Thermo Scientific HyPerforma 5.1 S.U.B. Hardware Integrator Manual
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Thermo Scientific HyPerforma 5.1 S.U.B. Hardware Integrator Manual

Thermo Scientific HyPerforma 5.1 S.U.B. Hardware Integrator Manual

Single-use systems
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Single-Use Systems Hardware
Integrator's Guide
DOC0039 • Revision A
July 2017

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Summary of Contents for Thermo Scientific HyPerforma 5.1 S.U.B.

  • Page 1 Single-Use Systems Hardware Integrator’s Guide DOC0039 • Revision A July 2017...

  • Page 3: Table Of Contents

    2.2 Thermo Scientific e-box information Chapter 3 Motor connection 3.1 Units without Thermo Scientific e-boxes 19 3.2 Units with the Thermo Scientific e-boxes 27 3.3 Motor general information Chapter 4 Resistive heater connection 4.1 Units without the Thermo Scientific e-box 31 4.2 Units with the Thermo Scientific e-box...
  • Page 4 Chapter 6 RTD connection 6.1 Units without the Thermo Scientific e-box 40 6.2 Units with the Thermo Scientific e-box 6.3 RTD connection general information Chapter 7 Pressure sensor connection 7.1 Units without the Thermo Scientific e-box 44 7.2 Units with the Thermo Scientific e-box...

  • Page 5: How To Use This Guide

    Input into Thermo Scientific publications Your satisfaction with the scope and content of this publication is important to us. Please send any corrections or suggestions you have for this guide (or for any other Thermo Scientific technical publication) to TechnicalDocumentation@ThermoFisher.com. Related publications Please contact Thermo Fisher for information about the related publications listed below.

  • Page 6: Safety, Warnings And Warranty Information

    REPLACEMENT PARTS WE HAVE NOT SUPPLIED, WILL IMMEDIATELY VOID AND CANCEL ALL WARRANTIES WITH RESPECT TO THE AFFECTED EQUIPMENT. WE MAY ALSO VOID YOUR WARRANTY IF YOU SHIP THE EQUIPMENT OUTSIDE OF THE UNITED STATES. Thermo Scientific Single-Use Systems Integrator’s Guide...
  • Page 7 Thermo Scientific Single-Use Systems Integrator’s Guide...

  • Page 8: Acronym Definitions

    Solid State Relay S.U.B. Single- Use Bioreactor S.U.F. Single-Use Fermentor S.U.M. Single- Use Mixer S.U.S. Single- Use System Thermal Control Unit (used on water-jacketed vessels) Volts Alternating Current Volts Direct Current Variable Frequency Drive Thermo Scientific Single-Use Systems Integrator’s Guide...

  • Page 9: Guidelines

    20% of a system’s working volume for 5.1 S.U.B. systems. • Operating the agitator above the recommended speeds based on qualified power input to volume (P/V) thresholds (see the next sec- tion of this guide). Thermo Scientific Single-Use Systems Integrator’s Guide...
  • Page 10 This relationship can be rearranged to solve for mixing speed as a function of the other variables. For known values of P/V, impeller power number, density, and impeller diameter, this equation can be simplified by consolidating all other values into a single coefficient (A). Thermo Scientific Single-Use Systems Integrator’s Guide...
  • Page 11 * Coefficient value is used to determine operating speeds for drive shafts implemented for a 180- day working duration at 20 W/m ** Consult Thermo Scientific engineers for the drive shaft working duration at 40 W/m Agitation speeds for P/V values of 20 and 40 W/m are provided in Tables 1.2 and 1.3.
  • Page 12 NOTE: Load cell values must be used with interlocks to keep the system operating within recommended P/V ranges. Thermo Scientific Single-Use Systems Integrator’s Guide...
  • Page 13 RPM for a working volume as found in the reference tables in this publication. Never rely strictly on an estimated magnitude of P/V when setting the agitator speed interlock levels. Thermo Scientific Single-Use Systems Integrator’s Guide...

