Christ Epsilon 1-4 LSCplus Operating Manual
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Christ Epsilon 1-4 LSCplus Operating Manual

Freeze-dryer
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Translation of the original operating manual
sb
Freeze-dryer
Rev. 2.13 of 01/12/2021
Epsilon 1-4 LSCplus;Freeze-dryer;Epsilon 2-4 LSCplus; ;
Version 04/2014
Epsilon 1-4 LSCplus
Part no. 112991, 112993, 112999
Epsilon 2-4 LSCplus
Part no. 112992, 112994, 113000
Operating Manual
Freeze-dryer
Please retain for later use!

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Summary of Contents for Christ Epsilon 1-4 LSCplus

  • Page 1 Translation of the original operating manual Freeze-dryer Rev. 2.13 of 01/12/2021 Epsilon 1-4 LSCplus;Freeze-dryer;Epsilon 2-4 LSCplus; ; Version 04/2014 Epsilon 1-4 LSCplus Part no. 112991, 112993, 112999 Epsilon 2-4 LSCplus Part no. 112992, 112994, 113000 Freeze-dryer Operating Manual Please retain for later use!
  • Page 2 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Version 04/2014, Rev. 2.13 of 01/12/2021 • sb 2 / 148 Translation of the original operating manual...
  • Page 3 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus In case of inquiries, please state the following numbers: Order number: Serial number: © Copyright by Martin Christ Gefriertrocknungsanlagen GmbH An der Unteren Söse 50 37520 Osterode am Harz Germany Tel.: +49 (0) 5522 / 5007-0...
  • Page 4 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Version 04/2014, Rev. 2.13 of 01/12/2021 • sb 4 / 148 Translation of the original operating manual...

  • Page 5: Table Of Contents

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Table of contents General information ......................9 Importance of the operating manual .................. 9 Further applicable documents ................... 9 Intended use ........................9 Warranty and liability....................... 12 Copyright ........................13 Explanation of symbols ....................13 Standards and regulations ....................
  • Page 6 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Table of contents 3.7.8 Hazards caused by contaminated condensate (defrosting water) ......34 3.7.9 Oil-sealed vacuum pump: hazards caused by contaminated vacuum pump exhaust gases ......................... 34 3.7.10 Oil-sealed vacuum pump: hazards caused by hot and contaminated vacuum pump oil ..........................
  • Page 7 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Table of contents LSCplus control system ....................58 6.6.1 User interface ......................58 6.6.1.1 Main window "Manual" ..................59 6.6.1.2 Main window "Program" ..................72 6.6.1.3 Main window "Options" ..................73 6.6.1.4 Main window "?"...
  • Page 8 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Table of contents Disinfection of the drying chamber and accessories ............. 123 Maintenance schedule ....................124 Maintenance schedule ....................125 Service ......................... 128 Return of defective parts ....................128 Disposal ..........................130 Disposal of the freeze-dryer ..................

  • Page 9: General Information

    The following documents apply in addition to these operating instructions if the freeze-dryer is equipped with the corresponding features: • Operating instructions of the CHRIST SCADA software LPCplus (instructions for the operation of the freeze-dryer by way of a SCADA system) Pos : 5 /010 U niv ersalm odul e/ Leerzeil e @ 0 \mod_1202116244500_0.docx @ 114 @ @ 1...
  • Page 10 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 1 General information Freeze-drying of solvent-containing products (non-aqueous media) With regards of corrosion resistance, the use of some organic solvents in aqueous solutions with low concentrations is acceptable. A freeze-dryer is designed to be chemically resistant to most compounds that are commonly used in freeze-drying processes.
  • Page 11 Freeze-drying of azide-containing products Freeze-drying of products containing azides is only permissible following a case-by-case examination and the written approval by Martin Christ Gefriertrocknungsanlagen GmbH, since azides may form explosive dust- air-mixtures and also explosive metal azides when combined with non- ferrous metals (e.g.

  • Page 12: Warranty And Liability

    LyoCoN process or removal of the LyoCoN reservoir and secured sealing of the access opening. Otherwise, there is a risk of personal injury. Consultation of Martin Christ Gefriertrocknungsanlagen GmbH is absolutely mandatory in order to define the measures that need to be taken! Any other use beyond this area of application is regarded as improper use.

  • Page 13: Copyright

    Pos : 10 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/010 Allgem eine Informationen/010- 0040 Ur heberrec ht @ 25\mod_1404983212403_68.doc x @ 182977 @ 2 @ 1 → Copyright The copyright concerning the operating manual remains with Martin Christ Gefriertrocknungsanlagen GmbH. The operating manual is solely intended for the operator and their personnel.

