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Christ Alpha 1 LSCbasic Operating Manual

Freeze-dryer
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Translation of the original operating manual
sb-ja
Rev. 1.0 of 19/07/2022
Alpha 1-2 LSCbasic
Version 07/2022
Alpha 1-2 LSCbasic
part no. 101700, 101702, 101704
Freeze-dryer
Operating Manual
Please retain for later use!

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  • Page 1 Translation of the original operating manual sb-ja Rev. 1.0 of 19/07/2022 Alpha 1-2 LSCbasic Version 07/2022 Alpha 1-2 LSCbasic part no. 101700, 101702, 101704 Freeze-dryer Operating Manual Please retain for later use!
  • Page 2 Freeze-dryer Alpha 1-2 LSCbasic Version 07/2022, Rev. 1.0 of 19/07/2022 • sb-ja 2 / 111 Translation of the original operating manual...
  • Page 3 Freeze-dryer Alpha 1-2 LSCbasic In case of inquiries, please state the following numbers: Order number: Serial number: © Copyright by Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode am Harz Germany Tel.: +49 (0) 5522 / 5007-0...
  • Page 4 Freeze-dryer Alpha 1-2 LSCbasic Version 07/2022, Rev. 1.0 of 19/07/2022 • sb-ja 4 / 111 Translation of the original operating manual...

  • Page 5: Table Of Contents

    Freeze-dryer Alpha 1-2 LSCbasic Table of contents General information ......................9 Importance of the operating manual .................. 9 Intended use ........................9 1.2.1 Freeze-drying of solvent-containing products (non-aqueous media) ......10 1.2.2 Freeze-drying of acid-containing products ..............11 Warranty and liability....................... 12 Copyright ........................
  • Page 6 Freeze-dryer Alpha 1-2 LSCbasic Table of contents Safety notes concerning the operation ................29 3.7.1 Hazards caused by electricity ..................29 3.7.2 Hazards caused by the refrigeration system (natural, flammable refrigerants) ... 30 3.7.3 Hazards caused by harmful products ................. 30 3.7.4 Hazards caused by solvents in the products ..............
  • Page 7 Freeze-dryer Alpha 1-2 LSCbasic Table of contents Operation ..........................49 Initial start-up ........................49 Installation of accessories ....................49 Preparation ........................49 Switching the freeze-dryer on ..................49 LSCbasic control system ....................50 6.5.1 User interface ......................50 6.5.1.1 Main window "Process" ..................51 6.5.1.2 Main window "Options"...
  • Page 8 Freeze-dryer Alpha 1-2 LSCbasic Table of contents Disposal ..........................88 Disposal of the freeze-dryer .................... 88 Disposal of the packaging ....................88 Technical data ........................89 10.1 Ambient conditions ......................90 10.2 Technical documentation ....................90 Appendix ..........................91 11.1 Brief operating instructions .....................

  • Page 9: General Information

    No unauthorised design modifications, additions or conversions without the written approval by Martin Christ Gefriertrocknungsanlagen GmbH have been performed. • The vacuum pump used is approved by Martin Christ Gefriertrocknungsanlagen GmbH. The vacuum pumps approved for this system are listed in chapter 5.5 - "Vacuum pumps". •...

  • Page 10: Freeze-Drying Of Solvent-Containing Products (Non-Aqueous Media)

    Exclusion of liability Any use of the freeze-dryer other than the one described here or any use going beyond this description is regarded as improper use. Martin Christ Gefriertrocknungsanlagen GmbH cannot be held liable for any damage resulting from such improper use.

  • Page 11: Freeze-Drying Of Acid-Containing Products

    Otherwise, there is a risk of damage to property and personal injury. Consultation of Martin Christ Gefriertrocknungsanlagen GmbH is absolutely mandatory in order to define the measures that need to be taken! →...

  • Page 12: Warranty And Liability

    → Copyright The copyright concerning the operating manual remains with Martin Christ Gefriertrocknungsanlagen GmbH. The operating manual is solely intended for the operator and their personnel. It includes instructions and information that may not be •...

  • Page 13: Scope Of Supply

    Freeze-dryer Alpha 1-2 LSCbasic 1 General information Scope of supply The scope of supply comprises: • 1 tube of high-vacuum grease Part no. 126210 • 1 drain hose 0.4 m (silicone 9 x 12 mm) Part no. 513200 • 1 operating manual Additional items if a vacuum pump is included: •...