  • Page 14: Agitation Acceleration And Deceleration Rates

    Customers are required to log their drive shaft usage for warranty purposes. For this reason, a new drive shaft should be employed by when customers start to use the system. Thermo Scientific Single-Use System Interegrator’s Guide...

  • Page 15: Pressure Regulation

    An optional safety switch may be installed on the motor cap of all single-use systems. This device uses a reed switch that is normally closed when the cap is closed. When the cap is open, a safety interlock should prevent the rotation of the drive shaft. Thermo Scientific Single-use Systems Integrator’s Guide...

  • Page 16: Chapter 2 Electrical Box Overview

    Single-Use Bioreactor (S.U.B.), Single-Use Mixer (S.U.M.) or Single-Use Fermentor (S.U.F.). Figure 2.1, View of a typical S.U.S., in this case a 300L Single-Use Fermentor. Thermo Scientific Single-Use System integrator’s Guide...

  • Page 17: Thermo Scientific E-Box Information

    2.2 Thermo Scientific e-box information The Thermo Scientific e-box can be purchased with any S.U.S. It may not be provided with fully integrated units, but it can be used by third-party integrators who do not want to spec out components...
  • Page 18 Chapter 2 Electrical Box Overview Figure 2.3. E-box bottom view. Figure 2.4. E-box side view. Thermo Scientific Single-Use Systems Integrator’s Guide...

  • Page 19: Chapter 3 Motor Connection

    Motor connection This section provides information for third-party integrators on how to connect standard AC- and DC-powered motors supplied on the S.U.S. 3.1 Units without Thermo Scientific e-boxes 3.1.1 AC motor The AC motor comes with a 4-pin male receptacle on the J-box, as shown in Figure 3.1.
  • Page 20 Figure 3.2 shows a close-up of the connector on the motor. Table 3.1. AC motor connection table. Description Item Thermo Scientific Electrical Box connector (male Part # C01620C00310012 receptacle) Controller connector (female inline) Part # C01620D00311012...
  • Page 21 4-pin connector on the motor and terminates at the opposite end as a 6-pin Walther connector. This is the same cord that is used to connect the motor to the Thermo Scientific e-box. Figure 3.3. Thermo Scientific motor power cable.
  • Page 22 Chapter 3 Motor Connection Figure 3.4. 6-pin connector on Thermo Scientific AC motor power cable. 3.1.2 DC motor The DC motor comes with power, hall effects sensor, encoder, and a fan cable. The cables are hardwired to the motor case. Figure 3.5, below, shows a typical DC motor.
  • Page 23 Chapter 3 Motor Connection Table 3.3. DC motor power connection table. Description Item Thermo Scientific Electrical Box connector (male Part # C01620K00310012 receptacle) Controller connector (female inline) Part # C01620D00311012 Controller connector (female receptacle) Part # C01620G00310012 Connector manufacturer Amphenol 16/4 –...
  • Page 24 Chapter 3 Motor Connection Table 3.4. DC motor connection table for hall effects cable. Description Item Thermo Scientific Electrical Box connector Part # BS 8251-0/PG9 (90°male receptacle) Controller connector (female inline) Part # B 8151-0/PG9 Controller connector (female receptacle) Part # FKFD4.5-0.5...
  • Page 25 Chapter 3 Motor Connection Table 3.5. DC motor connection table for encoder cable. Description Item Thermo Scientific Electrical Box connector Part # BSWS 8251-0 (90°male receptacle) Controller connector (female inline) Part # BWS 8151-0 Controller connector (female receptacle) Part # FKFDW 4.5-0.5...
  • Page 26 Chapter 3 Motor Connection Table 3.6. DC motor fan power cable connection table. Description Item Shell Pins Thermo Scientific Electrical Box connector PX0410-03P-5560 SA3350 (crimp pin) (male receptacle) SA3348 (crimp Controller connector (female inline) PX0411-03S-5560 socket SA3348 (crimp Controller connector (female receptacle)

  • Page 27: Units With The Thermo Scientific E-Boxes

    3.2.1 AC motor Units supplied with Thermo Scientific electrical boxes (e-boxes) have the motor pre-connected to the e-box. The Thermo Scientific e-box contains a variable frequency drive (VFD) that converts the input voltage into 3-phase power to energize the motor. The 16-pin communication cable has the necessary I/O to communicate with the VFD and sufficiently control the motor.

