Related Manuals for Bruker SamplePro hr-MAS
Summary of Contents for Bruker SamplePro hr-MAS
- Page 1 SamplePro hr-MAS Sample Changer User Manual Version NMR Spectroscopy Innovation with Integrity...
- Page 2 © November 8, 2010: Bruker Biospin GmbH Rheinstetten, Germany P/N: Z31914 DWG-Nr.: Z4D11177 For further technical assistance on the SamplePro hr-MAS unit, please do not hesitate to contact your nearest BRUKER dealer or contact us directly at: BRUKER BioSpin GMBH...
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Page 3: Table Of Contents
Table of Contents Contents About ......................7 This Manual......................7 Policy Statement ...................... 7 Symbols and Conventions..................7 Introduction....................9 Concept ........................9 Limitations of Liability ..................... 10 Copyright ........................ 10 Warranty Terms...................... 10 Customer Service....................10 Safety......................11 Intended Use ......................11 Owner‘s Responsibility ................... - Page 4 Switching On the Device ..................40 8.2.2 Switching Off the Device ..................40 Assembling the Tray with Rotors ..............41 Operation......................45 10.1 SamplePro hr-MAS Main Display ................45 10.1.1 System View......................46 10.1.2 Holder View ......................47 10.1.3 Sample Holder List ....................48 10.1.4...
- Page 5 11.1.2 Weekly Maintenance ....................60 11.1.3 Cleaning and Lubrication..................60 11.1.3.1 Pickup Adapter and Object Sensor Z-racks ............60 11.2 Cleaning the Outside of the SamplePro hr-MAS and Units........61 11.2.1 After Cleaning......................61 11.2.2 Other Cleaning Operations..................61 11.3 Cleaning the Robot Barcode Reader ..............
- Page 6 Table of Contents Z31914_00_01...
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Page 7: About
Policy Statement It is the policy of Bruker to improve products as new techniques and components become available. Bruker reserves the right to change specifications at any time. Every effort has been made to avoid errors in text and figure presentation in this publica- tion. - Page 8 About WARNING This combination of symbol and signal word indicates a potentially hazardous situa- tion which could result in death or serious injury unless avoided. CAUTION This combination of symbol and signal word indicates a possibly hazardous situation which could result in minor or slight injury unless avoided. NOTICE This combination of symbol and signal word indicates a possibly hazardous situation which could result in damage to property or the environment unless avoided.
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Page 9: Introduction
(hr-MAS) applications, such as the measurement of biological samples. The new sample changer is part of a Bruker NMR system for standard NMR MAS appli- cations and is used to transfer prepared MAS samples to and from Bruker NMR instru- ments to ensure they stay in continuous operation. -
Page 10: Limitations Of Liability
Introduction Limitations of Liability All specifications and instructions in this manual have been compiled taking account of applicable standards and regulations, the current state of technology and the experience and insights we have gained over the years. The manufacturer accepts no liability for damage due to: •... -
Page 11: Safety
Non-compliance with the action guidelines and safety instructions contained in this man- ual may result in serious hazards. Intended Use The SamplePro hr-MAS sample changer has been designed and constructed solely for the intended use described here. The sample changer must only be used for keeping NMR samples in a specially designed rotor container, inserting them into the NMR spectroscopy magnet and ejecting them after measurement back into the rotor container. - Page 12 Safety Owner‘s Obligations The device is used in the industrial sector, universities and research laboratories. The owner of the device must therefore comply with statutory occupational safety require- ments. In addition to the safety instructions in this manual, the safety, accident prevention and environmental protection regulations governing the operating area of the device must be observed.
