Christ Epsilon 2-4 LSCplus Operating Manual
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Christ Epsilon 2-4 LSCplus Operating Manual

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Translation of the original operating manual
sb
Rev. 1.0 of 14/06/2016
Epsilon 2-4 LSCplus; ;
Version 06/2016
Epsilon 2-4 LSCplus
part no. 113019
Freeze-dryer
Operating Manual
Please retain for later use!

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Summary of Contents for Christ Epsilon 2-4 LSCplus

  • Page 1 Translation of the original operating manual Rev. 1.0 of 14/06/2016 Epsilon 2-4 LSCplus; ; Version 06/2016 Epsilon 2-4 LSCplus part no. 113019 Freeze-dryer Operating Manual Please retain for later use!
  • Page 2 Freeze-dryer Epsilon 2-4 LSCplus Version 06/2016, Rev. 1.0 of 14/06/2016 • sb 2 / 142 Translation of the original operating manual...
  • Page 3 Freeze-dryer Epsilon 2-4 LSCplus In case of inquiries, please state the following numbers: Order number: Serial number: © Copyright by Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode am Harz Germany Tel.: +49 (0) 5522 / 5007-0...
  • Page 4 Freeze-dryer Epsilon 2-4 LSCplus Version 06/2016, Rev. 1.0 of 14/06/2016 • sb 4 / 142 Translation of the original operating manual...

  • Page 5: Table Of Contents

    Freeze-dryer Epsilon 2-4 LSCplus Table of contents General information ......................9 Importance of the operating manual .................. 9 Intended use ........................9 Warranty and liability ....................... 12 Copyright ........................12 Explanation of symbols ....................12 Standards and regulations ....................12 Scope of supply ......................
  • Page 6 Freeze-dryer Epsilon 2-4 LSCplus Table of contents 3.7.9 Hazards caused by contaminated exhaust air ............38 3.7.10 Hazards caused by the loading door ................38 3.7.11 Hazards caused by hot surfaces ................38 3.7.12 Hazards caused by cold surfaces ................39 3.7.13 Hazards caused by overpressure in the chamber ............
  • Page 7 Freeze-dryer Epsilon 2-4 LSCplus Table of contents LSCplus control system ....................63 6.6.1 User interface ......................63 6.6.1.1 Main window "Manual" ..................64 6.6.1.2 Main window "Program" ..................72 6.6.1.3 Main window "Options" ..................73 6.6.1.4 Main window "?" ....................87 6.6.2...
  • Page 8 Freeze-dryer Epsilon 2-4 LSCplus Table of contents Disposal ..........................126 Disposal of the freeze-dryer ..................126 Disposal of the packaging ..................... 126 Technical data ........................127 10.1 Ambient conditions......................128 10.2 Technical documentation ....................128 Appendix .......................... 129 11.1 Mathematical relations ....................129 11.2...

  • Page 9: General Information

    Freeze-dryer Epsilon 2-4 LSCplus 1 General information Pos: 1 /2 00 C hrist/ 360 GT -BA Lab or-Pilot (STANDARDM ODULE)/ 010 Allg emei ne I nfor mati one n/01 0 Allge mein e In for matio nen == == === == == === == == == === == == === == @ 24 \mo d_1 404 983 207 982_ 68. docx @ 18 2921 @ 1 @ 1 General information Pos: 2 /2 00 C hrist/ 360 GT -BA Lab or-Pilot (STANDARDM ODULE)/ 010 Allg emei ne I nfor mati one n/01 0-0 010 Stelle nwert de r Betri ebsa nleitu ng @ 25\ mod _14 049 832 092 48_6 8.d ocx @ 182 935 @ 2 @ 1...
  • Page 10 Freeze-drying of azide-containing products Freeze-drying of products containing azides is only permissible following a case-by-case examination and the written approval by Martin Christ Gefriertrocknungsanlagen GmbH, since azides may form explosive dust- air-mixtures and also explosive metal azides when combined with non- ferrous metals (e.g.
  • Page 11 • adapted control system Otherwise, there is a risk of personal injury. Consultation of Martin Christ Gefriertrocknungsanlagen GmbH is absolutely mandatory in order to define the measures that need to be taken! Any other use beyond this area of application is regarded as improper use.

  • Page 12: Warranty And Liability

    Pos: 10 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /01 0 Allgem eine Info rm ation en/0 10- 005 0 Zeich ene rklär ung @ 2 5\mo d_1 404 983 213 429 _68.

  • Page 13: Scope Of Supply

    Pos: 14 / 200 Christ /36 1 GT -BA La bor -Pilot (PROJEKTE )/Epsilon 4e r/Epsilon 2- 4 LSCplu s SN 21 863/ 010 Allgem eine I nfo rma tione n/0 10- 007 0 Li efer umf ang SN 218 63 @ 42\ mod _14 5931 714 129 9_6 8.do...

  • Page 14: Layout And Mode Of Operation

    Pos: 17 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /02 0 Aufb au u nd Wirk ungs weise/ 020 Aufb au u nd Wir kung sweise == === == == === == == === == == === = @ 25\ mod _14 049 832 3599 4_6 8.d...
  • Page 15 Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Sight glass Locking handle Fig. 2: Detailed view A – Loading door Door contact switch Connection block for the product sensors and a LyoRX sensor Pressure plate (hydraulic system) Shelf...
  • Page 16 Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation 13 Control system LSCplus 14 Button "Up" (hydraulic system) 15 Button "Down" (hydraulic system) 16 Key switch "aqueous / non aqueous" 17 "Emergency stop" button 18 Control system on/off 19 Button "Release"...
  • Page 17 Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation 22 Switch cabinet (behind the side panel) Fig. 6: Right side of the freeze-dryer Version 06/2016, Rev. 1.0 of 14/06/2016 • sb 17 / 142 Translation of the original operating manual...
  • Page 18 Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation 23 Silencer of the vacuum pump 24 Vacuum pump 25 Pressure control valve 26 Adsorption filter 27 Access flange with WTMplus antenna 28 Access flange with weighing system 29 Measuring box of the...
  • Page 19 Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation 32 Vacuum sensor Pfeiffer CMR 373 33 Vacuum sensor Thyracont VSP63 34 Pressure transmitter Jumo dTrans p30 Fig. 8: Detailed view D – Vacuum sensors 35 Name plate 36 Main switch...