  • Page 28: Motor General Information

    IP65 protection rating, and delivers ~230 VAC to the motor. The external fan attached to the back of the motor helps to cool the unit. The motor’s RPM at 60 Hz is ~1780 when using the Thermo Scientific- supplied VFD. The output shaft and all fasteners are stainless steel.
  • Page 29 7.5:1 64.1 100 L 400 W 7.5:1 64.1 200 L 400 W 7.5:1 64.1 S.U.M. 500 L 400 W 7.5:1 64.1 1000 L 400 W 7.5:1 64.1 2000 L 30 L S.U.F. 300 L Thermo Scientific Single-Use Systems Integrator’s Guide...

  • Page 30: Resistive Heater Connection

    It also discusses the functionality of the proportional, integral, derivative (PID) temperature control loop included in the Thermo Scientific e-box. Resistive heaters are only offered on the S.U.B. product line. This guide only covers integration of generation II- style S.U.B.s, approximately 2013 or newer.
  • Page 31 Resistive Heater Connection 4.1 Units without Thermo Scientific e-boxes Units without Thermo Scientific e-boxes will be provided with a 5+PE connector, which features a cord length of 5 feet. Each heater has multiple thermostats, which will open the heating circuit if the temperature reaches 65 °C.

  • Page 32: Units With The Thermo Scientific E-Box

    4.2 Units with Thermo Scientific e-boxes Units equipped with Thermo Scientific e-boxes have the resistive heater power cable plugged into the 10- pin connector on the side of the e-box. Two options to control the heaters are available. Each option is described below.
  • Page 33 The external temperature control option enables pins 9, 10 and 11, and disables pins 12 and 13 on the 16 pin communication cable. Table 4.2. Pinout for external temperature control plug. Description Item Shell Contactor Thermo Scientific connector (male PX0412-02S SA3349 (socket) receptacle) Integrator connector (female inline) Flying leads Flying leads...

  • Page 34: Resistive Heater General Information

    Chapter 1 Chapter Title Table 4.3. Pinout for 16-pin communication cable. Description Item Shell Insert Thermo Scientific connector (male SH616 710216 receptacle) Integrator connector Flying leads Flying leads Connector manufacturer Walther Walther AWG of flying leads Connector Wiring RTD output signal + (PT-100) (enabled or...
  • Page 35 PXG4CRM1-FVY00 Fuji controller mA output Note: Thermo Scientific will not take responsibility for the installation, wiring, documentation, support, and/or parameter setup of the recommended components. The part numbers listed in the previous table are only provided as a reference for integrators who may not be familiar with the components.

  • Page 36: Load Cell Connection

    This section provides information for third-party integrators on how to use the load cell signal from the Thermo Scientific tank. Load cells are an optional item, and can be installed at any point in the life of a vessel.
  • Page 37 Chapter 5 Load cell connection Table 5.1. Pinout for load cell summing block cable. Description Item Thermo Scientific connector (90°male Part # 1522545 receptacle) Integrator connector (female inline) Part # B 8181-0 Integrator connector (female receptacle) Part # FKFD 8-0.5...

  • Page 38: Units With The Thermo Scientific E-Box

    Chapter 5 Load cell connection 5.2 Units with Thermo Scientific e-boxes If a unit is supplied with a Thermo Scientific e-box, and a Mettler ™ Toledo load cell display, the integrator will receive the load cell signal through the 16-pin communication cable. Depending on the type of load cell display terminal ordered, the type of signal will be: •...

  • Page 39: Load Cell Communication Information

    Multimount family of load cells. Multimount – Used on all legacy products starting ~March 2014. ™ MTB load cell – Used on all Thermo Scientific HyPerforma S.U.B.s and S.U.M.s, except for the 2,000 L units. This load cell type is used on all S.U.F.