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Page 13: Personnel Requirements
Personnel Requirements 3.3.1 Qualifications Note: Only trained Bruker personnel are allowed to mount, retrofit, repair, adjust and dis- mantle the unit! This manual specifies the personnel qualifications required for the different areas of work, listed below: Laboratory Personnel... -
Page 14: Unauthorized Persons
Safety 3.3.2 Unauthorized Persons WARNING Risk to life for unauthorized persons due to hazards in the danger and working areas. Unauthorized persons who do not meet the requirements described here will not be familiar with the dangers in the working zone. Therefore, unauthorized persons face the risk of serious injury or death. -
Page 15: Basic Dangers
Safety Basic Dangers The following section specifies residual risks which may result from using the device and have been established by means of a risk assessment. In order to minimize health hazards and avoid dangerous situations, follow the safety instructions specified here as well as in the following chapters of this manual. 3.5.1 Location of the Robot ON/OFF Switch The robot ON/OFF switch is located on the right side of the deck tray:... -
Page 16: General Workplace Dangers
Safety 3.5.2 General Workplace Dangers NOTICE Material damage hazard from overflow of cryogens. Material damage may result from the overflow of cryogens. Turn off the unit during magnet servicing. Cover the unit with a protective cover to avoid contact with cold gases. Be sure to use sufficient transfer line and Teflon evacuation hose for nitrogen and helium refills based on recommendations in the magnet manual. -
Page 17: Caution
Infection, contamination, or other health endangerment as a result of contact with biological or chemical substances, e.g. from broken samples. Clean the unit before maintenance work and/or returning to Bruker for repair. Prepare a list of materials in which the unit came into contact with or measured. -
Page 18: Danger
Safety DANGER Accident and/or material damage hazard from sample breakage. Contact with hazardous substances contained in sample rotors that break may result in a life threatening situation or material damage. The contents of the sample rotors are the responsibility of the laboratory supervisor. The laboratory supervisor is responsible for: Defining disinfectant and cleaning procedures. -
Page 19: Environmental Protection
Safety To avoid mix-up of the contents in rotors, proper standard laboratory operating proce- dures must be followed. Environmental Protection CAUTION Danger to the environment from incorrect handling of pollutants! Incorrect handling of pollutants, particularly incorrect waste disposal, may cause seri- ous damage to the environment. -
Page 20: Signage
Safety Signage 3.7.1 Warning Signs Warning indicating a danger zone in work rooms. Warning indicating a biological hazard. Warning indicating severe hand injury. Z31914_00_01... -
Page 21: Technical Data
Technical Data General Weight Data Value Unit System Robot Exchange Unit Cooling Unit Accessories Table 4.1 Technical Data: Weight Dimensions Data Height Width Depth Unit System 1800 Robot Exchange Unit Table 4.2 Technical Data: Dimensions Noise Level Data Value Unit The highest measured workstation accepted value, 71.5 dB(A) -
Page 22: Electrical
Technical Data Height The SamplePro hr-Mas System can be operated in a height up to maximum 2000 m. Cooling Range Data Value Unit Cooling device temperature range -16 to room temperature °C Table 4.4 Cooling Device Temperature Range Sample Usage SamplePro hr-MAS can utilize standard MAS 4 mm rotors. -
Page 23: Operating Conditions
°C Relative humidity at 30 °C, maximum, non-condensing 10-85 Table 4.7 Operating Environment For the appropriate temperature see also the Bruker site planning guides on the BASH CD (Bruker Advanced Service Handbook): Manual Bruker Part Number Site Planning for AVANCE Systems 300-700 MHz (UM) -
Page 24: Rating Plate Robot
Technical Data Rating Plate Robot Model Input Voltage Frequency, Power Consumption CE Approval Manufacturer Serial Number Figure 4.1 Rating Plate Robot Rating Plate Exchange Unit Manufacturer Model Part Number Serial Number Variation Number Engineering Change Level Input Voltage Frequency, Power Consumption Figure 4.2 Rating Plate Exchange Unit Z31914_00_01... -
Page 25: Design And Function
Design and Function Overview The principal components of the SamplePro hr-MAS system are: Figure 5.1 SamplePro hr-MAS Overview The SamplePro Exchange Unit, which is used to transfer rotors from rotor containers to the NMR probe and back. Flexible hoses, which are connected between the SamplePro robotic sys- tem, the SamplePro Exchange Unit and the MAS probe. -
Page 26: Brief Description
(hr-MAS) applications, such as the measurement of biological samples. The new sample changer is part of a Bruker NMR system for standard NMR MAS appli- cations and is used to transfer prepared MAS samples to and from Bruker NMR instru- ments to ensure they stay in continuous operation. -
Page 27: Description Of The Samplepro Robotic System
Design and Function Description of The SamplePro Robotic System The SamplePro Robotic System consists of the following parts: Object sensor to detect rotors and rotor containers. Barcode reader (rotor containers). Pickup adapter. Safety door locker. The control unit for the cooling device. The control wheel for the nitrogen flow to prevent the formation of con- densed water. -
