cytiva Biacore 1 Series Operating Instructions Manual
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cytiva Biacore 1 Series Operating Instructions Manual

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Biacore™ 1 series
Operating Instructions
Original instructions
cytiva.com

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Summary of Contents for cytiva Biacore 1 Series

  • Page 1 Biacore™ 1 series Operating Instructions Original instructions cytiva.com...

  • Page 2: Table Of Contents

    Troubleshooting ....................74 Troubleshooting tools ..........................75 Instrument problems ........................... 77 Reference information ..................82 System specifications ..........................83 Chemical resistance of wetted parts ..................... 85 Recycling information ..........................87 Regulatory information ..........................88 Biacore 1 series Operating Instructions 29706295 AB...
  • Page 3 Regulations for North America ....................... 94 8.4.6 Regulatory statements ..........................95 8.4.7 Declaration of Hazardous Substances (DoHS) ................96 Ordering information ........................... 98 Health and Safety Declaration Form ...................... 99 Index ........................... 101 Biacore 1 series Operating Instructions 29706295 AB...

  • Page 4: Introduction

    This chapter contains important user information, descriptions of safety notices, intended use of the Biacore™ system, and information concerning associated docu- mentation. In this chapter Section See page Important user information About this manual Associated documentation Glossary Biacore 1 series Operating Instructions 29706295 AB...

  • Page 5: Important User Information

    Prerequisites In order to operate the Biacore 1 series in a safe way, and according to the intended purpose, the following prerequisites must be met: • You must read and understand the Safety Instructions chapter of these Operating Instructions.

  • Page 6: About This Manual

    Note: A note is used to indicate information that is important for trouble-free and optimal use of the product. Tip: A tip contains useful information that can improve or optimize your proce- dures. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 7: Associated Documentation

    Cytiva. User documentation The main components of the documentation for the Biacore 1 series are listed in the table below. Translations of the Biacore 1 series Operating Instructions are provided in PDF format on the documentation CD inside the back cover of the printed Operating Instructions.
  • Page 8 User documentation on the web Links to laboratory guidelines, application notes, documentation and other online resources can be found on cytiva.com/biacore. You need to register on the website to access some of these links. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 9: Glossary

    Attachment by capture is normally rever- sible. Capturing A molecule that is permanently attached to the sensor surface molecule with the purpose of capturing ligand by high affinity binding. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 10 The flow cell(s) in the channel used as reference. surface In the Biacore 1 series, the flow cells that are used as references can be selected within the software. It is common to have every second flow cell in series as reference, or, to only have the first flow cell in series as reference.
  • Page 11 A flow pattern where the same liquid flows through two or more flow cells, one after another. In the Biacore 1 series, the flow cells can be addressed in series or separately, see also Flow cells. Surface plasmon resonance, the detection principle used in Biacore instruments.

  • Page 12: Safety Instructions

    All users must read and understand the entire contents of this general safety chapter, and the specific safety precau- tions information in each subsequent chapter of this manual to become aware of the hazards involved. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 13: Safety Precautions

    It is important not to proceed until all stated conditions are met and clearly understood. NOTICE NOTICE indicates instructions that must be followed to avoid damage to the product or other equipment. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 14 Dispose of all waste products in accordance with national and local regula- tions. CAUTION Do not block the air inlet and outlet vents on the rear of the instru- ment. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 15 WARNING Always wear appropriate protective clothing and equipment during operation and maintenance of the product. Use required safety equipment when handling hazardous substances. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 16 Installation of the rotation guide must be done correctly to avoid tipping the instrument during rota- tion. WARNING The product is not intended for use in locations with explosion risks or fire hazards. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 17 A fume hood or similar ventilation system shall be installed when flammable or noxious substances are used. WARNING Heavy objects. Bottles and waste containers with capacity 5 L or more may be heavy. Take appropriate precautions when lifting. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 18 All service and repairs, with the exception of operations explicitly described in the user documentation, must be carried out by personnel authorized by Cytiva. Do not open any covers or replace any parts unless specifically stated in the user documentation.
  • Page 19 WARNING Explosion hazard. Do not run any maintenance procedures that use 20% ethanol at sample compartment temperatures above 25°C. Decommissioning WARNING Decontaminate the equipment before decommissioning to ensure that hazardous residues are removed. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 20: Labels And Symbols

