Bruker AVANCE NEO User Manual
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Bruker AVANCE NEO User Manual

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AVANCE NEO
Site Planning for AVANCE NEO Systems 300-800
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MHz
User Manual
Version 011
NMR
Innovation with Integrity

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Summary of Contents for Bruker AVANCE NEO

  • Page 1 AVANCE NEO Site Planning for AVANCE NEO Systems 300-800 ● User Manual Version 011 Innovation with Integrity...
  • Page 2 Product names used are trademarks or registered trademarks of their re- spective holders. © March 05, 2020 Bruker Corporation Document Number: 10000055448 P/N: H157654...

  • Page 3: Table Of Contents

    Contents Contents Introduction............................. Units Used Within This Manual..................Safety............................... The Magnetic Field ......................2.1.1 Exclusion Zone ....................... 10 2.1.2 Security Zone........................10 2.1.3 The Safety Lines ......................10 2.1.3.1 The 0.5 mT (5 Gauss) Line ..................... 11 2.1.3.2 The 3.0 mT (30 Gauss) Line ................... 11 2.1.4 Standards on Health and Safety in the Workplace ............
  • Page 4 Floor Vibration Guidelines: Bruker EMI Damping System ..........50 7.1.5 Floor Vibration Guidelines: Bruker Nano-C and Nano-D ..........52 7.1.6 Floor Vibration Guidelines: Bruker Nano-C API Damping System ......... 53 Magnetic Environment ....................55 7.2.1 Guidelines for Static Objects................... 55 7.2.2...
  • Page 5 Contents HVAC (Heating Ventilation Air Conditioning) ..............71 8.7.1 Heat Dissipation into the Room ..................72 8.7.2 System Stability ......................73 Emergency Ventilation During Installation and Quenches..........73 8.8.1 Emergency Exhaust Solutions ..................75 Fire Detection System and Fire Extinguishers..............77 Floor Plan ............................
  • Page 6 Contents List of Figures..........................113 List of Tables ..........................115 Index ..............................117 vi / 120 H157654_9_011...

  • Page 7: Introduction

    For specific questions that may not be addressed in this manual, or for further information on a topic, do not hesitate to contact your local Bruker office. Please also review the Installation Questionaire at the end of the manual.

  • Page 8: Table 1.1: Metric To American Conversion Factors

    Introduction Wherever possible both the metric and American (North and South) measure units have been used throughout this manual. In most cases the weights and measures have been rounded upwards where necessary. The following table offers the common metric to American conver- sion factors used in this manual: Measure Metric Units...

  • Page 9: Safety

    It is essential that clear information signs are placed and maintained to effec- tively warn people that they are entering a hazardous area. Please refer to Bruker’s General Safety Considerations for the Installation and Opera- tion of Superconducting Magnets, available from Bruker.

  • Page 10: Exclusion Zone

    Safety Ensure that all loose ferromagnetic objects are outside the 5 Gauss (0.5 mT) field zone of the magnet before the magnet is ramped to field. Human experience and reaction speed are totally inadequate to cope with the extremely nonlinear forces the magnet exerts on iron ob- jects.

  • Page 11: The 0.5 Mt (5 Gauss) Line

    Safety 2.1.3.1 The 0.5 mT (5 Gauss) Line People at particular risk People with active implanted devices, e.g. cardiac pacemakers where an interference with magnetic fields can lead to serious health consequences, are at particular risk. The employer and/or system owner (with reference to the EU directive 2013/35/EU – Chapter II Obligations of Employers, Art.

  • Page 12: Standards On Health And Safety In The Workplace

    ICNIRP and the EU and to study them together with the safety information given in this section and in Bruker manuals. See guide information and links below (Rev. Oct. 2017). • ICNIRP – Info and guidelines to Static Magnetic Fields: http://www.icnirp.org/en/frequencies/static-magnetic-fields-0-hz/index.html...

  • Page 13: Table 2.3: Example Of Maximum Retention Periods

    Safety The next table shows the maximum retention periods within different fringe field regions be- low 5 Tesla for standard precautionary situations. The corresponding spatial regions within and around the super-conducting magnet can be worked out from the fringe-field plots of the magnet being used.

  • Page 14: Transport And Rigging Safety

    Table 2.5: BGV B15 Standards Under Special Conditions for Selected Subgroups Transport and Rigging Safety The following safety notices pertain to the transport and rigging of AVANCE NEO systems: • The magnet should always be transported gently in an upright position.

  • Page 15: Ventilation

    Safety Ventilation Typical NMR superconducting magnets use liquid cryogens as cooling agents. During normal operation of the magnet system it can be expected that a boil-off will occur: • A normal boil-off of liquids contained in the magnet will occur based on the established boil-off specifications.

  • Page 16: Oxygen Level Sensors

    Safety 2.3.3 Oxygen Level Sensors Oxygen (O ) monitors, or level sensors, are required in the magnet room to detect low levels of O due to cryogenic gases. At a minimum the following sensors must be provided: • One oxygen level sensor must be above the magnet, to detect low oxygen levels caused by high helium gas levels.

