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Summary of Contents for Endress+Hauser analytikjena Biometra TMS
- Page 1 Operating Manual Biometra TMS Temperature Measuring System for Thermal Cyclers...
- Page 2 Manufacturer Analytik Jena GmbH+Co. KG Konrad-Zuse-Straße 1 07745 Jena, Germany Phone +49 3641 77 70 Fax +49 3641 77 92 79 Email: info@analytik-jena.com Technical Service Biometra GmbH Rudolf-Wissell-Straße 15 37079 Göttingen / Germany Phone: +49 3641 77 7407 Fax: +49 3641 77 9279 E-mail: service@analytik-jena.com For a proper and safe use of this product follow the instructions. Keep the operating manual for future reference.
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Page 3: Table Of Contents
Biometra TMS Table of contents Table of contents 1 Notes on this operating manual........................... 2 Intended use ................................. 3 Security ................................. Safety labeling on the device ........................... Requirements for the operating personnel..................... Safety instructions, transport and commissioning ..................Safety instructions: during operation ......................3.4.1 General safety instructions during operation.................... - Page 4 Table of contents Biometra TMS Returning the product ............................40 Storage ................................41 10 Disposal ................................42 11 Specifications................................ 43 11.1 Technical data..............................43 11.2 Ambient conditions ............................44...
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Page 5: Notes On This Operating Manual
Biometra TMS Notes on this operating manual Notes on this operating manual Content The operating manual describes the following device model: Biometra TMS ¡ Within this document, this model will be referred to as the device or the temperature measuring system. The device is used to calibrate automated and manually operated thermal cyclers. -
Page 6: Intended Use
Intended use Biometra TMS Intended use The Biometra TMS is a temperature measuring system for calibrating thermal cy- clers. The measured temperatures of the sample block under test are compared with specific predefined values. NOTICE! The temperature measuring system cannot be used for adjusting the de- vice. -
Page 7: Security
Biometra TMS Security Security For your own safety and to ensure error-free and safe operation of the device, please read this chapter carefully before commissioning. Observe all safety instructions listed in this user manual and all messages and infor- mation displayed on the monitor by the control and analysis software. Safety labeling on the device Warning and mandatory action labels have been attached to the device and must al- ways be observed. -
Page 8: Safety Instructions: During Operation
Security Biometra TMS Safety instructions: during operation 3.4.1 General safety instructions during operation The operator must make sure that the device and its safety equipment is in sound condition each time before starting up the device. This applies in particular after each modification or extension of the device or its repair. -
Page 9: Safety Instructions - Maintenance And Repair
Biometra TMS Security Avoid biological contamination of the device. The housing of the measuring ¡ head cannot be disinfected and can only be wiped with a damp cloth. Clean, dis- infect and dry the thermal cycler to be tested, and especially the sample block, before inserting the measuring head. -
Page 10: Design And Function
Design and function Biometra TMS Design and function Calibration of a thermal cycler using a Biometra TMS is carried out as follows: The temperature measuring system measures the temperatures of the sample block and, if required, of the heated lid of the tested thermal cycler. The software of the tem- perature measuring system which is installed on a separate PC logs the captured data, compares them with a predefined temperature program, detects any deviations, and dis- plays them. -
Page 11: Multimeter
Biometra TMS Design and function Fig. 2 Power and USB cable Multimeter The measurement requires a Keithley multimeter configured and customized especially for Analytik Jena. The control elements of the multimeter can be found on the front of the device. The functions described in this operating manual only require two of these control elements: Power button: For switching the multimeter on and off ¡... -
Page 12: Measuring Tree
Design and function Biometra TMS Fig. 4 Rear of the multimeter 1 Interface for PC connection cable 2 Multiplexer plug-in module 3 Power module with mains connection 4 D-SUB connector to the measuring tree and fuse compartment The fuse compartment on the power module can be used to adapt the operating voltage to the mains voltage. -
Page 13: Fig. 6 Measuring Tree With Bottom Side Of The Measuring Head
Biometra TMS Design and function The arrangement of these sensors on the various measuring trees matches the tempera- ture characteristics of the block, i.e. the mean value, spread and uniformity. Depending on the block type and manufacturer, these can be distributed differently across the block. -
Page 14: Fig. 8 D-Sub Connector On The Multimeter
Design and function Biometra TMS Measuring tree variants Analytik Jena offers measuring trees with matching measuring heads for calibrating dif- ferent types of sample blocks. These measuring trees can be connected to the multime- ter using a simple plug-in system. The software will automatically read the serial num- ber of the measuring tree that is connected. -
Page 15: Software
Biometra TMS Design and function Software Functional scope of the software: Automatic setup of the multimeter ¡ Identification of the connected measuring tree ¡ Logging of device data and customer-specific data ¡ ¡ Logging of measured values ¡ Different live display options for the measured values ¡... -
Page 16: Installation And Commissioning
Installation and commissioning Biometra TMS Installation and commissioning Installation prerequisites Climatic conditions The requirements for the climatic conditions at the installation location are set out in the specifications. If required, ensure that the room is temperature-controlled. Installation location require- This laboratory device is designed for inside use. ¡... -
Page 17: Installation
Biometra TMS Installation and commissioning Installation WARNING Danger from electric current ¡ Only connect the device to a properly grounded mains outlet. ¡ When installing the device, refer to the respective instructions on the electrical con- nection conditions and the correct setting of the operating voltage in the multimeter manual. - Page 18 Installation and commissioning Biometra TMS } When the multimeter is switched on: Use the power button at the front of the device to switch the multimeter off (3, soft power-off). } Use the D-SUB connector to connect the measuring tree to the multime- ter (4).
