Epson DS-50000 User Manual page 76

Select Descreening as the image quality setting.
Try changing the Resolution setting.
Uneven color, smears, dots, or straight lines appear in your image
Clean the product.
Cleaning the Product
The scanning area or direction is unsatisfactory
The edges of your original are not scanned
Move the document or photo more than 3 mm (0.12 inch) away from the horizontal and vertical edges of the document
glass to avoid cropping.
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