  • Page 17: Liquid Nitrogen Refills

    Safety 2.4.2 Liquid Nitrogen Refills Keep contact with air at a minimum. When liquid nitrogen is exposed to air, it can con- dense and become as hazardous as liquid oxygen. The pressure relief valve for the nitro- gen vessel should be mounted at all times, even when the vessel is being refilled. Special at- tention is required for the transportation of cryogens by elevator, no one should be al- lowed to be in the elevator with a cryogen dewar.

  • Page 18: Earthquake Safety

    If the installation site is regarded as an earthquake area, please contact Bruker for informa- tion on earthquake securing equipment. Safety from Nearby Construction In a magnet system hazards come basically from two sources: •...

  • Page 19: Emergency Planning

    Safety Emergency Planning Due to the strong magnetic fields and presence of cryogens when using NMR systems, it is important to define and communicate what to do in case of problems or an emergency. An Emergency Plan can be defined as a documented set of instructions on what to do if some- thing goes wrong.
  • Page 20 Safety 20 / 120 H157654_9_011...

  • Page 21: System Components

    System Components System Components This section describes the types and functions of the various sub-systems that are delivered as part of our AVANCE NEO NMR systems. These include the following: • Superconducting Magnet Components [} 21]. • Console and Other System Components [} 22].

  • Page 22: Console And Other System Components

    NMR equipment should be placed. Figure 3.1: Spectrometer and Magnet Control The AVANCE NEO console main cabinet, where the actual NMR data acquisi- tion is performed. The probe, which is designed to hold the sample, transmit radio frequency sig- nals which excite the sample and receive the emitted response.

  • Page 23: Cryoprobe System (Optional)

    System Components CryoProbe System (Optional) The Bruker CryoProbe Accessory for the AVANCE NEO NMR spectrometers offers dra- matic increases in signal to noise ratio, stability, and ease of use. For site planning details for the CryoProbe accessory, refer to CryoProbe and Other Accessories [} 91].

  • Page 24: Cryoprobe Prodigy System (Optional)

    System Components CryoProbe Prodigy System (Optional) The CryoProbe Prodigy is an NMR probe with 5 mm sample diameter. The integrated NMR coil assembly and cryo-preamplifier are cooled with evaporating liquid nitrogen (LN2). These results in a substantial sensitivity enhancement over room temperature (RT) probes. The Prodigy package is comprised of the probe, a control unit (PCU) and a liquid nitrogen vessel, thus siting is easy and no additional infrastructure is required.

  • Page 25: Other Optional Components

    SampleCase is a 24 sample, random-access, automation system that fits al- most all shielded Bruker standard bore magnets. SampleXpress allows automatic measurement of NMR samples with Bruker NMR spectrometers. SampleXpress is controlled by TopSpin or IconNMR, and is equipped with integrated barcode reader registration, which is under control of SampleTrack.
  • Page 26 System Components 26 / 120 H157654_9_011...

  • Page 27: Magnet Access And Rigging

    Magnet Access and Rigging Magnet Access and Rigging The magnet is very heavy and fragile, thus requires special consideration during delivery and movement to its final installation point. The other components of the spectrometer system (console, options, etc.) can typically be removed from the trucks with forklifts and are posi- tioned in the NMR lab with a pallet jack.

  • Page 28: Considerations For Transport To The Nmr Laboratory

    Magnet Access and Rigging Equipment Requirements All rigging equipment required to off-load the magnet system must be selected to handle the size and transport weights of the system. Generally a pallet is integrated in the magnet crate. The top and sides of the crate are re- moved or lifted off the magnet, leaving the pallet under the magnet for transportation into the lab.

  • Page 29: Transport Dimensions And Weights

    Magnet Access and Rigging Transport Dimensions and Weights 4.3.1 Magnet Transport Dimensions Door Dimensions for Magnet Access Crate Size (m) Magnet Transport Dimensions (m) (for transport to the magnet room) Magnet Type Width Un- Height Un- Height Un- crated crated w/o crated with (MHz/mm) Pallet Jack*...

  • Page 30: Table 4.2: Door Dimensions: Wide Bore 89 Mm

    Magnet Access and Rigging Crate Size (m) Magnet Transport Dimensions (m) (for transport to the magnet room) Magnet Type Width Un- Height Un- Height Un- crated crated w/o crated with (MHz/mm) Pallet Jack* Pallet Jack** 300/89 Ascend 1.14 0.93 1.99 0.80 1.60 1.71...

  • Page 31: Magnet Stand Transport Dimensions

    Magnet Access and Rigging 4.3.2 Magnet Stand Transport Dimensions Door Dimensions for Magnet Stand & Accessories Access Accessories Crate Size - including stand if applicable (m) Magnet Stand 300/54 Ascend ULH F80 570 0.97 0.75 1.20 300/54 Ascend ULH F80 700 0.97 0.75 1.20...