  • Page 20: Name Plate

    Pos: 21 / 200 Christ /36 1 GT -BA La bor -Pilot (PROJEKTE )/Epsilon 4e r/Epsilon 2- 4 LSCplu s SN 21 863/ 020 Aufba u u nd Wirk ungsw eise/0 20- 001 0-0 020 T ypen schild SN2 186 3 @ 42\m od_ 145 931 716 493 1_68 .docx...

  • Page 21: Mode Of Operation

    Pos: 24 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /02 0 Aufb au u nd Wirk ungs weise/ 020 -00 20- 001 0 G efrie rtr ocknu ng allgem ein @ 25\ mod _14 049 832 548 15_ 68.d...
  • Page 22 Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Pressure (mbar) LIQUID Melting SOLID 6.11 mbar Triple point Sublimation 0.37 mbar GASEOUS Temperature (°C) -30°C Fig. 11: Vapour pressure curve above ice From a physical point of view, the freeze-drying process covers three phases (see figure below): (1) Freezing: The product to be dried is frozen under atmospheric pressure.

  • Page 23: Freeze-Drying Process

    Pos: 28 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /02 0 Aufb au u nd Wirk ungs weise/ 020 -00 20- 002 0-0 010 Vorb er eitun g @ 2 5\m od_ 140 498 3256 926 _68 .docx...

  • Page 24: Freezing

    Pos: 30 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /02 0 Aufb au u nd Wirk ungs weise/ 020 -00 20- 002 0-0 020 Gef rier en @ 25\ mod _14 049 832 579 55_ 68.d...

  • Page 25: Main Drying

    Pos: 32 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /02 0 Aufb au u nd Wirk ungs weise/ 020 -00 20- 002 0-0 030 Hau pttr ocknu ng @ 25\ mo d_14 049 832 592 60_ 68.d...

  • Page 26: End Of Drying And Aeration

    Pos: 36 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /02 0 Aufb au u nd Wirk ungs weise/ 020 -00 20- 002 0-0 050 T rockn ungs end e u nd Belüf...

  • Page 27: Safety

    Pos: 42 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /03 0 Sicher heit/ 030 -00 10 B eschilde ru ng d es Ge räts @ 2 5\mo d_1 404 983 297 040 _68.

  • Page 28: Explanation Of The Symbols And Notes

    Pos: 44 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /03 0 Sicher heit/ 030 -00 20 Sy mbol - un d Hinw eiserkl äru nge n @ 2 5\m od_ 140 498 3298 133 _68 .docx...

  • Page 29: Responsibility Of The Operator

    Pos: 46 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /03 0 Sicher heit/ 030 -00 31 V era ntwor tun g des Betr eiber s Epsilon @ 2 5\mo d_1 404 983 299 227 _68.

  • Page 30: Operating Personnel

    Pos: 50 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /03 0 Sicher heit/ 030 -00 50 Info rm elle Siche rheits hinweis e @ 25\m od_ 140 498 330 128 4_6 8.docx...

  • Page 31: Hazards Caused By Improper Transport

    Pos: 58 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /03 0 Sicher heit/ 030 -00 20 Sich erh eit Epsilon /03 0-0 060 -00 30 Gefa hre n d urch unsa chg emä ße...

  • Page 32: Hazards During The Initial Start-Up

    Pos: 65 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /03 0 Sicher heit/ 030 -00 20 Sich erh eit Epsilon /03 0-0 061 Sich er heitshi nweise z um Be trie b @ 3 6\m od_ 143 584 261 1820 _68 .docx...

  • Page 33: Hazards Caused By The Refrigeration System

    Pos: 69 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /03 0 Sicher heit/ 030 -00 20 Sich erh eit Epsilon /03 0-0 061 -00 20 Gefa hre n d urch das Käl...

  • Page 34: Hazards Caused By The Pressure Plate

    Pos: 73 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /03 0 Sicher heit/ 030 -00 20 Sich erh eit Epsilon /03 0-0 061 -00 40 Gefa hre n d urch Stick stoff @ 3 6\mo d_1 435 844 827 939 _68.

  • Page 35: Hazards Caused By Harmful Products

    Pos: 75 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /03 0 Sicher heit/ 030 -00 20 Sich erh eit Epsilon /03 0-0 061 -00 60 Gefa hre n d urch gesu ndh eitssch ädlich...

  • Page 36: Hazards Caused By Solvents In The Products

    Pos: 77 / 200 Christ /36 1 GT -BA La bor -Pilot (PROJEKTE )/Epsilon 4e r/Epsilon 2- 4 LSCplu s SN 21 863/ 030 Sicher heit/ 030 -006 1- 0070 Ge fah ren dur ch L ösun...

  • Page 37: Hazards Caused By Azides In The Products

    Pos: 79 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /03 0 Sicher heit/ 030 -00 20 Sich erh eit Epsilon /03 0-0 061 -00 80 Gefa hre n d urch Azi de in den Ausga ngsp rod ukte n @ 3 6\m od_ 143 590 106 7482 _68 .docx...

  • Page 38: Hazards Caused By Contaminated Exhaust Air

    Pos: 85 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /03 0 Sicher heit/ 030 -00 20 Sich erh eit Epsilon /03 0-0 061 -01 20 Gefa hre n d urch die Bel adet ür...

