Christ Epsilon 2-10D LSCplus Operating Manual
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Christ Epsilon 2-10D LSCplus Operating Manual

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Translation of the original operating manual
sb
Rev. 3.0 of 20/07/2022
Epsilon 2-10D LSCplus; ; ; ;
Version 07/2022
Epsilon 2-10D LSCplus
Part no. 111122
Freeze-dryer
Operating Manual
Read the manual thoroughly before use and retain it for later use!

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Summary of Contents for Christ Epsilon 2-10D LSCplus

  • Page 1 Translation of the original operating manual Rev. 3.0 of 20/07/2022 Epsilon 2-10D LSCplus; ; ; ; Version 07/2022 Epsilon 2-10D LSCplus Part no. 111122 Freeze-dryer Operating Manual Read the manual thoroughly before use and retain it for later use!
  • Page 2 Freeze-dryer Epsilon 2-10D LSCplus Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 2 / 161 Translation of the original operating manual...
  • Page 3 Freeze-dryer Epsilon 2-10D LSCplus In case of inquiries, please state the following numbers: Order number: Serial number: © Copyright by Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode am Harz Germany Tel.: +49 (0) 5522 / 5007-0...
  • Page 4 Freeze-dryer Epsilon 2-10D LSCplus Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 4 / 161 Translation of the original operating manual...

  • Page 5: Table Of Contents

    Freeze-dryer Epsilon 2-10D LSCplus Table of contents General information ......................9 Importance of the operating manual .................. 9 Further applicable documents ................... 9 Intended use ........................9 1.3.1 Freeze-drying of solvent-containing products (non-aqueous media) ......11 1.3.2 Freeze-drying of acid-containing products ..............12 1.3.3...
  • Page 6 Freeze-dryer Epsilon 2-10D LSCplus Table of contents Safety notes concerning the operation ................31 3.7.1 Hazards caused by electricity ..................31 3.7.2 Hazards caused by natural, flammable refrigerants ........... 31 3.7.3 Hazards caused by the hydraulic system ..............32 3.7.4 Hazards caused by nitrogen ..................
  • Page 7 Freeze-dryer Epsilon 2-10D LSCplus Table of contents 5.2.4 Vacuum pumps ......................51 5.2.4.1 Oil-sealed vacuum pump and exhaust filter (oil mist separator) ......51 5.2.4.2 Dry-running vacuum pump and silencer ............. 52 5.2.5 Pressure control valve ....................53 5.2.6 Vacuum sensor ......................54 5.2.7...
  • Page 8 Freeze-dryer Epsilon 2-10D LSCplus Table of contents Maintenance and service ....................118 Maintenance ......................... 118 8.1.1 General ........................118 8.1.2 Ice condenser chamber ................... 120 8.1.3 Drying chamber ....................... 120 8.1.3.1 Lamination of the loading door with a special film ..........120 8.1.3.2...

  • Page 9: General Information

    No unauthorised design modifications, additions or conversions without the written approval by Martin Christ Gefriertrocknungsanlagen GmbH have been performed. • The vacuum pump used is approved by Martin Christ Gefriertrocknungsanlagen GmbH. The vacuum pumps approved for this system are listed in chapter 5.2.4 - "Vacuum pumps". •...
  • Page 10 Exclusion of liability Any use of the freeze-dryer other than the one described here or any use going beyond this description is regarded as improper use. Martin Christ Gefriertrocknungsanlagen GmbH cannot be held liable for any damage resulting from such improper use.

  • Page 11: Freeze-Drying Of Solvent-Containing Products (Non-Aqueous Media)

    Freeze-dryer Epsilon 2-10D LSCplus 1 General information → 1.3.1 Freeze-drying of solvent-containing products (non-aqueous media) With regards of corrosion resistance, the use of some organic solvents in aqueous solutions with low concentrations is acceptable. A freeze-dryer is designed to be chemically resistant to most compounds that are commonly used in freeze-drying processes.

  • Page 12: Freeze-Drying Of Acid-Containing Products

    Freeze-drying of azide-containing products Freeze-drying of products containing azides is only permissible following a case-by-case examination and the written approval by Martin Christ Gefriertrocknungsanlagen GmbH, since azides may form explosive dust- air-mixtures and also explosive metal azides when combined with non- ferrous metals (e.g.

  • Page 13: Copyright

    Freeze-dryer Epsilon 2-10D LSCplus 1 General information → Copyright The copyright concerning the operating manual remains with Martin Christ Gefriertrocknungsanlagen GmbH. The operating manual is solely intended for the operator and their personnel. It includes instructions and information that may not be •...

  • Page 14: Layout And Mode Of Operation

    Freeze-dryer Epsilon 2-10D LSCplus 2 Layout and mode of operation → Layout and mode of operation → Layout of the freeze-dryer → 2.1.1 Functional and operating elements Control system Drying chamber with loading door Vacuum pump (example, chapter 5.2.4 - "Vacuum pumps"...
  • Page 15 Freeze-dryer Epsilon 2-10D LSCplus 2 Layout and mode of operation Fig. 2: Detailed view A – drying chamber 13 Switch cabinet (behind the side panel) 14 Control system on/off 15 Drying cartridge (adsorption filter, chapter 5.2.7 - "Drying cartridge (adsorption filter)")
  • Page 16 Freeze-dryer Epsilon 2-10D LSCplus 2 Layout and mode of operation 18 Aeration valve 19 Vacuum sensor (behind the side panel) 20 Sight glass of the ice condenser 21 Vacuum connection 22 Precision control needle valve for gas injection 23 Access flanges DN40 (e.g.
  • Page 17 Freeze-dryer Epsilon 2-10D LSCplus 2 Layout and mode of operation 27 Filler neck for the heat transfer medium (with installed drying cartridge) 28 Main switch 29 Name plate (see chapter 2.1.2 - "Name plate") 30 Heat exchanger for the heat transfer...

