Metrohm 761 Compact IC Instructions For Use Manual
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Metrohm 761 Compact IC Instructions For Use Manual

Compact ion chromatography analyzer
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METROHM Ltd.
CH-9101 Herisau
Switzerland
Phone
++41 71 353 85 85
Fax
++41 71 353 89 01
761 Compact IC
Instructions for Use
8.761.1063

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  • Page 1 761 Compact IC 8.761.1063 METROHM Ltd. CH-9101 Herisau Instructions for Use Switzerland Phone ++41 71 353 85 85 ++41 71 353 89 01...
  • Page 2 CH-9101 Herisau/Switzerland Phone ++41 71 353 85 85 ++41 71 353 89 01 Internet www.metrohm.ch E-Mail info@metrohm.ch 761 Compact IC Program «761 PC Software 1.1» 8.761.1063 Instructions for Use 07.07.2004 / chs...

  • Page 3: Table Of Contents

    1.4.2 General precautionary rules ..............12 2 Installation ......................Overview ........................ 13 2.1.1 Flow chart ..................... 13 2.1.2 Connections in the 761 Compact IC ............ 13 Setting up the instrument..................15 2.2.1 Packaging..................... 15 2.2.2 Check....................15 2.2.3 Location ....................15 Attaching the accessories ..................15...
  • Page 4 Start/stop hardware and record baseline ........79 Start/stop determinations............. 80 Options for determinations............80 4.3.4 System settings ..................82 Modify system window ..............82 Watch window display..............82 Set start mode ................82 Print system parameters .............. 83 4.3.5 PC icon ....................83 761 Compact IC...
  • Page 5 Chromatograms....................141 4.5.1 Chromatogram window ..............141 4.5.2 Chromatogram file handling............... 142 Open chromatogram ..............142 Save chromatogram ..............143 Close chromatogram..............143 Delete chromatogram..............143 Export chromatogram..............143 Import chromatogram ..............144 4.5.3 Graphical representation ..............145 761 Compact IC...
  • Page 6 Reprocess options window............163 Merge chromatograms .............. 166 4.7.3 Batch reprocessing queue editor............167 Open batch reprocessing queue editor window ....... 167 Batch reprocessing queue editor functions....... 168 Print batch reprocessing queue..........168 Close batch reprocessing queue editor ........168 761 Compact IC...
  • Page 7 6.3.3 Separating columns and precolumns ..........200 6.3.4 Additional devices and cables ............205 Warranty and conformity...................206 6.4.1 Warranty....................206 6.4.2 EU Declaration of conformity.............. 207 6.4.3 Certificate of conformity and system validation ......... 208 Index ........................209 761 Compact IC...
  • Page 8 Table of contents List of figures Fig. 1: Front of the 761 Compact IC ................3 Fig. 2: Rear of the 761 Compact IC................4 Fig. 3: Interior of the 2.761.0010 Compact IC ............6 Fig. 4: Interior of the 2.761.0020 Compact IC ............8 Fig.
  • Page 9 PEEK coupling .......7,9,40 Absorber tube........28 Leak detector ........7,9 Manufit housing........32 Connection capillary .....7,9,26 Steel connector ........32 Filter unit PEEK ....7,9,18,26,40 PTFE gasket .........32 Connection capillary ......7,9,26 2 Steel meshes........32 Connection capillary ......7,9 Precolumn cartridge......32 Purge valve........7,9,26 Steel spacer .........32 761 Compact IC...
  • Page 10 Ceramic holder........179 Suppressor inlet capillary Seal ............179 for H ........39,41,43 Screw nut ...........183 Suppressor outlet capillary Connection piece.......183 for H O ..........41,43 Suppressor rotor ........183 Suppressor outlet capillary for H ......... 41,43 Suppressor holder ......183 VIII 761 Compact IC...

  • Page 11: Introduction

    1.1 Instrument description Introduction Instrument description The 761 Compact IC is a PC-controlled system for ion chroma- tographic analyses. The two following versions are available: • 2.761.0010 Compact IC without suppressor module • 2.761.0020 Compact IC with suppressor module The extremely compact housing of the 761 Compact IC contains every-...
  • Page 12 1 Introduction The operation of the 761 Compact IC takes place via a PC connected to the RS232 interface with the help of the control and evaluation pro- gram «761 Compact IC». This PC program can be used to create sys- tems for recording and evaluating chromatograms.

  • Page 13: Parts And Controls

    1.2 Parts and controls Parts and controls 761 Compact IC POWER Fig. 1: Front of the 761 Compact IC Door to interior Connection for drain tube for discharge of spilled liquid from the interior Connection for 6.2816.020 Syringe Feedthrough for capillaries...