    Fuse rating: number of fuses, type F (fast), trip current (A), maximum Fuse rating voltage (V) Mfg. Year Year (YYYY) and month (MM) of manufacture Safety labels and other symbols The following labels are attached to the instrument. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 21 2 Safety instructions 2.2 Labels and symbols Symbol Placement Description /text Caution - pinch risk. Moving Inside the sample hotel. parts in the sample hotel. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 22: Emergency Procedures

    2 Safety instructions 2.3 Emergency procedures Emergency procedures Introduction This section describes how to perform an emergency stop of the Biacore 1 series in acute and controlled situations. The section also describes the consequences of a power failure. Acute emergency shutdown To stop the system in an acute emergency, disconnect the mains power from the instrument.
  • Page 23 Follow the steps below if you need to recover microplates or reagent racks with samples from the sample hotel before the power is restored. Recovery of samples from the sample compartment during a power failure requires assistance from a Cytiva service representative.
  • Page 24 The instrument attempts to return any sample tray in the sample compart- ment to the sample hotel. If this does not succeed, contact Cytiva service. If you need to clean the liquid handling system, eject the sensor chip and insert a maintenance chip.

  • Page 25: System Description

    3 System description System description About this chapter This chapter describes the Biacore 1 series. In this chapter Section See page Instrument components Flow system Temperature control Sample handling Signal detection and processing System software Biacore 1 series Operating Instructions 29706295 AB...

  • Page 26: Instrument Components

    3 System description 3.1 Instrument components Instrument components Overview The main parts of the Biacore 1 series are identified in the illustration below. Part Function Hotel door release button Sample hotel door with window Sample compartment with window Sensor chip port...
  • Page 27 Control Software. Switch the illumination off if your samples are light- sensitive. Sensor chip port The sensor chip port is controlled from the software and cannot be opened by hand. Insert a sensor chip for further details. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 28 The illustration below shows the Biacore 1S+ instrument. Electrical connections are in the equivalent position on the Biacore 1K and Biacore 1K+ instruments. Part Function USB connector (for connection to controlling computer) Mains power connector Mains fuses Mains power switch Biacore 1 series Operating Instructions 29706295 AB...

  • Page 29: Flow System

    Buffer inlets are selectable from the Control Software. Biacore 1K has one buffer inlet. The buffer/BUFFER A and WATER tubes should be supplied with liquid at all times during instrument operation, including standby. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 30 Three peristaltic pumps provide a supply of running buffer and water for washing the needle during a run. The peristaltic pumps also pump the effluent from the liquid supply block to waste. The peristaltic pumps are not accessible to the user. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 31 Grooves on the IFC surface that comes into contact with the sensor chip form the flow cells when the sensor chip is docked in the instrument. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 32 If significant volumes are observed under other circumstances, check the sample compartment for leaks or blockage in the waste drainage from the liquid supply block (see Chapter 7 Troubleshooting, on page 74). Biacore 1 series Operating Instructions 29706295 AB...

  • Page 33: Temperature Control

    Sample hotel temperature In the Biacore 1 series, the sample hotel is actively maintained at the same tempera- ture as the sample compartment. For optimal temperature regulation, keep the sample hotel door closed except when handling sample trays in the hotel.

  • Page 34: Sample Handling

    Samples and low volume reagents are placed in 96- or 384-well standard or deep-well microplates. Microplate specifications and recommendations can be found in the Related Documents tab of the system product page at cytiva.com/biacore. Using microplates of other models or brands may impair the system.
  • Page 35 Samples are aspirated from a sample tray and injected over the sensor chip surface by the needle in the sample compartment. Switching between sample and running buffer during analysis is controlled by micro-valves in the IFC (see Integrated microfluidic cartridge (IFC), on page 31). Biacore 1 series Operating Instructions 29706295 AB...

