Christ Epsilon 1-4 LSCplus Operating Manual
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Christ Epsilon 1-4 LSCplus Operating Manual

Freeze-dryer
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Translation of the original operating manual
sb
Freeze-dryer
Rev. 3.0 of 20/07/2022
Epsilon 1-4 LSCplus;Freeze-dryer;Epsilon 2-4 LSCplus; ;
Version 07/2022
Epsilon 1-4 LSCplus
Epsilon 2-4 LSCplus
Read the manual thoroughly before use and retain it for later use!
Freeze-dryer
Operating Manual
Part no. 111141
Part no. 111144

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Summary of Contents for Christ Epsilon 1-4 LSCplus

  • Page 1 Translation of the original operating manual Freeze-dryer Rev. 3.0 of 20/07/2022 Epsilon 1-4 LSCplus;Freeze-dryer;Epsilon 2-4 LSCplus; ; Version 07/2022 Epsilon 1-4 LSCplus Part no. 111141 Epsilon 2-4 LSCplus Part no. 111144 Freeze-dryer Operating Manual Read the manual thoroughly before use and retain it for later use!
  • Page 2 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 2 / 152 Translation of the original operating manual...
  • Page 3 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus In case of inquiries, please state the following numbers: Order number: Serial number: © Copyright by Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode am Harz Germany Tel.: +49 (0) 5522 / 5007-0...
  • Page 4 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 4 / 152 Translation of the original operating manual...

  • Page 5: Table Of Contents

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Table of contents General information ......................9 Importance of the operating manual .................. 9 Further applicable documents ................... 9 Intended use ........................9 1.3.1 Freeze-drying of solvent-containing products (non-aqueous media) ......11 1.3.2...
  • Page 6 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Table of contents Safety notes concerning the operation ................30 3.7.1 Hazards caused by electricity ..................30 3.7.2 Hazards caused by natural, flammable refrigerants ........... 30 3.7.3 Hazards caused by nitrogen ..................31 3.7.4...
  • Page 7 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Table of contents Operation ..........................53 Initial start-up ........................53 Installation of accessories ....................53 Preparation ........................53 Switching the freeze-dryer on ..................53 Loading door ........................54 LSCplus control system ....................56 6.6.1...
  • Page 8 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Table of contents Maintenance and service ....................114 Maintenance ......................... 114 8.1.1 General ........................114 8.1.2 Chamber ........................115 8.1.2.1 Lamination of the loading door with a special film ..........116 8.1.2.2 Door latch ......................

  • Page 9: General Information

    Martin Christ Gefriertrocknungsanlagen GmbH have been performed. • The vacuum pump used is approved by Martin Christ Gefriertrocknungsanlagen GmbH. The vacuum pumps approved for this system are listed in (see chapter 5.2.3 - "Vacuum pumps"). •...
  • Page 10 Exclusion of liability Any use of the freeze-dryer other than the one described here or any use going beyond this description is regarded as improper use. Martin Christ Gefriertrocknungsanlagen GmbH cannot be held liable for any damage resulting from such improper use.

  • Page 11: Freeze-Drying Of Solvent-Containing Products (Non-Aqueous Media)

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 1 General information Pos : 8 /200 C hrist/360 GT- BA Labor-Pil ot ( STAND ARDMODU LE) /010 Allgem eine Inform ationen/010- 0022-0010 Tr ock nung lös ungsmittelhaltiger Ausg angs produkte Labor+ Epsil on @ 89\m od_1648541810572_68.docx @ 942484 @ 3 @ 1 →...

  • Page 12: Freeze-Drying Of Acid-Containing Products

    Freeze-drying of azide-containing products Freeze-drying of products containing azides is only permissible following a case-by-case examination and the written approval by Martin Christ Gefriertrocknungsanlagen GmbH, since azides may form explosive dust- air-mixtures and also explosive metal azides when combined with non- ferrous metals (e.g.

  • Page 13: Copyright

    Pos : 16 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/010 Allgem eine Informationen/010- 0040 Ur heberrec ht @ 25\mod_1404983212403_68.doc x @ 182977 @ 2 @ 1 → Copyright The copyright concerning the operating manual remains with Martin Christ Gefriertrocknungsanlagen GmbH. The operating manual is solely intended for the operator and their personnel.

  • Page 14: Layout And Mode Of Operation

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Pos : 25 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/020 Aufbau und Wirk ungsw eise/020 Aufbau und Wirk ungsw eis e=========================== @ 25 \mod_1404983235994_68.doc x @ 183019 @ 1 @ 1 →...
  • Page 15 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Control switch Fig. 3: Right side of the freeze-dryer 10 Aeration valve 11 Access flange DN40 (e.g. for standard option "WTMplus”, behind the side panel) Fig. 4: Left side of the freeze-dryer Version 07/2022, Rev.
  • Page 16 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation 12 Name plate 13 Heat exchanger for the heat transfer medium (behind the panel) 14 Vacuum connection Fig. 5: Rear view of the freeze-dryer 15 Connection for a...

  • Page 17: Name Plate

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation 19 Vacuum sensor connection 20 Internal fuse 21 Power supply of the pressure control valve 22 Power supply of the vacuum pump 23 Automatic circuit breaker 1F1...