  • Page 39: 3.7.12 Hazards Caused By Cold Surfaces

    Pos: 89 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /03 0 Sicher heit/ 030 -00 20 Sich erh eit Epsilon /03 0-0 061 -01 50 Gefa hre n d urch kalte Obe rfläch...
  • Page 40 Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Main switch (line disconnector) and control switch Position see chapter 2.1.1 - "Functional and operating elements" The main switch is used to disconnect the freeze-dryer from the mains power supply. As a result, all of the automatic valves will be closed and all of the units will be switched off.

  • Page 41: Procedures In The Event Of Hazards And Accidents

    Pos: 96 / 200 Christ /36 0 GT -BA La bor -Pilot (S TANDARDMODULE) /03 0 Sicher heit/ 030 -00 20 Sich erh eit Epsilon /03 0-0 081 Verh alte n bei Gefa hre n u nd Un fällen...

  • Page 42: Emission Of Vapours

    Pos: 98 / 200 Christ /36 1 GT -BA La bor -Pilot (PROJEKTE )/Epsilon 4e r/Epsilon 2- 4 LSCplu s SN 21 863/ 030 Sicher heit/ 030 -009 0 E mission v on D ämpf...

  • Page 43: Maintenance And Cleaning Of The Freeze-Dryer

    • Stop the freeze-dryer immediately in the event of a malfunction. Eliminate the malfunction (see chapter 7 - "Malfunctions and error correction") or contact the after-sales service of Firma Martin Christ Gefriertrocknungsanlagen GmbH (see chapter 7.3 - "Service contact"). •...

  • Page 44: Remaining Hazards

    Pos: 106 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 30 Siche rhei t/03 0-0 090 Rest risiken @ 2 5\mo d_1 404 983 315 577 _68. docx @ 18 345 3 @ 2 @ 1 3.14 Remaining hazards All CHRIST freeze-dryers were built state-of-the-art and according to the accepted safety rules. Danger to life and limb of the operator, or of third parties, or impairments of the units or other material assets, however, cannot be completely excluded when the units are being used.

  • Page 45: Storage And Transport

    Pos: 110 /20 0 Ch rist/3 61 G T-BA L abo r-Pilot (PROJEKTE)/Epsilo n 4 er/Epsilo n 2 -4 LSC plus SN 2 186 3/04 0 La ger ung un d T rans por t/04 0-0 010 Abm essun gen un d Gewic ht SN21 863 @ 42 \mo d_1 459 317 1827 82_ 68. docx @ 32 4159 @ 2 @ 1 Dimensions and weight Epsilon 2-4 LSCplus (serial no. 21863) Height:...

  • Page 46: Packaging

    Freeze-dryer Epsilon 2-4 LSCplus 4 Storage and transport Pos: 114 /20 0 Ch rist/3 61 G T-BA L abo r-Pilot (PROJEKTE)/Epsilo n 4 er/Epsilo n 2 -4 LSC plus SN 2 186 3/04 0 La ger ung un d T rans por t/04 0-0 040 Ver packu ng SN2 186 3 @ 4 2\m od_ 145 9317 183 326 _68 .docx @ 32 419 1 @ 2 @ 1...

  • Page 47: Transport

    Freeze-dryer Epsilon 2-4 LSCplus 4 Storage and transport Pos: 116 /20 0 Ch rist/3 61 G T-BA L abo r-Pilot (PROJEKTE)/Epsilo n 4 er/Epsilo n 2 -4 LSC plus SN 2 186 3/04 0 La ger ung un d T rans por t/04 0-0 020 T rans por t SN218 63 @ 42\ mo d_1 4593 171 830 62_ 68.d ocx @ 324 175 @ 2 @ 1...

  • Page 48: Set-Up And Connection

    Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pos: 121 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 40 L age run g un d T ran spo rt/05 0 Aufst ellun g un d Anschl uss/0 50 Aufs tellun g un d Ansc hluss Epsilo n/0 50 Au fstellu ng u nd Ansc hluss Ep silon === == == == === == == === == == === @ 3 6\m od_ 1436 508 805 195 _68. docx @ 26 727 2 @ 1 @ 1...

  • Page 49: Customer-Provided Fuses

    Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection • Do not set up the vacuum pump directly next to the heat exchanger (condenser). • In the case of water-cooled systems, ensure that the water circuit provides a sufficient amount of cooling water.
  • Page 50 Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Vacuum sensor Pfeiffer CMR 373 Vacuum sensor Thyracont VSP63 Pressure transmitter Jumo dTrans p30 Fig. 17: Position of the vacuum sensors behind the left side panel • Plug the connector (installed on the unit) onto the vacuum sensor and hand-tighten the screw on the connector.

  • Page 51: Operation Of The Loading Door

    Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pos: 129 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 40 L age run g un d T ran spo rt/05 0 Aufst ellun g un d Anschl uss/0 50 Aufs tellun g un d Ansc hluss Epsilo n/0 50- 005 0 Bedi enu ng d er Bel adet ür Epsil on - Übe rsch rift- --- --- -- --- -- --- -- --- --- -- --- -- --- --- @ 2 5\m od_ 1404 984 628 128 _68. docx @ 18 572 1 @ 2 @ 1 Operation of the loading door Pos: 130 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 40 L age run g un d T ran spo rt/05 0 Aufst ellun g un d Anschl uss/0 50 Aufs tellun g un d Ansc hluss Epsilo n/0 50- 005 1 Bedi enu ng d er Bel adet ür Epsil on Text @ 25 \mo d_1 404 9846 293 22_ 68.d ocx @ 185 735 @ @ 1...

