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Summary of Contents for Thermo Scientific GeneTitan Scanner
- Page 1 ™ GeneTitan Scanner USE AND MAINTENANCE GUIDE Catalog Numbers 00-0442 and 00-0443 Publication Number MAN0018315 Revision A.0 For Research Use Only. Not for use in diagnostic procedures.
- Page 2 Affymetrix Inc. | 3450 Central Expressway | Santa Clara, CA 95051 | USA For descriptions of symbols on product labels or product documents, go to thermofisher.com/symbols-definition. The information in this guide is subject to change without notice. DISCLAIMER: TO THE EXTENT ALLOWED BY LAW, THERMO FISHER SCIENTIFIC INC. AND/OR ITS AFFILIATE(S) WILL NOT BE LIABLE FOR SPECIAL, INCIDENTAL, INDIRECT, PUNITIVE, MULTIPLE, OR CONSEQUENTIAL DAMAGES IN CONNECTION WITH OR ARISING FROM THIS DOCUMENT, INCLUDING YOUR USE OF IT.
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Page 3: Table Of Contents
Contents ■ CHAPTER 1 Product information ........5 Instrument overview . - Page 4 Contents ™ GCC log files for the GeneTitan Scanner ........26 ™...
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Page 5: Chapter 1 Product Information
Product information Instrument overview ™ ™ The Applied Biosystems GeneTitan Scanner is a high-throughput imaging device with multi-axis robotic handling capability for imaging 24-, 96-, mini 96, and 384HT- array plate formats. The scanner is designed to measure the fluorescence signals of labeled DNA targets that are hybridized to the array plates. -
Page 6: Genetitan ™ Scanner
Chapter 1 Product information Parts of the instrument system GeneTitan ™ Scanner Yellow LED light Green LED light ™ ™ ™ GeneChip Command Console software controls the power to the GeneTitan Scanner. Power the instrument on or off using the software. Instrument status indicator The two indicator lights in the lower left front of the instrument display various patterns of light and color indicating different instrument conditions. - Page 7 Chapter 1 Product information Parts of the instrument system GeneTitan ™ Scanner drawer door ™ The GeneTitan Scanner drawer door is on the left side of the scanner. The drawer door is controlled by the GCC software, and opens during operation to receive or expel the array plate and scan tray combination.
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Page 8: Workstation Setup
Chapter 1 Product information Parts of the instrument system Connections ™ Figure 1 GeneTitan Scanner back connections Power receptacle—connect to the Lambda LS Power cable and circuit breaker button BNC port for CCD camera cable to control the external shutter—connect to the Lambda SC TTL IN receptacle Kvaser USB port for motion controller communication cable—connect to the computer ™... - Page 9 Chapter 1 Product information Parts of the instrument system Computer back panel connections Serial port—connect to Lambda LS USB 2.0 port (2)—connect to the keyboard and mouse USB 3.0 port—connect to scanner USB 3.0 port—spare Ethernet port—connect to local network USB 3.0 port—connect to Kvaser USB cable from scanner USB 2.0 port (1)—spare DVI and HDMI video ports—connect to monitor...
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Page 10: Lambda Ls Light Source
Chapter 1 Product information Parts of the instrument system Lambda LS light The Lambda LS is a stand-alone xenon arc lamp and power supply system that is ™ equipped with a SmartShutter component. source The system consists of a xenon-arc lamp, lamp housing, cold mirror, SmartShutter ™... - Page 11 Chapter 1 Product information Parts of the instrument system Lambda SC back panel Fuse Label—Information found here includes the instrument model number, appropriate supply voltage, and the type of fuse required for the supply voltage. Power Switch—Used with power socket to turn power on and off to the Lambda SC and the attached Lambda LS light source.
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Page 12: Uninterruptible Power Supply
Chapter 1 Product information Parts of the instrument system Uninterruptible The GeneTitan ™ Scanner has an external uninterruptible power supply (UPS). The UPS provides and maintains power to the scanner, workstation, and external light power supply source with shutter. Chassis ground connection screw Battery connector Outlets Input circuit breaker... -
Page 13: Chapter 2 Genetitan ™ Scanner Operation
GeneTitan Scanner operation ™ This chapter describes the basic scanner operations. For detailed information see the ™ ™ GeneChip Command Console User Guide, Pub. No. 702569. Guidelines Review and understand the following guidelines regarding the use and safe operation of the scanner. Also, it is important to read and be familiar with the safety guidelines that are presented in Appendix D, “Safety“. - Page 14 Chapter 2 GeneTitan Scanner operation ™ GeneChip Command Console (GCC) ™ ™ Never manually switch the lamp and the shutter controller on or off using the power switch on the back panel of the units. The power switch on both of the Lambda units ™...