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Page 19: Operation
Biometra TMS Operation Operation Switching the device on and off Switching the device on ð The multimeter is connected to the mains supply and the PC via the mains cable and the USB cable. ð The measuring tree is connected to the multimeter. ð... -
Page 20: Fig. 9 Modification Of The Shortcut Path For Configuring The Software Language
Operation Biometra TMS Fig. 9 Modification of the shortcut path for configuring the software language Exiting the software Click the button X in the top right corner of the window to exit the software. Clicking this button will close the window and stop the execution of the software. -
Page 21: Fig. 10 Start Screen Of The Software
Biometra TMS Operation Start screen The software’s start screen shows the menu Thermal cycler calibration. The start screen contains the following items: Fig. 10 Start screen of the software Buttons in the soft- Minimize, zoom out or close the window – closing the win- ware window dow will quit the program. -
Page 22: Thermal Cycler Calibration
Operation Biometra TMS Page Can be used to start the calibration process. The data of the Retrieve data connected multimeter and measuring tree are captured and entered on this page. Mask Mask for entering the specifications of the connected multi- Multimeter meter. -
Page 23: Fig. 11 Inserting A Measuring Head With Cables Routed At The Side; Observe The Direction Of The Cable Routing To The Left (Blue Arrow)
Biometra TMS Operation Inserting the measuring head ð The temperature measuring system is connected to the mains and to the PC, switched on and ready for operation (observe the required the warm-up time of 30 minutes!). ð The thermal cycler is connected to the mains, switched on and ready for operation. -
Page 24: Fig. 13 Correctly Laid Cable Harness Routed At The Front
Operation Biometra TMS } Ensure that the thermal cycler’s lid closes properly when attaching the ca- ble harness of the measuring tree to the thermal cycler. If the cable harness is not attached correctly this may trigger the emer- gency stop of the closing mechanism in the lid. Fig. 13 Correctly laid cable harness routed at the front... -
Page 25: Fig. 15 Start Screen For The Measurement
Biometra TMS Operation Fig. 15 Start screen for the measurement } Select the menu item Thermal cycler calibration (1). } Click the button Start on the page Retrieve data (2). The software populates the information boxes according to the data retrieved for the detected multimeter and the detected measuring tree. -
Page 26: Fig. 16 Information To Be Filled Out On The Measurement
Operation Biometra TMS Fig. 16 Information to be filled out on the measurement } Enter the required data in the input mask on the page Measurement details (4). The software will prompt the user to enter the required information on the thermal cycler to be tested, the name of the person performing the test and the customers. -
Page 27: Display Options During The Measurement
Biometra TMS Operation NOTICE! User-defined programs are configured under the menu item “Settings/ Tests”. NOTICE! When selecting a user-defined program, the system does not carry out a calibration and does not compare the data with the specifications. The issued report only contains the measured values and does not include an evaluation of the measure- ment results. -
Page 28: Fig. 19 Drop-Down Menu To Select The Display Option
Operation Biometra TMS The display of the measured data can be enlarged via the context menu. The help func- tion in the context menu also provides information on how to use keyboard shortcuts to change the display options. Fig. 19 Drop-down menu to select the display option You can choose between the following options for displaying the data: Bar graph: Live temperature at the individual sensor positions and deviation from ¡... -
Page 29: Fig. 20 Drop-Down Menu To Highlight The Measured Values For Individual Sensors
Biometra TMS Operation Fig. 20 Drop-down menu to highlight the measured values for individual sensors Fig. 21 Drop-down menu to select the recognized temperature steps The software recognizes the different sample block temperatures and assigns numbers to these temperatures. -
Page 30: Testing The Heated Lid
Operation Biometra TMS 6.3.3 Testing the heated lid After testing the sample block function, the system will test the proper functioning of the heated lid. Before doing this, the results of the sample block test must be checked. Depending on the test results, you can proceed as follows: ¡... -
Page 31: Saving Measurement Results And Exiting The Measurement
Biometra TMS Operation Fig. 24 Carrying out the test of the heated lid 6.3.4 Saving measurement results and exiting the measurement ð The measurements of the sample block and the heated lid are completed. } Click the button Continue. Fig. 25 Saving the measurement results } Save the report of the measurement results on the page Save results:... - Page 32 Operation Biometra TMS – Set one directory for saving the file (1). When enabling the option Set as default Folder, the selected directory is set as the default directory for saving reports. The command Load default Folder allows opening a default directory that was defined earlier.