  • Page 52: Vacuum Pump And Silencer

    Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pos: 132 /20 0 Ch rist/3 61 G T-BA L abo r-Pilot (PROJEKTE)/Epsilo n 4 er/Epsilo n 2 -4 LSC plus SN 2 186 3/05 0 Aufst ellung un d Anschl uss/05 0- 0042 Vaku um pum pe u nd Sch alldä mpfe r SN21 863 @ 4 2\mo d_1 459 317 202 416 _68. docx @ 32 425 6 @ 2 @ 1 5.4.6...
  • Page 53 Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pressure plate Shelf Fig. 19: Hydraulic components in the chamber By means of the two push-buttons "Up" (4) and "Down" (3) installed at the operating panel of the LSCplus control system it is possible to move the pressure plate vertically for loading / unloading, stoppering product vials inside the drying chamber as well as for maintenance purposes.

  • Page 54: Pressure Control Valve

    Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection In order to seal the product vials by means of the hydraulic shelf movement facility, the shelves must be completely loaded with identical vessels to avoid damaging shelves and guiding rods as well as breakage of vessels.

  • Page 55: Establishment Of The Supply And Disposal Connections

    DANGER CHRIST freeze-dryers are units of safety class I. The freeze-dryer of the type Epsilon 2-4 LSCplus (serial no. 21863) has a five-wire power cord with a 5-pin Cekon-plug (see chapter 10 - "Technical data"). Prior to connecting the unit to the power supply system, check the rotary...
  • Page 56 Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Risk of suffocation caused by nitrogen If the chamber is aerated with nitrogen, the gas may escape through openings in the system (e.g. supply lines that are not properly connected or a loading door that is not closed correctly). If the freeze-dryer is...

  • Page 57: Media Drain

    Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pos: 144 /20 0 Ch rist/3 61 G T-BA L abo r-Pilot (PROJEKTE)/Epsilo n 4 er/Epsilo n 2 -4 LSC plus SN 2 186 3/05 0 Aufst ellung un d Anschl uss/05 0- 0060 -00 30 Me dien ablau f SN 21 863 @ 43 \mo d_1 463 465 792 356_ 68. docx @ 35 016 3 @ 3 @ 1 5.8.3...

  • Page 58: Weighing System Lyobalance

    Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pos: 148 /20 0 Ch rist/3 61 G T-BA L abo r-Pilot (PROJEKTE)/Epsilo n 4 er/Epsilo n 2 -4 LSC plus SN 2 186 3/05 0 Aufst ellung un d Anschl uss/05 0- 0100 Wäg esyst em SN 2 186 3 @ 43\m od_ 146 364 219 120 6_6 8.docx @ 3 503 87 @ 2 @ 1...
  • Page 59 Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Dummy plug with earthing cable Fig. 23: Weighing system LyoBalance is deactivated (for non-aqueous samples) Pos: 149 /01 0 Univ ersal mod ule/Absc hnittsw echsel @ 0\ mod _12 021 245 140 62_ 0.docx @ 4 18 @ @ 1 Pos: 150 /01 0 Univ ersal mod ule/Seit enwec hsel @ 0\m od_ 120 211 624 4312 _0.

  • Page 60: Operation

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos: 151 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 60 Bet rieb/ 060 B etrie b= === == == === == == === == == === == == == === == == == @ 25\ mod _14 049 837 597 58_6 8.d ocx @ 183 578 @ 1 @ 1 Operation Pos: 152 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 60 Bet rieb/ 060 -00 11 E rste I nbe trie bnah me E psilon ++ +++ ++ ++ +++ ++ ++ +++ ++ ++ +++ @ 3 6\m od_ 143 6509 116 118 _68.

  • Page 61: Freeze-Drying Products Containing Solvents

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos: 160 /20 0 Ch rist/3 61 G T-BA L abo r-Pilot (PROJEKTE)/Epsilo n 4 er/Epsilo n 2 -4 LSC plus SN 2 186 3/06 0 Betri eb/ 060 -004 1 Tr ocknu ng v on lös ungs mittel haltig en Aus gang spr odukt en SN 2186 3 @ 43\ mod _146 217 050 571 4_6 8.doc x @ 3 477 12 @ 2 @ 1...

  • Page 62: Door-Controlled Inertisation

    LSCplus control system (see chapter 6.6.1.3 - "Main window "Options""/"General – Inertisation (5)") or via the SCADA system (see separate operating manual of the Christ SCADA-Software LPCplus, index "Inertisation (parameterisation)"). Pos: 163 /01 0 Univ ersal mod ule/Seit enwec hsel @ 0\m od_ 120 211 624 4312 _0. docx @ 10 5 @ @ 1 Version 06/2016, Rev.

  • Page 63: Lscplus Control System

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos: 164 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 60 Bet rieb/ LSCplus/ 060 -00 50 LSCplus Anl age nsteu eru ng Epsil on - -- --- -- --- --- -- --- -- --- --- -- --- -- --- -- --- --- @ 3 3\m od_ 1420 529 818 242 _68. docx @ 22 476 0 @ 2 @ 1...

  • Page 64: Main Window "Manual

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation The user interface is divided into four main windows that can be called up by touching the corresponding buttons: Manual This window is also the standard user interface. It is used to control the freeze-drying process manually.
  • Page 65 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Status line (1) This line shows the operating status of the freeze-dryer as well as the active phase. The status line also shows the current date and time. The clock is battery- buffered and must be reset after a failure (see chapter 6.6.1.3 - "Main window "Options"", section "Administration").
  • Page 66 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Actual values of the current process (4) This area shows the current process data. The fields can be configured as desired: • Select the button of the field that is to be adapted. A dialog box opens: Fig.
  • Page 67 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Option: USB process recording (see chapter 6.7 - "Optional extensions and special equipment") • Select the "Process recording" function in the dialog box "Tools". • Select the input fields ("Batch data"). A keyboard for the data input will be displayed.
  • Page 68 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Fig. 30: Dialog box "Pressure increase test" • The "Test stop" button stops the pressure increase test. Option: LyoBalance weighing system If the freeze-dryer is equipped with a LyoBalance weighing system (see chapter 6.7 - "Optional extensions and special equipment"), then the corresponding parameters must be configured in this dialog box.
  • Page 69 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Dialog box "Process and equipment messages" (7) This dialog box shows and saves all of the error messages and other messages. In the event of an error or message, the window “Process and equipment messages” will open automatically. In addition, a sound signal is emitted until the error is acknowledged.
  • Page 70 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Details Touching the message calls up details concerning the error message: • Cause of the message, • Effects of the message, • Measures to eliminate the error, • Reference designator, • Error counter (indicates how often this error has occurred) and the time stamp of the last error message.
  • Page 71 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Dialog box "Operating mode: select/start" (8) After the set values have been entered for the process, the process can be started manually with this function (see chapter 6.6.2 - "Manual freeze- drying"). Fig. 35: Dialog box "Operating mode: select/start" (The version of the dialog box that is displayed depends on the equipment of the freeze-dryer.)