  • Page 18: Mode Of Operation

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Pos : 31 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/020 Aufbau und Wirk ungsw eise/020-0020 Wirkungsweis e------------------------ @ 25\m od_1404983253850_68.docx @ 183047 @ 2 @ 1 →...
  • Page 19 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Fig. 9: Vapour pressure curve for ice and water From a physical point of view, the freeze-drying process covers three phases (see figure below): (1) Freezing: The product to be dried is frozen under atmospheric pressure.

  • Page 20: Freeze-Drying Process

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Fig. 10: Freeze-drying phases Please find further information about basic principles, optimum procedures and applications in the brochure "Smart freeze-drying", which can be downloaded at www.martinchrist.de → [Applications] →...

  • Page 21: Freezing

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Pos : 38 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/020 Aufbau und Wirk ungsw eise/020-0020-0020- 0020 Gefrier en Epsilon ( Lös ungsmittel z ulässig) @ 25\m od_1404983257955_68.docx @ 183103 @ 4 @ 1 →...

  • Page 22: Final Drying

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation 2.2.2.4 Final drying Final drying is an option whenever one requires a product with minimal residual moisture. In the physical sense, this process is a desorption process, i.e.

  • Page 23: Safety

    Pos : 51 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0010 Besc hilderung des Geräts GT @ 25\m od_1404983297040_68.docx @ 183215 @ 2 @ 1 → Marking of the unit The following symbols are used for Christ freeze-dryers: Dangerous voltage On (Power)

  • Page 24: Explanation Of The Symbols And Notes

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 53 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0020 Symbol- und Hi nweis erklär ung en @ 25\mod_1404983298133_68.docx @ 183229 @ 2 @ 1 →...

  • Page 25: Responsibility Of The Operator

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 55 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0031 Ver antwortung des Betrei bers Epsilon Standard 2.0 @ 90\mod_1648641245328_68.docx @ 942767 @ 2 @ 1 →...

  • Page 26: Freeze-Drying Of Solvent-Containing Products

    • ensure that the freeze dryer is operated with one of the vacuum pumps approved by Martin Christ Gefriertrocknungsanlagen GmbH (see chapter 5.2.3 - "Vacuum pumps"). • have the system maintained at regular intervals (see chapter 8 - "Maintenance and service").

  • Page 27: Requirements Concerning The Personnel

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 59 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0041 Pers onalanforder ungen Epsilon allgemei n @ 25\m od_1404983300275_68.docx @ 183257 @ 2 @ 1 →...

  • Page 28: Informal Safety Notes

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Qualified electrician Due to their special training, knowledge, experience and familiarity with the relevant standards and regulations, qualified electricians are in the position to perform work on electrical systems and to autonomously identify and prevent possible hazards.

  • Page 29: Hazards Caused By Improper Transport

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 67 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0020 Sic her heit Epsilon/030- 0060-0020 Gefahren durc h uns ac hgem äßen Transport @ 36\mod_1435840039491_68.docx @ 266725 @ 3 @ 1 3.6.2...

  • Page 30: Safety Notes Concerning The Operation

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 75 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0070 Si cherheits hinw eis e z um Betri eb @ 36\m od_1435842611820_68.docx @ 266767 @ 2 @ 1...

  • Page 31: Hazards Caused By Nitrogen

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 81 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0020 Sic her heit Epsilon/030- 0070-0040 Gefahren durc h Sticks toff (Allgem ei n) @ 60\m od_1540884652312_68.docx @ 602426 @ 3 @ 1 3.7.3...

  • Page 32: Hazards Caused By Acids In The Products

    (e.g. a special vacuum pump) and following a case-by-case examination and the written approval by Martin Christ Gefriertrocknungsanlagen GmbH! Risk of poisoning caused by azides in the products When loading and unloading the shelves, the personnel are exposed to the product.

  • Page 33: Hazards Caused By Contaminated Condensate (Defrosting Water)

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 91 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0070-0090 Gefahren durch kontamini ertes Kondens at (Abtauwasser) @ 36\mod_1435902634359_68.docx @ 266885 @ 3 @ 1 3.7.8...

  • Page 34: Oil-Sealed Vacuum Pump: Hazards Caused By Hot And Contaminated Vacuum Pump Oil

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 95 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0020 Sic her heit Epsilon/030- 0070-0110 Gefahren durc h heiß es und kontamini ertes Vak uumpum penöl @ 36\m od_1435911705318_68.docx @ 266921 @ 3 @ 1 3.7.10 Oil-sealed vacuum pump: hazards caused by hot and contaminated vacuum...

  • Page 35: 3.7.13 Hazards Caused By The Loading Door

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 101 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/030 Sicherheit/030- 0020 Si cherheit Epsilon/030-0070- 0120 Gefahr en durch di e Bel adetür @ 36\m od_1435912260731_68.docx @ 266935 @ 3 @ 1 3.7.13 Hazards caused by the loading door...