  • Page 36: Signal Detection And Processing

    (resonance units, RU). As a rough approximation for proteins on Sensor Chip CM5, 1 RU corresponds to a change in surface concentration of 1 pg/mm This correlation can differ for different molecules and on different sensor chip surfaces. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 37 1 or 10 Hz for Biacore 1K and Biacore 1K+. For Biacore 1S+ the time resolution of the measurement can be set to 1, 10 or 40 Hz. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 38: System Software

    System software Introduction The Biacore 1 series include control software for controlling the instrument and running experiments, and a separate evaluation software for evaluating the results. The software is provided as a basic package with the essential functionality for running and evaluating experiments, and optional extension packages that offer additional functionality.

  • Page 39: Installation

    All lifting and moving must be performed in accordance with local regulations. WARNING Heavy object. The trolley or bench on which the product is installed must have a load capacity of at least 130 kg. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 40 Wear protective shoes with steel toecaps when moving the instru- ment to protect against falling objects. CAUTION Make sure that hands or fingers are not trapped under the instru- ment when the instrument is lifted or moved. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 41: Site Requirements

    A minimum bench or trolley depth of 60 cm is required. Biacore 1 series can be placed with the rear directly against a wall. At least 10 cm clear- ance above and 20 cm clearance at the sides of the instrument is needed for adequate air circulation.
  • Page 42 Instrument ventilation Biacore 1 series can be placed with the rear directly against a wall. At least 10 cm clear- ance above and 20 cm clearance at the sides of the instrument is required for adequate air circulation. Other heat generating equipment close by can impact the thermo- stating performance of the system.
  • Page 43 Protective ground. The product must always be connected to a grounded power outlet. WARNING Use only mains cables supplied or approved by Cytiva. WARNING Access to power switch and power cord with plug. Do not block access to the power switch and power cord. The power switch must always be easy to access.
  • Page 44 4.1 Site requirements Parameter Specification Power outlet Grounded Frequency 50/60 Hz Maximum power (excluding Biacore 1K: 350 VA controlling computer) Biacore 1K+: 350 VA Biacore 1S+: 350 VA Transient overvoltages Overvoltage category II Biacore 1 series Operating Instructions 29706295 AB...

  • Page 45: Unpacking, Assembly And Transport

    Cytiva representative. Contact Cytiva if you need to re-pack the instrument for storage or transport. Assembly The Biacore 1 series requires no special assembly other than that performed by the Cytiva representative during installation. Lift and move Follow the steps below to lift or move the instrument.
  • Page 46 Observe applicable ergonomic regulations and recommendations when lifting the instrument. Transport To avoid damage, the instrument must be secured before transport over more than limited distances within the laboratory. Contact Cytiva for assistance. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 47: Computer And Software

    Cytiva for additional concurrent users. Database installation Data from the Biacore 1 series (methods, results, run logs, and so on) is stored in a Microsoft® SQL Server database, either locally on the controlling computer or on a network server. SQL server versions 2017 and 2019 are supported. A local database can be installed automatically together with the software.
  • Page 48 Follow the steps below if you need to re-install the software for any reason. Step Action Download the software from cytiva.com/eDelivery. You need to provide your account credentials. Contact Cytiva customer support if you require assis- tance. Install the software according to the instructions on the download portal.

  • Page 49: Connections

    The computer should be placed on a bench at the left-hand side of the instrument. Connect the supplied USB cable between the USB ports on the computer and the instrument (see Electrical connections, on page 28). Biacore 1 series Operating Instructions 29706295 AB...
  • Page 50 Make sure that the software is installed on the computer and that the computer is switched on. Switch on the power to the instrument. Connect the instrument to the computer (see Connect the instrument to the computer, on page 49). Biacore 1 series Operating Instructions 29706295 AB...

  • Page 51: Operation

    A fume hood or similar ventilation system shall be installed when flammable or noxious substances are used. WARNING Heavy objects. Bottles and waste containers with capacity 5 L or more may be heavy. Take appropriate precautions when lifting. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 52 The product is designed to be used with liquid supply bottles on the right-hand side of the instrument and the controlling computer on the left. Do not place the computer on the right where there is a risk of spillage. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 53: Starting The System