  • Page 14: Layout And Mode Of Operation

    Freeze-dryer Alpha 1-2 LSCbasic 2 Layout and mode of operation → Layout and mode of operation → Layout of the freeze-dryer → 2.1.1 Functional and operating elements Ice condenser chamber with an internal ice condenser User interface (see chapter 6.5.1 - "User interface") Mains power switch Fig.
  • Page 15 Freeze-dryer Alpha 1-2 LSCbasic 2 Layout and mode of operation Aeration and media drain valve Fig. 3: Left side of the freeze-dryer Power supply of the pressure control valve Name plate (see chapter 2.1.2 - "Name plate") Power supply of the vacuum pump 10 Equipotential bonding screw...

  • Page 16: Name Plate

    Freeze-dryer Alpha 1-2 LSCbasic 2 Layout and mode of operation → 2.1.2 Name plate Serial number Type Refrigerant data of the 1 stage Nominal voltage Year of manufacture (month/year) Part number Rated current / apparent power Fig. 6: Example of a name plate Version 07/2022, Rev.

  • Page 17: Mode Of Operation

    Freeze-dryer Alpha 1-2 LSCbasic 2 Layout and mode of operation → Mode of operation → 2.2.1 General information on freeze-drying What is freeze-drying? Freeze-drying or lyophilisation is a procedure for the gentle drying of high- quality products. The product is dried by → sublimation without passing through the liquid phase.
  • Page 18 Freeze-dryer Alpha 1-2 LSCbasic 2 Layout and mode of operation Fig. 7: Vapour pressure curve for ice and water From a physical point of view, the freeze-drying process covers three phases (see figure below): (1) Freezing: The product to be dried is frozen under atmospheric pressure. This can be done either directly in the freeze-dryer or in a separate deep- freeze.

  • Page 19: Freeze-Drying Process

    Freeze-dryer Alpha 1-2 LSCbasic 2 Layout and mode of operation Fig. 8: Freeze-drying phases Please find further information about basic principles, optimum procedures and applications in the brochure "Smart freeze-drying", which can be downloaded at www.martinchrist.de → [Applications] → [Lyophilisation]. NOTE →...

  • Page 20: Freezing

    Freeze-dryer Alpha 1-2 LSCbasic 2 Layout and mode of operation 2.2.2.2 Freezing First, the product that is to be dried is frozen. Especially in the case of small filling quantities, we recommend pre-cooling the shelves as well in order to prevent the product from thawing during the evacuation.

  • Page 21: Final Drying

    Freeze-dryer Alpha 1-2 LSCbasic 2 Layout and mode of operation 2.2.2.4 Final drying Final drying is an option whenever one requires a product with minimal residual moisture. In the physical sense, this process is a desorption process, i.e. the removal of adsorptively bound water. Final drying is performed under the lowest possible final pressure that depends on the ice condenser temperature in accordance with the vapour pressure curve for ice and water as well as on the final vacuum of the vacuum pump that is...

  • Page 22: Defrosting

    Freeze-dryer Alpha 1-2 LSCbasic 2 Layout and mode of operation 2.2.2.6 Defrosting Defrosting of the ice condenser is carried out at room temperature or with warm water. • At a maximum, the ice condenser chamber may be half filled with water. •...

  • Page 23: Safety

    Freeze-dryer Alpha 1-2 LSCbasic 3 Safety → Safety → Marking of the unit The following symbols are used for Christ freeze-dryers: Dangerous voltage On (Power) Hot surface Off (Power) Name plate (see chapter Caution! Risk of bruising 2.1.2 - "Name plate")

  • Page 24: Explanation Of The Symbols And Notes

    Freeze-dryer Alpha 1-2 LSCbasic 3 Safety → Explanation of the symbols and notes This operating manual uses the following names and symbols to indicate hazards: This symbol stands for a direct hazard to the life and health of persons. Non-observance of these symbols causes serious health problems up to life-endangering injuries.

  • Page 25: Responsibility Of The Operator

    Freeze-dryer Alpha 1-2 LSCbasic 3 Safety → Responsibility of the operator The operator is the person who uses the freeze-dryer for commercial or economic purposes or lets a third party use it and who bears the legal product responsibility for the protection of the users, personnel or third parties during operation.

  • Page 26: Freeze-Drying Of Solvent-Containing Products

    3 Safety • ensure that the freeze dryer is operated with one of the vacuum pumps approved by Martin Christ Gefriertrocknungsanlagen GmbH (see chapter 5.5 - "Vacuum pumps"). • have the system maintained at regular intervals (see chapter 8 - "Maintenance and service").