  • Page 14: Layout And Mode Of Operation

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Pos : 19 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/020 Aufbau und Wirk ungsw eise/020 Aufbau und Wirk ungsw eis e=========================== @ 25 \mod_1404983235994_68.doc x @ 183019 @ 1 @ 1 →...
  • Page 15 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Connections for the product sensors and a LyoRX sensor Shelf Ice condenser Defrosting water collecting tray Fig. 2: Detailed view A – drying chamber Mains switch Fig.
  • Page 16 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Aeration valve 10 Access flange DN40 (e.g. for weighing device, behind the side panel) Fig. 4: Left side of the freeze-dryer Standard: Air-cooled freeze-dryer 11 Name plate...
  • Page 17 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Special equipment: water-cooled freeze-dryer 16 Connector for the cooling water outlet 17 Connector for the cooling water inlet Fig. 6: Rear view of a water-cooled freeze-dryer...

  • Page 18: Name Plate

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Pos : 23 /200 C hrist/361 GT-BA Labor-Pilot (PR OJEKT E)/Epsilon 4er/Epsilon 1-4_2-4 LSCpl us Standard/020 Aufbau und Wirk ungsw eis e/020-0010-0020 T ypenschil d E2- 4 @ 25\m od_1404984709736_68.docx @ 185973 @ 3 @ 1 →...

  • Page 19: Mode Of Operation

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Pos : 25 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/020 Aufbau und Wirk ungsw eise/020-0020 Wirkungsweis e------------------------ @ 25\m od_1404983253850_68.docx @ 183047 @ 2 @ 1 →...
  • Page 20 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Fig. 9: Vapour pressure curve for ice and water From a physical point of view, the freeze-drying process covers three phases (see figure below): (1) Freezing: The product to be dried is frozen under atmospheric pressure.

  • Page 21: Freeze-Drying Process

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Fig. 10: Freeze-drying phases Please find further information about basic principles, optimum procedures and applications in the brochure "Smart freeze-drying", which can be downloaded at www.martinchrist.de → [Applications] →...

  • Page 22: Freezing

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation Pos : 32 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/020 Aufbau und Wirk ungsw eise/020-0020-0020- 0020 Gefrier en Epsilon ( Lös ungsmittel z ulässig) @ 25\m od_1404983257955_68.docx @ 183103 @ 4 @ 1 →...

  • Page 23: Final Drying

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 2 Layout and mode of operation → 2.2.2.4 Final drying Final drying is an option whenever one requires a product with minimal residual moisture. In the physical sense, this process is a desorption process, i.e.

  • Page 24: Safety

    Pos : 45 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0010 Besc hilderung des Geräts GT @ 25\m od_1404983297040_68.docx @ 183215 @ 2 @ 1 → Marking of the unit The following symbols are used for Christ freeze-dryers: Dangerous voltage On (Power)

  • Page 25: Explanation Of The Symbols And Notes

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 47 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0020 Symbol- und Hi nweis erklär ung en @ 25\mod_1404983298133_68.docx @ 183229 @ 2 @ 1 →...

  • Page 26: Responsibility Of The Operator

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 49 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0031 Ver antwortung des Betrei bers Epsilon allgemei n+chemi efest @ 25\mod_1404983299227_68.doc x @ 183243 @ 2 @ 1 →...
  • Page 27 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety • having maintained the system at regular intervals (see chapter 8 - "Maintenance and service"). • having the safety devices checked regularly in terms of their correct operation (see chapter 3.8 - "Safety devices") Any parts or components that are not in perfect working order must be replaced without delay.

  • Page 28: Requirements Concerning The Personnel

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Requirements concerning the personnel Risk of injury if the personnel are not sufficiently qualified If unqualified personnel perform work on the freeze-dryer or are present in the danger zone of the freeze-dryer, hazards result that can cause serious injuries and considerable damage to property.

  • Page 29: Informal Safety Notes

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 53 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0050 Informell e Sic herheits hinw eise @ 25\m od_1404983301284_68.docx @ 183271 @ 2 @ 1 →...

  • Page 30: Hazards Caused By Improper Set-Up

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 62 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0060-0030 Gefahren durch uns achg emäß e Aufstellung @ 36\m od_1436261069141_68.docx @ 267141 @ 3 @ 1 3.6.3...

  • Page 31: Safety Notes Concerning The Operation

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 68 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0070 Si cherheits hinw eis e z um Betri eb @ 36\m od_1435842611820_68.docx @ 266767 @ 2 @ 1...

  • Page 32: Hazards Caused By Nitrogen

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 74 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0020 Sic her heit Epsilon/030- 0070-0040 Gefahren durc h Sticks toff (Allgem ei n) @ 60\m od_1540884652312_68.docx @ 602426 @ 3 @ 1 3.7.3...

  • Page 33: Hazards Caused By Acids In The Products

    (e.g. a special vacuum pump) and following a case-by-case examination and the written approval by Martin Christ Gefriertrocknungsanlagen GmbH! Risk of poisoning caused by azides in the products When loading and unloading the shelves, the personnel are exposed to the product.

  • Page 34: Hazards Caused By Contaminated Condensate (Defrosting Water)

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 84 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0070-0090 Gefahren durch kontamini ertes Kondens at (Abtauwasser) @ 36\mod_1435902634359_68.docx @ 266885 @ 3 @ 1 3.7.8...