  • Page 18: Name Plate

    Freeze-dryer Epsilon 2-10D LSCplus 2 Layout and mode of operation 2.1.2 Name plate Serial number Type Refrigerant data of RM 1, 1 stage Refrigerant data of RM 1, 2 stage Nominal voltage Year of manufacture (month/year) Part number Refrigerant data of...

  • Page 19: Mode Of Operation

    Freeze-dryer Epsilon 2-10D LSCplus 2 Layout and mode of operation → Mode of operation → 2.2.1 General information on freeze-drying What is freeze-drying? Freeze-drying or lyophilisation is a procedure for the gentle drying of high- quality products. The product is dried by → sublimation without passing through the liquid phase.
  • Page 20 Freeze-dryer Epsilon 2-10D LSCplus 2 Layout and mode of operation Fig. 8: Vapour pressure curve for ice and water From a physical point of view, the freeze-drying process covers three phases (see figure below): (1) Freezing: The product to be dried is frozen under atmospheric pressure.

  • Page 21: Freeze-Drying Process

    Freeze-dryer Epsilon 2-10D LSCplus 2 Layout and mode of operation Fig. 9: Freeze-drying phases Please find further information about basic principles, optimum procedures and applications in the brochure "Smart freeze-drying", which can be downloaded at www.martinchrist.de → [Applications] → [Lyophilisation].

  • Page 22: Freezing

    Freeze-dryer Epsilon 2-10D LSCplus 2 Layout and mode of operation → 2.2.2.2 Freezing First, the product that is to be dried is frozen. This can be carried out either directly in the freeze-dryer or in a separate deep-freeze. Especially in the case of small filling quantities, we recommend pre-cooling the shelves as well in order to prevent the product from thawing during the evacuation.

  • Page 23: Final Drying

    Freeze-dryer Epsilon 2-10D LSCplus 2 Layout and mode of operation 2.2.2.4 Final drying Final drying is an option whenever one requires a product with minimal residual moisture. In the physical sense, this process is a desorption process, i.e. the removal of adsorptively bound water. Final drying is...

  • Page 24: Safety

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety → Safety → Marking of the unit The following symbols are used for Christ freeze-dryers: Dangerous voltage On (Power) Hot surface Off (Power) Name plate (see chapter Caution! Risk of bruising 2.1.2 - "Name plate")

  • Page 25: Explanation Of The Symbols And Notes

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety → Explanation of the symbols and notes This operating manual uses the following names and symbols to indicate hazards: This symbol stands for a direct hazard to the life and health of persons. Non-observance of these symbols causes serious health problems up to life-endangering injuries.

  • Page 26: Responsibility Of The Operator

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety → Responsibility of the operator The operator is the person who uses the freeze-dryer for commercial or economic purposes or lets a third party use it and who bears the legal product responsibility for the protection of the users, personnel or third parties during operation.

  • Page 27: Freeze-Drying Of Solvent-Containing Products

    • ensure that the freeze dryer is operated with one of the vacuum pumps approved by Martin Christ Gefriertrocknungsanlagen GmbH (see chapter 5.2.4 - "Vacuum pumps"). • have the system maintained at regular intervals (see chapter 8 - "Maintenance and service").

  • Page 28: Requirements Concerning The Personnel

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety → Requirements concerning the personnel Risk of injury if the personnel are not sufficiently qualified If unqualified personnel perform work on the freeze-dryer or are present in the danger zone of the freeze-dryer, hazards result that can cause serious injuries and considerable damage to property.

  • Page 29: Informal Safety Notes

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety Qualified electrician Due to their special training, knowledge, experience and familiarity with the relevant standards and regulations, qualified electricians are in the position to perform work on electrical systems and to autonomously identify and prevent possible hazards.

  • Page 30: Hazards Caused By Improper Transport

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety 3.6.2 Hazards caused by improper transport Risk of injury caused by the uncontrolled movement of loads Units or components that are not properly fastened or secured may shift, or fall over. This may lead to severe damage to health or even life-threatening injuries.

  • Page 31: Safety Notes Concerning The Operation

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety Safety notes concerning the operation The following notes and instructions concerning the operation of the freeze- dryer must be observed in order to protect all persons and property. 3.7.1 Hazards caused by electricity Danger of life caused by electric shock There is a risk of electric shock when touching current-carrying components.

  • Page 32: Hazards Caused By The Hydraulic System

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety 3.7.3 Hazards caused by the hydraulic system Risk of a high pressure injection with hydraulic oil When working on the hydraulic system of the freeze-dryer, or due to the ageing of the hose lines, hydraulic oil may escape.

  • Page 33: Hazards Caused By Solvents In The Products

    This may lead to severe injuries. DANGER Freeze-drying of products containing acids is only permissible if special protective measures and equipment-related precautions are taken! Consultation of Martin Christ Gefriertrocknungsanlagen GmbH is absolutely mandatory in order to define the measures that need to be taken! •...

  • Page 34: Hazards Caused By Azides In The Products

    (e.g. a special vacuum pump) and following a case-by-case examination and the written approval by Martin Christ Gefriertrocknungsanlagen GmbH! Risk of poisoning caused by azides in the products When loading and unloading the shelves, the personnel are exposed to the product.

  • Page 35: Oil-Sealed Vacuum Pump: Hazards Caused By Contaminated Vacuum Pump Exhaust Gases

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety 3.7.10 Oil-sealed vacuum pump: hazards caused by contaminated vacuum pump exhaust gases Risk of poisoning/infection caused by vacuum pump exhaust gases The exhaust gases of the vacuum pump may contain harmful substances originating from the product.