  • Page 36: 3.7.16 Hazards Caused By Overpressure In The Chamber

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 107 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/030 Sicherheit/030- 0020 Si cherheit Epsilon/030-0070- 0160 Gefahr en durch Überdr uck ohne Ü berdrucksic her ung ( Standar d) @ 36\m od_1435915684375_68.docx @ 266991 @ 3 @ 1 3.7.16 Hazards caused by overpressure in the chamber...

  • Page 37: Procedures In The Event Of Hazards And Accidents

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 111 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/030 Sicherheit/030- 0020 Si cherheit Epsilon/030-0091 Ver hal ten bei Gefahr en und Unfäll en Epsilon 1-4/2- 4 ++++++++++++++ @ 36\mod_1436336802184_68.docx @ 267237 @ 2 @ 1 →...

  • Page 38: Maintenance And Cleaning Of The Freeze-Dryer

    • Stop the freeze-dryer immediately in the event of a malfunction. Eliminate the malfunction (see chapter 7 - "Malfunctions and error correction") or contact the after-sales service of Firma Martin Christ Gefriertrocknungsanlagen GmbH (see chapter 7.3 - "Service contact"). •...
  • Page 39 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Fire prevention • Fuses protect certain electrical circuits within the freeze-dryer against over-current conditions. Always use fuses of the same type and rating. Safety area • Maintain a safety distance of at least 30 cm (12 inches) around the freeze-dryer.

  • Page 40: Remaining Hazards

    → 3.13 Remaining hazards All Christ freeze-dryers were built state-of-the-art and according to the accepted safety rules. Danger to life and limb of the operator, or of third parties, or impairments of the units or other material assets, however, cannot be completely excluded when the units are being used.

  • Page 41: Storage And Transport

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 4 Storage and transport Pos : 122 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/040 Lag erung und Trans port/040 Lager ung und Tr ansport=========================== @ 25\m od_1404983713664_68.docx @ 183467 @ 1 @ 1 →...

  • Page 42: Unpacking The Freeze-Dryer

    • Take the centre of gravity of the load in consideration (off-centre)! DANGER The freeze-dryer Epsilon 1-4 LSCplus weighs approx. 110 kg! The freeze-dryer Epsilon 2-4 LSCplus weighs approx. 140 kg ! CAUTION The freeze-dryer is packaged in a wooden crate.

  • Page 43: Transport

    The freeze-dryer Epsilon 1-4 LSCplus weighs approx. 110 kg! The freeze-dryer Epsilon 2-4 LSCplus weighs approx. 140 kg! CAUTION Freeze-dryers of the type Epsilon 1-4 LSCplus and Epsilon 2-4 LSCplus that are filled with natural, flammable refrigerants are not approved as air freight! NOTE •...

  • Page 44: Transport Safety Devices

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 4 Storage and transport Pos : 131 /200 Chris t/361 GT-BA Labor-Pil ot ( PROJ EKTE)/Epsilon 4er/Epsilon 1-4_2- 4 LSC plus Standar d/040 Lag erung und Trans port/040-0040- 0010 Tr ans portsic her ung en E1-4_2- 4 @ 25\m od_1404984722823_68.docx @ 186029 @ 3 @ 1 →...

  • Page 45: Set-Up And Connection

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pos : 134 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/050 Aufstellung und Ansc hluss/050 Aufstellung und Ans chl uss Epsilon/050 Aufstellung und Ansc hlus s Epsil on ========================== @ 36\mod_1436508805195_68.docx @ 267272 @ 1 @ 1 →...

  • Page 46: Supply And Disposal Connections

    The operating voltage on the name plate must correspond to the local supply voltage DANGER Christ freeze-dryers are units of safety class I. Epsilon 1-4 LSCplus and Epsilon 2-4 LSCplus units have a three-wire power cord with a CEE 7/4 plug (type F) (see chapter 10 - "Technical data").

  • Page 47: Vacuum Pumps

    Rotary vane pump Pascal 2010 C1 (only for Epsilon 1-4 LSCplus) Dry vacuum pumps: • Scroll pump Edwards nXDS 10iC (in the case of Epsilon 1-4 LSCplus only with an external power supply) • Scroll pump Pfeiffer HiScroll 12 Atex (only for Epsilon 1-4 LSCplus) •...
  • Page 48 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection The vacuum pump is supplied with power by the unit, but the maximum current for the vacuum pump is limited. It is absolutely essential to refer to the label of the electrical outlet for the vacuum pump (see the following...

  • Page 49: Dry-Running Vacuum Pump With Silencer

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pos : 150 /200 Chris t/361 GT-BA Labor-Pil ot ( PROJ EKTE)/Epsilon 4er/Epsilon 1-4_2- 4 LSC plus Standar d/050 Aufstellung und Ansc hl uss/050- 0020- 0050-0020 Vak uumpumpe E1-4_2- 4 (Troc kenläufer) @ 85\m od_1632728134833_68.docx @ 898161 @ 4 @ 1 Vak uumpumpe →...

  • Page 50: Pressure Control Valve

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection The freeze-dryer is equipped with a dry-running vacuum pump. As a result, the vacuum exhaust gases are completely free from oil particles. However, small quantities of debris from worn seals may be emitted. That is why,...

