MSI 865PE Neo2-P Platinum Edition User Manual page 80

Here it provides the Karaoke function which will automatically remove
human voice (lyrics) and leave melody for you to sing the song. Note that this
function applies only for 2-channel audio operation.
Just check the Voice Cancellation box and then click OK to activate the
Karaoke function.
Using 2-, 4- & 6-Channel Audio Function
A-5