  • Page 36: 3.7.12 Dry-Running Vacuum Pump: Hazards Caused By Contaminated Exhaust Air

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety 3.7.12 Dry-running vacuum pump: hazards caused by contaminated exhaust air Danger of poisoning/infection due to contaminated exhaust air The exhaust air may contain harmful substances originating from the product. Contact with particles in the exhaust air (especially by inhalation) may WARNING result in severe damage to health.

  • Page 37: 3.7.16 Hazards Caused By Hot Surfaces

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety 3.7.16 Hazards caused by hot surfaces Risk of burns on hot surfaces During the operation of the freeze-dryer and half an hour afterwards, the outer surface of the freeze-dryer (especially the pipes and units) may be hot.

  • Page 38: Safety Devices

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety → Safety devices The safety devices are aimed at protecting the operating personnel. In case of safety devices that are not operating correctly or of safety- relevant operating elements that are not freely accessible, there is a risk of severe damage to health.

  • Page 39: Procedures In The Event Of Hazards And Accidents

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety → Procedures in the event of hazards and accidents Hazardous electrical incident: • Switch the main switch and the control switch of the freeze-dryer off in order to interrupt the power supply completely. Fire: •...

  • Page 40: Maintenance And Cleaning Of The Freeze-Dryer

    Freeze-dryer Epsilon 2-10D LSCplus 3 Safety Chemical burns: • Eyes: Rinse the eyes thoroughly with plenty of water with the lid gap wide open for at least 15 minutes (eyewash bottle). Consult an ophthal- mologist immediately even if there are no immediate symptoms. If possible, continue rinsing the eyes during the transport to the ophthal- mologist.

  • Page 41: Measures To Be Taken To Ensure Safe Operation Of The Freeze-Dryer

    • Stop the freeze-dryer immediately in the event of a malfunction. Eliminate the malfunction (see chapter 7 - "Malfunctions and error correction") or contact the after-sales service of Firma Martin Christ Gefriertrocknungsanlagen GmbH (see chapter 7.3 - "Service contact"). •...

  • Page 42: Remaining Hazards

    → 3.13 Remaining hazards All Christ freeze-dryers were built state-of-the-art and according to the accepted safety rules. Danger to life and limb of the operator, or of third parties, or impairments of the units or other material assets, however, cannot be completely excluded when the units are being used.

  • Page 43: Storage And Transport

    Freeze-dryer Epsilon 2-10D LSCplus 4 Storage and transport → Storage and transport → Dimensions and weight Epsilon 2-10D LSCplus Height: 1,303 mm Width: 1,190 mm Depth: 968 mm incl. vacuum connection Weight: approx. 665 kg → Storage conditions In order to ensure the protection against mechanical and climatic...

  • Page 44: Unpacking The Freeze-Dryer

    DANGER • Prior to transporting the freeze-dryer, read this chapter of the operating manual thoroughly! The freeze-dryer Epsilon 2-10D LSCplus weighs approx. 665 kg! CAUTION The freeze-dryer is packaged in a wooden crate. • After opening the packaging, take out the accessories.

  • Page 45: Transport

    Prior to transporting the freeze-dryer, read this chapter of the operating manual thoroughly! The freeze-dryer Epsilon 2-10D LSCplus weighs approx. 665 kg! CAUTION Freeze-dryers of the type Epsilon 2-10D LSCplus that are filled with natural, flammable refrigerants are not approved as air freight! NOTE •...

  • Page 46: Transport Safety Devices

    Freeze-dryer Epsilon 2-10D LSCplus 4 Storage and transport → 4.4.1 Transport safety devices The following transport safety devices must be removed prior to start-up: • Remove the polystyrene blocks between the shelves. • Unscrew the sealing cap of the expansion vessel of the heat transfer medium and install the drying cartridge (adsorption filter) (see chapter 5.2.7 - "Drying cartridge (adsorption filter)").

  • Page 47: Set-Up And Connection

    Freeze-dryer Epsilon 2-10D LSCplus 5 Set-up and connection → Set-up and connection Risk of injury caused by poor accessibility of the freeze-dryer In cramped spaces or locations with poor accessibility, sharp edges and corners may protrude into the work area.

  • Page 48: Supply And Disposal Connections

    The operating voltage on the name plate must correspond to the local supply voltage DANGER Christ freeze-dryers are units of safety class I. Epsilon 2-10D LSCplus units have a five-wire power cord with a 5-pin CEE plug (see chapter 10 - "Technical data").

  • Page 49: Aeration

    Freeze-dryer Epsilon 2-10D LSCplus 5 Set-up and connection → 5.2.2 Aeration Risk of injury caused by bursting of the chamber The double chamber is designed for vacuum. It is not a pressure vessel! In the event of a malfunction, an impermissible excess pressure may build up in the chamber, which may cause the chamber to burst.

  • Page 50: Drain

    Freeze-dryer Epsilon 2-10D LSCplus 5 Set-up and connection Pre-adjusting the volume flow: We recommend to proceed as follows: 1. Close the precision control needle valve completely by turning the adjusting knob clockwise to the stop (several turns may be needed).

  • Page 51: Vacuum Pumps

    5 Set-up and connection Vak uumpumpe → 5.4.6 5.2.4 Vacuum pumps For an intended use, the Epsilon 2-10D LSCplus freeze-dryer must be operated with one of the vacuum pumps listed below: Oil-sealed vacuum pumps: • Rotary vane pump Vacuubrand RZ9 •...

  • Page 52: Dry-Running Vacuum Pump And Silencer

    Freeze-dryer Epsilon 2-10D LSCplus 5 Set-up and connection Vac uum pum p → 5.4.6 5.2.4.2 Dry-running vacuum pump and silencer Danger of poisoning/infection due to exhaust air The exhaust air may contain harmful substances originating from the product. Contact with particles in the exhaust air (especially by inhalation) may WARNING result in severe damage to health.

