Epson Stylus Pro 4400 Reference Manual page 150

Folded Booklet double-sided printing
You can also make single-fold booklets using the double-sided
printing feature. When you create a single-fold booklet, the pages
that appear on the outside (after the booklet is folded) are printed
first. The pages that will appear inside the booklet can then be
printed after the paper is reloaded into the printer.
✽ Binding Edge
A booklet can be created by printing pages 1 and 4 on the first
sheet of paper, pages 5 and 8 on the second sheet of paper, and
pages 9 and 12 on the third sheet of paper. After these sheets are
reloaded into the sheet feeder, you can then print pages 2 and 3
on the back of the first sheet of paper, pages 6 and 7 on the back
of the second sheet of paper, and pages 10 and 11 on the back of
the third sheet of paper. The resulting pages can then be folded
and bound together into a booklet.
To create the booklet, follow the steps below.
150
Printing with Mac OS 9.x
2 4
1 3 5 7
Single-fold booklet
✽
6 8 10 12
9 11