  • Page 14: Fig. 2: Rear Of The 761 Compact Ic

    = 50-60 Hz S = 100 VA Analog Output Remote Fuse 100-120V: 1,0A(T) 220-240V: 0,5A(T) RS 232 Detector Block Made by Metrohm Herisau Switzerland Fig. 2: Rear of the 761 Compact IC 761 Compact IC...

  • Page 15: Opening For Detector Cable 5

    Remote interface (closed with plastic stopper) for remote I/O lines for connection of additional supply and discharge lines to external devices and from the inner compartment Detachable rear panel Serial number access to upper part of inner compartment 761 Compact IC...

  • Page 16: Fig. 3: Interior Of The 2.761.0010 Compact Ic

    1 Introduction Fig. 3: Interior of the 2.761.0010 Compact IC (with permanently attached accessories and 1.733.0110 Detector block) 761 Compact IC...
  • Page 17 Injection valve Connection capillary in pump head, fixed mounting PEEK coupling (6.2744.040) Inlet capillary for detector block PEEK capillary, fixed mounting Leak detector Detector block (1.732.0110) Connection capillary 6.1831.010 PEEK capillary, length L = 13 cm 761 Compact IC...

  • Page 18: Fig. 4: Interior Of The 2.761.0020 Compact Ic

    1 Introduction 36 35 34 Fig. 4: Interior of the 2.761.0020 Compact IC (with permanently attached accessories and 1.733.0110 Detector block) 761 Compact IC...
  • Page 19 Connection capillary Pump drive 6.1831.010 PEEK capillary, roller head with contact rollers length L = 13 cm Connection capillary Mounting pin 6.1831.030 PEEK capillary, for attaching the tubing cartridges length L = 20 cm 761 Compact IC...

  • Page 20: Information On The Instructions For Use

    Information on the Instructions for Use Please read through these Instructions for Use carefully before you put the 761 Compact IC into operation. The Instructions for Use contain information and warnings to which the user must pay attention in order to assure safe operation of the instrument.

  • Page 21: Notation And Pictograms

    Caution This symbol marks important information. First read the associ- ated directions before you conti- nue. Comment This symbol marks additional information and tips. 761 Compact IC...

  • Page 22: Safety Notes

    Safety notes 1.4.1 Electrical safety While electrical safety in the handling of the 761 Compact IC is assured in the context of the specifications IEC 1010-1 (protection class 1, de- gree of protection IP20), the following points should be noted: •...

  • Page 23: Installation

    2.9 Connecting external devices sect. 2.10 2.1.2 Connections in the 761 Compact IC The two following illustrations show the internal connections in the 761 Compact IC in schematic form. The meanings of the various numbered components are given in the detailed illustrations and descriptions in sections 2.2 –...

  • Page 24: Fig. 5: Connecting Diagram For 2.761.0010 Compact Ic Without Suppressor

    Injection valve Waste Eluent Sample Fig. 5: Connecting diagram for 2.761.0010 Compact IC without suppressor 97 33 45 29 32 Detector Column 36 35 Waste Eluent Sample Fig. 6: Connecting diagram for 2.761.0020 Compact IC with suppressor 761 Compact IC...

  • Page 25: Setting Up The Instrument

    2.3.1 Connection of detector block The metal-free 1.732.0110 Detector block belongs to the scope of supply of the 761 Compact IC; it must be inserted in the instrument and connected up. Proceed as follows: Note the cell constant • The cell constant c = XX,X /cm is printed on the rear of the detector block.

  • Page 26: Connection Of Syringe And Aspirating Tubing

    3 to fix the aspirating tubing 4 in place. 2.3.3 Connection of the drain tube for the inner compartment The 761 Compact IC has a connection at the front to which a drain tube for discharged liquids in the inner compartment can be attached. Pro- ceed as follows: Connect drain tube •...

  • Page 27: Connection Of The Drain Tube For Bottle Rack

    2.3 Attaching the accessories 2.3.4 Connection of the drain tube for bottle rack The 761 Compact IC has a connection at the rear to which a drain tube for discharged liquids in the bottle rack can be attached. Proceed as follows: Connect drain tube •...

  • Page 28: Filter Unit Peek

    Filter unit PEEK (6.2821.120) Filter-Screw of Filter Unit Part of 6.2821.120 Filter unit Compression fitting (6.2744.010) Filter 6.2821.130 Part of 6.2821.120 Filter unit Capillary Filter-Housing of Filter Unit 6.1831.010 PEEK capillary or Part of 6.2821.120 Filter unit 6.1822.010 PTFE microcapillary 761 Compact IC...