Page 28: The Robot Back Panel
The system is initializing or running tasks. Green: The SamplePro robotic system is ready and waiting for requests. Red: A SamplePro hr-MAS device error has occurred. Further tasks cannot be performed. Orange: The system is running in service mode. Z31914_00_01... -
Page 29: The Door Lock
• A transfer to the MAS probe or a transfer back has been started within the control software SamplePro hr-MAS. After a transfer the door is automatically unlocked. The SamplePro Exchange Unit The SamplePro Exchange Unit (EU) was designed to transfer 4 mm MAS rotors from one end of a flexible hose to the other. -
Page 30: Table 5.1 Exchange Unit Back Panel
Design and Function Name Notes Vacuum Generator Used for the exhaust of the vacuum generator. Ensure that the outlet Exhaust channels are not covered or congested. Ventilation Valve Used for the ventilation of the valves, supplied from gas inlet 1. The ventilation provides a protective atmosphere for the EU. -
Page 31: Description Of The Mas Pneumatic Control Unit
Design and Function Description of the MAS Pneumatic Control Unit The SamplePro hr-MAS uses the MAS/MAS II Pneumatic Control Unit to control the spinning rate of the samples. The MAS/MAS II units also are used to control the drive gas pressure in an NMR system. -
Page 32: Description Of The Hr-Mas Probe
Design and Function Use the Up and Down buttons to move to the checkboxes for Com. mode old MAS. Use the Change button to select YES. Press the Return button. The Storing MAS Setup Changes window will appear: Figure 5.7 Storing MAS Setup Changes Store the changes by pressing the Perm button. -
Page 33: Transport, Packaging And Storage
Transport, Packaging and Storage Installation, initial commissioning, retrofitting, repairs, adjustments or dismantling of the device must only be carried out by employees of the manufacturer or persons authorised by the manufacturer. Symbols on the Packaging The following symbols are affixed to the packaging material. Always observe the sym- bols during transport and handling. - Page 34 Transport, Packaging and Storage Attach Here Lifting gear (lifting chain, lifting strap) must only be attached to points bearing this symbol. Center of Gravity Marks the center of gravity of packages. Note the location of the center of gravity when lifting and trans- porting.
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Page 35: Inspection At Delivery
Transport, Packaging and Storage Component Sensitive to Electrostatic Charge The packaging contains components which are sensitive to an electrostatic charge. Only allow packaging to be opened by trained personnel. Establish potential equalisation before opening. Protect from Heat Protect packages against heat and direct sunlight. Protect from Heat and Radioactive Sources Protect packages against heat, direct sunlight and radioactive sources. -
Page 36: Packaging
Therefore do not destroy the packaging and only remove the parts from the packaging if instructed to do so by the Bruker Service Engineer. Handling Packaging Materials Dispose of packaging material in accordance with the relevant applicable legal require- ments and local regulations. -
Page 37: Installation And Initial Commissioning
Installation and Initial Commissioning Installation and initial commissioning of the SamplePro hr-MAS sample changer must be done by a trained Bruker representative in the diagnostic or NMR laboratory. WARNING Danger to life from incorrect installation and initial commissioning! Errors during installation or initial commissioning may result in potentially fatal situa- tions and may cause significant damage to property. - Page 38 Installation and Initial Commissioning Z31914_00_01...
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Page 39: Operation Overview
Operation Overview Safety Improper Operation WARNING Danger of injury from improper operation! Improper operation can result in serious injury and significant damage to property. Carry out all operating steps in accordance with the specifications and instructions in this manual. Before starting work, ensure that all covers and safety devices are installed and functioning properly. -
Page 40: General Operating Guidelines
NMR Measurement During an NMR measurement try to minimize interaction with the SamplePro hr-MAS system, e.g. exchanging samples, as this may disturb the NMR measurement results. The laboratory supervisor should define procedures regarding access to the unit and/or the 5 Gauss area around the magnet. -
Page 41: Assembling The Tray With Rotors
Assembling the Tray with Rotors Severe Hand Injury WARNING Severe hand injury. When accessing the work area of the robot, movements of the robot may cause per- sonal injury. Always open the safety door before accessing the working area of the robot. If the safety door cannot be opened, stop the automation using the control soft- ware (IconNMR). - Page 42 Assembling the Tray with Rotors Remove the rotor from the slot and insert it, cap first, into the flexible nozzle. Insert the nozzle with the cap into the intended posi- tion in the tray. Eject the rotor by moving the slider downward. Insert the other rotors as described in steps 2-5.