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Page 15: Start The Scanner
Help 1. Check the remaining lamp life under System Status in the upper left of the GeneTitan Scanner window. If needed, change the xenon lamp. (See “Replace the xenon lamp“ on page 22.) Note: There is a lamp life threshold of 10 hours. When this value is reached, the software prevents plate imaging and the lamp must be replaced. -
Page 16: Shut Down The Scanner
7. Click OK in the Start Processing confirmation window to continue. Scanning proceeds. When the scan is complete, color-coded results are displayed in the array graphic in the System Status section of the GeneTitan Scanner window. See the GeneChip ™... -
Page 17: Chapter 3 Maintain The Instrument
Maintain the Instrument ™ GeneTitan Maintenance ™ The GeneTitan family of instruments requires little in the way of customer maintenance. The instruments must be kept clean and free of dust. Dust buildup can degrade performance. Wipe the exterior surfaces clean using a mild dish detergent solution in water. -
Page 18: Lambda Ls Xenon Arc Lamp
Chapter 3 Maintain the Instrument Lambda LS xenon arc lamp 3. Pull the filter cartridge from the right rear underside of the scanner. 4. Remove the old filter from the cartridge, then replace with a new filter. 5. Return the filter cartridge to the right rear underside of the scanner, then reconnect the power cord. -
Page 19: Xenon Lamp Replacement
Chapter 3 Maintain the Instrument Lambda LS xenon arc lamp Power switch Side view of the fuse holder Pry here to remove the fuse holder Active fuse Top view of the fuse holder Press here for spare fuse 3. Press down on compartment end, then push it out of the other end. You can use the old fuse to push out the spare fuse compartment. - Page 20 Chapter 3 Maintain the Instrument Lambda LS xenon arc lamp Note: The 300-watt xenon lamp in the GeneTitan ™ Scanner is warranted for 500 hours. The instructions to remove and replace the lamp are found in “Remove the xenon lamp“ on page 20, and “Replace the xenon lamp“ on page 22. After changing the lamp, you must manually reset the lamp life clock.
- Page 21 Chapter 3 Maintain the Instrument Lambda LS xenon arc lamp 2. Remove, then set aside the warning cover to reveal the xenon lamp that is contained inside. 3. Place a hand on each side of the blue plastic flange, then lift out the lamp in a vertical motion.
- Page 22 Chapter 3 Maintain the Instrument Lambda LS xenon arc lamp Replace the xenon lamp ™ A new Cermax Xenon Arc Lamp (Cat. No. 01-0740) is required for this procedure. IMPORTANT! Ensure that you install the lamp in the correct orientation. 1.
- Page 23 Chapter 3 Maintain the Instrument Lambda LS xenon arc lamp Reset the lamp life counter Using the GCC Standalone Scanner Control module accessed from the Launcher window, you must alert the software that the lamp has been replaced so that the hours of the lamp counter are reset.
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Page 24: Lambda Sc Smart Shutter ™ Controller
Chapter 3 Maintain the Instrument Lambda SC SmartShutter Controller ™ Smart Shutter ™ Lambda SC Controller Replace the If the controller does not power on when you power on the power switch, check the line power fuse to see if it has blown. The fuse is in the fuse holder on the power input Lambda SC fuse module on the back of the controller. -
Page 25: Appendix A Troubleshooting
Troubleshooting ™ GeneTitan Instrument support files for troubleshooting ™ ™ Log files The different GeneChip Command Console (GCC) components generate log files. The logs provide a record of the tasks performed by the different components, such as the migration tools and installer. These log files provide useful information for troubleshooting problems. -
Page 26: Gcc Log Files For The Genetitan ™ Scanner
Appendix A Troubleshooting GeneTitan Instrument support files for troubleshooting ™ GCC log files for Log files for the GeneTitan ™ Scanner control processes are placed in subdirectories of the C:\Command_Console\Logs\ folder. Thermo Fisher Scientific sometimes the GeneTitan ™ requests the following files for troubleshooting. Scanner •... - Page 27 Appendix A Troubleshooting GeneTitan Instrument support files for troubleshooting ™ Observation Possible cause Recommended action Plate trapped in the GeneTitan Scanner • Plate (or plate with lid) 1. Restart the GeneTitan ™ ™ not properly loaded in Scanner by unplugging drawer.