  • Page 40: Rtd Connection

    Table 18 lists several available RTDs. 6.1 Units without Thermo Scientific e-boxes The RTD on units supplied without a Thermo Scientific e-box will need to be plugged into the integrator’s control panel for temperature feedback. Thermo Scientific...
  • Page 41 6.2 Units with Thermo Scientific e-boxes The RTD on units supplied with Thermo Scientific e-boxes will plug into the side of the e-box, as shown in Figure 2.4. It communicates through the 16-pin communication cable. On resistive e-boxes, verify that the dip switch that controls the PID temperature control loop is set in the “Up”...
  • Page 42 Chapter 6 RTD Connection Table 6.2. Pinout for 16-pin RTD communication cable. Description Item Shell Insert Thermo Scientific connector (male SH616 710216 receptacle) Integrator connector Flying leads Flying leads Connector manufacturer Walther Walther AWG of flying leads Connector Wiring RTD output signal + (PT-100) (enabled or...

  • Page 43: Rtd Connection General Information

    Thermo SV50177.240 DB9 – male single RTD for Scientific Neslab TCUs 60-inch single Lemo Thermo SV50177A.08 RTD for Lauda connector Scientific TCUs 60-inch single Bulgin Thermo SV50999.03 RTD for 30 L (standard) Scientific S.U.F.s Thermo Scientific Single-Use Systems Integrator’s Guide...

  • Page 44: Pressure Sensor Connection

    7.1 Units without Thermo Scientific e-boxes On units supplied without the Thermo Scientific e-box, the integrator will connect to the pressure sensor cable, Thermo Scientific part number: SV50177.118. This cable will hook into the disposable pressure sensor on one end, and to the third-party controller on the other end.

  • Page 45: Units With The Thermo Scientific E-Box

    Figure 2.4. The raw pressure signal is then routed internally to the pressure transducer, and output as a 4-20 mA signal. This signal is scaled at 0-10 psi. The default excitation voltage of Thermo Scientific e-boxes is 10 VDC.
  • Page 46 Pressure signal -4-20 mA A pressure alarm signal is also routed from the pressure transducer to a 3-pin plug on the side of the Thermo Scientific e-box. The alarm set point comes preset at 0.5 psi. It is recommended that this set point remain at the default value.
  • Page 47 It is supplied with a 3-pin male connection on each end. Table 7.4. Pinout for pressure alarm cable. Description Item Shell Pins Thermo Scientific connector (male PX0410-03P-5560 SA3350 (crimp pin) receptacle) Integrator connector (female inline) PX0411-03S-5560 SA3349 (crimp socket)

  • Page 48: Pressure Sensors General Information

    Thermo Fisher will take no responsibility or consultation on the installation, wiring, documentation, support, and/or parameter setup of the recommended components. The part numbers listed above are only provided as a reference to integrators who may not be familiar with the components. Thermo Scientific Single-Use Systems Integrator’s Guide...

  • Page 49: Vent Filter Heater Connection

    46 series heaters come with an IEC C14 male plug that will plug directly into the bottom of the Thermo Scientific e-box. Each Type K heater comes with an M12-style fitting that connects to and is managed by the integrator’s control box.
  • Page 50 Chapter 8 Venter Filter Heater Connection 8.1 Units without Thermo Scientific e-boxes 8.1.1 46 series heaters The 46 series heaters should be plugged into an appropriate voltage plug per the voltage rating of the heater. Adapters can be purchased to convert the IEC C14 plug into the appropriate country-specific plug.
  • Page 51 The temperature set point should be targeted at 55 °C. Table 8.2. Pinout for type K vent filter heater plug Description Item Thermo Scientific connector (male inline) BS 8141-0/PG 9 Integrator connector (female inline) B 8141-0/PG 9 Integrator connector (female receptacle) FKFD 4.4-0.5...

  • Page 52: Units With The Thermo Scientific E-Box

    The temperature must also be controlled by the integrator. It is recommended that 46 series heaters be used when the S.U.S. has a Thermo Scientific- supplied e-box. Pinouts for this style of heater are shown in the previous section.