  • Page 32: Magnet Transport Weights

    Magnet Access and Rigging Accessories Crate Size - including stand if applicable (m) Magnet Stand 300/89 Ascend F80 770 0.97 0.75 1.20 400/89 Ascend F80 770 0.97 0.75 1.20 500/89 Ascend F80 950 0.97 0.75 1.49 600/89 Ascend F95 950 1.32 0.74 1.31...

  • Page 33: Spectrometer And Accessories Transport Dimensions And Weights

    1.47 Note: The pallet is now integrated into the crate. Weights include pallets and packing material as re- quired. Weights are for a standard AVANCE NEO configuration, actual weights may increase depending on options selected. * Transport width = width indicated + minimum 1 cm clearance on each side. These are the widths if the console is inserted lengthways through the entrance.

  • Page 34: Table 4.11: Crate Dimensions And Weights For Accessories

    Magnet Access and Rigging Crate Size (m) Weight Accessory (kg) LC-NMR Unit, LC-NMR Control Unit (host n/a* n/a* n/a* 50-250 computer), plus any additional options/acces- sories Imaging Cabinet n/a* n/a* n/a* SampleXpress 0.96 0.96 0.52 SampleXpress Lite 0.57 0.69 0.42 SampleJet 1.20 0.80...

  • Page 35: Rigging Equipment

    Magnet Access and Rigging Rigging Equipment Rigging equipment is not included with the NMR system order. The following rigging equip- ment will be needed for a typical delivery and installation of an NMR magnet system: • Pallet Jack and/or Fork Lift: For transporting system magnet and accessories to the lab- oratory.
  • Page 36 Magnet Access and Rigging 36 / 120 H157654_9_011...

  • Page 37: Ceiling Height Requirements

    Ceiling Height Requirements Ceiling Height Requirements The assembly of the magnet system, the magnet energization, and refills with liquid helium require minimum height clearances. • The ceiling height requirements for the magnet installation and cryogen refills do not need to be met over the entire laboratory. The height requirements need only be met immedi- ately above the magnet, over an area to allow for assembly of the lifting system (if appli- cable), and over an area to allow for insertion of the helium transfer line.

  • Page 38: Helium Transfer Line

    Ceiling Height Requirements Helium Transfer Line Figure 5.1: Ceiling Height Requirements Ceiling height must allow for insertion of helium transfer lines. Liquid helium dewar. Ceiling height requirements must be met over this area. Magnet. 38 / 120 H157654_9_011...

  • Page 39: Figure 5.2: Helium Transfer Lines

    Ceiling Height Requirements Figure 5.2: Helium Transfer Lines Refer to the figure above for the following helium transfer line dimensions. Magnets Part Nr. X (mm) Y (mm) Z (mm) V (mm) W (mm) Remarks Ascend 53962 1455 1508 2060 D3XX 29085 1455 1508 2060...

  • Page 40: Minimum Ceiling Height

    BST and Adapter WB -> SB: tant factor for the ceiling height. For special small ceil- ing heights, Bruker has a Bruker Sample Transport (BST) as a 2-piece system available. For all wide bore systems, the minimum ceiling height is calculated to the top of the upper part reduction adapter WB ->...

  • Page 41: Table 5.2: Minimum Ceiling Height Requirements: Standard Bore 54 Mm

    Table 5.4: Minimum Ceiling Height Requirements: Super Wide Bore 154 mm Ceiling Height for Installation Bruker is using different tools to lift the magnet up to the magnet stand. A-Frames and tripods are typically height adjustable. Worst case a magnet system can be lifted from the magnet bottom plate or assembled nearby.
  • Page 42 Ceiling Height Requirements 42 / 120 H157654_9_011...

  • Page 43: Magnetic Fringe Fields

    0.5 mT (5 G) line. For further information on acceptable magnetic field limits contact your countries health authorities or your area Bruker office. Various devices are affected by the magnet and must be located outside the limits specified in the following section.

  • Page 44: Horizontal Fringe Fields

    Magnetic Fringe Fields The accompanying tables in this chapter display the horizontal fringe fields in the radial, di- rection, as well as, the vertical fringe field in the axial direction. Please note all measurements in the following tables are in meters! Horizontal Fringe Fields Magnet Type 0.05 mT...

  • Page 45: Vertical Fringe Fields

    Magnetic Fringe Fields Vertical Fringe Fields Magnet Type 0.05 mT mT (5 mT (2 mT (1 (0.5 G) (50 G) (30 G) (10 G) 300/54 Ascend ULH 0.50 0.55 0.69 0.80 1.00 1.19 1.45 400/54 Ascend 0.64 0.70 0.87 1.00 1.24 1.47 1.77...

  • Page 46: Fringe Field Plots

    Magnetic Fringe Fields Fringe Field Plots Figure 6.1: Example of a Fringe Field Plot 46 / 120 H157654_9_011...