  • Page 35: Oil-Sealed Vacuum Pump: Hazards Caused By Hot And Contaminated Vacuum Pump Oil

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 88 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0020 Sic her heit Epsilon/030- 0070-0110 Gefahren durc h heiß es und kontamini ertes Vak uumpum penöl @ 36\m od_1435911705318_68.docx @ 266921 @ 3 @ 1 3.7.10 Oil-sealed vacuum pump: hazards caused by hot and contaminated vacuum...

  • Page 36: 3.7.12 Hazards Caused By The Loading Door

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 92 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0020 Sic her heit Epsilon/030- 0070-0120 Gefahren durc h die Beladetür @ 36\mod_1435912260731_68.docx @ 266935 @ 3 @ 1 3.7.12 Hazards caused by the loading door...

  • Page 37: 3.7.15 Hazards Caused By Overpressure In The Chamber

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 98 /200 C hrist/360 GT-BA Labor-Pilot (ST ANDARDM ODU LE)/030 Sic her heit/030-0020 Sic her heit Epsilon/030- 0070-0160 Gefahren durc h Ü ber druck ohne Überdr ucksic herung (Standard) @ 36 \mod_1435915684375_68.doc x @ 266991 @ 3 @ 1 3.7.15 Hazards caused by overpressure in the chamber...

  • Page 38: Procedures In The Event Of Hazards And Accidents

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety Pos : 102 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/030 Sicherheit/030- 0020 Si cherheit Epsilon/030-0091 Ver hal ten bei Gefahr en und Unfäll en Epsilon 1-4/2- 4 ++++++++++++++ @ 36\mod_1436336802184_68.docx @ 267237 @ 2 @ 1 →...

  • Page 39: Maintenance And Cleaning Of The Freeze-Dryer

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 3 Safety • Skin: Wash with plenty of water. Remove contaminated clothing. Rinse the affected skin areas under flowing water for at least 10 minutes. Get medical attention immediately! • Oesophagus: Do not put anything into the mouth of an unconscious person. Wash the mouth out with water, If the person is conscious: Give the affected person plenty of water to drink (2 glasses maximum).

  • Page 40: Measures To Be Taken To Ensure Safe Operation Of The Freeze-Dryer

    • Stop the freeze-dryer immediately in the event of a malfunction. Eliminate the malfunction (see chapter 7 - "Malfunctions and error correction") or contact the after-sales service of Firma Martin Christ Gefriertrocknungsanlagen GmbH (see chapter 7.3 - "Service contact"). •...

  • Page 41: Remaining Hazards

    → 3.13 Remaining hazards All Christ freeze-dryers were built state-of-the-art and according to the accepted safety rules. Danger to life and limb of the operator, or of third parties, or impairments of the units or other material assets, however, cannot be completely excluded when the units are being used.

  • Page 42: Storage And Transport

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 4 Storage and transport Pos : 116 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/040 Lag erung und Trans port/040 Lager ung und Tr ansport=========================== @ 25\m od_1404983713664_68.docx @ 183467 @ 1 @ 1 →...

  • Page 43: Unpacking The Freeze-Dryer

    Prior to the transport of the freeze-dryer, read this chapter of the operating manual thoroughly! The freeze-dryer Epsilon 1-4 LSCplus weighs approx. 110 kg without base frame and approx. 164 kg with base frame! The freeze-dryer Epsilon 2-4 LSCplus weighs approx. 140 kg without base frame and approx.

  • Page 44: Transport

    Prior to the transport of the freeze-dryer, read this chapter of the operating manual thoroughly! The freeze-dryer Epsilon 1-4 LSCplus weighs approx. 110 kg without base frame and approx. 164 kg with base frame! The freeze-dryer Epsilon 2-4 LSCplus weighs approx. 140 kg without base frame and approx.

  • Page 45: Transport Safety Devices

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 4 Storage and transport Pos : 125 /200 Chris t/361 GT-BA Labor-Pil ot ( PROJ EKTE)/Epsilon 4er/Epsilon 1-4_2- 4 LSC plus Standar d/040 Lag erung und Trans port/040-0040- 0010 Tr ans portsic her ung en E1-4_2- 4 @ 25\m od_1404984722823_68.docx @ 186029 @ 3 @ 1 →...

  • Page 46: Set-Up And Connection

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pos : 128 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/050 Aufstellung und Ansc hluss/050 Aufstellung und Ans chl uss Epsilon/050 Aufstellung und Ansc hlus s Epsil on ========================== @ 36\mod_1436508805195_68.docx @ 267272 @ 1 @ 1 →...

  • Page 47: Supply And Disposal Connections

    The operating voltage on the name plate must correspond to the local supply voltage DANGER Christ freeze-dryers are units of safety class I. Epsilon 1-4 LSCplus and Epsilon 2-4 LSCplus units have a three-wire power cord with a CEE 7/4 plug (type F) (see chapter 10 - "Technical data").

  • Page 48: Aeration

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection 5.2.2 Aeration Risk of injury caused by bursting of the chamber The double chamber is designed for vacuum. It is not a pressure vessel! In the event of a malfunction, an impermissible excess pressure may build up in the chamber, which may cause the chamber to burst.