  • Page 53: Pressure Control Valve

    Freeze-dryer Epsilon 2-10D LSCplus 5 Set-up and connection → 5.2.5 Pressure control valve The pressure control valve is integrated in the suction pipe between the vacuum pump and ice condenser chamber. During certain, specified process phases, it interrupts the volume flow to the vacuum pump (see chapter 2.2.1 - "General information on freeze-drying")

  • Page 54: Vacuum Sensor

    Freeze-dryer Epsilon 2-10D LSCplus 5 Set-up and connection 5.2.6 Vacuum sensor → Please refer to the separate operating manual of the vacuum sensor! NOTE As standard, the freeze-dryer is equipped with a Pirani vacuum sensor (e.g. Thyracont VCP63, position see chapter 2.1.1 - "Functional and operating elements").

  • Page 55: Drying Cartridge (Adsorption Filter)

    The silica gel of the drying cartridge has a limited adsorption capacity. If the colour of the silica gel changes from orange to green (see label on the drying cartridge), the drying cartridge must be replaced (Christ order no. 610 993).

  • Page 56: Operation

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Operation Initial start-up Risk of injury caused by consequences of transport damage, or improper connections (e.g. escaping media). Leaks after the transport, set-up, and connection of the freeze-dryer may lead to problems, e.g. the escape of media (depending on the WARNING configuration of the freeze-dryer, e.g.

  • Page 57: Loading Door

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation → Loading door Risk of crushing caused by the movement of the loading door Due to its relative high mass, the movement of the loading door can hardly be slowed down or stopped. There is a risk of crushing of body parts between the door and the front of DANGER the chamber.

  • Page 58: Hydraulic System

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Radiation Shield film for loading doors made of acrylic glass Loading doors made of acrylic glass have a special, transparent film on the exterior side of the acrylic glass door. This film reduces the transfer of radiant heat onto the product and ensures homogeneous freeze-drying results.
  • Page 59 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation In order to move the shelves, the respective push-button has to be kept pressed in combination with "Release". The shelves will move continuously until one of the buttons is released or the upper or lower hard stop position has been reached.

  • Page 60: Lscplus Control System

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation LSCplus control system The control system LSCplus (Lyo Screen Control plus) was specifically developed for the control of freeze-drying processes. The clear user interface enables the intuitive operation of the unit. Fig. 15: Start screen of the LSCplus control unit (example) 6.7.1...

  • Page 61: Main Window "Manual

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation The user interface is divided into four main windows that can be called up by touching the corresponding buttons: Manual This window is also the standard user interface. It is used to control the freeze-drying process manually.
  • Page 62 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Status line (1) This line shows the operating status of the freeze-dryer as well as the active phase. The status line also shows the current date and time. The clock is battery- buffered and must be reset after a failure (see chapter 6.7.1.3 - "Main window "Options"", section "Administration").
  • Page 63 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Fig. 18: Dialog box "Select actual value" • Select the desired configuration or quit the dialog box by pressing the "return" button. In this way, it is possible to configure a personalised overview of the actual values.
  • Page 64 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Option: USB process recording (see chapter 6.8 - "Optional extensions and special equipment") • Select the "Process recording" function in the dialog box "Tools". • Select the input fields ("Batch data"). A keyboard for the data input will be displayed.
  • Page 65 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Fig. 21: Dialog box "Pressure increase test" • The "Test stop" button stops the pressure increase test. Option: LyoBalance weighing system If the freeze-dryer is equipped with a LyoBalance weighing system (see chapter 6.8 - "Optional extensions and special equipment"), then the corresponding parameters must be configured in this dialog box.
  • Page 66 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Dialog box "Process and equipment messages" (7) This dialog box shows and saves all of the error messages and other messages. In the event of an error or message, the window “Process and equipment messages” will open automatically. In addition, a sound signal is emitted until the error is acknowledged.
  • Page 67 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Details Touching the message calls up details concerning the error message: • Cause of the message, • Effects of the message, • Measures to eliminate the error, → Reference designator, • • Error counter (indicates how often this error has occurred) and the time stamp of the last error message.
  • Page 68 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Dialog box "Operating mode: select/start" (8) After the set values have been entered for the process, the process can be started manually with this function (see chapter 6.7.2 - "Manual freeze- drying"). Fig. 26: Dialog box "Operating mode: select/start" (The version of the dialog box that is displayed depends on the equipment of the freeze-dryer.)
  • Page 69 Fig. 28: Results of the performance test Evaluation: Please contact the Christ support team for the evaluation of the test run. Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 69 / 161...
  • Page 70 • Select "Leakage test" and start the test via the "Run" button. The parameters for the leakage test have been developed by Martin Christ Gefriertrocknungsanlagen specifically for freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.
  • Page 71 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation In the "Freezing" phase, the shelves are cooled to -30°C. The parameters for the subsequent "Main drying" and "Secondary drying" sections have been configured in such a way that the water will be completely sublimated out of the dishes and bound on the ice condenser after 24 hours.
  • Page 72 (confirmation prompt) opens. Following the confirmation of this enquiry, the freeze-dryer will be switched to standby. Evaluation: Please contact the Christ support team for the evaluation of the test run. Shelf mapping test (6) The shelf mapping test is a freeze-drying program for bringing the shelves to a temperature of +20°C, -40°C, and +40°C for a specific period of time in...
  • Page 73 The external measurement recording process can then be stopped. Evaluation: Please contact the Christ support team for the evaluation of the test run. Button "Stop" (9) Pressing this button stops the current process. The system switches to the standby status.