  • Page 51: Vacuum Sensor

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pos : 154 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/050 Aufstellung und Ansc hluss/050 Aufstellung und Ans chl uss Epsilon/050-0020- 0070 Vak uumm esss onde neu - Ü berschrift--------------------------------- @ 48\mod_1490093443168_68.docx @ 492582 @ 3 @ 1 5.2.5...

  • Page 52: Rubber Valves

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pos : 157 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/050 Aufstellung und Ansc hluss/050 Aufstellung und Ans chl uss Epsilon/050-0020- 0090 Gummiventile Epsilon @ 48\mod_1490094630187_68.docx @ 492622 @ 3 @ 1 →...

  • Page 53: Operation

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 160 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/060 Betri eb======================================== @ 25 \mod_1404983759758_68.doc x @ 183578 @ 1 @ 1 Operation Pos : 161 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/060-0011 Ers te Inbetriebnahm e Epsil on ++++++++++++++++++++++++++ @ 36 \mod_1436509116118_68.docx @ 267286 @ 2 @ 1...

  • Page 54: Loading Door

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 169 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/060-0050 Bel adetür Epsil on - Übersc hrift-------------------------------------- @ 25\m od_1404984628128_68.docx @ 185721 @ 2 @ 1 →...
  • Page 55 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Radiation Shield film for loading doors made of acrylic glass Loading doors made of acrylic glass have a special, transparent film on the exterior side of the acrylic glass door. This film reduces the transfer of radiant heat onto the product and ensures homogeneous freeze-drying results.

  • Page 56: Lscplus Control System

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 172 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/LSC plus /060- 0050 LSC plus Anlagens teuerung Epsilon --------------------------------------------- @ 72\mod_1593154316973_68.doc x @ 766493 @ 2 @ 1...

  • Page 57: Main Window "Manual

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation The user interface is divided into four main windows that can be called up by touching the corresponding buttons: Manual This window is also the standard user interface. It is used to control the freeze-drying process manually.
  • Page 58 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Status line (1) This line shows the operating status of the freeze-dryer as well as the active phase. The status line also shows the current date and time. The clock is battery- buffered and must be reset after a failure (see chapter 6.6.1.3 - "Main...
  • Page 59 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Fig. 21: Dialog box "Select actual value" • Select the desired configuration or quit the dialog box by pressing the "return" button. In this way, it is possible to configure a personalised overview of the actual values.
  • Page 60 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Option: USB process recording (see chapter 6.7 - "Optional extensions and special equipment") • Select the "Process recording" function in the dialog box "Tools". • Select the input fields ("Batch data"). A keyboard for the data input will be displayed.
  • Page 61 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Fig. 24: Dialog box "Pressure increase test" • The "Test stop" button stops the pressure increase test. Option: LyoBalance weighing system If the freeze-dryer is equipped with a LyoBalance weighing system (see chapter 6.7 - "Optional extensions and special equipment"), then the...
  • Page 62 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Dialog box "Process and equipment messages" (7) This dialog box shows and saves all of the error messages and other messages. In the event of an error or message, the window “Process and equipment messages”...
  • Page 63 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Details Touching the message calls up details concerning the error message: • Cause of the message, • Effects of the message, • Measures to eliminate the error, → Reference designator, •...
  • Page 64 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Dialog box "Operating mode: select/start" (8) After the set values have been entered for the process, the process can be started manually with this function (see chapter 6.6.2 - "Manual freeze- drying").
  • Page 65 Fig. 31: Results of the performance test Evaluation: Please contact the Christ support team for the evaluation of the test run. Leakage test (2) The leakage test enables the chamber of the freeze-dryer to be tested for tightness in view of any gaseous or liquid media.
  • Page 66 • Select "Leakage test" and start the test via the "Run" button. The parameters for the leakage test have been developed by Martin Christ Gefriertrocknungsanlagen specifically for freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.
  • Page 67 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation At the end of the process, a pop-up window with a safety enquiry (confirmation prompt) opens. Following the confirmation of this enquiry, the freeze-dryer will be switched to standby. Evaluation: The test is passed if the dishes do not contain any water/ice after the end of the process.
  • Page 68 (confirmation prompt) opens. Following the confirmation of this enquiry, the freeze-dryer will be switched to standby. Evaluation: Please contact the Christ support team for the evaluation of the test run. Shelf mapping test (6) The shelf mapping test is a freeze-drying program for bringing the shelves to a temperature of +20°C, -40°C, and +40°C for a specific period of time in...
  • Page 69 The external measurement recording process can then be stopped. Evaluation: Please contact the Christ support team for the evaluation of the test run. Pos : 179 /010 Univ ers almodul e/ Leerz eile @ 0\mod_1202116244500_0.docx @ 114 @ @ 1 Pos : 180 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/LSC plus /060- 0050-0010- 0010c Hauptfenster Manuell Labor/Epsilon T eil 3 @ 72\m od_1593154320311_68.docx @ 766569 @ @ 1...

  • Page 70: Main Window "Program

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 182 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/LSC plus /060- 0050-0010- 0021 H auptfens ter Programm Epsilon @ 72\mod_1593154326974_68.doc x @ 766699 @ 4 @ 1 6.6.1.2...