  • Page 72: Main Window "Program

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos: 171 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 60 Bet rieb/ LSCplus/ 060 -00 50- 001 0-0 021 Hau ptfe nster Prog ra mm Epsil on @ 33\ mod _14 205 298 2561 4_6 8.d ocx @ 224 802 @ 4 @ 1 6.6.1.2...

  • Page 73: Main Window "Options

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos: 173 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 60 Bet rieb/ LSCplus/ 060 -00 50- 001 0-0 031 Hau ptfe nster Opti one n Epsilon - 1 Vakuu mpu mp e @ 3 3\m od_ 142 052 9827 777 _68 .docx @ 2 2481 6 @ 4 @ 1 6.6.1.3...
  • Page 74 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Change scale unit (2) This dialog box is used to change the unit of measurement for the temperature and vacuum. Fig. 39: Dialog box "Change scale unit" Special equipment: Preselection of the aeration medium (3) This function can be performed in the manual mode or saved together with a program (see chapter 6.6.3.1 - "Creating a program").
  • Page 75 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation The following media preselection settings are possible: • Air: Preselects the media connection "Air". • Inert gas: Preselects the media connection "Inert Gas". • Automatic: Automatic media connection preselection depending on the chamber pressure and stoppering status of the product vials: –...
  • Page 76 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Special equipment: Inertisation (5) (see chapter 6.7 - "Optional extensions and special equipment") If the "Inertisation" option is active and the freeze-dryer is in the "Standby", "Manual - Freezing", "Program - Loading" or "Program - Freezing" mode, the automatic inertisation of the drying chamber will be performed for the preselected inertisation time after the loading door has been closed.
  • Page 77 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Administration "Administration" options: "Date/Time" "Network" "System properties" "Access protection" "Device options" "Configuration of sensors" "WTMplus configuration" Fig. 43: Dialog box "Options/Administration" Date/Time (1) The LSCplus control system is equipped with an integrated, battery- buffered clock. After a failure of the buffer battery, the date and time must be reset.
  • Page 78 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Network (2) This dialog box is used to change various system settings. The modifications will not become effective until after a restart of the unit. NOTE Fig. 45: Dialog box "Network" System properties (3) This dialog box is used to change various system settings.
  • Page 79 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Click on touch: If this function is active, a clicking sound can be heard whenever the system registers that a button has been touched. Behaviour of the pressure control valve in the case of insufficient ice condenser cooling: If this function is active (button "closed"), the pressure...
  • Page 80 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation • The button with the lock symbol blocks the access immediately and the system switches to the default setting. Fig. 49: Access blocked, the data cannot be edited Operator/maintenance/administrator password: For each of these access levels, certain editing rights have been defined.They can be enabled with...
  • Page 81 • Press the button "Add option". An input window opens. • Enter the six-digit Christ activation code that was supplied for this option. Note that the keys are case sensitive. Options can be removed in the same way. The modifications will not become effective until after a restart of the unit.
  • Page 82 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation WTMplus configuration (7) The dialog box is displayed for information purposes only. The configuration can be changed only via the LPCplus user interface. NOTE This dialog box shows all of the existing WTMplus sensors. Every sensor is assigned to a measuring channel based on its serial number.
  • Page 83 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Maintenance "Service" options: "Operating hours" "Failure memory" "Vacuum pump oil change" "Maintenance" "Sensor adjustment" Fig. 53: Dialog box "Service" (varies depending on the type of system) Operating hours (1) This dialog box is used to call up the number of operating hours of the various components of the freeze-dryer, e.g.
  • Page 84 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Failure memory (2) Equipment information system. These messages can be viewed in this dialog box. The failure memory includes the last 32 messages. If this number is exceeded, the oldest message will be overwritten.
  • Page 85 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Fig. 56: Dialog box "Vacuum pump oil change" Maintenance (5) The maintenance interval of the unit is fixed at 3,000 operating hours or at least one maintenance per year. When the end of a maintenance interval is reached, a corresponding message will be displayed.
  • Page 86 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Sensor adjustment (6) Misadjusted sensors will lead to incorrect measurement values, which in turn will have a negative effect on the process control. CAUTION In this dialog box, the sensors are adjusted in terms of a predefined reference value.

  • Page 87: Main Window

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos: 175 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 60 Bet rieb/ LSCplus/ 060 -00 50- 001 0-0 041 Hau ptfe nster "? " Epsilo n @ 33\ mod_ 142 052 983 042 7_6 8.doc x @ 2 248 30 @ 4 @ 1 6.6.1.4...

  • Page 88: Entering Set Values In The Manual Mode

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation In the manual mode, the set values of the active phase can be changed during the process run. In this case, the control system adapts the unit to the new set values as quickly as possible.
  • Page 89 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Viewing or editing the set values: • Press the button "Set values: view/edit" (see chapter 6.6.1.1 - "Main window "Manual""). The following dialog box will be displayed: "Aeration" button "Defrosting" button "Media drain" button (special equipment) "Leakage test"...

