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Summary of Contents for Thermo Scientific DHX Series
- Page 1 DHX Heat Exchanger User’s Guide DOC0050 • Revision A May 2019...
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Page 2: Table Of Contents
Contents Warnings and safety information How to use this guide Chapter 1 DHX Heat Exchanger overview 1.1 General information 1.2 Main components Chapter 2 Installing the DHX 2.1 Performing an incoming inspection 2.2 Installing the system 2.3 DHX plate system optional configurations Chapter 3 Operating information 3.1 Loading the BPC... - Page 3 Contents Chapter 6 General ordering information 6.1 Ordering instructions 6.2 Ordering/support contact information 6.3 Technical support...
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Page 4: Warnings And Safety Information
2.06 bar (30 psi). WARNING: Moving and tipping hazard. ™ Due to the weight of the Thermo Scientific DHX Heat Exchanger, two operators are required to move the unit. Use caution when moving the equipment. Ensure that the pathway is clear and free of obstacles. - Page 5 “research use only” product label or “limited use” label license. This equipment is intended for research use or further manufacturing in bioprocessing applications and not for diagnostic Thermo Scientific DHX Heat Exchanger User's Guide...
- Page 6 ASCE 7, it should be noted that such equipment is susceptible to overturning during a seismic event. Therefore, it is the responsibility of the buyer to address seismic safety for movable equipment at the designated facility. Thermo Scientific DHX Heat Exchanger User's Guide...
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Page 7: How To Use This Guide
Heat Exchanger, including hardware, components, product design verification methods, installation, operation and specifications. It is intended for use by people who may or may not have experience with Thermo Scientific systems, but who have some knowledge of bioproduction processes and large-scale mixing systems. -
Page 8: Dhx Heat Exchanger Overview
The system provides efficient, sterile heat transfer that easily integrates into any new or existing process. 1.2 Main components Figure 1.1 illustrates the components of the Thermo Scientific DHX Heat Exchanger. Thermo Scientific DHX Heat Exchanger User's Guide... - Page 9 (on each end plate) Tabs (hold BPC in place) High point Single-use tubing vent valves (connects BPC assemblies) Wing nut (6 total) Fanning lever Flexible hoses connect plate system Cart base Locking lever Clean room-grade casters Thermo Scientific DHX Heat Exchanger User's Guide...
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Page 10: Installing The Dhx
1. Unlock all four (4) casters and transport the DHX to the desired location. 2. Ensure the DHX is on a level surface and lock the casters in place. 3. Refer to Figure 2.1 for the recommended installation setup for the DHX system. Thermo Scientific DHX Heat Exchanger User's Guide... - Page 11 5. Connect the heat transfer fluid inlet and outlet connections, as shown in Figure 2.2. Figure 2.2. DHX fluid inlet and outlet connections. HTF inlet HTF outlet Thermo Scientific DHX Heat Exchanger User's Guide...
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Page 12: Dhx Plate System Optional Configurations
The heat transfer fluid may run through all five plates when using an assembly consisting of one to three single-use bags. Flexible insulation foam spacers are provided by Thermo Scientific. These spacers must be inserted between every unused plate—after the bags have been installed—to prevent damage or warping (Figure 2.3). - Page 13 2.1 and 2.2 must be followed accordingly for the plates in use. Note: Any unused plates should be capped or sealed appropriately. Figure 2.4. DHX system Configuration Option 2. Insulation foam spacers Disconnected DHX plates Thermo Scientific DHX Heat Exchanger User's Guide...
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Page 14: Operating Information
Figure 3.1. Note: It is recommended to keep a free hand under the wing nut during its removal to prevent it from dropping to the floor. Figure 3.1. Six (6) DHX plate system hinges. Thermo Scientific DHX Heat Exchanger User's Guide... - Page 15 The DHX is now in the open position and the single-use BPC assembly can be placed. Figure 3.3. Moving fanning lever towards the locking lever to open position. Fanning lever Fanning lever Locking lever Thermo Scientific DHX Heat Exchanger User's Guide...
- Page 16 The process fluid should cascade through each BPC in the series in the opposite direction of the heat transfer fluid path (Figure 3.5). Thermo Scientific DHX Heat Exchanger User's Guide...
- Page 17 DHX unit is being closed. To prevent this, rest the single-use flow path tubing across the top of the heat transfer hose assemblies (Figure 3.6). Figure 3.6. Flow path tubing. Incorrect Correct Thermo Scientific DHX Heat Exchanger User's Guide...
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Page 18: Operating The Dhx
(Figure 3.8). A piece of tubing should be used to direct any fluid that may exit the valves to a waste receptacle. Figure 3.8. Bleed valve locations. Thermo Scientific DHX Heat Exchanger User's Guide... -
Page 19: Removing The Bpc
To use the process inlet, the process outlet and low-point drain manifold outlet tubing should be closed using a clamp. Open the pinch clamps on each individual drain line Thermo Scientific DHX Heat Exchanger User's Guide... - Page 20 Open the clamps on each individual drain line before starting the process fluid flow. 7. Discard the assembly in the appropriate waste stream as dictated by the end user's requirements. Thermo Scientific DHX Heat Exchanger User's Guide...
- Page 21 Hoses are recommended to be replaced at least every two years. Preventive maintenance intervals may be revised at the discretion of the end user based on system use and service. Thermo Scientific DHX Heat Exchanger User's Guide...
- Page 22 1. Inspect the single-use BPCs to ensure the bottom and top tabs are secure. Single-use BPC assembly is improperly set up. 2. Inspect the fit of each single-use BPC to ensure that the serpentine pattern matches the corresponding DHX. Thermo Scientific DHX Heat Exchanger User's Guide...
- Page 23 DHX. Follow the trapped between the heat on top of the heat transfer instructions provided in this guide to properly align transfer hoses. hoses before closing the DHX. the flow path tubing. Thermo Scientific DHX Heat Exchanger User's Guide...
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Page 24: Hardware Specifications
Effective heat transfer area Up to 2.5 m (27 ft Material of construction 316L Stainless steel FV/965 kPa (140 psig) at 60°C (150°F), Pressure/temperature rating standard ASME U-1 (standard—each plate individually Code stamp wrapped) Thermo Scientific DHX Heat Exchanger User's Guide... - Page 25 Thermo Fisher Scientific for spare parts. Other parts may be replaced, if needed. Figure 5.1 and Table 5.3 detail each of the recommended spare parts. Figure 5.1. DHX Heat Exchanger parts. Note: See Table 5.3 for descriptions and recommended number of spares. Thermo Scientific DHX Heat Exchanger User's Guide...
- Page 26 30-DHX-1005 30-DHX-1020 Locking caster 30-DHX-1006 High point bleed valve 30-DHX-1007 DHX plate hose assembly 30-DHX-1008 DHX support bolt 30-DHX-1009 DHX support wingnut 30-DHX-1010 Hinge pin 30-DHX-1011 Flexible insulation insert 30-DHX-1012 1 (if applicable) Thermo Scientific DHX Heat Exchanger User's Guide...
- Page 27 Tel: +1 435 792 8500 Email: customerservice.bioprocessing@thermofisher.com In Europe Unit 9 Atley Way Cramlington, NE 23 1WA Great Britain Tel: +44 (1) 670 734 093 Fax: +44 (1) 670 732 537 Email: customerservice.bioprocessing@thermofisher.com Thermo Scientific DHX Heat Exchanger User's Guide...
- Page 28 Find out more at thermofisher.com For Research or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals. © 2019 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
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