  • Page 27: Informal Safety Notes

    Freeze-dryer Alpha 1-2 LSCbasic 3 Safety Operating personnel (users) The operating personnel operates and monitors the freeze-dryer during normal operation and within the framework of its intended use. In the event of malfunctions or other problems, the operating personnel informs the respective specialised personnel.

  • Page 28: Safety Notes Concerning The Transport, Set-Up And Connection And Initial Start-Up Of The Freeze-Dryer

    Freeze-dryer Alpha 1-2 LSCbasic 3 Safety Safety notes concerning the transport, set-up and connection and initial start-up of the freeze-dryer The following notes and instructions must be observed in order to protect all persons and property. 3.6.1 General hazards General risk of injury Among the general hazards during the transport, set-up and connection and start-up of the freeze-dryer are impact hazards, crushing hazards, grazing hazards, cutting hazards, etc.

  • Page 29: Hazards Caused By Improper Connection

    Freeze-dryer Alpha 1-2 LSCbasic 3 Safety 3.6.4 Hazards caused by improper connection Risk of injury caused by consequences of improper connection Improper connection may lead to a hazardous electrical incident at a later time during the operation of the freeze-dryer. This may lead to severe damage to health or even life-threatening injuries.

  • Page 30: Hazards Caused By The Refrigeration System (Natural, Flammable Refrigerants)

    Freeze-dryer Alpha 1-2 LSCbasic 3 Safety 3.7.2 Hazards caused by the refrigeration system (natural, flammable refrigerants) Risk of explosion due to refrigerants The refrigerants used are highly flammable and can form an explosive mixture if their concentration in the ambient air is sufficiently high. There is an explosion hazard.

  • Page 31: Hazards Caused By Acids In The Products

    This may lead to severe injuries. DANGER Freeze-drying of products containing acids is only permissible if special protective measures and equipment-related precautions are taken! Consultation of Martin Christ Gefriertrocknungsanlagen GmbH is absolutely mandatory in order to define the measures that need to be taken! •...

  • Page 32: Oil-Sealed Vacuum Pump: Hazards Caused By Hot And Contaminated Vacuum Pump Oil

    Freeze-dryer Alpha 1-2 LSCbasic 3 Safety 3.7.8 Oil-sealed vacuum pump: hazards caused by hot and contaminated vacuum pump oil Risk of scalding caused by the vacuum pump oil When working on the vacuum pump and exhaust gas filter (especially when changing the oil or filter), the maintenance personnel are exposed to the hot vacuum pump oil.

  • Page 33: Safety Devices

    Freeze-dryer Alpha 1-2 LSCbasic 3 Safety → Safety devices → 3.8.1 System check An internal system check system monitors the data transfer and sensor signals with regard to plausibility. Errors are detected by continuous self- monitoring of the system. Error messages are displayed in the main window under "Process &...

  • Page 34: Maintenance And Cleaning Of The Freeze-Dryer

    • Stop the freeze-dryer immediately in the event of a malfunction. Eliminate the malfunction (see chapter 7 - "Malfunctions and error correction") or contact the after-sales service of Firma Martin Christ Gefriertrocknungsanlagen GmbH (see chapter 7.3 - "Service contact"). •...

  • Page 35: Remaining Hazards

    → 3.12 Remaining hazards All Christ freeze-dryers were built state-of-the-art and according to the accepted safety rules. Danger to life and limb of the operator, or of third parties, or impairments of the units or other material assets, however, cannot be completely excluded when the units are being used.

  • Page 36: Storage And Transport

    Freeze-dryer Alpha 1-2 LSCbasic 4 Storage and transport → Storage and transport → Dimensions and weight Values for the freeze-dryer without a vacuum pump: Alpha 1-2 LSCbasic Height: 345 mm Width: 315 mm Depth (including vacuum connection): 470 mm Weight: approx.

  • Page 37: Notes On Transport

    Freeze-dryer Alpha 1-2 LSCbasic 4 Storage and transport → Notes on transport • Use suitable packaging for the transport, and if at all possible, the original packaging. • Install all transport safety devices (see chapter 4.5 - "Transport safety device"). •...

  • Page 38: Packaging

    Freeze-dryer Alpha 1-2 LSCbasic 4 Storage and transport → Packaging The freeze-dryer is packaged in a cardboard box or in a wooden crate, depending on the scope of supply. • After opening the packaging, take out the box containing the accessories.