  • Page 90: Freeze-Drying With The Pgmplus Programmer Module

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Numerical values can be edited with the aid of a numerical keypad: Set value display Button for changing the sign (e.g. when entering temperature values) " " (infinite) Button for editing the value in pre-defined...
  • Page 91 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Program sections When the programmer module executes a freeze-drying process, it executes the various sections that were created one after the other until the last section is completed. Within the various sections, the system calculates linear ramps for the temperature and vacuum.
  • Page 92 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation T product: This value defines the permissible deviation of the product temperature (measured by product sensor 1) from the set value. During the freezing phase, the product temperature may exceed the set value by the defined value.

  • Page 93: Creating A Program

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation T/°C Pressure/mbar First Last Section section section “freezing” “freezing” “drying” 0.01 0.001 Warm-up phase of the vacuum pump Fig. 65: The warm-up phase of the vacuum pump is shifted to the freezing phase prior to the first drying section Pos: 184 /01 0 Univ ersal mod ule/Seit enwec hsel @ 0\m od_ 120 211 624 4312 _0.
  • Page 94 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Creating a blank program (1) This button is used to call up a blank program template. Only section 1 is pre-defined as the loading section. In this phase, the start conditions of the programs are defined. The room temperature (20°C) is the standard default.
  • Page 95 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation • Pressing the button “Program name” (2) calls up an input field in which the name of the program can be changed. • The button “Save” (7) can be used in between or at the end of the program creation in order to save the program.
  • Page 96 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation exceeded, the pressure increase test will be aborted in order to prevent the product from thawing. • Progress condition: In the last main drying or final drying section, two pressure increase tests will be performed and evaluated. The start point will be calculated automatically by the control system.
  • Page 97 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Option: Comparative pressure measurement (see chapter 6.7 - "Optional extensions and special equipment") The indication of the measurement value "dp Comp" can be configured in chapter 6.6.1.1 - "Main window "Manual"" under "Actual values of the current process"...
  • Page 98 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Option: LyoBalance weighing system If the freeze-dryer is equipped with a LyoBalance weighing system (see chapter 6.7 - "Optional extensions and special equipment"), then the corresponding parameters must be configured in this dialog box.
  • Page 99 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation The product vials must be sealed at a chamber pressure below 900 mbar in order to prevent the stoppers from being pushed out of the vials at low atmospheric pressure. NOTE 2. Stoppering followed by aeration up to atmospheric pressure...
  • Page 100 Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Special equipment: Preselection of the aeration medium If the freeze-dryer is equipped with an automatic aeration valve and automatic valves for media selection, this dialog box can be used to preselect the medium that is to be used for the aeration medium requests during the execution of the particular program.

  • Page 101: Editing A Program

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation suggestions for orientation purposes and must be adapted to the specific area of application of the freeze-dryer. Some of the tests that are described under chapter 6.6.1.1 - "Main window "Manual"", section "Operating mode: select/start", are also available in the form of program templates.

  • Page 102: Copying A Program

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos: 189 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 60 Bet rieb/ LSCplus/ 060 -00 50- 003 3-0 030 Prog ra mm k opie ren @ 33 \mo d_1 420 529 8453 64_ 68. docx @ 224 914 @ 4 @ 1 6.6.3.3...

  • Page 103: Deleting A Program

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Fig. 75: The freeze-drying process can be started with the aid of the button “Program start”. • During the freeze-drying process, the description of the active program can also be called up from the main window "Program" and via the button "Info".

  • Page 104: Optional Extensions And Special Equipment

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos: 196 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 60 Bet rieb/ LSCplus/ 060 -00 60 Optio nale Erw eite run gen und S onde ra usstatt ung en Epsil on- --- -- --- -- --- --- -- --- -- --- --- -- @ 33 \mo d_1 420 529 853 784_ 68. docx @ 22 4956 @ 2 @ 1...
  • Page 105 During the freezing process, the resistance increases. The LyoRx control sensor measures the electrical resistance. LyoLogplus data logging software LyoLogplus is a data logging software program by Martin Christ Gefriertrocknungsanlagen GmbH that is specifically adapted to the requirements of freeze-drying processes. Apart from the graphical representation of the measurement data of currently running processes, it also enables the data export for additional evaluation.

  • Page 106: Switching The Freeze-Dryer Off

    Freeze-dryer Epsilon 2-4 LSCplus 6 Operation LPCplus SCADA system The Christ LPCplus system consists of the Supervisory Control And Data Acquisition (SCADA) software program by Martin Christ Gefriertrocknungsanlagen GmbH and a dedicated PC. The system is connected to the LSCplus controller of the freeze-dryer via Ethernet and...

  • Page 107: Malfunctions And Error Correction

    Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction Pos: 202 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 70 Stö run gen und Fe hlers uche /07 0 Stö run gen und Fe hlers uche == == === == == === == == === == == == @ 25\ mo d_14 049 840 560 39_ 68.d ocx @ 184 111 @ 1 @ 1 Malfunctions and error correction Malfunctions are displayed in the dialog box "Process &...

  • Page 108: Power Failure

    Ensure sufficient air circulation tripped. (see chapter 7.1.3 - "Insufficient ice condenser temperature") If it is impossible to eliminate the errors, contact the Christ service department! NOTE Pos: 205 /01 0 Univ ersal mod ule/ Lee rzeile @ 0\ mo d_12 021 162 445 00_ 0.doc x @ 1 14 @ @ 1 Pos: 206 /01 0 Univ ersal mod ule/ Lee rzeile @ 0\ mo d_12 021 162 445 00_ 0.doc x @ 1 14 @ @ 1...

  • Page 109: Insufficient Vacuum

    Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction Pos: 209 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 70 Stö run gen und Fe hlers uche /07 0-0 010 -00 20 Kei n au sreic hend es Vak uum @ 2 5\mo d_1 404 984 060 039 _68. docx @ 18 416 7 @ 3 @ 1 7.1.2...