  • Page 53: Pinch Clamp Connection

    2-D film manifold that is 5.375 inches between the two mounting pins. The Thermo Scientific e-box does not support the pinch clamp, so there is no difference of integration based on the presence of the e-box. It is recommended that the pinch clamp be interlocked with the pressure feedback.

  • Page 54: Film Manifold Style Pinch Clamp

    This 24 VDC voltage should be applied for a minimum of 5 seconds to ensure the clamp remains open. It is also up to the integrator to interlock this signal with the e-stop of the system. Thermo Scientific Single-Use Systems Integrator’s Guide...
  • Page 55 Chapter 9 Pinch Clamp Connection Table 9.1. Pinout for film manifold style pinch clamp Description Item Thermo Scientific connector (male inline) Flying leads Integrator connector (female inline) Choice of integrator Integrator connector (female receptacle) Choice of integrator Connector manufacturer 22/5...

  • Page 56: Tcu Communication Connection

    TCU communication, so there is no difference of integration based on e-box presence. The temperature control scheme may differ when a Thermo Scientific e-box is present, but this will not impact the connections of the TCU. Each TCU type features RTD connection and communication ports.

  • Page 57: Neslab Tcus

    DB9 connector. RS232 and RS485 signals are the industry standards. The pinout is not presented in this publication. Figure 10.1. Neslab TCUs back panel connections. Thermo Scientific Single-Use Systems Integrator’s Guide...
  • Page 58 14 Remote set point, tie to pin 1 to allow control via remote set point Remote start, connect to pin 1 to remotely start unit Remote set point, analog voltage input 0-10 VDC Thermo Scientific Single-Use Systems Integrator’s Guide...

  • Page 59: Lauda Tcus

    RS232 and RS485 serial communication for communication to the third-party controller. Read and write commands are discussed in the Lauda operation manual. RS232, RS485 signals are the industry standards. The pinout is not provided in this publication. Thermo Scientific Single-Use Systems Integrator’s Guide...
  • Page 60 Integrator connector (female ERA.1S.304.CLL (mixed female and male) receptacle) Integrator connector FFA.1S.304.CLAC42Z Connector manufacturer LEMO AWG of flying leads 3-wire RTD Connector Wiring - PT100 signal - PT100 signal (jumper) + PT100 signal + PT100 signal Thermo Scientific Single-Use Systems Integrator’s Guide...

  • Page 61: Tcu Connections General Information

    0 V reference 0-10 VDC process value output from Lauda 10.3 TCU connections general information Table 10.5 shows a list of RTDs offered by Thermo Scientific for use with the TCUs. Table 10.5. Available RTDs for use with TCUs. Thermo Number...

  • Page 62: Dip Switch Functionality

    Scientific e-box, it will be critical to position these switches in the correct orientation. There are currently a total of 7 dip switches inside the Thermo Scientific e-box. These switches are grouped into two groups: two switches on the top DIN rail, and five switches on the bottom DIN rail.

  • Page 63: Bottom Din Rail In The Leftmost Position

    On/Up – The temperature controller is off, which allows external control of temperature; RTD PT100 signal is sent through 16-pin output. Off/Down – The temperature controller is on; temperature is displayed and controlled locally from front panel. Thermo Scientific Single-Use Systems Integrator’s Guide...

  • Page 64: 16-Pin Communication Cable

    RTD output signal + (PT-100) Temp output signal + 4-20 mA Temp output signal - 4-20 mA Pressure output signal + 4-20 mA Pressure output signal - 4-20 mA E-stop status dry contact or load cell communication Thermo Scientific Single-Use System integrator’s Guide...
  • Page 65 Find out more at thermofisher.com/sut Logan, Utah 84321 Cramlington NE23 1WA United States of America United Kingdom +(1) 435-792-8500 +44 (0) 1670-734093 Millersburg, Pennsylvania 17061 Matamoros, Tamaulipas 011152 United States of America Mexico +(1) 717-692-2104 +011 (52) 565-8109700 For Research Use or Further Manufacturing. Not for diagnostic use or direct administration in to humans or animals.

This manual is also suitable for:

Hyperforma 2.1 s.u.b.Hyperforma s.u.f.Hyperforma s.u.m

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