  • Page 49: Oil-Seales Vacuum Pump

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection The cooling water demand is controlled automatically by the cooling water control valves in line with the load of the refrigeration units. For preadjustment, the cooling water control valves are equipped with an adjusting knob which can be adjusted with the aid of a screwdriver.
  • Page 50 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Refer to the separate instruction manual of the vacuum pump and exhaust filter (if applicable)! NOTE The vacuum pump must be connected to the vacuum connection of the unit and to the electrical socket at the back of the unit, which is marked accordingly (see chapter 2.1.1 - "Functional and operating elements").

  • Page 51: Dry-Running Vacuum Pump

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pos : 146 /200 Chris t/361 GT-BA Labor-Pil ot ( PROJ EKTE)/Epsilon 4er/Epsilon 1-4_2- 4 LSC plus Standar d/050 Aufstellung und Ansc hl uss/050- 0020- 0051 Vak uum pumpe E1- 4_2-4 (Trock enläufer) @ 85\mod_1632728134833_68.docx @ 898161 @ 3 @ 1 Vak uumpumpe →...

  • Page 52: Pressure Control Valve

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection The freeze-dryer is equipped with a dry-running vacuum pump. As a result, the vacuum exhaust gases are completely free from oil particles. However, small quantities of debris from worn seals may be emitted. That is why,...

  • Page 53: Vacuum Sensor

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pos : 150 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/050 Aufstellung und Ansc hluss/050 Aufstellung und Ans chl uss Epsilon/050-0020- 0070 Vak uumm esss onde neu - Ü berschrift--------------------------------- @ 48\mod_1490093443168_68.docx @ 492582 @ 3 @ 1 5.2.7...

  • Page 54: Rubber Valves

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 5 Set-up and connection Pos : 153 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/050 Aufstellung und Ansc hluss/050 Aufstellung und Ans chl uss Epsilon/050-0020- 0090 Gummiventile Epsilon @ 48\mod_1490094630187_68.docx @ 492622 @ 3 @ 1 →...

  • Page 55: Operation

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 156 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/060 Betri eb======================================== @ 25\mod_1404983759758_68.doc x @ 183578 @ 1 @ 1 Operation Pos : 157 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/060-0011 Ers te Inbetriebnahm e Epsil on ++++++++++++++++++++++++++ @ 36 \mod_1436509116118_68.docx @ 267286 @ 2 @ 1...

  • Page 56: Loading Door

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 165 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/060-0050 Bel adetür Epsil on - Übersc hrift-------------------------------------- @ 25\m od_1404984628128_68.docx @ 185721 @ 2 @ 1 →...
  • Page 57 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Radiation Shield film for loading doors made of acrylic glass Loading doors made of acrylic glass have a special, transparent film on the exterior side of the acrylic glass door. This film reduces the transfer of radiant heat onto the product and ensures homogeneous freeze-drying results.

  • Page 58: Lscplus Control System

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 168 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/LSC plus /060- 0050 LSC plus Anlagens teuerung Epsilon --------------------------------------------- @ 72\mod_1593154316973_68.doc x @ 766493 @ 2 @ 1...

  • Page 59: Main Window "Manual

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation The user interface is divided into four main windows that can be called up by touching the corresponding buttons: Manual This window is also the standard user interface. It is used to control the freeze-drying process manually.
  • Page 60 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Status line (1) This line shows the operating status of the freeze-dryer as well as the active phase. The status line also shows the current date and time. The clock is battery- buffered and must be reset after a failure (see chapter 6.6.1.3 - "...
  • Page 61 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Fig. 22: Dialog box "Select actual value" • Select the desired configuration or quit the dialog box by pressing the "return" button. In this way, it is possible to configure a personalised overview of the actual values.
  • Page 62 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Option: USB process recording (see chapter 6.7 - "Optional extensions and special equipment") • Select the "Process recording" function in the dialog box "Tools". • Select the input fields ("Batch data"). A keyboard for the data input will be displayed.
  • Page 63 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Fig. 25: Dialog box "Pressure increase test" • The "Test stop" button stops the pressure increase test. Option: LyoBalance weighing system If the freeze-dryer is equipped with a LyoBalance weighing system (see chapter 6.7 - "Optional extensions and special equipment"), then the...
  • Page 64 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Fig. 26: Schematic system diagram with the name and reference designator of the component Dialog box "Process and equipment messages" (7) This dialog box shows and saves all of the error messages and other messages.
  • Page 65 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation The malfunction has been eliminated, but the message has not been acknowledged The malfunction has not be eliminated and the message has not been acknowledged The malfunction has not been...
  • Page 66 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Dialog box "Operating mode: select/start" (8) After the set values have been entered for the process, the process can be started manually with this function (see chapter 6.6.2 - "Manual freeze- drying").
  • Page 67 Fig. 32: Results of the performance test Evaluation: Please contact the Christ support team for the evaluation of the test run. Version 04/2014, Rev. 2.13 of 01/12/2021 • sb 67 / 148...
  • Page 68 • Select "Leakage test" and start the test via the "Run" button. The parameters for the leakage test have been developed by Martin Christ Gefriertrocknungsanlagen specifically for freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.
  • Page 69 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation In the "Freezing" phase, the shelves are cooled to -30°C. The parameters for the subsequent "Main drying" and "Secondary drying" sections have been configured in such a way that the water will be completely sublimated out of the dishes and bound on the ice condenser after 24 hours.
  • Page 70 (confirmation prompt) opens. Following the confirmation of this enquiry, the freeze-dryer will be switched to standby. Evaluation: Please contact the Christ support team for the evaluation of the test run. Shelf mapping test (6) The shelf mapping test is a freeze-drying program for bringing the shelves to a temperature of +20°C, -40°C, and +40°C for a specific period of time in...
  • Page 71 The external measurement recording process can then be stopped. Evaluation: Please contact the Christ support team for the evaluation of the test run. Pos : 176 /010 Univ ers almodul e/ Leerz eile @ 0\mod_1202116244500_0.docx @ 114 @ @ 1 Pos : 177 /010 Univ ers almodul e/ Leerz eile @ 0\mod_1202116244500_0.docx @ 114 @ @ 1...