  • Page 39: Set-Up And Connection

    Freeze-dryer Alpha 1-2 LSCbasic 5 Set-up and connection → Set-up and connection → Location of use Use the freeze-dryer solely in closed and dry spaces. Refrigeration problems of the freeze-dryer are often caused by insufficient conditions at the location of use. This is why compliance with the following conditions is absolutely mandatory! NOTE •...

  • Page 40: Power Supply

    The operating voltage on the name plate must correspond to the local supply voltage! DANGER Christ freeze-dryers are units of protection class I. Freeze-dryers of this type have a three-wire power cord with an IEC C13 connector (see chapter 10 - "Technical data").

  • Page 41: Aeration And Media Drain Valve

    Freeze-dryer Alpha 1-2 LSCbasic 5 Set-up and connection → Aeration and media drain valve The aeration and media drain valve is located on the left side of the unit (see chapter 2.1.1 - "Functional and operating elements"). After the end of a freeze-drying process, the unit will be aerated via the aeration valve.
  • Page 42 Freeze-dryer Alpha 1-2 LSCbasic 5 Set-up and connection Installation of the vacuum sensor In order to protect the vacuum sensor against transport damage, it comes supplied in its original packaging. Prior to commissioning the freeze-dryer, the sensor must be installed. Vacuum sensor Clamping rings Connection socket...

  • Page 43: Vacuum Pumps

    Freeze-dryer Alpha 1-2 LSCbasic 5 Set-up and connection Vak uumpumpe → 5.4.6 Vacuum pumps To ensure its intended use, the freeze-dryer Alpha 1-2 LSCbasic must be used with one of the following vacuum pumps: Oil-sealed vacuum pumps: • Rotary vane pump Vacuubrand RZ2.5 •...

  • Page 44: Use Of An Interface Box

    Freeze-dryer Alpha 1-2 LSCbasic 5 Set-up and connection The oil mist that escapes from the pump during operation must be retained or discharged via an exhaust filter (oil mist separator). • We strongly recommend using an oil mist separator. The filter prevents air pollution by the oil mist that is emitted more or less strongly by the pump depending on the working pressure.
  • Page 45 Freeze-dryer Alpha 1-2 LSCbasic 5 Set-up and connection • Connect the connecting cable of the vacuum pump with the designated IEC C13 connector of the interface box (see the following picture, item 1). IEC C13 connector for the vacuum pump Abb.
  • Page 46 Freeze-dryer Alpha 1-2 LSCbasic 5 Set-up and connection IEC C13 connector for the vacuum pump at the back of the freeze-dryer Fig. 17: Back of the freeze-dryer (example) Version 07/2022, Rev. 1.0 of 19/07/2022 • sb-ja 46 / 111 Translation of the original operating manual...

  • Page 47: Pressure Control Valve

    Freeze-dryer Alpha 1-2 LSCbasic 5 Set-up and connection → Pressure control valve The pressure control valve is integrated in the suction pipe between the vacuum pump and ice condenser chamber. During certain, specified process phases, it interrupts the volume flow to the vacuum pump (see chapter 2.2.1 - "General information on freeze-drying").

  • Page 48: Rubber Valves

    Freeze-dryer Alpha 1-2 LSCbasic 5 Set-up and connection → Rubber valves The rubber valves (part no. 121860) enable the connection of round-bottom flasks, wide-neck filter bottles, or distributors for ampoules to a manifold or drying chamber. Depending on the connector of the components, the blue plug can be removed.

  • Page 49: Operation

    Freeze-dryer Alpha 1-2 LSCbasic 6 Operation Operation Initial start-up Before the initial start-up, please ensure that your freeze-dryer is properly set up and installed (see chapter 5 - "Set-up and connection") WARNING → Installation of accessories The accessories must be completed in accordance with the drying method that is applied as well as in accordance with the scope of supply.

  • Page 50: Lscbasic Control System

    Freeze-dryer Alpha 1-2 LSCbasic 6 Operation LSCbasic control system The control system LSCbasic (Lyo Screen Control basic) was specifically developed for the control of freeze-drying processes. The clear user interface enables the intuitive operation of the unit. Fig. 21: Start screen of the LSCbasic control unit (example) 6.5.1 User interface The system is operated via a touch panel, i.e.