  • Page 71: Main Window "Options

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 184 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/LSC plus /060- 0050-0010- 0031 H auptfens ter Optionen Epsilon - 1 Vakuumpum pe @ 72\m od_1593154328879_68.docx @ 766737 @ 4 @ 1 6.6.1.3...
  • Page 72 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Change scale unit (2) This dialog box is used to change the unit of measurement for the temperature and vacuum. Fig. 35: Dialog box "Change scale unit" Special equipment: Preselection of the aeration medium (3) This function can be performed in the manual mode or saved together with a program (see chapter 6.6.3.1 - "Creating a program").
  • Page 73 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation The following media preselection settings are possible: • Air: Preselects the media connection "Air". • Inert gas: Preselects the media connection "Inert Gas". • Automatic: Automatic media connection preselection depending on the chamber pressure and stoppering status of the product vials: –...
  • Page 74 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Special equipment: Inertisation (5) (see chapter 6.7 - "Optional extensions and special equipment") If the "Inertisation" option is active and the freeze-dryer is in the "Standby", "Manual - Freezing", "Program - Loading" or "Program - Freezing" mode, the automatic inertisation of the drying chamber will be performed for the preselected inertisation time after the loading door has been closed.
  • Page 75 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation If the volume flow through the inertisation line falls below a certain threshold for more than 5 seconds (the value can be preset at the flow meter) or if the loading door is opened during an inertisation sequence, the process will also be aborted immediately.
  • Page 76 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Network (2) This dialog box is used to change various system settings. The modifications will not become effective until after a restart of the unit. NOTE Fig. 41: Dialog box "Network"...
  • Page 77 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Click on touch: If this function is active, a clicking sound can be heard whenever the system registers that a button has been touched. Behaviour of the pressure control valve in the case of insufficient ice condenser cooling: If this function is active (button "closed"), the pressure...
  • Page 78 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation • The button with the lock symbol blocks the access immediately and the system switches to the default setting. Fig. 45: Access blocked, the data cannot be edited Operator/maintenance/administrator password: For each of these access levels, certain editing rights have been defined.
  • Page 79 • Press the button "Add option". An input window opens. • Enter the six-digit Christ activation code that was supplied for this option. Note that the keys are case sensitive. Options can be removed in the same way. The modifications will not become effective until after a restart of the unit.
  • Page 80 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Product temperature sensor (see the illustration above, item B) Only for systems with a WTMplus system The wired product temperature sensor 1 is the default sensor for determining the value "ΔT product" (see chapter 6.6.3 - " Freeze-drying with the PGMplus programmer module ", section "Conditions for switching...
  • Page 81 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation WTMplus configuration (7) The dialog box is displayed for information purposes only. The configuration can be changed only via the LPCplus user interface. NOTE This dialog box shows all of the existing WTMplus sensors. Every sensor is assigned to a measuring channel based on its serial number.
  • Page 82 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Maintenance "Service" options: "Operating hours" "Failure memory" "Vacuum pump oil change" "Maintenance" "Sensor adjustment" Fig. 50: Dialog box "Service" (varies depending on the type of system) Operating hours (1) This dialog box is used to call up the number of operating hours of the various components of the freeze-dryer, e.g.
  • Page 83 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Failure memory (2) Equipment information system. These messages can be viewed in this dialog box. The failure memory includes the last 32 messages. If this number is exceeded, the oldest message will be overwritten.
  • Page 84 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Vacuum pump oil change (3) This option only applies to oil-sealed vacuum pumps! NOTE The system monitors the oil change interval of the vacuum pump. The interval can be adapted to the vacuum pump model and utilisation.
  • Page 85 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Maintenance (4) The maintenance interval of the unit is fixed at 3,000 operating hours or at least one maintenance per year. When the end of a maintenance interval is reached, a corresponding message will be displayed.

  • Page 86: Main Window

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 186 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/LSC plus /060- 0050-0010- 0041 H auptfens ter " ?" Epsilon @ 72\m od_1593154331423_68.docx @ 766775 @ 4 @ 1 6.6.1.4...

  • Page 87: Entering Set Values In The Manual Mode

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation After the completion of a phase, the system switches to the next phase without switching the unit to standby. The transition from "freezing" to "warm-up" takes place automatically. After the completion of the warm-up phase, this dialog box will be displayed: Fig.
  • Page 88 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Viewing or editing the set values: • Press the button "Set values: view/edit" (see chapter 6.6.1.1 - "Main window "Manual""). The following dialog box will be displayed: "Aeration" button "Defrosting" button "Media drain"...

  • Page 89: Freeze-Drying With The Pgmplus Programmer Module

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Numerical values can be edited with the aid of a numerical keypad: Set value display Button for changing the sign (e.g. when entering temperature values) "" (infinite) Button for editing the...
  • Page 90 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Fig. 59: Representation of a freeze-drying program Program sections When the programmer module executes a freeze-drying process, it executes the various sections that were created one after the other until the last section is completed.
  • Page 91 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Conditions for switching to the next section For all of the program sections to be executed automatically, certain switching conditions must be fulfilled at the end of each section. If these conditions are not fulfilled, e.g.
  • Page 92 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation T comparative (option): This value indicates the difference between a Pirani sensor and a capacitive vacuum sensor in per cent based on the actual value of the capacitive vacuum sensor. When the sublimation rate decreases, the difference decreases as well.