    Follow the steps below to start the system and Biacore Insight Control Software: Step Action Switch on the power to the instrument (see Electrical connections, on page 28). Start the computer. Start Biacore Insight Control Software. Result: The login dialog is displayed. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 54 Account credentials do not have to be the same for login to Windows and the Biacore Insight software, provided that valid credentials are used in both cases. Note: Biacore Insight software does not support Windows Fast User Switching. Click Log in. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 55 If the system is in standby mode (the instrument status panel at the bottom of the screen shows Running standby flow), no further action is needed. Standby mode is stopped automatically when a new instrument activity is started. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 56: Preparing For A Run

    (see Standby mode for volumes required during standby). Step Action Fill a bottle with distilled water and place it on the right-hand side of the instrument. Insert the tube marked WATER. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 57 Select New chip and enter the details of the sensor chip for the run. Alterna- tively, select Existing chip and choose a chip from the list. Insert the sensor chip and close the chip door. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 58 If you need to make any adjustments, return to the Method Defi- nition tab and adjust the necessary settings. (Optional) Print the Plate layout information as an aid in preparing microplates and reagent racks. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 59: Preparing And Loading Samples

    Close the lid of the reagent rack. Mount the microplate and the reagent rack on a sample tray Follow the steps below to mount the microplate or the reagent rack on the sample tray. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 60 Correct plate and rack positions are important to ensure that the injection needle is not damaged. Do not move them once they have been pushed all the way in. Release the microplate and reagent rack by pulling the locking levers on the sides. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 61: Performing The Run

    Navigate to the required folder and provide a name for the run. Click Save. Result: The run starts as soon as all previously queued activities are complete. Actual run start can be delayed if the flow cell temperature is not stable (see Flow cell temperature). Biacore 1 series Operating Instructions 29706295 AB...
  • Page 62 7 days. Make sure there is sufficient liquid supplied to each inlet for the intended standby period. Approxi- mate liquid consumption for each inlet tubing is listed below: Biacore 1 series Operating Instructions 29706295 AB...
  • Page 63 5 Operation 5.4 Performing the run Tubing Consumption (mL/24 h) Passes over sensor surface BUFFER WATER Biacore 1 series Operating Instructions 29706295 AB...

  • Page 64: Closing Down The Software

    Activity running or pending The software cannot be closed until the activity is completed or aborted. Standby continues to run for up to 7 days after the software is closed. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 65: Maintenance

    Do not use more than 250 mL 20% ethanol on any single occasion for maintenance procedures. WARNING Explosion hazard. Do not run any maintenance procedures that use 20% ethanol at sample compartment temperatures above 25°C. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 66 All service and repairs, with the exception of operations explicitly described in the user documentation, must be carried out by personnel authorized by Cytiva. Do not open any covers or replace any parts unless specifically stated in the user documentation.

  • Page 67: Cleaning Before Planned Service

    Health and safety declaration forms Health and safety declaration forms are available for copying or printing in the Refer- ence information chapter of this manual, or on digital media supplied with the user documentation. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 68: User Maintenance Operations

    Regular maintenance is important for continued high performance of the system. This section describes the maintenance operations that must be performed by the user. More extensive maintenance must be performed on a regular basis by a Cytiva service representative. Maintenance schedule Perform user maintenance operations at regular intervals according to the table below.
  • Page 69 Press the metal lever positioned on the left inner wall, above the lower tray. Drag the tray all the way to the left. Lift the front of the tray and pull the tray to remove it. Clean the tray with water and mild detergent. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 70 To clean the sample hotel, remove all sample trays and wipe the hotel surfaces with a moistened cloth or tissue. Clean the trays with water and mild detergent. If cleaning is required in inaccessible places, contact Cytiva for assistance. Insert the sample tray Follow the steps below to put the sample tray back:...
  • Page 71 CAUTION Do not replace the mains fuses if you suspect that there may be a malfunction in the instrument. Contact your Cytiva service repre- sentative for advice. Follow the instructions below to replace the mains fuses.
  • Page 72 Insert a small flat-bladed screwdriver under the tab on the fuse drawer cover. Prise open the fuse drawer cover. Replace both fuses. See the instrument product label for fuse ratings. Close the fuse drawer cover and reconnect the mains supply. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 73: Storage

    Maintain normal conditions of temperature and humidity while the system is in storage: • Temperature: preferably room temperature, not below freezing • Relative humidity: non-condensing, preferably low humidity Contact Cytiva if you are uncertain of storage conditions. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 74: Troubleshooting

    7 Troubleshooting Troubleshooting About this chapter This chapter describes troubleshooting procedures. In this chapter Section See page Troubleshooting tools Instrument problems Biacore 1 series Operating Instructions 29706295 AB...

