heat due to ice formation from the collector by
means of a refrigeration system. In essence, the freeze
dry process is a balance between the heat absorbed by
the sample to vaporize the water and the heat removed
from the collector to convert the water vapor into ice.

Freeze Dry Rates

The efficiency of the freeze drying process is dependent
upon the surface area and the thickness of the sample;
the collector temperature and vacuum obtained; the
eutectic point and solute concentration of the sample. It
is important to remember these three factors when
trying to obtain efficient utilization of your freeze dry
system. A listing of selected materials and their
approximate drying times are shown in Table 1 for your
reference.
SAFE TEMPERATURE AND DRYING TIMES
FOR SELECTED MATERIALS
Material Safe
10mm Thick Temperature
°C
Milk -5
Urea -7
Blood Plasma -10 to -25
Serum -25
Vaccinia -30 to -40
Influenza Vaccine -30
Human Tissue -30 to -40
Vegetable Tissue -50
*Total sample quantities are contingent on various freeze dryer capacities.
Table 1
Collector Hours
Temperature (Approx.)
°C
-40 10
-40 10
-40 16
-40 18
-50 22
-50 24
-50 48
-80 60