  • Page 93: Creating A Program

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 194 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/LSC plus /060- 0050-0032- 0011 Programm erstellen Epsilon @ 72\m od_1593154338701_68.docx @ 766927 @ 4 @ 1 6.6.3.1...
  • Page 94 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation "Program" buttons: "Program" "Program name" "Show diagram" "Insert section" "Delete section" Button for calling up more functions and set values "Save" Fig. 63: Editing a blank program template • The button “Delete section” (5) can be used to delete sections.
  • Page 95 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Button ">>more" The button ">>more" can be used to enter more functions and set values in a program-related manner. Fig. 64: Selection of program-related functions and set values Vacuum pump warm-up see chapter 6.6.3 - "...
  • Page 96 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation next section is fulfilled and the next section will be initiated. If the condition for switching to the next section is not fulfilled, a process message will be issued, the current section will be extended, and further pressure increase tests will be executed periodically until the condition is fulfilled.
  • Page 97 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation → Option: Comparative pressure measurement (see chapter 6.7 - "Optional extensions and special equipment") The indication of the measurement value "dp Comp" can be configured in chapter 6.6.1.1 - "Main window "Manual"" under "Actual values of the current process"...
  • Page 98 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Option: LyoBalance weighing system If the freeze-dryer is equipped with a LyoBalance weighing system (see chapter 6.7 - "Optional extensions and special equipment"), then the corresponding parameters must be configured in this dialog box.
  • Page 99 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation "Aeration, (stoppering), storage" procedure: 1. Aeration up to the desired partial vacuum ("Aeration" value): After the actual freeze-drying process has been completed, the ice condenser continues to be cooled and the shelves are held at the temperature of the last drying section.
  • Page 100 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Special equipment: Preselection of the aeration medium If the freeze-dryer is equipped with an automatic aeration valve and automatic valves for media selection, this dialog box can be used to preselect the medium that is to be used for the aeration medium requests during the execution of the particular program.

  • Page 101: Editing A Program

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Program templates (2) The PGMplus programmer module offers various program templates that include recipes for all kinds of freeze-drying applications. They are suggestions for orientation purposes and must be adapted to the specific area of application of the freeze-dryer.

  • Page 102: Copying A Program

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  • Page 103: Deleting A Program

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Fig. 71: The freeze-drying process can be started with the aid of the button “Program start”. • During the freeze-drying process, the description of the active program can also be called up from the main window "Program" and via the button "Info".

  • Page 104: Optional Extensions And Special Equipment

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 204 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/LSC plus /060- 0062 Opti onale Erw eiterungen und Sonder auss tattung en Epsilon Allgemei n ----------------- @ 72\m od_1593154343014_68.docx @ 767041 @ 2 @ 1 Optional extensions and special equipment The freeze-dryer can be equipped with the following optional equipment.
  • Page 105 Option: LPCplus SCADA System The Christ LPCplus system consists of the Supervisory Control And Data Acquisition (SCADA) software program by Martin Christ Gefriertrocknungsanlagen GmbH and a dedicated PC. The system is...
  • Page 106 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Option: USB process recording see also chapter 6.6.1.1 - "Main window "Manual"", section "Dialog box "Tools"" This feature enables the recording of a running process on a USB storage medium. After the end of the process recording, the process data can be viewed on the PC with LyoLogplus and they can be printed.

  • Page 107: Switching The Freeze-Dryer Off

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Switching the freeze-dryer OFF The freeze-dryer must be in the standby status. • Switch the freeze-dryer off by pressing the mains switch. Pos : 207 /010 Univ ers almodul e/ Abs chnittswec hs el @ 0 \mod_1202124514062_0.docx @ 418 @ @ 1...

  • Page 108: Malfunctions And Error Correction

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction Pos : 209 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/070 Störungen und F ehl ersuche/070 Störungen und F ehl ersuche=========================== @ 25\m od_1404984056039_68.docx @ 184111 @ 1 @ 1 →...

  • Page 109: Power Failure

    (see chapter 7.3 - "Service contact") If it is impossible to eliminate the errors, contact the Christ service department! NOTE Pos : 212 /010 Univ ers almodul e/ Leerz eile @ 0\mod_1202116244500_0.docx @ 114 @ @ 1 Pos : 213 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/070 Störungen und F ehl ersuche/070- 0010- 0010 Netzaus fall @ 25\mod_1404984058964_68.doc x @ 184153 @ 3 @ 1...

  • Page 110: Insufficient Vacuum

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction Pos : 215 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/070 Störungen und F ehl ersuche/070- 0010- 0020 Kein ausr eichendes Vakuum @ 25\m od_1404984060039_68.docx @ 184167 @ 3 @ 1 →...

  • Page 111: Aeration Valve

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction Pos : 219 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/070 Störungen und F ehl ersuche/070- 0010- 0020-0020 Bel üftungsventil (z.B. E2-4) @ 25\mod_1404984751036_68.doc x @ 186099 @ 4 @ 1 →...