  • Page 47: Environment And Site Survey Measurement

    • Measuring the extent of vibrations at the magnet location is a relatively simple matter; if you suspect a problem you should contact your local Bruker office. • For new constructions, Bruker is enforcing a well established method of thick and large concrete foundations.

  • Page 48: Integrated Isolator Options

    7.1.1 Integrated Isolator Options All Bruker magnets are delivered standard with integrated isolators as follows: • EMI (Elastomeric Isolators) – Standard for 300-500 MHz magnets. • ADI (Air Spring and Damped Isolators) – Standard for 600 MHz magnets, optional for 300-500 MHz magnets.

  • Page 49: Table 7.1: Application And Interpretation Of The Generic Vibration Criterion (Vc) Curves

    Environment and Site Survey Measurement Criterion Amplitude µm/s Description of Use Curve (11µi/s) Barely perceptible vibration. Appropriate to sleep areas in most instances. Usually adequate for computer equipment, hospital recovery rooms. Residential day 200 (8 000) semiconductor probe test equipment, and micro- (ISO) scopes less than 40x.

  • Page 50: Measuring Floor Vibrations

    7.1.3 Measuring Floor Vibrations Bruker offers a service for measuring floor vibrations using specialized hardware and soft- ware. We recommend measurements to be done over a period of at least 1 hour (ideally much longer) to try capturing both steady state conditions and transient events.

  • Page 51: Figure 7.3: Example Of The Bruker Tolerance Level For Elastomer Dampers. Resolution <0.125

    Environment and Site Survey Measurement Figure 7.3: Example of the Bruker Tolerance Level for Elastomer Dampers. Resolution <0.125 Hz, 1… 200 Hz, > 30 min, Average Measurement 1 (displayed in velocity) Figure 7.4: Elastomer Dampers H157654_9_011 51 / 120...

  • Page 52: Floor Vibration Guidelines: Bruker Nano-C And Nano-D

    >20 Hz 12 µm/s 6.4 µm/s Table 7.3: ADI Damping System (Elastomeric Isolators) Figure 7.5: Example of the Bruker Tolerance Level for ADI Dampers. Resolution <0.125 Hz, 1…200 Hz, > 30 min, Average Measurement 1 (displayed in velocity) 52 / 120 H157654_9_011...

  • Page 53: Floor Vibration Guidelines: Bruker Nano-C Api Damping System

    Environment and Site Survey Measurement Figure 7.6: ADI Dampers 7.1.6 Floor Vibration Guidelines: Bruker Nano-C API Damping System API Damping System Figure 7.7: Tolerance Level Nano-C for API Dampers H157654_9_011 53 / 120...

  • Page 54: Figure 7.8: Example Of The Bruker Tolerance Level For Api Dampers. Resolution <0.125 Hz

    According to VDI 2038 (2013) Bruker is following the threshold values of sensitive laboratory equipment. Bruker implemented a Nano-C limit which is less critical as Nano-D. The only big difference in observing these data is to use a higher resolution as only 1/3 octave. We recom- mend to measure with a resolution of <...

  • Page 55: Magnetic Environment

    It must be emphasized however, that such recommendations represent a situation that may not be achievable. Please consult with Bruker for possible solutions if one or more of these recommendations cannot be satisfied.

  • Page 56: Electromagnetic Interference

    If you suspect that you have a source of interference located near the proposed magnet site then you should contact Bruker BioSpin for a site survey. Bruker offers a service for measuring EMF interferences using specialized hardware and soft- ware. We recommend measurements to be done over a period of at least one hour (ideally much longer) to try capturing both steady state conditions and transient events.

  • Page 57: Measuring Dc Fluctuating Fields

    Bruker office for further clarification. 7.3.2.3 Reducing DC Interference Two Bruker technologies help to suppress the DC field perturbations: • Modern magnets with EDS technology (External Disturbance Suppression) efficiently suppress interferences by a factor ~25-1000, depending on the model and disturbance frequency.

  • Page 58: Ac Emf Interference

    Environment and Site Survey Measurement 7.3.3 AC EMF Interference In high resolution NMR AC disturbances in the frequency range of 1Hz to several 100 Hz cause modulation sidebands in NMR spectra, as long as the disturbance frequency is equal to or larger than the line width. As long as these sidebands are small in amplitude they disap- pear in the noise floor.

  • Page 59: Guidelines For Ac Emf Interference

    Figure 7.10: Specification Framework with the Magnetic Field Represented as 0 to Peak Values 7.3.3.3 Reducing AC EMF Interference Two Bruker technologies help to suppress the DC field perturbations: • Modern magnets with EDS technology (External Disturbance Suppression) efficiently suppress AC interferences by a factor ~25-10000, depending on the model and distur- bance frequency.

  • Page 60: Measuring Hf Fluctuating Fields

    Furthermore, the advanced BSMS digital lock system - included with all Bruker AVANCE NEO spectrometers - allows a shift in the 2H lock frequency with certain limits. This may allow enough variation in the absolute magnet field strength to shift the NMR signal away from that of local broadcasting frequencies.

