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System Overview
The 4000 QTRAP
mass spectrometer, a Turbo V™ ion source, a computer, and the Analyst
software.
WARNING! If you need to move the system, contact an FSE to assist you. Risk of
personal injury or instrument damage
Note: Before you operate the instrument, make sure you have read the Safety Practices
guide.
Principles of the System
The 4000 QTRAP
mass spectrometer designed specifically for quantitative and qualitative
applications.
The Q3 region can be operated as either a standard quadrupole mass
spectrometer, or as a linear ion trap mass spectrometer. The unique scan modes
of both configurations can be linked to provide more and higher quality data
than either technique alone.
Applications for the System
The 4000 QTRAP
Quantitative Analysis of Small Molecules
This application involves measurement of specific molecular weight compounds
(usually a drug or metabolite in urine or other bodily fluid) and their resulting
fragment ions for determining the exact quantity of the compound in the sample
of interest. Quantitation is performed using a standard curve of mass
spectrometer signal intensity for various known concentrations of the compound.
The signal in the test sample is compared to the standard curve to determine the
concentration.
The typical scan type used for this application in the 4000 QTRAP system (as well
as all triple quadrupole instruments) is MRM (Multiple Reaction Monitoring).
Document Number: D1000092200 B
system includes a hybrid triple quadrupole/LIT (linear ion trap)
®
system includes a hybrid triple quadrupole LIT (linear ion trap)
®
system is best suited to three specific applications:
®
•
Quantitative analysis of small molecules
•
Qualitative analysis of small molecules
•
Qualitative analysis of proteins and peptides
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