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Page 43: Figure 9.1 Adapter Plate For Room Temperature In Last Position To The Right
Assembling the Tray with Rotors Notice: The tray must be inserted with the barcode on the left side. Cover the cooling rack with the cap. Notice: The slot must be on the left side, so that the barcode labels can be read. Notice: When working in the mode 48 Rotors no cooling device, use a non-cooled rotor container. - Page 44 Assembling the Tray with Rotors Z31914_00_01...
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Page 45: 10 Operation
Using the application control software SamplePro hr-MAS. This chapter will describe the application control software in detail. The next section describes the user interfaces for the SamplePro hr-MAS, if you are already familiar with this program you may proceed to the "Basic Commands"... -
Page 46: System View
The control software controls the transfer of the sample to the probe and the transfer back to the SamplePro hr-MAS. The tab System View graphically displays the current rotor position during the transport of the sample between the SamplePro hr-MAS system and the probe in the magnet. -
Page 47: Holder View
Operation 10.1.2 Holder View The main display tab Holder View displays rotor container information based on what has been read by the container barcode reader (optionally) or detected by the object detector: Deck Tray Rotor Container Rotor Position Figure 10.2: Holder View The information about the selected area is displayed on the right information panel by selecting an area by clicking on it with a mouse. -
Page 48: Sample Holder List
Operation 10.1.3 Sample Holder List The tab Sample Holder List provides information on the status of the measurement orders. Figure 10.3 Sample Holder List 10.1.4 Right Window Panel The window panel on the right side of the main window provides information about the current system status, including: •... -
Page 49: Figure 10.4: Container Information - Rotor
Operation Displaying Rotor Information To display information about the rotor in the container information section, click on the rotor. Figure 10.4: Container Information - Rotor Displaying Rotor Container Information To display information about the rotor container in the container information panel, click on the rotor container, i.e. -
Page 50: Robot Information
Operation 10.1.4.2 Robot Information The Robot Information panel provides status information about the safety door and the rotor container barcode reader. Figure 10.6 Robot Information about the Safety Door and Rotor Container Barcode Reader. Safety Door There are four possible status for the safety door: •... -
Page 51: Nitrogen/Air Flow Information
Operation 10.1.4.4 Nitrogen/Air Flow Information The nitrogen or air flow are used on cooled racks to keep samples from freezing. The Nitrogen/Air Flow Information panel displays a target flow value and the current flow. The value fields are color coded, when the flow value is within the target flow value, the Current Flow field border is green. -
Page 52: Menu And Button Navigation Overview
Used to export a file containing device information (part number, serial number, etc.), device statistics (total run- time minutes, etc.) and other helpful information for diag- nostic. This data should be sent to Bruker when problems occur. Service and Settings Used to open the service window (for service personnel only). -
Page 53: Basic Commands
Operation • Zoom 100% • Overview 10.2 Basic Commands Procedures that can be initiated from SamplePro hr-MAS include: "Insert Sample" "Eject Sample" During a sample transfer: • The container information fields will be continuously updated to the present status. •... -
Page 54: Insert Sample
Operation 10.2.1 Insert Sample Note: The safety door must be closed before a sample can be transferred! To insert a new sample into the probe: Press the Insert Sample button or select Changer -> Insert Sample from the main menu. The Insert Sample dialog window will open displaying all the sample positions. -
Page 55: Eject Sample
Operation 10.2.2 Eject Sample Note: The safety door must be closed before a sample can be transferred! To eject a sample from the probe: Press the Eject Sample button or select Changer -> Eject Sample from the main menu. The system will transfer the sample back to the rotor container. When the transfer is complete, the four positions in the System View (Figure 10.1) will all be blank. -
Page 56: Activity History
10.4 Activity History The SamplePro hr-MAS program offers an activity history that can be used, for example, by the laboratory manager to monitor user activities or troubleshooting. To open the activity history select in the menu View - Activity History. -
Page 57: Figure 10.14Activity History
Operation Figure 10.14Activity History Z31914_00_01... - Page 58 Operation Z31914_00_01...