  • Page 61: Utility Requirements

    AVANCE NEO cabinet. Other Power Requirement Considerations • For installation of the AVANCE NEO system a 230V/16A outlet is needed for the turbo- pumps, as well as an additional 230V/16A outlet for the magnet power supply (during in- stallation and service).

  • Page 62: Table 8.1: Requirements Of Basic System (2 Channels)

    USA 0.27 (with cooling) UPS for (CCU) UPS requirements: At least 5 kW for the AVANCE NEO and CCU. UPS for AVANCE UPS requirements: At least 2.6 kW for the spectrometer cabinet NEO Spectrometer (depends on configuration). The battery time must be selected ac- Cabinet cording to the maximum duration anticipated for a power failure.

  • Page 63: System Grounding And Potential Equalization Of Avance Systems

    Utility Requirements 8.1.1 System Grounding and Potential Equalization of Avance Systems In order to ensure a safe handling of the spectrometer under any condition, AVANCE sys- tems must be part of the general potential equalization at the user's site. To establish a complete potential equalization of the whole system, each system is delivered with grounding cables that have to be attached to the console, the HPPR and the magnet as follows: •...

  • Page 64: Telecommunication

    • Telephone/data ports behind the workstation. • Ethernet cable between the AVANCE NEO cabinet and the workstation. Compressed Gas Some components of the AVANCE NEO system and the vibration isolators, which are inte- grated into the magnet legs, operate with compressed gas. 8.3.1...

  • Page 65: Gas Supply

    • 600-800 MHz: Nitrogen gas with >96% purity. Notes: • A nitrogen separator (offered by Bruker as an option) can be built into the spectrometer cabinet as an available solution. This will produce the nitrogen gas required for VT work.

  • Page 66: Other Specifications

    Utility Requirements 8.3.3 Other Specifications Oil Content: Purity: ISO 8573-1 2010 [1:1:0] (oil free). ISO 8573-1:2010 specifies purity classes of compressed air with respect to particles, water and oil independent of the location in the compressed air system at which the air is specified or measured.

  • Page 67: Compressed Air System

    Utility Requirements 8.3.4 Compressed Air System When designing a suitable compressed air system, the following points must be taken into consideration: • To prevent magnetic impurities from entering the magnet use only copper or stainless steel lines. Do not use iron or steel pipes. Plastic piping is unsuitable where very low dew points are required.

  • Page 68: Air Compressors

    The plastic tubing used to carry the supply from the fi- nal gate valve to the console has an outside diameter of 8 mm and is supplied by Bruker. • Some types of dryers, e.g., absorption dryers can use up to 25% of the air flow to regen- erate the drying material.

  • Page 69: Dryers

    Utility Requirements 8.3.4.2 Dryers Refrigeration Dryers This type of dryer removes moisture from gas by cooling to within a few degrees of the freez- ing point of water. The condensed moisture is removed in a separator and drain trap mecha- nism located immediately downstream of the dryer.

  • Page 70: Filters

    Liquid Nitrogen Requirements Purity of Liquid Nitrogen Bruker has no specification for the quality of the liquid nitrogen. Inhouse we are using a purity of >99.9 %. There are no field gradients known because of the para-magnetism of oxygen. Nitrogen and oxygen are fully mixable over the whole concentration range.

  • Page 71: Lighting

    (air-return) closer to the NMR spectrometer equipment (AVANCE NEO console, UPS, CryoCooling unit, BCU-I) that releases most of the heat output into the space. This would help with removing the heat closer to its sources and ultimately help with the overall temperature stability in the room.

  • Page 72: Heat Dissipation Into The Room

    He Compressor CryoProbe - outdoor air-cooled 0.5 kW He Compressor BNL - inside water-cooled 0.5 kW - residual He Compressor BNL - inside air-cooled 2.2 kW Table 8.5: Heat Dissipation into the Room by Typical AVANCE NEO Systems 72 / 120 H157654_9_011...

  • Page 73: System Stability

    Devices (EAPD), which, for example, holds the pressure at 1030 HPa, stabilize field drift and helium boil-off when changes in atmospheric pressure occur. The atmospheric pressure device is available as an option for many Bruker magnets, contact Bruker for details.

  • Page 74: Table 8.6: Total Gas Volume And Maximum He Gas Flow: Standard Bore 54 Mm

    Utility Requirements Total Volume of Gas and Maximum Helium Gas Flow Magnet Type Total Volume of He Maximum He Gas Gas (m Flow (m /min.) 300/54 Ascend ULH 83.6 41.8 400/54 Ascend 75.5 37.8 400/54 Ascend ULH 101.4 50.7 500/54 Ascend 62.9 31.5 500/54 Ascend ULH...