  • Page 74: Main Window "Program

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation 6.7.1.2 Main window "Program" In the main window "Program", pre-programmed freeze-drying processes can be loaded and edited and new programs can be created with the PGMplus programmer module. Program list Button "New program" Buttons "Load"...

  • Page 75: Main Window "Options

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation 6.7.1.3 Main window "Options" The main window "Options" is used to perform fundamental basic settings of the control system in order to adapt it perfectly to the respective area of application of the freeze-dryer.
  • Page 76 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Change scale unit (2) This dialog box is used to change the unit of measurement for the temperature and vacuum. Fig. 32: Dialog box "Change scale unit" Special equipment: Preselection of the aeration medium (3) This function can be performed in the manual mode or saved together with a program (see chapter 6.7.3.1 - "Creating a program").
  • Page 77 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation The following media preselection settings are possible: • Air: Preselects the media connection "Air". • Inert gas: Preselects the media connection "Inert Gas". • Automatic: Automatic media connection preselection depending on the chamber pressure and stoppering status of the product vials: –...
  • Page 78 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Special equipment: Inertisation (5) (see chapter 6.8 - "Optional extensions and special equipment") If the "Inertisation" option is active and the freeze-dryer is in the "Standby", "Manual - Freezing", "Program - Loading" or "Program - Freezing" mode, the automatic inertisation of the drying chamber will be performed for the preselected inertisation time after the loading door has been closed.
  • Page 79 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation If the volume flow through the inertisation line falls below a certain threshold for more than 5 seconds (the value can be preset at the flow meter) or if the loading door is opened during an inertisation sequence, the process will also be aborted immediately.
  • Page 80 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Network (2) This dialog box is used to change various system settings. The modifications will not become effective until after a restart of the unit. NOTE Fig. 38: Dialog box "Network" System properties (3) This dialog box is used to change various system settings.
  • Page 81 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Click on touch: If this function is active, a clicking sound can be heard whenever the system registers that a button has been touched. Behaviour of the pressure control valve in the case of insufficient ice condenser cooling: If this function is active (button "closed"), the pressure...
  • Page 82 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation • The button with the lock symbol blocks the access immediately and the system switches to the default setting. Fig. 42: Access blocked, the data cannot be edited Operator/maintenance/administrator password: For each of these access levels, certain editing rights have been defined.
  • Page 83 • Press the button "Add option". An input window opens. • Enter the six-digit Christ activation code that was supplied for this option. Note that the keys are case sensitive. Options can be removed in the same way. The modifications will not become effective until after a restart of the unit.
  • Page 84 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Product temperature sensor (see the illustration above, item B) Only for systems with a WTMplus system The wired product temperature sensor 1 is the default sensor for determining the value "ΔT product" (see chapter 6.7.3 - " Freeze-drying with the PGMplus programmer module ", section "Conditions for switching...
  • Page 85 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation WTMplus configuration (7) The dialog box is displayed for information purposes only. The configuration can be changed only via the LPCplus user interface. NOTE This dialog box shows all of the existing WTMplus sensors. Every sensor is assigned to a measuring channel based on its serial number.
  • Page 86 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Maintenance "Service" options: "Operating hours" "Failure memory" "Vacuum pump oil change" "Maintenance" "Sensor adjustment" Fig. 47: Dialog box "Service" (varies depending on the type of system) Operating hours (1) This dialog box is used to call up the number of operating hours of the various components of the freeze-dryer, e.g.
  • Page 87 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Failure memory (2) Equipment information system. These messages can be viewed in this dialog box. The failure memory includes the last 32 messages. If this number is exceeded, the oldest message will be overwritten.
  • Page 88 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Vacuum pump oil change (3) This option only applies to oil-sealed vacuum pumps! NOTE The system monitors the oil change interval of the vacuum pump. The interval can be adapted to the vacuum pump model and utilisation.
  • Page 89 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Maintenance (4) The maintenance interval of the unit is fixed at 3,000 operating hours or at least one maintenance per year. When the end of a maintenance interval is reached, a corresponding message will be displayed.

  • Page 90: Main Window

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation 6.7.1.4 Main window "?" This main window includes the most important information concerning your freeze-dryer: Freeze-dryer type Control system type Serial number Manufacturer contact data Details concerning the software version Fig. 52: Freeze-dryer system information In the event of enquiries at the manufacturer, please state the number that is stated here.

  • Page 91: Entering Set Values In The Manual Mode

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation In the manual mode, the set values of the active phase can be changed during the process run. In this case, the control system adapts the unit to the new set values as quickly as possible.
  • Page 92 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Viewing or editing the set values: • Press the button "Set values: view/edit" (see chapter 6.7.1.1 - "Main window "Manual""). The following dialog box will be displayed: "Aeration" button "Defrosting" button "Media drain" button (special equipment) "Leakage test"...

  • Page 93: Freeze-Drying With The Pgmplus Programmer Module

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Numerical values can be edited with the aid of a numerical keypad: Set value display Button for changing the sign (e.g. when entering temperature values) "" (infinite) Button for editing the value in pre-defined...
  • Page 94 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Fig. 56: Representation of a freeze-drying program Program sections When the programmer module executes a freeze-drying process, it executes the various sections that were created one after the other until the last section is completed.
  • Page 95 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Conditions for switching to the next section For all of the program sections to be executed automatically, certain switching conditions must be fulfilled at the end of each section. If these conditions are not fulfilled, e.g. due to incorrect set values, a corresponding process message will be displayed and the section will be extended.
  • Page 96 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation T comparative (option): This value indicates the difference between a Pirani sensor and a capacitive vacuum sensor in per cent based on the actual value of the capacitive vacuum sensor. When the sublimation rate decreases, the difference decreases as well.