  • Page 75: Troubleshooting Tools

    Prepare vials with HBS-EP+ buffer and Biacore test solution according to the Positioning information. Note: You can change the sample positioning if desired. The reagent rack type is however fixed. Choose Start run and provide a location and name for the result file. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 76 Incorrect test solution or buffer. values Noise Noisy Make sure that the instrument is not exposed to vibration sources such as centrifuges. Drifting baseline A new chip was not used. Temperature not stable. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 77: Instrument Problems

    Cytiva. Problems and solutions The table below summarizes problems and corrective actions. For problems not listed here or explained in an on-screen notification, contact your Cytiva service representa- tive. Symptom...
  • Page 78 Mechanical disturb- Close the sample hotel door gently ance. if it is opened during a run. Avoid bumping into the instrument or trolley bench. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 79 10 minutes if possible. Response out of Insufficient sample Make sure that sample volumes range at the end volume. correspond with the recommenda- of injection. tions in the software. Decrease the flow rate. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 80 Do not use foil for microplates with pooled samples. Microplate wells over- Use recommended sample filled so that vent holes volumes. Do not overfill wells. in the microplate septa are blocked by liquid. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 81 Delayed injection Air in flow system. start. Leakage. Contact Cytiva service. Injection from empty Make sure all used sample posi- microplate well. Injec- tions contain sufficient liquid. tion of air can delay subsequent injections. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 82: Reference Information

    8 Reference information Reference information About this chapter This chapter provides technical specifications for the Biacore 1 series, chemical resist- ance, recycling, and regulatory information. In this chapter Section See page System specifications Chemical resistance of wetted parts Recycling information...

  • Page 83: System Specifications

    Sample compartment Biacore 1K: 4°C to 37°C temperature Biacore 1K+: 4°C to 37°C Biacore 1S+: 4°C to 40°C Cooling possible to at least 18°C below ambient (all three instruments) Acoustic noise level <70 dB(A) Biacore 1 series Operating Instructions 29706295 AB...
  • Page 84 36 plastic vials Ø7 mm (BR100212) and 7 glass or plastic 4 ml vials (Ø 16 and 15 mm, BR100209 and 29266981) Reagent rack 14 plastic vials Ø11 mm (BR100287) and 7 glass or plastic 4 ml vials (Ø 16 and 15 mm, BR100209 and 29266981) Biacore 1 series Operating Instructions 29706295 AB...

  • Page 85: Chemical Resistance Of Wetted Parts

    This section gives some general guidelines concerning chemical resistance for the Biacore 1 series flow system. The flow system and sensor chip are the only wetted parts of the Biacore 1 series. In most analysis situations, the chemical resistance of the system as a whole is limited by the properties of the sensor surface and the attached ligand.
  • Page 86 8 Reference information 8.2 Chemical resistance of wetted parts Solution Concentration Compatibility Sodium hydroxide 250 mM Short term Urea Short term Biacore 1 series Operating Instructions 29706295 AB...

  • Page 87: Recycling Information

    Waste electrical and electronic equipment must not be disposed of as unsorted munic- ipal waste and must be collected separately. Please contact an authorized representa- tive of the manufacturer for information concerning the decommissioning of the equipment. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 88: Regulatory Information

    8 Reference information 8.4 Regulatory information Regulatory information Introduction This section lists the directives and standards that apply to the Biacore 1 series. In this section Section See page 8.4.1 Contact information 8.4.2 European Union and European Economic Area 8.4.3 Great Britain 8.4.4...

  • Page 89: Contact Information

    The table below summarizes the required manufacturing information. Requirement Information Name and address of manufacturer Cytiva Sweden AB Björkgatan 30 SE 751 84 Uppsala Sweden Telephone number of manufacturer + 46 771 400 600 Biacore 1 series Operating Instructions 29706295 AB...