  • Page 75: Emergency Exhaust Solutions

    Utility Requirements • O level sensors: Oxygen level sensors are required to detect low O levels within the laboratory for each system. One sensor is needed above the magnet for detecting low O levels due to He gas exhaust in case of a quench or during He fills. An additional sensor is needed close to the floor for detecting low O levels due to N gas exhaust during mag-...

  • Page 76: Figure 8.4: Emergency Quench Pipes

    Utility Requirements Please contact Bruker if the implementation of quench pipes is planned! Figure 8.4: Emergency Quench Pipes Pits When a magnet is installed in a pit, it is important to ensure there is continuous air-flow (ex- haust) within the pit. This is done to prevent any buildup of nitrogen gas in the confines of the pit.

  • Page 77: Fire Detection System And Fire Extinguishers

    Utility Requirements Fire Detection System and Fire Extinguishers Rooms containing NMR magnets should be equipped with temperature sensors for fire de- tection. These must respond only to a sudden rise of temperature, and not be triggered by a quench (sudden drop of temperature). Optical smoke detectors cannot discriminate between smoke from a fire and fog from either a helium refill or caused by a quench, so these may not be used.
  • Page 78 Utility Requirements 78 / 120 H157654_9_011...

  • Page 79: Floor Plan

    Floor Plan Floor Plan Magnet Location When locating the magnet, certain considerations must be made with regards to the labora- tory environment: • To increase magnet homogeneity, the magnet should be located away from permanent iron structures such as support beams in walls and floors. Reference: Electromagnetic In- terference [} 56].

  • Page 80: Dimensions And Mass Of Equipment

    (filled with cryogens and in- cluding stand). The assembly of the magnet system, the magnet energization and refills with liquid helium require additional ceiling height. Component Length (m) Width (m) Height (m) Weight (kg) AVANCE NEO 0.69 0.83 1.30 OneBay AVANCE NEO 0.69 0.83 1.58...

  • Page 81: Figure 9.2: Magnet Dimensions

    Floor Plan Magnet Dimensions and Mass The values in the following table correspond to the following figure: Figure 9.2: Magnet Dimensions Maximum magnet diameter Magnet height from the floor, including stand. Overall footprint diameter Refer to the Magnet Dimensions and Total Weights table for the values of A, B, and C. H157654_9_011 81 / 120...

  • Page 82: Table 9.2: Magnet Dimensions And Weight: Standard Bore 54 Mm

    Floor Plan Magnet Type Total Magnet Weight incl. Maximum Mag- Magnet Height Overall Foot- Stand & Cryo- net Diameter from the Floor In- print Diameter gens cluding Stand (kg)* 300/54 Ascend ULH 0.75 2.14 1.40 400/54 Ascend 0.75 2.14 1.40 400/54 Ascend ULH 0.75 2.14...

  • Page 83: Floor Types

    Emergency Ventilation During Installation and Quenches [} 73]). • Magnet refills and access for transport dewars. • Cable lengths. • Siting the BCU-I or BCU-II cooling unit. • Siting the CryoPlatform Consult your local Bruker Installation Engineer for details. H157654_9_011 83 / 120...

  • Page 84: Magnet Platform

    The platform must be constructed of wood or other non-magnetic material. It must accommo- date the magnet and provide safe access for sample insertion and cryogen fills. Consult you Bruker office for further guidelines when using a magnet platform. Figure 9.3: Example of a Simple Magnet Platform...

  • Page 85: Maximum Field Strengths For Nmr Equipment

    Table 9.5: Maximum Field Strength for NMR Equipment Cabinet Position The various units within the AVANCE NEO cabinet, especially the acquisition computer, must be kept at a minimum distance from the magnet. Protection of the acquisition computer and digital electronics from the magnet’s fringe field is best achieved by positioning the cabinet so that the acquisition computer is no closer than the 1.0 mT (10 G) line.

  • Page 86: Service Access Requirements

    • Ventilation: A minimum of 30 cm must left between the back of the cabinet and any wall to ensure proper ventilation. • Service access - AVANCE NEO: Sufficient space (~ 60 cm) must be left in front of the AVANCE NEO so the cabinet may be pulled away from the wall for service. Service ac- cess to the sides is not required.

  • Page 87: Layout Examples

    Floor Plan 9.12 Layout Examples The following layout examples of some NMR systems include the equipment and utilities. A description of each of the NMR system components is presented in the chapter System Com- ponents [} 21], while the details regarding the utility requirements are presented in the chap- Utility Requirements [} 61].

  • Page 88: Figure 9.5: Top View Of The Ascend 400 Magnet

    Floor Plan Figure 9.5: Top View of the Ascend 400 Magnet Temperature Control Unit BCU I Operator Desk Magnet System AVANCE NEO Console 0.5 mT (5 Gauss) Line 88 / 120 H157654_9_011...

  • Page 89: Figure 9.6: 800 Mhz Layout Example

    Floor Plan Figure 9.6: 800 MHz Layout Example H157654_9_011 89 / 120...