  • Page 72: Main Window "Program

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 180 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/LSC plus /060- 0050-0010- 0021 H auptfens ter Programm Epsilon @ 72\mod_1593154326974_68.doc x @ 766699 @ 4 @ 1 6.6.1.2...

  • Page 73: Main Window "Options

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  • Page 74 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Change scale unit (2) This dialog box is used to change the unit of measurement for the temperature and vacuum. Fig. 36: Dialog box "Change scale unit" Special equipment: Preselection of the aeration medium (3) This function can be performed in the manual mode or saved together with a program (see chapter 6.6.3.1 - "Creating a program").
  • Page 75 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation The following media preselection settings are possible: • Air: Preselects the media connection "Air". • Inert gas: Preselects the media connection "Inert Gas". • Automatic: Automatic media connection preselection depending on the chamber pressure and stoppering status of the product vials: –...
  • Page 76 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Special equipment: Inertisation (5) (see chapter 6.7 - "Optional extensions and special equipment") If the "Inertisation" option is active and the freeze-dryer is in the "Standby", "Manual - Freezing", "Program - Loading" or "Program - Freezing" mode, the automatic inertisation of the drying chamber will be performed for the preselected inertisation time after the loading door has been closed.
  • Page 77 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation If the volume flow through the inertisation line falls below a certain threshold for more than 5 seconds (the value can be preset at the flow meter) or if the loading door is opened during an inertisation sequence, the process will also be aborted immediately.
  • Page 78 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Network (2) This dialog box is used to change various system settings. The modifications will not become effective until after a restart of the unit. NOTE Fig. 42: Dialog box "Network"...
  • Page 79 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Click on touch: If this function is active, a clicking sound can be heard whenever the system registers that a button has been touched. Behaviour of the pressure control valve in the case of insufficient ice condenser cooling: If this function is active (button "closed"), the pressure...
  • Page 80 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation • The button with the lock symbol blocks the access immediately and the system switches to the default setting. Fig. 46: Access blocked, the data cannot be edited Operator/maintenance/administrator password: For each of these access levels, certain editing rights have been defined.
  • Page 81 • Press the button "Add option". An input window opens. • Enter the six-digit Christ activation code that was supplied for this option. Note that the keys are case sensitive. Options can be removed in the same way. The modifications will not become effective until after a restart of the unit.
  • Page 82 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Product temperature sensor (see the illustration above, item B) Only for systems with a WTMplus system The wired product temperature sensor 1 is the default sensor for determining the value "ΔT product" (see chapter 6.6.3 - " Freeze-drying with the PGMplus programmer module ", section "Conditions for switching...
  • Page 83 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation WTMplus configuration (7) The dialog box is displayed for information purposes only. The configuration can be changed only via the LPCplus user interface. NOTE This dialog box shows all of the existing WTMplus sensors. Every sensor is assigned to a measuring channel based on its serial number.
  • Page 84 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Maintenance "Service" options: "Operating hours" "Failure memory" "Vacuum pump oil change" "Maintenance" "Sensor adjustment" Fig. 51: Dialog box "Service" (varies depending on the type of system) Operating hours (1) This dialog box is used to call up the number of operating hours of the various components of the freeze-dryer, e.g.
  • Page 85 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Always indicate the error code in the event of enquiries or service requests! NOTE Fig. 53: Dialog box "Failure memory" Vacuum pump oil change (3) This option only applies to oil-sealed vacuum pumps! NOTE The system monitors the oil change interval of the vacuum pump.
  • Page 86 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Maintenance (4) The maintenance interval of the unit is fixed at 3,000 operating hours or at least one maintenance per year. When the end of a maintenance interval is reached, a corresponding message will be displayed.

  • Page 87: Main Window

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 184 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/LSC plus /060- 0050-0010- 0041 H auptfens ter " ?" Epsilon @ 72\m od_1593154331423_68.docx @ 766775 @ 4 @ 1 6.6.1.4...