  • Page 51: Main Window "Process

    Freeze-dryer Alpha 1-2 LSCbasic 6 Operation The user interface is divided into three main windows that can be called up by touching the corresponding buttons: Process This window is also the standard user interface. It is used to control the freeze-drying process manually.
  • Page 52 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation Status line (1) This line shows the operating status of the freeze-dryer as well as the active phase. The status line also shows the current date and time. The clock is battery- buffered and must be reset after a failure (chapter 6.5.1.2 - " Main window "Options"", section "Administration").
  • Page 53 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation Value windows (3) This area shows the current process data. The three value windows can be configured as desired. • Select the button of the value window that is to be adapted. A dialogue box with the possible parameters opens: –...
  • Page 54 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation Vapour pressure curve for ice and water A diagram shows the relationship between the pressure and sample temperature for aqueous systems. The pressure and temperature values can be changed by way of the buttons or by moving the arrows (see item 1 in the screenshot).
  • Page 55 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation Option: Lifting hoist (see chapter 6.6 - "Optional extensions") This function is described in the separate operating manual of the lifting hoist. Button "Set" (5) This button is used to enter the set values for the individual phases of the freeze-drying process prior to the start of the process.
  • Page 56 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation The fault has been eliminated, but the message has not been acknowledged The fault has not be eliminated and the message has not been acknowledged The fault has not been eliminated yet, but the message has been acknowledged Fig.
  • Page 57 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation The texts of the process and error messages are not included in this operating manual. The associated documents can be requested from our service department. NOTE Dialogue box "Operating mode: select/start" (7) After the set values have been entered for the process, the process can be started with this function (see chapter 6.5.2 - "Starting a freeze-drying process").
  • Page 58 (see the following illustration). Fig. 33: Results of the performance tests Evaluation: Please contact Martin Christ Gefriertrocknungsanlagen GmbH for an assessment of the results. Button "Stop" (8) Pressing this button stops the current process. The freeze-dryer switches to standby.

  • Page 59: Main Window "Options

    Freeze-dryer Alpha 1-2 LSCbasic 6 Operation 6.5.1.2 Main window "Options" The main window "Options" is where the basic configuration of the control system is defined. It enables the optimum adaptation of the freeze-dryer to its specific area of application. General "General"...
  • Page 60 • Double-chamber method LyoCube: Drying outside the ice condenser  chamber, but with the CHRIST LyoCube (a rectangular drying chamber that can be loaded from the front) Fig. 37: Dialogue box "Freeze-drying process" Version 07/2022, Rev. 1.0 of 19/07/2022 • sb-ja...
  • Page 61 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation Administration "Administration" options: "Date/Time" "Network" "System properties" "Access protection" "Device options" Fig. 38: Dialogue box "Options" / "Administration" Date/Time (1) The control system is equipped with an integrated, battery-buffered clock. After a failure of the buffer battery, the date and time must be reset. Fig.
  • Page 62 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation Network (2) This dialogue box is used to change the network settings. The changes will not become effective until after a restart of the freeze- dryer. NOTE Fig. 40: Dialogue box "Change network settings" System properties (3) This dialogue box is used to change the system settings.
  • Page 63 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation Click on touch: If this function is active, a clicking sound can be heard whenever the system registers that a button has been touched. Behaviour of the pressure control valve in the case of insufficient ice condenser cooling: If this function is active (button "closed"), the pressure control valve will close at an ice condenser temperature of ≥...
  • Page 64 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation • The button with the lock symbol blocks any access immediately and the system switches to the default setting. Fig. 44: Access blocked, data editing not possible Operator/maintenance/administrator password: For each of these access levels, certain editing rights have been defined.
  • Page 65 • Select the button "Add option". An input window opens. • Enter the six-digit CHRIST activation code that was supplied for this option. Note that the code is case-sensitive. Options can be removed in the same way. The changes will not become effective until after a restart of the freeze- dryer.
  • Page 66 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation Service "Service" options: "Operating hours" "Failure memory" "Vacuum pump oil change" "Maintenance" "Sensor adjustment" Fig. 47: Dialogue box "Service" (varies depending on the type of freeze-dryer) Operating hours (1) This dialogue box is used to view the number of operating hours of the various components of the freeze-dryer, e.g.
  • Page 67 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation Always indicate the error code in the event of enquiries or service requests! NOTE Fig. 49: Dialogue box "Failure memory" Vacuum pump oil change (3) The system monitors the oil change interval of the vacuum pump. The interval can be adapted to the vacuum pump model and utilisation.
  • Page 68 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation Maintenance (4) The maintenance interval of the freeze-dryer is set at 3,000 operating hours or at least one maintenance per year. When the end of a maintenance interval is reached, a corresponding message will be displayed. •...