  • Page 112: Insufficient Ice Condenser Temperature

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction Pos : 227 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/070 Störungen und F ehl ersuche/070- 0010- 0030 Eisk ondensatortem per atur Al pha bis D elta, E1-4/2-4 @ 25\m od_1404984066757_68.docx @ 184251 @ 3 @ 1 →...

  • Page 113: Service Contact

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction Pos : 231 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/070 Störungen und F ehl ersuche/070- 0031 Kontak t im Servic efall_Epsil on @ 25\m od_1404984069705_68.docx @ 184293 @ 2 @ 1 →...

  • Page 114: Maintenance And Service

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  • Page 115: Chamber

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Cleaning of the freeze-dryer Risk of burns on hot surfaces Housing of the freeze-dryer During the operation of the freeze-dryer and half an hour afterwards, the outer surface of the freeze-dryer (especially the pipes and units) may be WARNING hot.

  • Page 116: Lamination Of The Loading Door With A Special Film

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos : 241 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/080 W artung und Instandhaltung/080-0010- 0022-0010 F olienbesc hichtung der Beladetür Epsilon Standar d 2.0 @ 92\m od_1658308697576_68.docx @ 967406 @ 4 @ 1 8.1.2.1...

  • Page 117: Door Latch

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  • Page 118: Heat Exchanger (Only Air-Cooled Freeze-Dryers)

    Check the heat exchanger at least once per month for soiling and clean it if necessary. • Please contact the Christ service department if you have any queries (see chapter 7.3 - "Service contact"). Pos : 248 /010 Univ ers almodul e/ Leerz eile @ 0\mod_1202116244500_0.docx @ 114 @ @ 1...

  • Page 119: Vacuum System With An Oil-Sealed Vacuum Pump

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  • Page 120: Vacuum System With A Dry-Running Vacuum Pump

    The number of operating hours of the vacuum pump can be monitored by way of the LSCplus control system and also by way of the CHRIST SCADA software LPCplus (see chapter 6.6.1.3 - "Main window "Options""/"Operating hours"...

  • Page 121: Refrigeration System

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos : 255 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/080 W artung und Instandhaltung/080-0010- 0091 Kältesystem Epsilon (natürliche, brennbare Kältemittel) @ 64\m od_1558595727235_68.docx @ 690977 @ 3 @ 1 8.1.8...

  • Page 122: Vacuum Sensor

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  • Page 123: Disinfection Of The Drying Chamber And Accessories

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  • Page 124: Maintenance Schedule (Oil-Sealed Vacuum Pump)

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos : 263 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/080 W artung und Instandhaltung/080-0030 W artungs plan Epsil on 4er (Vak uum pumpen mit Öl) @ 25\m od_1404984679421_68.docx @ 185916 @ 2 @ 1...
  • Page 125 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Static gaskets: 100 steril. cycles O-rings, clamp, KF Wires: fastened Cable trays: closed Framework: Remove corrosion no corrosion...
  • Page 126 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Cooling water Cleaning of the valve controller Heat exchanger Cleaning Mechanical Vial stoppering components: system operation Leakages...
  • Page 127 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Switch cabinet: Replacement of the 1 year filter cooling system Wiring Power readings of components LSCplus control...

  • Page 128: Maintenance Schedule (Dry-Running Vacuum Pump)

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos : 265 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/080 W artung und Instandhaltung/080-0031 W artungs plan Epsil on 4er (Troc kenläuferpum pe) @ 85\mod_1631771127780_68.doc x @ 897660 @ 2 @ 1...
  • Page 129 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Static gaskets: 100 steril. cycles O-rings, clamp, KF Wires: fastened Cable trays: closed Framework: Remove corrosion no corrosion...
  • Page 130 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Ice condenser: temperature low end Cooling water Cleaning of the valve controller Heat exchanger Cleaning Mechanical Vial stoppering...
  • Page 131 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Switch cabinet: Replacement of the 1 year filter cooling system Wiring Power readings of components LSCplus control...

  • Page 132: Service

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos : 267 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/080 W artung und Instandhaltung/080-0041 Ins tandhaltungs arbeiten Epsilon (mit W artungsv ertrag nur de) @ 25\m od_1404984109982_68.docx @ 184489 @ 2 @ 1...
  • Page 133 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service 1. Declaration of decontamination As a certified company and due to the legal regulations for the protection of our employees and of the environment, we are obliged to certify the harmlessness of all incoming goods.

  • Page 134: Disposal

    Pos : 273 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/090 Entsorgung/090-0010 Entsorgung der Gefriertr ock nungsanlag e @ 25\m od_1404984141122_68.docx @ 184531 @ 2 @ 1 → Disposal of the freeze-dryer Martin Christ Gefriertrocknungsanlagen GmbH is a registered manufacturer of electric and electronic devices that are solely intended for commercial use.

  • Page 135: 10 Technical Data

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 10 Technical data Pos : 278 /200 Chris t/361 GT-BA Labor-Pil ot ( PROJ EKTE)/Epsilon 4er/Epsilon 1-4_2- 4 LSC plus Standar d/100 T ec hnis che D aten/100 Tec hnisc he D aten E1- 4_2-4 Standard 2.0 =================================== @ 25 \mod_1404984770073_68.doc x @ 186141 @ 1 @ 1 →...

