Lexus ES-300 2001 Manual page 315

STARTING AND DRIVING
Turning on the system
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To operate the cruise control, push the main switch. This
turns the system on. The indicator light in the instrument
cluster shows that you can now set your desired cruising
speed. Another push on the switch will turn the system
completely off.
When the ignition key is turned off, the main switch is
also automatically turned off. To use the cruise control
again, push the main switch again to turn it on.
CAUTION
To avoid accidental cruise control engagement, keep
the main switch off when not using the cruise control.
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