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Page 28: Appendix B Parts And Materials
Parts and materials Replacement parts MLS: Fisher Scientific (fisherscientific.com) or other major laboratory supplier. Part Source Cat. No. GeneTitan ™ Scanner Cooling Fan Filter Thermo Fisher 01-0785 Scientific Lambda LS ™ Cermax Xenon Arc Lamp Thermo Fisher 01-0740 Scientific Fuse: 5 Amp, 250 V, 5 × 20 mm, time delay fuse (EIC 60127-2) —... -
Page 29: Appendix C Instrument Specifications
Instrument specifications Environmental requirements Condition Acceptable range Installation site Indoor use only Electromagnetic Do not use this device in close proximity to sources of strong electromagnetic radiation (for interference example, unshielded intentional RF sources). Strong electromagnetic radiation may interfere with the proper operation of the device. This equipment has been designed and tested to CISPR 11 Class A. -
Page 30: Electrical Requirements
Appendix C Instrument specifications Electrical requirements Electrical requirements CAUTION! Do not unpack or plug in any components until they are configured for the proper operating voltage by the service representative. WARNING! For safety, the power outlet for the instrument must be accessible at all times. -
Page 31: Component Clearances Required For Installation And Maintenance
Appendix C Instrument specifications Component clearances required for installation and maintenance Component clearances required for installation and maintenance During installation and maintenance, it is necessary to access the front, back, and right side of the product. If the back of the product faces a wall, ensure that there is sufficient clearance on the bench to rotate the product. -
Page 32: Lambda Sc Controller Cables
Appendix C Instrument specifications Lambda SC controller cables Parameter Value Power cord 10 A, 250 V with safety grounded plug Mains Fuse (rear of 5 Amp, 250 V, 5 x 20 mm, Time Delay fuse (EIC cabinet) 60127-2) Examples: Bussmann GDC-5A, S506-5A (RoHS), or Littelfuse 218.005 or 218.005.P (RoHS) Lambda SC controller cables Maximum cable... -
Page 33: Appendix D Safety
Safety WARNING! GENERAL SAFETY. Using this product in a manner not specified in the user documentation may result in personal injury or damage to the instrument or device. Ensure that anyone using this product has received instructions in general safety practices for laboratories and the safety information provided in this document. -
Page 34: Additional Safety Symbols
Appendix D Safety Symbols on this instrument Symbol and description CAUTION! Hot surface. CAUTION! Ultraviolet light. Symbole et description MISE EN GARDE ! Risque de danger. Consulter le manuel pour d’autres renseignements de sécurité. MISE EN GARDE ! Risque de choc électrique. MISE EN GARDE ! Surface chaude. -
Page 35: Location Of Safety Labels
Appendix D Safety Symbols on this instrument Location of safety labels Label and location CAUTION ATTENTION Object lourd. Heavy object. Deux personnes Two person lift requises pour CAUTION ATTENTION required. Object lourd. Heavy object. soulever. Deux personnes Two person lift requises pour required. -
Page 36: Conformity Symbols
Appendix D Safety Safety information for instruments not manufactured by Thermo Fisher Scientific ™ Conformity We declare under sole responsibility that the GeneTitan Scanner and associated workstation with software is manufactured in the United States of America, with U.S. symbols and Non-U.S. -
Page 37: Physical Injury
Appendix D Safety Instrument safety Physical injury CAUTION! Moving and Lifting Injury. The instrument is to be moved and positioned only by the personnel or vendor specified in the applicable site preparation guide. Improper lifting can cause painful and permanent back injury. -
Page 38: Electrical Safety
Appendix D Safety Instrument safety Electrical safety WARNING! Fuse Installation. Before installing the instrument, verify that the fuses are properly installed and the fuse voltage matches the supply voltage. Replace fuses only with the type and rating specified for the unit. Improper fuses can damage the instrument wiring system and cause a fire. -
Page 39: Cleaning And Decontamination
Appendix D Safety Instrument safety Cleaning and CAUTION! Cleaning and Decontamination. Use only the cleaning and decontamination decontamination methods that are specified in the manufacturer user documentation. It is the responsibility of the operator (or other responsible person) to ensure that the following requirements are met: ·... -
Page 40: Laser Safety
Appendix D Safety Safety and electromagnetic compatibility (EMC) standards Laser safety WARNING! LASER HAZARD. Under normal operating conditions, the ™ GeneTitan Scanner is categorized as a Class 1 laser product. However, removing the protective covers and (when applicable) defeating the interlocks can result in exposure to the internal Class 2 (II) laser. -
Page 41: Safety Standards
Appendix D Safety Safety and electromagnetic compatibility (EMC) standards Safety standards Reference Description EU Directive 2014/35/EU European Union “Low Voltage Directive” Safety requirements for electrical equipment for measurement, control, and laboratory IEC 61010-1 use – Part 1: General requirements EN 61010-1 UL 61010-1 CAN/CSA C22.2 No. -
Page 42: Chemical Safety
Appendix D Safety Chemical safety Chemical safety WARNING! GENERAL CHEMICAL HANDLING. To minimize hazards, ensure laboratory personnel read and practice the general safety guidelines for chemical usage, storage, and waste provided below. Consult the relevant SDS for specific precautions and instructions: ·... -
Page 43: Biological Hazard Safety
Appendix D Safety Biological hazard safety · Vérifier régulièrement l’absence de fuite ou d’écoulement des produits chimiques. En cas de fuite ou d’écoulement d’un produit, respecter les directives de nettoyage du fabricant recommandées dans la FDS. · Manipuler les déchets chimiques dans une sorbonne. ·... -
Page 44: Appendix E Documentation And Support
Documentation and support Related documentation Publication Document Description number GeneTitan Scanner Site Preparation Guide ™ MAN0018316 Provides guidance on creating and maintaining the proper environment required for the GeneTitan ™ Scanner. GeneChip Command Console User Guide ™ ™ 702569 This user guide provides instructions on using GeneChip ™... -
Page 45: When To Call Technical Support
Appendix E Documentation and support When to call technical support When to call technical support If the instrument requires servicing, call Thermo Fisher Scientific Technical Support. Under any of the following conditions, unplug the instrument from the power source and contact Technical Support: •... - Page 46 thermofisher.com/support | thermofisher.com/askaquestion thermofisher.com 31 December 2019...
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