  • Page 97: Creating A Program

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation 6.7.3.1 Creating a program To create a new program: • Press the button "New program" in the main window "Program". The dialog box that is displayed offers various different program templates. The scroll bar on the right-hand side can be used to scroll through the list.
  • Page 98 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation "Program" buttons: "Program" "Program name" "Show diagram" "Insert section" "Delete section" Button for calling up more functions and set values "Save" Fig. 60: Editing a blank program template • The button “Delete section” (5) can be used to delete sections.
  • Page 99 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Button ">>more" The button ">>more" can be used to enter more functions and set values in a program-related manner. Fig. 61: Selection of program-related functions and set values Vacuum pump warm-up see chapter 6.7.3 - " Freeze-drying with the PGMplus programmer module "...
  • Page 100 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation next section is fulfilled and the next section will be initiated. If the condition for switching to the next section is not fulfilled, a process message will be issued, the current section will be extended, and further pressure increase tests will be executed periodically until the condition is fulfilled.
  • Page 101 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation → Option: Comparative pressure measurement (see chapter 6.8 - "Optional extensions and special equipment") The indication of the measurement value "dp Comp" can be configured in chapter 6.7.1.1 - "Main window "Manual"" under "Actual values of the current process"...
  • Page 102 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Option: LyoBalance weighing system If the freeze-dryer is equipped with a LyoBalance weighing system (see chapter 6.8 - "Optional extensions and special equipment"), then the corresponding parameters must be configured in this dialog box.
  • Page 103 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation "Aeration, (stoppering), storage" procedure: 1. Aeration up to the desired partial vacuum ("Aeration" value): After the actual freeze-drying process has been completed, the ice condenser continues to be cooled and the shelves are held at the temperature of the last drying section.
  • Page 104 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Special equipment: Preselection of the aeration medium If the freeze-dryer is equipped with an automatic aeration valve and automatic valves for media selection, this dialog box can be used to preselect the medium that is to be used for the aeration medium requests during the execution of the particular program.

  • Page 105: Editing A Program

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Program templates (2) The PGMplus programmer module offers various program templates that include recipes for all kinds of freeze-drying applications. They are suggestions for orientation purposes and must be adapted to the specific area of application of the freeze-dryer.

  • Page 106: Copying A Program

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation 6.7.3.3 Copying a program If a new program is to be created based on an already existing program, the already existing program can be copied. A free program storage location must be available for this purpose.

  • Page 107: Deleting A Program

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation • Press the button "Load" in order to accept the program data. The display switches to the standard user interface. • Press the button "Program start" in order to start the freeze-drying process. Fig. 68: The freeze-drying process can be started with the aid of the button “Program start”.

  • Page 108: Optional Extensions And Special Equipment

    "Freezing" phase to support the cooling of the heat transfer fluid. This enables higher freezing rates This option is only available for freeze-dryers of the Epsilon 2-6D LSCplus and Epsilon 2-10D LSCplus type. Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 108 / 161...
  • Page 109 Option: LPCplus SCADA System The Christ LPCplus system consists of the Supervisory Control And Data Acquisition (SCADA) software program by Martin Christ Gefriertrocknungsanlagen GmbH and a dedicated PC. The system is...
  • Page 110 Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Option: USB process recording see also chapter 6.7.1.1 - "Main window "Manual"", section "Dialog box "Tools"" This feature enables the recording of a running process on a USB storage medium. After the end of the process recording, the process data can be viewed on the PC with LyoLogplus and they can be printed.

  • Page 111: Switching The Freeze-Dryer Off

    Freeze-dryer Epsilon 2-10D LSCplus 6 Operation Switching the freeze-dryer OFF The freeze-dryer must be in the standby status. • Switch the control system off by pressing the control switch. • Pressing the main switch disconnects the freeze-dryer from the power.

  • Page 112: Malfunctions And Error Correction

    Freeze-dryer Epsilon 2-10D LSCplus 7 Malfunctions and error correction → Malfunctions and error correction Malfunctions are displayed in the dialogue box "Process & equipment messages" (see chapter 7.2 - "Process and error messages"). An acoustic signal sounds when an error message is generated.

  • Page 113: Power Failure

    (see chapter 7.3 - "Service contact") If it is impossible to eliminate the errors, contact the Christ service department! NOTE → 7.1.1 Power failure The control system continues with the process after a power failure.

  • Page 114: Insufficient Vacuum

    Freeze-dryer Epsilon 2-10D LSCplus 7 Malfunctions and error correction → 7.1.2 Insufficient vacuum The vacuum checks must be carried out when the ice condenser is frozen. NOTE → 7.1.2.1 Small flange connections Leakages are often due to improper small flange connections between the various components and hose connections or to leakages in the valves.

  • Page 115: Aeration Valve, Media Drain Valve

    Freeze-dryer Epsilon 2-10D LSCplus 7 Malfunctions and error correction → 7.1.2.2 Aeration valve, media drain valve Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.

  • Page 116: Insufficient Ice Condenser Temperature

    Freeze-dryer Epsilon 2-10D LSCplus 7 Malfunctions and error correction → 7.1.3 Insufficient ice condenser temperature Ensure sufficient ventilation. Do not place any paper, cloth, or similar material behind or under the unit, since otherwise the air circulation will be impaired.

  • Page 117: Service Contact

    Freeze-dryer Epsilon 2-10D LSCplus 7 Malfunctions and error correction → Service contact In the event of queries, malfunctions, or spare part enquiries: From Germany: Contact Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) Tel. +49 (0) 55 22 / 50 07-33 33 E-mail: support.epsilon@martinchrist.de...