  • Page 110: Aeration Valve

    Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction 7.1.2.2 Aeration valve A malfunction of the aeration valve may have several causes. One potential source are contaminants such as product residues within the valve. • Switch the freeze-dryer off and disconnect the mains plug.

  • Page 111: Insufficient Ice Condenser Temperature

    Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction Pos: 219 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 70 Stö run gen und Fe hlers uche /07 0-0 010 -00 31 Eisko nde nsat or- un d Stellfläc hent emp era tur E psilon @ 25\ mo d_1 404 9846 659 83_ 68.d ocx @ 185 861 @ 3 @ 1 7.1.3...

  • Page 112: Service Contact

    Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction Pos: 223 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 70 Stö run gen und Fe hlers uche /07 0-0 031 Kont akt im S ervice fall_Epsilo n @ 25\m od_ 140 498 406 970 5_68 .docx @ 1 842 93 @ 2 @ 1...

  • Page 113: Maintenance And Service

    Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos: 226 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 80 Wa rtun g u nd In stan dhalt ung/ 080 Wa rtun g un d Ins tan dhalt ung == === == == === == == === == == == == @ 25\ mod _14 049 840 9570 4_6 8.d ocx @ 184 307 @ 1 @ 1...

  • Page 114: Ice Condenser Chamber

    Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Cleaning of the freeze-dryer Risk of burns on hot surfaces Housing of the freeze-dryer During the operation of the freeze-dryer and half an hour afterwards, the outer surface of the freeze-dryer (especially the pipes and units) may be WARNING hot.

  • Page 115: Special Equipment: Stainless Steel Door Latch At The Loading Door

    Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos: 234 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 80 Wa rtun g u nd In stan dhalt ung/ 080 -00 10- 002 2-0 010 Son der ausst attu ng: Tüve rschl ussrie gel a us Edels tahl Ep silon @ 25\ mod _14 049 846 771 36_ 68.d ocx @ 185 889 @ 4 @ 1 8.1.2.1...

  • Page 116: Heat Exchanger (Only Air Cooled Freeze-Dryers)

    Check the heat exchanger at least once per month for soiling and clean it if necessary. • Please contact the Christ service department if you have any queries (see chapter 7.3 - "Service contact"). Pos: 239 /01 0 Univ ersal mod ule/ Lee rzeile @ 0\ mo d_12 021 162 445 00_ 0.doc x @ 1 14 @ @ 1...

  • Page 117: Vacuum System

    The number of operating hours of the vacuum pump can be monitored by way of the LSCplus control system and also by way of the CHRIST SCADA software LPCplus (see chapter 6.6.1.3 - "Main window "Options""/Vacuum pump oil change or separate operating manual of the Christ SCADA software LPCplus, index "Oil change interval (vacuum pump)").

  • Page 118: Refrigeration System

    Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos: 244 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 80 Wa rtun g u nd In stan dhalt ung/ 080 -00 10- 009 0 Kält esyste m Epsilo n @ 37\ mod_ 143 651 524 119 2_6 8.doc x @ 2 673 75 @ 3 @ 1 8.1.7...

  • Page 119: Hydraulic System

    Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos: 246 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 80 Wa rtun g u nd In stan dhalt ung/ 080 -00 10- 011 0 Hy dra uliksyste m Epsilo n @ 3 7\m od_ 143 651 636 0083 _68 .docx @ 2 674 03 @ 4 @ 1 8.1.7.1...

  • Page 120: Accessories

    Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos: 250 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 80 Wa rtun g u nd In stan dhalt ung/ 080 -00 10- 013 0 Zub ehö r @ 25\ mod_ 140 498 410 669 3_6 8.doc x @ 1 844 47 @ 3 @ 1 8.1.9...

  • Page 121: Maintenance Schedule

    Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos: 254 /20 0 Ch rist/3 61 G T-BA L abo r-Pilot (PROJEKTE)/Epsilo n 4 er/Epsilo n 2 -4 LSC plus SN 2 186 3/08 0 War tun g un d Ins tan dhalt ung/ 080 -00 31 W art ungs plan Epsil on SN 2 186 3 @ 4 3\m od_ 146 355 103 0889 _68 .docx @ 3 503 20 @ 2 @ 1...
  • Page 122 Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Machinery – Wires: fastened general Cable trays: closed Framework: Remove corrosion no corrosion Vacuum Inspection and Pump: Inlet strainer system cleaning annually...
  • Page 123 Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Refrigeration Ice condenser: system temperature low end Instrumentation Vacuum sensors Calibration Temperature sensors Calibration at freeze-dryer Pressure sensors Calibration chamber Calibration,...

  • Page 124: Service

    Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos: 256 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 80 Wa rtun g u nd In stan dhalt ung/ 080 -00 41 Inst and haltu ngsa rbeit en Epsil on @ 25\ mod _14 049 8410 998 2_6 8.do cx @ 1844 89 @ 2 @ 1...
  • Page 125 Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service 1. Declaration of decontamination As a certified company and due to the legal regulations for the protection of our employees and of the environment, we are obliged to certify the harmlessness of all incoming goods. For this purpose, we require a declaration of decontamination.

  • Page 126: Disposal

    Pos: 263 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/0 90 Ents org ung/ 090 -00 10 Entso rgu ng d er G efri ertr ockn ungs anlag e @ 25\ mod _140 498 414 112 2_6 8.doc x @ 1 845 31 @ 2 @ 1 Disposal of the freeze-dryer Martin Christ Gefriertrocknungsanlagen GmbH is a registered manufacturer of electric and electronic devices that are solely intended for commercial use.

  • Page 127: 10 Technical Data

    Freeze-dryer Epsilon 2-4 LSCplus 10 Technical data Pos: 268 /20 0 Ch rist/3 61 G T-BA L abo r-Pilot (PROJEKTE)/Epsilo n 4 er/Epsilo n 2 -4 LSC plus SN 2 186 3/10 0 T echnisc he D aten /10 0 Tech nische D ate n SN218 63 == === == == === == == === == == == === == == === @ 4 2\m od_1 459 494 354 475 _68. docx @ 32 437 3 @ 1 @ 1...