  • Page 136: Ambient Conditions

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 10 Technical data Regrigerant data Epsilon 1-4 LSCplus Epsilon 2-4 LSCplus Refrigerant: R1270 R1270 - Global warming potential (GWP): - Filling quantity: 62 g 64 g - Max. permissible pressure: 25 bar...

  • Page 137: 11 Appendix

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos : 286 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/110 Anhang/0110 Anhang================================================= @ 25\m od_1404984177994_68.docx @ 184601 @ 1 @ 1 → 11 Appendix Pos : 287 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/110 Anhang/0110-0010 Mathematische Z us ammenhänge @ 25\m od_1404984178952_68.docx @ 184615 @ 2 @ 1 →...
  • Page 138 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos : 289 /200 Chris t/36 1 GT-BA Labor-Pil ot ( PROJ EKTE)/Epsilon 4er/Epsilon 1-4_2- 4 LSC plus Standar d/110 Anhang/0110-0030 C E-Erklär ung M asc hR L 1-4_2- 4 LSC plus Standar d 2.0 @ 25\m od_1404984777923_68.docx @ 186153 @ 2 @ 1 →...

  • Page 139: Ec Declaration Of Conformity In Accordance With The Ec Machinery Directive

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix 11.2 EC declaration of conformity in accordance with the EC Machinery Directive Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 139 / 152 Translation of the original operating manual...
  • Page 140 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos : 290 /010 Univ ers almodul e/ Seitenwechs el @ 0\mod_1202116244312_0.docx @ 105 @ @ 1 Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 140 / 152 Translation of the original operating manual...

  • Page 141: Ec Declaration Of Conformity In Accordance With The Pressure Equipment Directive

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos : 291 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/110 Anhang/0110-0031 CE- Erklär ung Dr uckger äteRL @ 38\m od_1438592143048_68.docx @ 275085 @ 2 @ 1 11.3 EC declaration of conformity in accordance with the Pressure Equipment Directive Version 07/2022, Rev.
  • Page 142 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos : 292 /010 Univ ers almodul e/ Seitenwechs el @ 0\mod_1202116244312_0.docx @ 105 @ @ 1 Version 07/2022, Rev. 3.0 of 20/07/2022 • sb 142 / 152 Translation of the original operating manual...

  • Page 143: Table Of The Sublimation Pressure Curve

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos : 293 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/110 Anhang/0110-0021 T abelle Sublim ations druc kkurv e @ 25\mod_1404984180168_68.doc x @ 184629 @ 2 @ 1 11.4 Table of the sublimation pressure curve °C...
  • Page 144 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos : 294 /010 Univ ers almodul e/ Abs chnittswec hs el @ 0\mod_1202124514062_0.docx @ 418 @ @ 1 Pos : 295 /010 Univ ers almodul e/ Seitenwechs el @ 0\mod_1202116244312_0.docx @ 105 @ @ 1 Version 07/2022, Rev.

  • Page 145: 12 Glossary

    Since absolutely tight components simply do not exist, a leak rate is determined. The parameters for the leakage test have been developed by Martin Christ Gefrier- trocknungsanlagen GmbH specifically for freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.
  • Page 146 Safety pressure Since the vacuum has a dominating influence on the product temperature, Martin Christ Gefriertrocknungsanlagen GmbH has integrated a so-called safety pressure feature into the freeze-dryers in order to ensure the protection of the product. If the pressure inside the drying chamber increases too strongly so that it exceeds the safety limit, the energy supply of the shelves will be interrupted and the →...

  • Page 147: 13 Index

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Index 13 Index CE mark in compliance with the directive 2006/42/EC ..........23 Access protection........77 Chamber, cleaning and care ....115 Accessories ....... 39, 114, 122 Changing of operating supplies ....38 Accident prevention ......
  • Page 148 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Index Danger of infection due to exhaust air ..49 Editing a program........101 Danger of poisoning due to exhaust air ..49 Electrical connection ........ 135 Dangerous materials ........ 123 Electrical system (maintenance) ....118 Data interface (LAN) ........
  • Page 149 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Index Gas injection with a proportional valve 73, 106 Ice condenser .......... 135 General conditions ........12 Ice condenser temperature ......91 General information on freeze-drying ..18 Importance of the operating manual ..... 9 General malfunctions .......
  • Page 150 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Index Main window "?" ......... 86 Main window "Manual" ....... 57 Oil mist separator ........48 Main window "Options" ......71 Oil mist separator (exhaust filter) and vacuum Main window "Program" ......70 pump (oil-sealed) ........
  • Page 151 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Index Power failure ..........109 Safety area ..........39 Power supply ..........46 Safety data sheets ........136 Preparation .......... 20, 53 Safety devices ........... 36 Preselection of the aeration medium .. 72, 106 Safety distance ..........
  • Page 152 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Index Storage ............41 UV radiation ........45, 114 Storage and transport ........ 41 Storage conditions ........41 Vacuum ............. 91 Stress-corrosion ........122 Vacuum connection ......... 136 Sublimation ..........146 Vacuum pump (dry-running) and silencer .. 49 Supply voltage ...........

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Epsilon 2-4 lscplus111141111144

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