Medical Use - CareFusion PrinterNOx Operating Manual

is the greater. The flow of gas in the sampling line is continuously
monitored and an alarm sounded if the line is occluded or the water
trap is full. A low battery condition is also alarmed.
The PrinterNOx has been designed with ease of use and reliability as
of foremost importance. To ensure accurate results, however, it is
essential to familiarise yourself with the contents of this short
manual.

Medical Use

Nitric oxide (NO) is evolving as a novel therapy used to reduce
pulmonary arterial pressure and improve gas exchange in paediatric
and adult intensive care settings. The NO is usually added to the
ventilator circuit from a cylinder of NO in nitrogen with a
concentration up to 1000ppm and diluted in the circuit to between 1
and 40ppm.
Therapeutic concentrations must be well controlled as levels as low
as 100ppm may cause lung injury.
For safety reasons sources with greater than 1000ppm NO should
not be used. Lower concentrations carry less risk either to the
patient in the case of accidental overdose, or to the hospital staff in
the case of leakage. However, if moderately high doses of NO are to
be administered then the decrease in the maximum FiO must be
2
considered and is given by the relationship:
FiO (max.) = (1 - Required NO Conc./Source NO Conc.) X
2
100%
Therefore, if 40ppm is required from a source of 500ppm NO in
nitrogen then the maximum oxygen available would be:
FiO (max.) = (1 - 40 / 500) X 100% = 92%
2
5