  • Page 90: Figure 9.7: Top View Of The Ascend 800 Magnet

    Floor Plan Figure 9.7: Top View of the Ascend 800 Magnet AVANCE NEO Console He Gas Cylinder 6.0 for CryoPlatform Temperature Control Unit BCU I Damping Post for CryoProbe Trans- fer Line Magnet System CryoPlatform 0.5 mT (5 Gauss) Line 10 Preamplifier...

  • Page 91: Cryoprobe And Other Accessories

    CryoProbe and Other Accessories 10 CryoProbe and Other Accessories The CryoProbe accessory for the AVANCE NEO NMR Spectrometers offers dramatic in- creases in signal to noise ratio (S/N) by reducing the operating temperature of the NMR coil assembly and the preamplifier.

  • Page 92: Figure 10.1: Cryoprobe System Overview

    CryoProbe and Other Accessories Figure 10.1: CryoProbe System Overview Refer to the layout examples for more information. 92 / 120 H157654_9_011...

  • Page 93: Cryocooling Unit

    (7.5 kW average, 8.5 kW peak), it must be cooled to prevent overheat- ing. Bruker offers both water cooled and air cooled helium compressors. In either case, plac- ing the compressor in a remote room (allowing He gas flex lines up to 20 m to reach the Cry- oCooling unit) or an enclosure will keep the noise of the unit out of your laboratory.

  • Page 94: Helium Compressor - Indoor Water Cooled

    CryoProbe and Other Accessories 10.2.1.1 Helium Compressor - Indoor Water Cooled • Requires chilled water source (supplied by customer) with a flow and temperature within the specified admissible ranges shown in the plots below. It is important that not only the temperature stays below the maximum temperature threshold but also the flow is not greater than the upper threshold shown.

  • Page 95: Table 10.2: Cooling Water Specifications

    CryoProbe and Other Accessories Inlet Temperature Range [°C] (°F) [4.0 ~ 28.0] (39.2 ~ 82.4) Inlet Pressure Range [MPa] (psig) [0.10 ~ 0.69] (14.5 ~ 100) Flow Rate [liter/min.] (gallon/min.) [4.0 ~ 10.0] (1.1 ~2.6) Characteristics Pressure Drop [MPa] (psig) [0.025 ~ 0.085] (3.55 ~ 12.1) Heat Output [kW ] (BTU/Hr) into <Steady State>...

  • Page 96: Helium Compressor - Indoor Air Cooled

    CryoProbe and Other Accessories • Ambient operating temperature 5–28 ºC. Figure 10.4: Helium Compressor - Indoor Water Cooled 10.2.1.2 Helium Compressor - Indoor Air Cooled • The room air handling system must be able to dissipate 7.5 kW of heat. • Siting this helium compressor in the same room as the NMR is not recommended. •...

  • Page 97: Helium Compressor - Outdoor Air Cooled

    CryoProbe and Other Accessories 10.2.1.3 Helium Compressor - Outdoor Air Cooled • The Outdoor Air Cooled helium compressor consists of an Outdoor Unit and an Indoor Unit. • The outdoor unit is specified to operate between the temperatures of –30 ºC to 45 ºC. Figure 10.6: Helium Compressor - Outdoor Air Cooled 10.2.2 Space Requirements and Specifications...

  • Page 98: Outdoor Helium Compressors

    CryoProbe and Other Accessories Sumitomo Type: F-50L F-50H CSA-71A Power Consumpton Cool Down max. 50/60 7.2/8.3 kW 7.2/8.3 kW 7.2/8.3 kW 6.5/7.5 kW 6.5/7.5 kW 6.5/7.2 kW Steady State max. 50/60 Water supply to remove Flow: 420 l/hour the heat load (cooling Temperature: 4-28°C power >...

  • Page 99: Helium Cylinders

    5 Gauss line in a serviceable location (i.e. changing the bottle should not interfere with nearby magnets). The helium regulator and a special He gas hose are supplied by Bruker. Two lengths for the He gas hose line are available (10 m and 20 m).
  • Page 100 CryoProbe and Other Accessories For Outdoor Helium Compressors (11 Options) • 3 m indoor line / 10 m outdoor line • 3 m indoor line / 20 m outdoor line • 3 m indoor line / 30 m outdoor line •...

  • Page 101: Cryoprobe Prodigy System (Optional)

    CryoProbe and Other Accessories Helium Compressor - Outdoor Air Cooled • Consists of one small indoor unit, one outdoor unit, and transfer lines connecting the units. • Located outside the 5 Gauss lines (for both the indoor and outdoor unit). •...

  • Page 102: Table 10.5: Prodigy System Equipment Dimensions

    Case 2: Use an N gas separator to generate the required gas on site (as specified in Case 1). Bruker of- Compressed air with dew point < fers a N Separator (P/N 46540). Requirements -25°C available.