  • Page 90: European Union And European Economic Area

    Operating Instructions or user manuals. Regulatory compliance of connected equipment Any electrical equipment connected to the Biacore 1 series shall meet the safety requirements of EN/IEC 61010-1, or other relevant national safety regulations and standards. Within EU, connected equipment must be CE marked.

  • Page 91: Great Britain

    • used according to the Operating Instructions or user manuals, and • used in the same state as it was delivered, except for alterations described in the Operating Instructions or user manuals. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 92: Eurasian Economic Union (Евразийский Экономический Союз)

    Telephone: +7 985 192 75 37 E-mail: rucis@cytiva.com Информация о производителе и импортере В следующей таблице приводится сводная информация о производителе и импортере, согласно требованиям Технических регламентов Таможенного союза и (или) Евразийского экономического союза. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 93 Member States of the Customs Union of the Eurasian Economic Union Данный знак о Евразийском соответствии указывает, что изделие одобрено для использования на рынках государств-членов Таможенного союза Евразийского экономического союза Biacore 1 series Operating Instructions 29706295 AB...

  • Page 94: Regulations For North America

    Note: The user is cautioned that any changes or modifications not expressly approved by Cytiva could void the user’s authority to operate the equip- ment. This equipment has been tested and found to comply with the limits for a Class A digital device, pursuant to part 15 of the FCC Rules.

  • Page 95: Regulatory Statements

    When used in a residential environment, there is a concern of radio interference. 유의사항 A급 기기 (업무용 방송통신 기자재) 이 기기는 업무용환경에서 사용할 목적으로 적합성평가를 받 은 기기 로서 가정용 환경에서 사용하는 경우 전파간섭의 우려가 있습 니다. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 96: Declaration Of Hazardous Substances (Dohs)

    EFUP shall be done in accordance with the Product Maintenance Procedures. This product must not be disposed of as unsorted municipal waste, and must be collected separately and handled properly after decommissioning. Biacore 1 series Operating Instructions 29706295 AB...
  • Page 97 Indicates that this hazardous substance contained in at least one of the homogeneous materials used for this part is above the limit requirement in GB/T 26572 • Data listed in the table represents best information available at the time of publication. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 98: Ordering Information

    8 Reference information 8.5 Ordering information Ordering information Ordering information for the Biacore 1 series and related products can be found on cytiva.com/biacore. Biacore 1 series Operating Instructions 29706295 AB...

  • Page 99: Health And Safety Declaration Form

    Service Ticket #: To make the mutual protection and safety of Cytiva service personnel and our customers, all equipment and work areas must be clean and free of any hazardous contaminants before a Service Engineer starts a repair. To avoid delays in the servicing of your equipment, complete this checklist and present it to the Service Engineer upon arrival.
  • Page 100 To make sure the mutual protection and safety of Cytiva personnel, our customers, transportation personnel and our environment, all equipment must be clean and free of any hazardous contaminants before shipping to Cytiva. To avoid delays in the processing of your equipment, complete this checklist and include it with your return.

  • Page 101: Index

    Dock chip, 57 Lifting and moving, 45 Drip tray, 32 Liquid supply, 29, 56 bottles, 29 setup, 56 Electrical connection panel, 28 tubing, 29 Liquid supply block, 31 Electrical requirements, 43 Login, 54 Biacore 1 series Operating Instructions 29706295 AB...
  • Page 102 Standby mode, 62 decontamination, 87 Start run, 61 disposal of electrical compo- Starting the system, 53 nents, 87 Storage conditions, 73 recycling of hazardous Surface plasmon resonance, 36 substances, 87 Syringe pumps, 30 Biacore 1 series Operating Instructions 29706295 AB...
  • Page 103 Tubing inlet panel, 29 Typographical conventions, 6 UK, 91 conformity, 91 UKCA, 91 marking, 91 Undock chip, 57 Unpacking, 45 User documentation, 7 User maintenance, 68 schedule, 68 Ventilation, 42 Waste tube, 32 Web resources, 8 Biacore 1 series Operating Instructions 29706295 AB...
  • Page 104 QR code. cytiva.com/biacore Cytiva and the Drop logo are trademarks of Life Sciences IP Holdings Corp. or an affiliate doing business as Cytiva. Biacore is a trademark of Global Life Sciences Solutions USA LLC or an affiliate doing business as Cytiva.

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