  • Page 88: Entering Set Values In The Manual Mode

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation In the manual mode, the set values of the active phase can be changed during the process run. In this case, the control system adapts the unit to the new set values as quickly as possible.
  • Page 89 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Viewing or editing the set values: • Press the button "Set values: view/edit" (see chapter 6.6.1.1 - "Main window "Manual""). The following dialog box will be displayed: "Aeration" button "Defrosting" button "Media drain"...

  • Page 90: Freeze-Drying With The Pgmplus Programmer Module

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Numerical values can be edited with the aid of a numerical keypad: Set value display Button for changing the sign (e.g. when entering temperature values) "" (infinite) Button for editing the...
  • Page 91 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Fig. 60: Representation of a freeze-drying program Program sections When the programmer module executes a freeze-drying process, it executes the various sections that were created one after the other until the last section is completed.
  • Page 92 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Conditions for switching to the next section For all of the program sections to be executed automatically, certain switching conditions must be fulfilled at the end of each section. If these conditions are not fulfilled, e.g.
  • Page 93 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation T comparative (option): This value indicates the difference between a Pirani sensor and a capacitive vacuum sensor in per cent based on the actual value of the capacitive vacuum sensor. When the sublimation rate decreases, the difference decreases as well.

  • Page 94: Creating A Program

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Pos : 194 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/060 Betrieb/LSC plus /060- 0050-0032- 0011 Programm erstellen Epsilon @ 72\m od_1593154338701_68.docx @ 766927 @ 4 @ 1 6.6.3.1...
  • Page 95 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation "Program" buttons: "Program" "Program name" "Show diagram" "Insert section" "Delete section" Button for calling up more functions and set values "Save" Fig. 64: Editing a blank program template • The button “Delete section” (5) can be used to delete sections.
  • Page 96 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Button ">>more" The button ">>more" can be used to enter more functions and set values in a program-related manner. Fig. 65: Selection of program-related functions and set values Vacuum pump warm-up see chapter 6.6.3 - "...
  • Page 97 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation next section is fulfilled and the next section will be initiated. If the condition for switching to the next section is not fulfilled, a process message will be issued, the current section will be extended, and further pressure increase tests will be executed periodically until the condition is fulfilled.
  • Page 98 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation → Option: Comparative pressure measurement (see chapter 6.7 - "Optional extensions and special equipment") The indication of the measurement value "dp Comp" can be configured in chapter 6.6.1.1 - "Main window "Manual"" under "Actual values of the current process"...
  • Page 99 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Option: LyoBalance weighing system If the freeze-dryer is equipped with a LyoBalance weighing system (see chapter 6.7 - "Optional extensions and special equipment"), then the corresponding parameters must be configured in this dialog box.
  • Page 100 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation "Aeration, (stoppering), storage" procedure: 1. Aeration up to the desired partial vacuum ("Aeration" value): After the actual freeze-drying process has been completed, the ice condenser continues to be cooled and the shelves are held at the temperature of the last drying section.
  • Page 101 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Special equipment: Preselection of the aeration medium If the freeze-dryer is equipped with an automatic aeration valve and automatic valves for media selection, this dialog box can be used to preselect the medium that is to be used for the aeration medium requests during the execution of the particular program.

  • Page 102: Editing A Program

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Program templates (2) The PGMplus programmer module offers various program templates that include recipes for all kinds of freeze-drying applications. They are suggestions for orientation purposes and must be adapted to the specific area of application of the freeze-dryer.

  • Page 103: Copying A Program

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  • Page 104: Deleting A Program

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Fig. 72: The freeze-drying process can be started with the aid of the button “Program start”. • During the freeze-drying process, the description of the active program can also be called up from the main window "Program" and via the button "Info".

  • Page 105: Optional Extensions And Special Equipment

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  • Page 106 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 6 Operation Comparative pressure measurement see also chapter 6.6.3.1 - "Creating a program", Button ">>more" During the → sublimation, i.e. when the concentration of water vapour molecules is rather high in the atmosphere, the value that is provided by the gas-type-dependent vacuum sensor of the "Pirani"...

  • Page 107: Switching The Freeze-Dryer Off

    LPCplus SCADA system The Christ LPCplus system consists of the Supervisory Control And Data Acquisition (SCADA) software program by Martin Christ Gefriertrocknungsanlagen GmbH and a dedicated PC. The system is...

  • Page 108: Malfunctions And Error Correction

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction Pos : 211 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/070 Störungen und F ehl ersuche/070 Störungen und F ehl ersuche=========================== @ 25\m od_1404984056039_68.docx @ 184111 @ 1 @ 1 →...

  • Page 109: Power Failure

    (see chapter 7.3 - "Service contact") If it is impossible to eliminate the errors, contact the Christ service department! NOTE Pos : 214 /010 Univ ers almodul e/ Leerz eile @ 0\mod_1202116244500_0.docx @ 114 @ @ 1 Pos : 215 /010 Univ ers almodul e/ Leerz eile @ 0\mod_1202116244500_0.docx @ 114 @ @ 1...