  • Page 103: Cryofit

    CryoProbe and Other Accessories Ventilation Requriements Free room volume (exchangeable >/= 70 m gas volume) V free room furniture Fresh air supply rate >/= 200 m . During LN2 refill: >/= 400 m Further local regulations may apply. Table 10.8: Prodigy System Ventilation Requirements 10.6 CryoFit This section describes the requirements for the site planning for the CryoFit.
  • Page 104 CryoProbe and Other Accessories 104 / 120 H157654_9_011...

  • Page 105: 11 Installation

    The spectrometer system will arrive at the site in crates. The crates should only be opened by the Bruker BioSpin service engineer. The commissioning of the magnet involves several stages as outlined in the table below. The installation time line given below is an approxima- tion;...

  • Page 106: Installation Requirements Checklist

    Installation 11.3 Installation Requirements Checklist For the installation the customer must provide the following: Lifting equipment and minimum ceiling height as outlined in the table in Charg- ing the Magnet [} 107]. Pallet jack and/or fork lift for transporting system acces- sories.

  • Page 107: Magnet Evacuation And Flushing With Nitrogen Gas

    Installation 11.4.2 Magnet Evacuation and Flushing with Nitrogen Gas Once the magnet has been assembled and placed in the magnet room, rough pumping of the cryostat can begin. At the same time the cryostat is flushed through with dry nitrogen gas. The customer must provide a 50l (4.6 grade)/200 bar (~2 cu.ft, 3000 psi) cylinder of dry nitro- gen gas (99.996% purity).

  • Page 108: Table 11.3: Magnet Transport Weights: Standard Bore 54 Mm

    Installation Magnet Transport Weights Magnet Type Magnet Magnet LHe After Weight Weight Needed Needed a Train- Empty Filled for Pre- for Cool- with with Mag- cool (l) down Quench Magnet net Stand Stand (kg) Charging (kg)* 300/54 Ascend ULH (stan- 311/399 411/499 dard/optional stand)

  • Page 109: Table 11.4: Magnet Transport Weights: Wide Bore 89 Mm

    Installation Magnet Type Magnet Magnet LHe After Weight Weight Needed Needed a Train- Empty Filled for Pre- for Cool- with with Mag- cool (l) down Quench Magnet net Stand Stand (kg) Charging (kg)* 300/89 Ascend (standard/ 382/470 optional stand) 400/89 Ascend (standard/ 593/681 optional stand) 500/89 Ascend...
  • Page 110 Installation 110 / 120 H157654_9_011...

  • Page 111: 12 Contact

    Bruker BioSpin Hotlines Contact our Bruker BioSpin service centers. Bruker BioSpin provides dedicated hotlines and service centers, so that our specialists can respond as quickly as possible to all your service requests, applications questions, software or technical needs. Please select the service center or hotline you wish to contact from our list available at: https://www.bruker.com/service/information-communication/helpdesk.html...
  • Page 112 Contact 112 / 120 H157654_9_011...
  • Page 113 Hz, 1…200 Hz, > 30 min, Average Measurement 1 (displayed in velocity)..... 51 Figure 7.4: Elastomer Dampers ......................51 Figure 7.5: Example of the Bruker Tolerance Level for ADI Dampers. Resolution <0.125 Hz, 1… 200 Hz, > 30 min, Average Measurement 1 (displayed in velocity)......... 52 Figure 7.6: ADI Dampers ........................53 Figure 7.7:...
  • Page 114 List of Figures 114 / 120 H157654_9_011...
  • Page 115 List of Tables List of Tables Table 1.1: Metric to American Conversion Factors................Table 2.1: Action Levels for Magnetic Flux Density of Static Magnetic Fields........10 Table 2.2: ELVs for External Magnetic Flux Density (B ) and 0 to 1 Hz ..........12 Table 2.3: Example of Maximum Retention Periods................
  • Page 116 List of Tables Table 8.5: Heat Dissipation into the Room by Typical AVANCE NEO Systems........72 Table 8.6: Total Gas Volume and Maximum He Gas Flow: Standard Bore 54 mm ......74 Table 8.7: Total Gas Volume and Maximum He Gas Flow: Wide Bore 89 mm ........74 Table 8.8:...
  • Page 117  19 Air conditioning  56 Emergency Sample Protection Device  65 Airplanes  47 ESD resistant flooring  83 Automobiles  47 External Disturbance Suppression  59 AVANCE NEO  62 Fans  47  62 Faraday cage  60 B-CU-I Ferromagnetic materials  55 Dimensions and weight  80 Ferromagnetic objects  10...
  • Page 118 Index Magnetic flux density  14 Exclusion zone  10 maximum point load  80 Ferromagnetic objects  10 Medical implants  9, 10 Magnetic field  9 MicroImaging Cabinet Medically active implants  10 Dimensions and weight  80 Safe handling of cryogenic liquids  16 minimum ceiling height  40 Safe handling of liquid nitrogen  17...
  • Page 120 ● Bruker Corporation info@bruker.com www.bruker.com Order No: H157654...

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