  • Page 29: Mains Connection

    2.4.1 Setting the mains voltage Before switching on the 761 Compact IC for the first time, check that the mains voltage set on the instrument (see Fig. 9) matches the local mains voltage. If this is not the case, you must reset the mains voltage...

  • Page 30: Fuses

    Fuses One of the two fuses 1 A/slow-blow for 100…120 V or 0.5 A/slow-blow for 220…240 V is installed in fuse holder 21 of the 761 Compact IC as standard. Ensure that the instrument is never put into operation with fuses of another type, otherwise there is danger of fire! For checking or changing fuses, process as described in section 2.4.1.

  • Page 31: Connection To The Pc

    Always switch off 761 Compact IC and PC before you connect the two instruments with the 6.2134.100 Cable. Connect the RS232 interface 22 at the 761 Compact IC to one of the serial COM ports at the PC using the 6.2134.100 Cable (9 pin/9 pin). If only a 25-pin COM interface is available on the PC then the 6.2125.110...

  • Page 32: Basic Settings

    2.5.3 Basic settings When the program is started for the first time several basic settings must be made for the 761 Compact IC. Proceed as follows: Start program • Double-click the software icon to start the program. The program window with the opening picture is opened and the Log In window appears on the screen: •...
  • Page 33 COM1 menu item to open the following window listing all Change available COM ports at the PC: • Select the desired COM port to which the 761 Compact IC has been connected and click on . The window is <OK>...
  • Page 34 #####.761 • If the connection between PC and Compact IC does not work then the message Detection of hardware failed[761 Compact IC appears in the window. In this case [ COM# ]] SYSTEM STATE...

  • Page 35: High-Pressure Pump

    61 of the pulsation dampener 60. The pulsation dampener is filled with isopropanol and must be rinsed with eluent before connection to a separating column (see section 2.6.4). The 6.2620.150 Pulsation dampener can be operated in both direc- tions. 761 Compact IC...

  • Page 36: Fig. 10: Connection Of The Pulsation Dampener

    Injection valve Pulsation dampener (6.2620.150) Connection capillary Connection to injection valve 6.1831.010 PEEK capillary, length L = 13 cm Filter unit PEEK (6.2821.120) Connection to purge valve Connection capillary 6.1831.010 PEEK capillary, length L = 13 cm 761 Compact IC...

  • Page 37: Connecting The Eluent Bottle

    • Fill eluent into eluent vessel 67 (clear glass, 2 L). • Place eluent bottle 67 at the front in bottle holder 10 on the 761 Compact IC (see Fig. 1). Install bottle attachment • Firmly screw threaded stopper 65 (6.1446.040; part of 6.1602.160) into the smaller threaded opening (M6) of bottle...

  • Page 38: Fig. 11: Connection Of Eluent Bottle

    Connect aspirating tubing to pump • Insert the free end of aspirating tubing 63 into one of the openings 12 in the interior of the 761 Compact IC (see Fig. 2). • Pull aspirating tubing 63 sufficiently far into the interior of the 761 Compact IC, cut off to the required length and push at least 5 mm of it onto aspirating capillary 40 (see Fig.

  • Page 39: Deaerating The Pump And Rinsing The Pulsation Dampener

    • Push 6.2816.020 Syringe (without needle) into connection 8 until the stop is reached. Open and connect system • Start the «761 Compact IC» PC program, if it has not been already been started (see section 2.5.3). • Select in the main window. Open either the...

  • Page 40: Column Connection

    <Off> IC pump pressure pump. Reduce flow rate • Reset the original flow rate under (e.g. Flow 0.5 mL/min • Click to send this value to the 761 Compact IC. <Send to unit> 761 Compact IC...

  • Page 41: Precolumns And Separating Columns

    The use of easily exchangeable precolumns protects the separating columns and prolongs their lifetime. The precolumns available from Metrohm (see section 6.3.2) are either real precolumns or precolumn cartridges, which are used together with the 6.2821.040 Cartridge head or the 6.2828.010 Precolumn cartridge holder.

  • Page 42: Fig. 12: Installation Of Precolumn Cartridges With Cartridge Head

    • Screw column connection capillary 28 to Manufit housing 73. The precolumn cartridge built into the cartridge head can only be rinsed together with the separating column (see section 2.7.7/8). This increases the rinsing time by approx. 20 min. 761 Compact IC...

  • Page 43: Precolumn Glass Cartridges With Cartridge Holder

    • If necessary, modify to the value suited for the Flow rate inserted separating column and click on <Send to unit> send this value to the 761 Compact IC. • Switch on high-pressure pump ( ) by clicking IC pump <On>...