  • Page 69: Main Window

    Freeze-dryer Alpha 1-2 LSCbasic 6 Operation 6.5.1.3 Main window "?" This main window includes the most important information concerning your freeze-dryer: Freeze-dryer type Control system type Serial number Manufacturer contact data Details concerning the software version Fig. 52: Freeze-dryer system information (example) In the event of enquiries at the manufacturer, please state the data that is stated here.

  • Page 70: Entering Set Values

    Freeze-dryer Alpha 1-2 LSCbasic 6 Operation If the value "∞" (infinite) is selected for a process phase, the next phase must be started manually via the button "Operating mode: select/start". NOTE The set values of the active phase can be changed during the process run. In this case, the control system adapts the freeze-dryer to the new set values as quickly as possible.
  • Page 71 Freeze-dryer Alpha 1-2 LSCbasic 6 Operation Viewing or editing the set values: • Press the button "Set" (see chapter 6.5.1.1 - "Main window "Process""). The following dialogue box will be displayed: "Defrosting" button Fig. 54: Dialogue box "Set values: view/edit" Fields that are displayed in the form of buttons can be edited.

  • Page 72: Optional Extensions

    Excel file after the completion of the process recording. LyoLogplus data logging software LyoLogplus is a data logging software program by Martin Christ Gefriertrocknungsanlagen GmbH that is specifically adapted to the requirements of freeze-drying processes. Apart from the graphical representation of the measurement data of currently running processes, it also enables the data export for additional evaluation.

  • Page 73: Malfunctions And Error Correction

    Freeze-dryer Alpha 1-2 LSCbasic 7 Malfunctions and error correction → Malfunctions and error correction Malfunctions are displayed in the dialogue box "Process & equipment messages" (see chapter 7.2 - "Process and error messages"). An acoustic signal sounds when an error message is generated. •...

  • Page 74: Power Failure

    (see chapter 7.3 - "Service contact") If it is impossible to eliminate the errors, contact the Christ service department! NOTE → 7.1.1 Power failure The control system continues with the process after a power failure.

  • Page 75: Insufficient Vacuum

    Freeze-dryer Alpha 1-2 LSCbasic 7 Malfunctions and error correction → 7.1.2 Insufficient vacuum The vacuum checks must be carried out when the ice condenser is frozen. NOTE → 7.1.2.1 Small flange connections Leakages are often due to improper small flange connections between the various components and hose connections or to leakages in the valves.

  • Page 76: Aeration Valve, Media Drain Valve

    Freeze-dryer Alpha 1-2 LSCbasic 7 Malfunctions and error correction → 7.1.2.2 Aeration valve, media drain valve Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health. •...

  • Page 77: Insufficient Ice Condenser Temperature

    Freeze-dryer Alpha 1-2 LSCbasic 7 Malfunctions and error correction → 7.1.3 Insufficient ice condenser temperature Ensure sufficient ventilation. Do not place any paper, cloth, or similar material behind or under the unit, since otherwise the air circulation will be impaired. CAUTION The refrigeration unit is equipped with a protective device against overpressure in the refrigeration system and with a thermal motor...

  • Page 78: Service Contact

    → Service contact In the event of queries, malfunctions, or spare part enquiries: From Germany: Contact Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) Tel. +49 (0) 55 22 / 50 07-44 44 E-mail: support.lab@martinchrist.de Outside Germany: Contact our agency in your country.

  • Page 79: Maintenance And Service

    Freeze-dryer Alpha 1-2 LSCbasic 8 Maintenance and service → Maintenance and service The freeze-dryer and the accessories are subject to high mechanical and chemical stress. Thorough maintenance performed by the user extends the service life and prevents premature failure. If corrosion or other damage occurs due to improper care, the manufacturer cannot be held liable or subject to any warranty claims.

  • Page 80: Ice Condenser Chamber

    Freeze-dryer Alpha 1-2 LSCbasic 8 Maintenance and service Cleaning of the freeze-dryer Risk of burns on hot surfaces After a drying process, some or all of the surfaces inside the chamber may still be hot. There is a risk of burns when touching the surfaces. WARNING •...

