F-SECURE ANTI-VIRUS FOR MICROSOFT EXCHANGE 7.10 Administrator's Manual page 256

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In centrally managed installations, you can use the F-Secure Anti-Virus
for Microsoft Exchange Web Console only for monitoring the F-Secure
Automatic Update Agent settings. To change these settings, you need to
use F-Secure Policy Manager Console. For more information, see
"F-Secure Automatic Update Agent
If necessary, reconfigure the firewall and other devices that may block the
database downloads.
In common deployment scenarios, make sure that the following
ports are open:
DNS (53, UDP and TCP)
HTTP (80)
Port used to connect to F-Secure Policy Manager Server
Settings", 135.