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Page 59: 11 Preventative Maintenance
Only trained personnel should carry out maintenance work. Robotic System Preventative Maintenance The SamplePro hr-MAS robotic system is designed with a minimum amount of mainte- nance by the user. However, to preserve the accuracy and reliability of the instrument, the following Preventive Maintenance (PM) procedures must be performed on a regular basis according to the maintenance schedules given below. -
Page 60: Cleaning And Decontamination
Weekly PM is performed by the operator at the end of the week, and takes only a few minutes in addition to the daily maintenance. Periodic Preventive Maintenance The SamplePro hr-MAS has been developed to be maintenance free, there is no peri- odic maintenance required. In the event problems should occur contact Bruker Service. Maintenance Log A log sheet should be used for verification of maintenance. -
Page 61: Cleaning The Outside Of The Samplepro Hr-Mas And Units
Preventative Maintenance 11.2 Cleaning the Outside of the SamplePro hr-MAS and Units Clean the outside of the SamplePro hr-MAS chassis and units with a soft, lint-free cloth dampened in water. • Do not use any detergent or other cleaning solvents. - Page 62 Preventative Maintenance Z31914_00_01...
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Page 63: 12 Dismantling And Disposal
12 Dismantling and Disposal 12.1 Repair Declaration Form A Safety and Repair Declaration Form must be filled out, whenever a probe or other unit situated in a magnet room are exposed to hazardous substances, and must be returned to Bruker. Z31914_00_01... -
Page 64: Figure 12.1: Repair Declaration Form
The safety & repair declaration form may be signed by a Bruker service engineer if the system was never operated by the customer (e.g. prior to completion of the installation). -
Page 65: 13 Ec-Declaration Of Conformity
13 EC-Declaration of Conformity Z31914_00_01... - Page 66 EC-Declaration of Conformity Z31914_00_01...
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Page 67: 14 Contact
NMR Hotlines Contact our NMR service centers. Bruker BioSpin NMR provide dedicated hotlines and service centers, so that our special- ists can respond as quickly as possible to all your service requests, applications ques- tions, software or technical needs. - Page 68 Contact Z31914_00_01...
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Page 69: Warning Signs
Note All panels and shields must be in place before operating this device! ....45 Only trained Bruker personnel are allowed to mount, retrofit, repair, adjust and dis- mantle the unit! ...................... 13 Reference measurements should be made at regular intervals to help detect possible vibration and/or electromagnetic interference. - Page 70 Warning Signs Z31914_00_01...
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Page 71: Figures
Storing MAS Setup Changes ............... 32 Figure 9.1 Adapter Plate for Room Temperature in Last Position to the Right ..43 Figure 10.1 The Main Window of the Control Software SamplePro hr-MAS ..46 Figure 10.2: Holder View..................47 Figure 10.3 Sample Holder List................ - Page 72 Figures Z31914_00_01...
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Page 73: Tables
Cooling Device Temperature Range ........... 22 Table 4.5 Electrical Connection Values .............. 22 Table 4.6 Maximum Power Consumption ............22 Table 4.7 Operating Environment ............... 23 Table 4.8 Bruker Site Planning Guides............... 23 Table 5.1 Exchange Unit Back Panel ..............30 Z31914_00_01... - Page 74 Tables Z31914_00_01...
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Page 75: Glossary
The SamplePro Exchange Unit Good Laboratory Practices hr-MAS High Resoluton Magic Angle Spinning. Icon NMR Bruker software package for automation. Magic Angle Spinning. Nuclear Magnetic Resonance. SamplePro Bruker name for the Sias Xantus robot (XANTUS and XANTUS Junior). Standard Operating Procedure Z31914_00_01... - Page 76 Glossary Z31914_00_01...
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Page 77: Index
Index Index Accidents ..........61 Air flow ............51 Barcode collars ......... 40 Button Bars ..........52 CAN Connector ........30 Cleaning ........... 60 Cleaning liquids ........19 Com Mode ..........31 Components ..........25 Contamination .......... 61 Control software ........46 Coolants ........... - Page 78 Index Laboratory Personnel ......13 Personnel qualifications Laboratory personnel ........13 LED ............28 liability ............10 Magic Angle Spinning .......32 Main Menu ..........52 MAS ............25 MAS Com Mode ........31 Nitrogen ............51 Object Sensor Z-racks ......60 Packaging ..........36 Packaging material ..........33 Symbols Personal protective equipment ....14 Policy Statement .........7 Power Supply Connector ......30 Preventative Maintenance ......59...
- Page 79 Index Transport damage ........35 Untrained personnel ......... 10 Vacuum Generator Exhaust ..... 30 Ventilation Valve ........30 warranty ............ 10 Z31914_00_01...
- Page 80 Index Z31914_00_01...
- Page 82 With more than 50 years of experience in meeting the needs of the scientific community across a range of disciplines, Bruker has built a sound rapport with professionals from the community through understand ing their specific requirements.
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