  • Page 81: Aeration Valve, Media Drain Valve

    Freeze-dryer Alpha 1-2 LSCbasic 8 Maintenance and service → 8.1.3 Aeration valve, media drain valve Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health. •...

  • Page 82: Heat Exchanger (Only For Air-Cooled Freeze-Dryers)

    • Check the heat exchanger at least once per month for soiling and clean it if necessary. • Please contact the Christ service department if you have any queries (see chapter 7.3 - "Service contact"). 8.1.5 Electrical system Danger of life caused by electric shock There is a risk of electric shock when touching current-carrying components.

  • Page 83: Exhaust Filter (Oil Mist Separator)

    The other oil changes depend on the operating conditions. In general, an interval of 500 to 1,000 operating hours is sufficient. • Please contact the Christ service department if you have any queries (see chapter 7.3 - "Service contact"). →...

  • Page 84: Vacuum Sensor

    Freeze-dryer Alpha 1-2 LSCbasic 8 Maintenance and service → 8.1.9 Vacuum sensor Please refer to the separate operating manual of the vacuum sensor! NOTE The vacuum sensor has only a limited service life. • The vacuum sensor is maintenance-free. • Remove any soiling on the outside with a cloth.

  • Page 85: Disinfection Of The Drying Chamber And Accessories

    This is why we recommend having the freeze-dryer checked by the manufacturer during an inspection once per year. Information and appointments: From Germany: Contact Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) Tel. +49 (0) 55 22 / 50 07-44 44 E-mail: support.lab@martinchrist.de Version 07/2022, Rev.

  • Page 86: Return Of Defective Parts

    Please fill in the following forms completely, sign them, enclose them with the return package, and send them together with the product to: Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) 1.
  • Page 87 Freeze-dryer Alpha 1-2 LSCbasic 8 Maintenance and service The part/unit must be packaged in a transport-safe manner. Please use the original packaging for the unit, if at all possible. If the product is dispatched to us in unsuitable packaging, you will be charged the cost for returning it to you in new packaging.

  • Page 88: Disposal

    Freeze-dryer Alpha 1-2 LSCbasic 9 Disposal → Disposal → Disposal of the freeze-dryer Martin Christ Gefriertrocknungsanlagen GmbH is a registered manufacturer of electric and electronic devices that are solely intended for commercial use. • Comply with all local rules and regulations. →...

  • Page 89: 10 Technical Data

    Freeze-dryer Alpha 1-2 LSCbasic 10 Technical data → 10 Technical data Manufacturer: Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) Type: Alpha 1-2 LSCbasic Part number: 101700 (230 V / 50 Hz, air-cooled) 101704 (115 V / 60 Hz, air-cooled)

  • Page 90: Ambient Conditions

    Freeze-dryer Alpha 1-2 LSCbasic 10 Technical data Refrigerant data Refrigerant: R1270 - Global warming potential (GWP): - Filling quantity: 36 g - Max. permissible pressure: 25 bar - CO equivalent: < 0.01 t Refrigerant: R170 - Global warming potential (GWP): - Filling quantity: - Max.

  • Page 91: 11 Appendix

    Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix 11 Appendix → 11.1 Brief operating instructions Functional and operating elements Ice condenser chamber with an internal ice condenser User interface Mains power switch Fig. 61: Front and left side of the freeze-dryer Pipe connection of the vacuum pump (behind the cover plate) Ice condenser...
  • Page 92 Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix Aeration and media drain valve Fig. 63: Right side of the freeze-dryer Power supply of the pressure control valve Name plate Power supply of the vacuum pump 10 Equipotential bonding screw 11 Mains connection 12 Vacuum connection 13 Connection of the vacuum sensor...
  • Page 93 Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix Step-by-step instructions – shelf drying 1 Freeze the sample separately, e.g. in a deep-freeze. Ensure that the layer thickness of 1 to 2 cm is not exceeded, since otherwise the drying time needs to be extended. NOTE 2 Check the ice condenser chamber and ensure that it is completely free from water residues.
  • Page 94 Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix 16 Switch the unit on again and start the defrosting process. Ensure that no water gets into the pipe connection of the vacuum pump or vacuum sensor. CAUTION 17 Drain the defrosting water via the media drain valve on the left-hand side of the unit.
  • Page 95 Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix 50°C to -54°C. The pressure decreases as a function of the ice condenser temperature. The drying time depends on the layer thickness of the sample, the solids content of the sample, and the amount of heat that is supplied during the drying process.
  • Page 96 Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix → Version 07/2022, Rev. 1.0 of 19/07/2022 • sb-ja 96 / 111 Translation of the original operating manual...