  • Page 110: Insufficient Vacuum

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  • Page 111: Aeration Valve

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction Pos : 222 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/070 Störungen und F ehl ersuche/070- 0010- 0020-0020 Bel üftungsventil (z.B. E2-4) @ 25\mod_1404984751036_68.doc x @ 186099 @ 4 @ 1 →...

  • Page 112: Insufficient Ice Condenser Temperature

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction Pos : 230 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/070 Störungen und F ehl ersuche/070- 0010- 0031 Eisk ondensator- und Stellflächentem peratur Epsilon (auß er E1-4/2- 4) @ 25\m od_1404984665983_68.docx @ 185861 @ 3 @ 1 →...

  • Page 113: Service Contact

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 7 Malfunctions and error correction Pos : 235 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/070 Störungen und F ehl ersuche/070- 0031 Kontak t im Servic efall_Epsil on @ 25\m od_1404984069705_68.docx @ 184293 @ 2 @ 1 →...

  • Page 114: Maintenance And Service

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  • Page 115: Chamber

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Cleaning of the freeze-dryer Risk of burns on hot surfaces Housing of the freeze-dryer During the operation of the freeze-dryer and half an hour afterwards, the outer surface of the freeze-dryer (especially the pipes and units) may be WARNING hot.

  • Page 116: Lamination Of The Loading Door With A Special Film

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  • Page 117: Special Equipment: Stainless Steel Door Latch At The Loading Door

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos : 248 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/080 W artung und Instandhaltung/080-0010- 0022-0020 Sonderauss tattung: Tüv ersc hlus sriegel aus Edelstahl Epsil on @ 25\mod_1404984677136_68.docx @ 185889 @ 4 @ 1 →...

  • Page 118: Heat Exchanger (Only Air-Cooled Freeze-Dryers)

    Check the heat exchanger at least once per month for soiling and clean it if necessary. • Please contact the Christ service department if you have any queries (see chapter 7.3 - "Service contact"). Pos : 253 /010 Univ ers almodul e/ Leerz eile @ 0\mod_1202116244500_0.docx @ 114 @ @ 1...

  • Page 119: Vacuum System With An Oil-Sealed Vacuum Pump

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos : 256 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/080 W artung und Instandhaltung/080-0010- 0082 Vak uumsy stem Epsil on ( Vakuumpum pen mit Öl) @ 36\m od_1436512296280_68.docx @ 267332 @ 3 @ 1 →...

  • Page 120: Vacuum System With A Dry-Running Vacuum Pump

    The number of operating hours of the vacuum pump can be monitored by way of the LSCplus control system and also by way of the CHRIST SCADA software LPCplus (see chapter 6.6.1.3 - " Main window "Options""/"Operating hours"...

  • Page 121: Refrigeration System

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos : 260 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/080 W artung und Instandhaltung/080-0010- 0091 Kältesystem Epsilon (natürliche, brennbare Kältemittel) @ 64\m od_1558595727235_68.docx @ 690977 @ 3 @ 1 8.1.8...

  • Page 122: Vacuum Sensor

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service 8.1.9 Vacuum sensor Please refer to the separate operating manual of the vacuum sensor! NOTE The vacuum sensor has only a limited service life. • The vacuum sensor is maintenance-free.

  • Page 123: Disinfection Of The Drying Chamber And Accessories

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  • Page 124: Maintenance Schedule

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  • Page 125: Maintenance Schedule

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos : 270 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/080 W artung und Instandhaltung/080-0031 W artungs plan Epsil on 4er (Troc kenläuferpum pe) @ 85\mod_1631771127780_68.doc x @ 897660 @ 2 @ 1...
  • Page 126 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Cable trays: closed Framework: Remove corrosion no corrosion Vacuum Inspection and Pump: Inlet strainer system cleaning annually...
  • Page 127 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service System/ Detail / Part Inspection Periodical Maintenance Repair / Rebuild Component Vial stoppering Mechanical system components: function Hydraulic system: maximum pressure reading Hydraulic system: oil in reservoir Replace hose lines...

  • Page 128: Service

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service Pos : 272 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/080 W artung und Instandhaltung/080-0041 Ins tandhaltungs arbeiten Epsilon (mit W artungsv ertrag nur de) @ 25\m od_1404984109982_68.docx @ 184489 @ 2 @ 1...
  • Page 129 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 8 Maintenance and service 1. Declaration of decontamination As a certified company and due to the legal regulations for the protection of our employees and of the environment, we are obliged to certify the harmlessness of all incoming goods.

  • Page 130: Disposal

    Pos : 279 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/090 Entsorgung/090-0010 Entsorgung der Gefriertr ock nungsanlag e @ 25\m od_1404984141122_68.docx @ 184531 @ 2 @ 1 → Disposal of the freeze-dryer Martin Christ Gefriertrocknungsanlagen GmbH is a registered manufacturer of electric and electronic devices that are solely intended for commercial use.