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Page 33: Report
Biometra TMS Operation 6.3.5 Report After completing the measurement, the software generates a report. This report is saved on the PC and can be printed out from there. Depending on the selected program for the measurement, the report is either issued as a measurement report or a test report: Measurement report: contains the results of a user-defined measurement program ¡... -
Page 34: Settings/Checks
Operation Biometra TMS Settings/Checks The menu Settings/ Checks allows changing individual settings in the software. The fol- lowing figure provides an overview of the menu: Fig. 26 Menu item Settings/Checks Tab Settings Use this tab to change the settings for saving data, the type of measurement and the multimeter that is used. - Page 35 Biometra TMS Operation Check box Caching When selected, the software temporarily saves the data en- the data about the tered in the mask User in the Measurement details. This user data is maintained in the mask temporarily as long as the software is not closed.
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Page 36: Troubleshooting
Troubleshooting Biometra TMS Troubleshooting This section describes a number of device errors that can partly be corrected by the users themselves. Most of the device errors described are easy to identify. If the sug- gested solutions do not eliminate the errors/problems, and if such problems occur frequently, contact the customer service department of Analytik Jena. -
Page 37: Maintenance And Care
Biometra TMS Maintenance and care Maintenance and care Overview of maintenance work The following maintenance work must be carried out on the thermal cycler at the speci- fied intervals: Maintenance interval Maintenance task Every year, when prompted by the software Calibration of the measuring tree: Send in the measuring tree for calibration once a year. - Page 38 Maintenance and care Biometra TMS NOTICE Substances containing oil can cause damage to the tubes of the measuring tree. Make sure that the tubes do not come into contact with substances containing oil! NOTICE The housings of the multimeter and the measuring tree must only be cleaned with a damp cloth.
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Page 39: Transport And Storage
Biometra TMS Transport and storage Transport and storage Moving the device in the laboratory CAUTION Risk of injury during transport Dropping the device can cause injury and damage the device. Proceed carefully when moving and transporting the device. Grip the device firmly at the bottom with both hands and lift it. -
Page 40: Returning The Product
Transport and storage Biometra TMS Fig. 27 Maximum possible bending of the measuring tree cable to avoid damage to the device. For the return shipment, you can alternatively insert the measuring tree into the original packaging: } Pack the measuring tree loosely in the bag. } Loosely wrap the bag containing the measuring tree with bubble wrap and pack it in the box. -
Page 41: Storage
Biometra TMS Transport and storage NOTICE Risk of device damage due to unsuitable packaging material ¡ Only use the original packaging to transport any of the components of the tempera- ture measuring system. ¡ Detach all connected cables before transport and place all the components into their respective transport lock. -
Page 42: Disposal
Disposal Biometra TMS Disposal At the end of its service life, the device and its electronic components must be dis- posed of as electronic waste in accordance with the applicable regulations. -
Page 43: Specifications
Biometra TMS Specifications Specifications 11.1 Technical data General information Product description Biometra TMS Software Biometra TMS software Permissible contact pressure Default contact pressure of the thermal cycler or ap- prox. 10 kg Test temperatures in the calibration 15 °C , 55 °C , 70 °C , 95 °C program Multimeter Model name... -
Page 44: 11.2 Ambient Conditions
Specifications Biometra TMS 11.2 Ambient conditions Temperature during operation 23 °C ± 5 °C Humidity during operation (at ≤ 80 % 35 °C) Maximum altitude 2000 m Temperature during storage -40 to +70 °C... - Page 45 Biometra TMS List of figures List of figures Fig. 1 Components of the temperature measuring system..................10 Fig. 2 Power and USB cable ............................11 Fig. 3 Front of the multimeter............................11 Fig. 4 Rear of the multimeter ............................12 Fig.
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