  • Page 97: Ec Declaration Of Conformity In Accordance With The Ec Machinery Directive

    Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix 11.2 EC declaration of conformity in accordance with the EC Machinery Directive Version 07/2022, Rev. 1.0 of 19/07/2022 • sb-ja 97 / 111 Translation of the original operating manual...
  • Page 98 Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix Version 07/2022, Rev. 1.0 of 19/07/2022 • sb-ja 98 / 111 Translation of the original operating manual...

  • Page 99: Declaration Of Conformity - China Rohs 2

    Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix Declaration of conformity – China RoHS 2 11.3 Version 07/2022, Rev. 1.0 of 19/07/2022 • sb-ja 99 / 111 Translation of the original operating manual...
  • Page 100 Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix Version 07/2022, Rev. 1.0 of 19/07/2022 • sb-ja 100 / 111 Translation of the original operating manual...

  • Page 101: Ec Declaration Of Conformity In Accordance With The Pressure Equipment Directive

    Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix 11.4 EC declaration of conformity in accordance with the Pressure Equipment Directive Version 07/2022, Rev. 1.0 of 19/07/2022 • sb-ja 101 / 111 Translation of the original operating manual...
  • Page 102 Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix Version 07/2022, Rev. 1.0 of 19/07/2022 • sb-ja 102 / 111 Translation of the original operating manual...

  • Page 103: Table Of The Sublimation Pressure Curve

    Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix 11.5 Table of the sublimation pressure curve °C = mbar °C = mbar °C = mbar °C = mbar 6,110 1,030 0,120 0,011 5,620 0,940 0,110 0,009 5,1770 0,850 0,100 0,008 4,760 0,770 0,090 0,007 4,370 0,700...
  • Page 104 Freeze-dryer Alpha 1-2 LSCbasic 11 Appendix Version 07/2022, Rev. 1.0 of 19/07/2022 • sb-ja 104 / 111 Translation of the original operating manual...

  • Page 105: 12 Glossary

    Freeze-dryer Alpha 1-2 LSCbasic 12 Glossary 12 Glossary Desorption Desorption (from Latin de-sorbere, sorbere = sup up, suck in) describes a phenomenon whereby molecules are released from the surface of a solid. In order to be able to desorb, the particle must have, or be provided with, a sufficient amount of energy in order to overcome the binding energy.
  • Page 106 Freeze-dryer Alpha 1-2 LSCbasic 12 Glossary Version 07/2022, Rev. 1.0 of 19/07/2022 • sb-ja 106 / 111 Translation of the original operating manual...

  • Page 107: 13 Index

    Freeze-dryer Alpha 1-2 LSCbasic Index 13 Index Compliance with the EC health and safety directives ..........25 Access protection........63 Condensate, contaminated (hazards) .... Accessories ......13, 35, 79, 84 ........... 31, 76, 81 Accident prevention ......25, 27 Connection..........34 Accident prevention regulations ....
  • Page 108 Freeze-dryer Alpha 1-2 LSCbasic Index Dialogue box "Process and equipment Freeze-dryer type ........69 messages ..........55 Freeze-dryer, cleaning and care ....80 Dialogue box "Schematic system diagram" 52 Freeze-drying of acid-containing products.. 11 Dialogue box "Tools" ........53 Freeze-drying of solvent-containing products Dimensions ..........
  • Page 109 Freeze-dryer Alpha 1-2 LSCbasic Index Heat exchanger of the refrigeration unit ..15 Maintenance and service ......79 Humidity ............. 90 Maintenance performed by the user ... 79 Malfunction of the pressure control valve ... 76 Malfunctions ..........73 Ice condenser ..........89 Manufacturer ......
  • Page 110 Freeze-dryer Alpha 1-2 LSCbasic Index Optional extensions ........72 Requirements concerning the personnel ..26 Responsibility of the operator ..... 25 Return of defective parts ......86 Packaging ..........38, 88 Risk assessment ........25 Part number ......... 16, 89 Rubber valves ........
  • Page 111 Freeze-dryer Alpha 1-2 LSCbasic Index Step-by-step instructions – drying in a flask 94 Type of connection ........40 Step-by-step instructions – shelf drying ..93 Storage ............36 USB process recorder ........ 72 Storage and transport ........ 36 USB process recording ......54 Storage conditions ........

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