  • Page 128: Ambient Conditions

    Freeze-dryer Epsilon 2-4 LSCplus 10 Technical data Filling quantities Refrigerant: see name plate Equipment connections Aeration – Air (B1-MC215): Clamp connections 21.3 x 1,6 (DN15) max. 0.2 bar overpressure Aeration – Nitrogen Inertisation (B1-MC216): Clamp connections 21.3 x 1,6 (DN15) max.

  • Page 129: 11 Appendix

    Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos: 276 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/1 10 Anh ang /011 0 Anh ang == == === == == == === == == === == == === == == === == == === == == = @ 25\m od_ 140 498 417 799 4_68 .docx @ 1 846 01 @ 1 @ 1 11 Appendix Pos: 277 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/1 10 Anh ang /011 0-0 010 M athe matisc he Zusa mm enh äng e @ 2 5\m od_ 140 498 4178 952 _68 .docx @ 1 8461 5 @ 2 @ 1...

  • Page 130: Conversion Table Of The Vapour Pressure Curve

    Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos: 279 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/1 10 Anh ang /011 0-0 021 Um rech nun gsta belle "Da mpfd ruck übe r Eis" @ 25\ mo d_1 4049 841 801 68_ 68.d ocx @ 184 629 @ 2 @ 1 11.2...

  • Page 131: Ec Declaration Of Conformity In Accordance With The Ec Machinery Directive

    Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos: 281 /20 0 Ch rist/3 61 G T-BA L abo r-Pilot (PROJEKTE)/Epsilo n 4 er/Epsilo n 2 -4 LSC plus SN 2 186 3/11 0 Anh ang/ 011 0-0 030 CE-Erklä run g M aschRL SN218 63 @ 42\ mod _14 593 172 707 91_ 68.d ocx @ 324 337 @ 2 @ 1 11.3...
  • Page 132 Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos: 282 /01 0 Univ ersal mod ule/Seit enwec hsel @ 0\m od_ 120 211 624 4312 _0. docx @ 10 5 @ @ 1 Version 06/2016, Rev. 1.0 of 14/06/2016 • sb 132 / 142...

  • Page 133: Ec Declaration Of Conformity In Accordance With The Pressure Equipment Directive

    Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos: 283 /20 0 Ch rist/3 60 G T-BA L abo r-Pilot (STANDARDMODU LE)/1 10 Anh ang /011 0-0 031 CE-Erkl äru ng Dr uckg erät eRL @ 38\ mo d_14 385 921 430 48_ 68.d ocx @ 275 085 @ 2 @ 1 11.4...
  • Page 134 Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos: 284 /01 0 Univ ersal mod ule/Seit enwec hsel @ 0\m od_ 120 211 624 4312 _0. docx @ 10 5 @ @ 1 Version 06/2016, Rev. 1.0 of 14/06/2016 • sb 134 / 142...

  • Page 135: 12 Glossary

    Since absolutely tight components simply do not exist, a leak rate is determined. The parameters for the leakage test have been developed by Martin Christ Gefrier- trocknungsanlagen GmbH specifically for freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.
  • Page 136 Safety pressure Since the vacuum has a dominating influence on the product temperature, Martin Christ Gefriertrocknungsanlagen GmbH has integrated a so-called safety pressure feature into the freeze-dryers in order to ensure the protection of the product. If the pressure inside the drying chamber increases too strongly so that it exceeds the safety limit, the energy supply of the shelves will be interrupted and the sublimation process slows down.

  • Page 137: 13 Index

    Freeze-dryer Epsilon 2-4 LSCplus Index 13 Index Cleaning agents ....... 113, 120 Cleaning the freeze-dryer and the Accessories ......... 13, 44, 120 accessories .......... 113 Accessprotection........79 Click on touch ..........79 Accident prevention ......29, 30 Commissioning .......... 13 Accidents ...........
  • Page 138 Freeze-dryer Epsilon 2-4 LSCplus Index Decontamination agents ......120 Emergency..........41 Decontamination with hydrogen peroxide Emission of vapours ........42 ) ............. 11 End of drying and aeration ......26 Defrosting ..........26 Entering set values in the manual mode ..88 Defrosting water, contaminated (hazards) ..
  • Page 139 Freeze-dryer Epsilon 2-4 LSCplus Index Hazards ............. 41 Initial start-up (hazards) ....... 32, 60 Hazards (azides) ........37 Injuries ............41 Hazards (connection) ......31, 48 Inspection by the manufacturer ....124 Hazards (contaminated condensate)....Installation of accessories ......60 ..........
  • Page 140 Freeze-dryer Epsilon 2-4 LSCplus Index Manually operated shelf movement, two-hand Part number ..........127 control ............ 40 Password input fails ......... 107 Manufacturer ..... 113, 120, 126, 127 Password operator/ maintenance/ Manufacturer contact data ......87 administrator .......... 80 Marking of the unit ........27 Password timer runtime ......
  • Page 141 Freeze-dryer Epsilon 2-4 LSCplus Index Responsibility of the operator ..... 29 Special equipment: Stainless steel door latch at the loading door ........ 115 Return flow, inertisation medium ....56 Special equipment:Inertisation ....76 Return of defective parts ......124 Special equipment:Preselection of the aeration medium ........
  • Page 142 Freeze-dryer Epsilon 2-4 LSCplus Index Viewing or editing the set values ....89 Vacuum ............. 91 Vacuum connection ......... 128 Warranty and liability ........12 Vacuum pump ........52, 58 Weighing system........98 Vacuum pump exhaust gases ....57 Weighing system LyoBalance ..58, 68, 105 Vacuum pump is not activated ....

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