  • Page 118: Maintenance And Service

    Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service → Maintenance and service The freeze-dryer and the accessories are subject to high mechanical and chemical stress. Thorough maintenance performed by the user extends the service life and prevents premature failure. If corrosion or other damage occurs due to improper care, the manufacturer cannot be held liable or subject to any warranty claims.
  • Page 119 Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service Cleaning of the freeze-dryer Risk of burns on hot surfaces Housing of the freeze-dryer During the operation of the freeze-dryer and half an hour afterwards, the outer surface of the freeze-dryer (especially the pipes and units) may be WARNING hot.

  • Page 120: Ice Condenser Chamber

    Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service → 8.1.2 Ice condenser chamber Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.

  • Page 121: Door Latch

    Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service Do not clean the film while dry. CAUTION • Use soft cloths, soft sponges made of synthetic fibres or rubber squeegees and common household cleaning agents (glass cleaner) for cleaning. The cleaning agents must be free from abrasive agents.

  • Page 122: Aeration Valve, Media Drain Valve

    Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service → 8.1.4 Aeration valve, media drain valve Risk of poisoning/infection caused by contaminated condensate (defrosting water) The condensate may contain harmful substances originating from the product. WARNING Contact with the condensate may cause severe damage to health.

  • Page 123: Heat Exchanger (Only Air-Cooled Freeze-Dryers)

    • Check the heat exchanger at least once per month for soiling and clean it if necessary. • Please contact the Christ service department if you have any queries (see chapter 7.3 - "Service contact"). 8.1.6 Electrical system Danger of life caused by electric shock There is a risk of electric shock when touching current-carrying components.

  • Page 124: Vacuum System With An Oil-Sealed Vacuum Pump

    Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service → 8.1.7 Vacuum system with an oil-sealed vacuum pump Please refer to the maintenance instructions of the vacuum pump and exhaust gas filter in the enclosed operating instructions of the manufacturer! NOTE...

  • Page 125: Vacuum System With A Dry-Running Vacuum Pump

    The number of operating hours of the vacuum pump can be monitored by way of the LSCplus control system and also by way of the CHRIST SCADA software LPCplus (see chapter 6.7.1.3 - "Main window "Options""/"Operating hours"...

  • Page 126: Refrigeration System

    Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service 8.1.9 Refrigeration system Risk of suffocation caused by the refrigerant When work is performed on the refrigeration system of the freeze-dryer, refrigerant may escape in the liquid or gas state and under high pressure.

  • Page 127: 8.1.11 Hydraulic System

    Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service 8.1.11 Hydraulic system Risk of a high pressure injection with hydraulic oil When working on the hydraulic system of the freeze-dryer, or due to the ageing of the hose lines, hydraulic oil may escape.

  • Page 128: 8.1.13 Accessories

    Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service → 8.1.13 Accessories For the care of the accessories, special safety measures must be considered as these are measures that will ensure operational safety at the same time. CAUTION Chemical reactions as well as stress-corrosion (combination of oscillating pressure and chemical reaction) can affect or destroy the metal and plastic parts.

  • Page 129: Maintenance Schedule

    Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service Maintenance schedule (oil-sealed vacuum pump) for freeze-dryers with an oil-sealed vacuum pump Tests and checks in accordance with the statutory rules and regulations Compliance with the applicable national and international laws, rules, and...
  • Page 130 Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Stainless steel door sight glasses: clean, illumination ok Acrylic glass door: surface clean and undamaged Machinery – Switch cabinet general Leakages...
  • Page 131 Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component springs: service life of 10 years Final vacuum Vacuum leak test Refrigeration Icing of components system Pressure readings / performance tests...
  • Page 132 Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Test sample (visual Water content of inspection, freezing heat transfer medium point, boiling point) Replace insulation Heat exchanger: (Armaflex) at heat...
  • Page 133 Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Switch cabinet: Replacement of the 1 year filter cooling system Wiring Power reading of components LSCplus control Replacemant of the 6 years...

  • Page 134: Maintenance Schedule

    Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service Maintenance schedule (dry-running vacuum pump) for freeze-dryers with a dry-running vacuum pump Tests and checks in accordance with the statutory rules and regulations Compliance with the applicable national and international laws, rules, and regulations concerning health and safety, the prevention of accidents, and the protection of the environment must be ensured.
  • Page 135 Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Stainless steel door sight glasses: clean, illumination ok Acrylic glass door: surface clean and undamaged Machinery – Switch cabinet general Leakages...
  • Page 136 Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component 9,000 Silencer: Exchange of the filter operating element Filter element hours Final vacuum Vacuum leak test Refrigeration Icing of components system...
  • Page 137 Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Test sample (visual Water content of the inspection, freezing heat transfer medium point, boiling point) Replace insulation Heat exchanger: (Armaflex) at heat...
  • Page 138 Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Switch cabinet: Replacement of the 1 year filter cooling system Wiring Power readings of components LSCplus control Replacemant of the 6 years...

  • Page 139: Service

    Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service Service In the event of service work that requires the removal of the panels, there is a risk of electric shock or mechanical injury. Only qualified specialist personnel is authorised to perform this service work.
  • Page 140 Freeze-dryer Epsilon 2-10D LSCplus 8 Maintenance and service 1. Declaration of decontamination As a certified company and due to the legal regulations for the protection of our employees and of the environment, we are obliged to certify the harmlessness of all incoming goods. For this purpose, we require a declaration of decontamination.

  • Page 141: Disposal

    Freeze-dryer Epsilon 2-10D LSCplus 9 Disposal → Disposal → Disposal of the freeze-dryer Martin Christ Gefriertrocknungsanlagen GmbH is a registered manufacturer of electric and electronic devices that are solely intended for commercial use. • Comply with all local rules and regulations. →...