  • Page 131: 10 Technical Data

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 10 Technical data Pos : 284 /200 Chris t/361 GT-BA Labor-Pil ot ( PROJ EKTE)/Epsilon 4er/Epsilon 1-4_2- 4 LSC plus Standar d/100 T ec hnis che D aten/100 Tec hnisc he D aten E2- 4 =================================== @ 25\m od_1404984770073_68.docx @ 186141 @ 1 @ 1 →...
  • Page 132 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 10 Technical data Physical data (without vacuum Epsilon 1-4 LSCplus Epsilon 2-4 LSCplus pump) EMC according to EN 55011: Class B Class B Heat emission: min. 620 W min. 1,100 W max. 1,100 W max.

  • Page 133: Ambient Conditions

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  • Page 134: 11 Appendix

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  • Page 135: Ec Declaration Of Conformity In Accordance With The Ec Machinery Directive

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos : 295 /200 Chris t/36 1 GT-BA Labor-Pil ot ( PROJ EKTE)/Epsilon 4er/Epsilon 1-4_2- 4 LSC plus Standar d/110 Anhang/0110-0030 C E-Erklär ung M asc hR L 1-4_2- 4 LSC plus @ 25\m od_1404984777923_68.docx @ 186153 @ 2 @ 1 →...
  • Page 136 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos : 296 /010 Univ ers almodul e/ Seitenwechs el @ 0\mod_1202116244312_0.docx @ 105 @ @ 1 Version 04/2014, Rev. 2.13 of 01/12/2021 • sb 136 / 148 Translation of the original operating manual...

  • Page 137: Ec Declaration Of Conformity In Accordance With The Pressure Equipment Directive

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos : 297 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/110 Anhang/0110-0031 CE- Erklär ung Dr uckger äteRL @ 38\m od_1438592143048_68.docx @ 275085 @ 2 @ 1 11.3 EC declaration of conformity in accordance with the Pressure Equipment Directive Version 04/2014, Rev.
  • Page 138 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos : 298 /010 Univ ers almodul e/ Seitenwechs el @ 0\mod_1202116244312_0.docx @ 105 @ @ 1 Version 04/2014, Rev. 2.13 of 01/12/2021 • sb 138 / 148 Translation of the original operating manual...

  • Page 139: Table Of The Sublimation Pressure Curve

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos : 299 /200 Chris t/360 GT-BA Labor-Pil ot ( STAND ARDMODULE)/110 Anhang/0110-0021 T abelle Sublim ations druc kkurv e @ 25\mod_1404984180168_68.doc x @ 184629 @ 2 @ 1 11.4 Table of the sublimation pressure curve °C...
  • Page 140 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus 11 Appendix Pos : 301 /010 Univ ers almodul e/ Seitenwechs el @ 0\mod_1202116244312_0.docx @ 105 @ @ 1 Version 04/2014, Rev. 2.13 of 01/12/2021 • sb 140 / 148 Translation of the original operating manual...

  • Page 141: 12 Glossary

    Since absolutely tight components simply do not exist, a leak rate is determined. The parameters for the leakage test have been developed by Martin Christ Gefrier- trocknungsanlagen GmbH specifically for freeze-dryers. In a first step, these parameters (vacuum, ice condenser temperature) must be reached.
  • Page 142 Safety pressure Since the vacuum has a dominating influence on the product temperature, Martin Christ Gefriertrocknungsanlagen GmbH has integrated a so-called safety pressure feature into the freeze-dryers in order to ensure the protection of the product. If the pressure inside the drying chamber increases too strongly so that it exceeds the safety limit, the energy supply of the shelves will be interrupted and the →...

  • Page 143: 13 Index

    Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Index 13 Index Chamber, cleaning and care ....115 Changing of operating supplies ....39 Access protection........79 Chemical burns .......... 38 Accessories ......13, 40, 114, 122 Chemical reactions ........122 Accident prevention ......
  • Page 144 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Index Door-controlled intertisation ....... 37 Double-chamber method ......141 Damage to the materials of construction .. 114 Danger of infection due to exhaust air ..51 Danger of poisoning due to exhaust air ..51 Earth conductor check .......
  • Page 145 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Index Freeze-drying of solvents (special equipment) Hazards (vacuum pump exhaust gases) ............... 27 ............34, 49 Freeze-drying phases ........ 21 Hazards (vacuum pump oil) ....35, 119 Freeze-drying process ....... 21...
  • Page 146 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Index LSCplus control system ......58 Nominal current ........131 Lyes ............39 Nominal power ......... 131 LyoBalance weighing system ..... 63, 106 Nominal voltage ......... 18 LyoControl measuring system ....107 Notes on safety and hazards .......
  • Page 147 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Index Pressure measurement, comparative ..106 Safety notes concerning the operation ..31 Prevention of accidents ........ 9 Safety notes concerning the transport ..29 Process and equipment messages .... 64 Safety pressure ........142 Process and error messages ....
  • Page 148 Freeze-dryer Epsilon 1-4 LSCplus Freeze-dryer Epsilon 2-4 LSCplus Index Stainless steel door latch at the loading door USB process recording ...... 62, 106 ............. 117 User interface ..........58 Standard unit test ........66 UV radiation ........47, 114 Standards and regulations ......13 Status line ..........

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