  • Page 142: 10 Technical Data

    Freeze-dryer Epsilon 2-10D LSCplus 10 Technical data 10 Technical data Manufacturer: Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode (Germany) Type: Epsilon 2-10D LSCplus Part number: 111122 Physical data Dimensions of the unit - Height: 1,303 mm...
  • Page 143 Freeze-dryer Epsilon 2-10D LSCplus 10 Technical data Performance data Ice condenser chamber 460 mm x 470 mm x 231 mm - Dimensions (W x H x D): approx. 50 l - Volume: Ice condenser - Capacity: 10 kg max. - Performance: 8 kg / 24 h max.

  • Page 144: Ambient Conditions

    Freeze-dryer Epsilon 2-10D LSCplus 10 Technical data Shelves Shelf width: R-vials Shelf length: ↨ mm Shelf ↨ Ø mm Number of Area Distance The data indicate the maximum loading. shelves Substract 10% when using frames! 0,14 0,28 1226 1226 0,42...

  • Page 145: 11 Appendix

    Freeze-dryer Epsilon 2-10D LSCplus 11 Appendix → 11 Appendix → 11.1 Mathematical relations The automatic processes in the “Programmer module” menu (see chapter 6.7.3 - " Freeze-drying with the PGMplus programmer module ") are based on the following considerations: T/°C...
  • Page 146 Freeze-dryer Epsilon 2-10D LSCplus 11 Appendix → Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 146 / 161 Translation of the original operating manual...

  • Page 147: Ec Declaration Of Conformity In Accordance With The Ec Machinery Directive

    Freeze-dryer Epsilon 2-10D LSCplus 11 Appendix 11.2 EC declaration of conformity in accordance with the EC Machinery Directive Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 147 / 161 Translation of the original operating manual...
  • Page 148 Freeze-dryer Epsilon 2-10D LSCplus 11 Appendix Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 148 / 161 Translation of the original operating manual...

  • Page 149: Ec Declaration Of Conformity In Accordance With The Pressure Equipment Directive

    Freeze-dryer Epsilon 2-10D LSCplus 11 Appendix 11.3 EC declaration of conformity in accordance with the Pressure Equipment Directive Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 149 / 161 Translation of the original operating manual...
  • Page 150 Freeze-dryer Epsilon 2-10D LSCplus 11 Appendix Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 150 / 161 Translation of the original operating manual...

  • Page 151: Table Of The Sublimation Pressure Curve

    Freeze-dryer Epsilon 2-10D LSCplus 11 Appendix 11.4 Table of the sublimation pressure curve °C = mbar °C = mbar °C = mbar °C = mbar 6,110 1,030 0,120 0,011 5,620 0,940 0,110 0,009 5,1770 0,850 0,100 0,008 4,760 0,770 0,090...
  • Page 152 Freeze-dryer Epsilon 2-10D LSCplus 11 Appendix Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 152 / 161 Translation of the original operating manual...

  • Page 153: 12 Glossary

    Since absolutely tight components simply do not exist, a leak rate is determined. The parameters for the leakage test have been developed by Martin Christ Gefrier- trocknungsanlagen GmbH specifically for freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.
  • Page 154 Safety pressure Since the vacuum has a dominating influence on the product temperature, Martin Christ Gefriertrocknungsanlagen GmbH has integrated a so-called safety pressure feature into the freeze-dryers in order to ensure the protection of the product. If the pressure inside the drying chamber increases too strongly so that it exceeds the safety limit, the energy supply of the shelves will be interrupted and the →...

  • Page 155: 13 Index

    Freeze-dryer Epsilon 2-10D LSCplus Index 13 Index CE mark in compliance with the directive 2006/42/EC ..........24 Access protection........81 Changing of operating supplies ....40 Accessories ....... 41, 118, 128 Chemical burns .......... 39 Accident prevention ......26, 29 Chemical reactions ........
  • Page 156 Freeze-dryer Epsilon 2-10D LSCplus Index Damage to the materials of construction .. 118 EC declaration of conformity (Machinery Directive) ........13, 147 Danger of infection due to exhaust air ..52 EC declaration of conformity (Pressure Danger of poisoning due to exhaust air ..52 Equipment Directive) ......
  • Page 157 Freeze-dryer Epsilon 2-10D LSCplus Index Freezing ............. 22 Health and safety rules and regulations and regulations for the prevention of accidents Functional and operating elements .... 14 ............26, 28 Further applicable documents ...... 9 Heat emission .......... 142 Heat exchanger ........123 Gas injection with a proportional valve 77, 110 Heat transfer media .........
  • Page 158 Freeze-dryer Epsilon 2-10D LSCplus Index Leakage in the media drain valve ..... 112 Materials of construction, damage ... 118 Leakage test ........70, 153 Mathematical relations ......145 Line disconnector ........38 Max. humidity ........... 144 Loading a program ........106 Measures to be taken to ensure safe operation ..........
  • Page 159 Freeze-dryer Epsilon 2-10D LSCplus Index Option: LyoBalance weighing system . 65, 110 Program list ..........74 Option: LyoCam monitoring camera system Program sections ........94 ............. 109 Program templates ........105 Option: LyoControl measuring system ..109 Protection class ........143 Option: LyoLogplus data logging software 109 Option: Pressure increase test ..
  • Page 160 Freeze-dryer Epsilon 2-10D LSCplus Index Service work ..........139 Technical documentation ......144 Set process values ........62 Thermal stress ........47, 118 Set-up ............41 Tools ............63 Set-up (hazards) ........30, 47 Topping-up of operating supplies ....40 Set-up and connection .......
  • Page 161 Freeze-dryer Epsilon 2-10D LSCplus Index Weighing system........102 WTMplus wireless product temperature measurement system ......108 Weighing system LyoBalance .... 65, 110 Weight ..........43, 142 Wireless product temperature measurement Year of manufacture ........18 system WTMplus ........108 WTMplus configuration ......85 Version 07/2022, Rev.

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