  • Page 44: Ic Anion Precolumn Supersep

    • If necessary, modify to the value suited for the Flow rate inserted separating column and click on <Send to unit> send this value to the 761 Compact IC. • Switch on high-pressure pump ( ) by clicking IC pump <On>...

  • Page 45: General Information On Separating Columns

    (check manufacturer's specifications). The IC separating columns and precolumns currently available from Metrohm are listed in section 6.3.2. A test chromatogram and an infor- mation leaflet is provided with each column. You will find additional in- formation concerning these columns in the 8.732.2003 Metrohm Mono- graph «Ion chromatography»...

  • Page 46: Installation Of The Separating Column Without Suppressor

    • If necessary, modify to the value suited for the Flow rate inserted separating column and click on <Send to unit> send this value to the 761 Compact IC. • Switch on high-pressure pump ( ) by clicking IC pump <On>...

  • Page 47: Installation Of The Separating Column With Suppressor

    • If necessary, modify to the value suited for the Flow rate inserted separating column and click on <Send to unit> send this value to the 761 Compact IC. • Switch on high-pressure pump ( ) by clicking IC pump <On>...

  • Page 48: Suppressor Module

    2.8.2 Preparation of the peristaltic pump Before start-up the accessories for the 2-channel peristaltic pump built into the 761 Compact IC must be mounted according to Fig. 15. Pro- ceed as follows: Attach pump tubings • Loosen both tubing cartridges 48 mounted above pump drive 52 from the holding clamp 50 by pressing down snap-action lever 51 and remove from mounting pin 53 (see Fig.

  • Page 49: Fig. 15: Installing Pump Tubings

    Filter-Screw of Filter Unit PTFE tubing (6.1803.020) Part of 6.2821.120 Filter unit Filter-Housing of Filter Unit Suppressor inlet capillary for H Part of 6.2821.120 Filter unit Aspirating tubing for H Suppressor inlet capillary for H Aspirating tubing for H 761 Compact IC...

  • Page 50: Fig. 16: Connection Of The Separating Column With Suppressor

    6.1803.020 PTFE tubing PEEK coupling (6.2744.040) Aspirating tubing for H 6.1803.020 PTFE tubing Filter unit PEEK (6.2821.120) Coupling (6.2744.030) Inlet capillary to detector block Pump tubing (6.1826.060) for H (fixed mounting) Detector block (1.733.0110) Pump tubing (6.1826.060) for H 761 Compact IC...

  • Page 51: Connection Of Supply Bottles

    • Insert the free end of aspirating tubing 90 into one of the openings in 12 of the 761 Compact IC (see Fig. 2) from above and pull it sufficiently far into the interior. • Mount a coupling 91 (6.2744.030) to the inlet end of the rear...

  • Page 52: Fig. 17: Connection Of Supply Bottles

    • Insert the free end of aspirating tubing 89 into one of the openings in 12 of the 761 Compact IC (see Fig. 2) from above and pull it sufficiently far into the interior. • Mount a coupling 91 (6.2744.030) to the inlet end of the front pump tubing 93.

  • Page 53: Connection Of The Suppressor Module

    • Pull outlet capillary 101 marked with "Waste" of the suppres- sor module 47 from below through one of the openings 13 out of the inner compartment of the 761 Compact IC. • Lead outlet capillary 101 to a sufficiently large waste con- tainer and fix it in place.
  • Page 54 • Pull outlet capillary 100 marked with "Waste" of the suppres- sor module 47 from below through one of the openings 13 out of the inner compartment of the 761 Compact IC. • Lead outlet capillary 100 to a sufficiently large waste con- tainer and fix it in place.

  • Page 55: Putting Into Operation

    Proceed as fol- lows: Open and connect system • Start the «761 Compact IC» PC program, if it has not already been started (see section 2.5.3). • Select in the main window. Select the File / Open / System system file suited for the inserted separating column (e.g.

  • Page 56: Putting Into Operation With Suppressor

    At the same time, the suppressor module must be conditioned. Proceed as follows: Open and connect system "Prep-MSM*.smt" • Start the «761 Compact IC» PC program, if it has not already been started (see section 2.5.3). • Select in the main window.
  • Page 57 Check for leaks • Check all capillaries and their connections between the high- pressure pump and the detector block for escaping liquid. If eluent escapes anywhere, the appropriate compression fitting must be tightened further or changed. 761 Compact IC...
  • Page 58 This is why the tubing cartridges should be raised completely by loosening snap-action lever on the right-hand side if the pump is to remain switched off for a considerable length of time (the set contact pressure remains unchanged). 761 Compact IC...

  • Page 59: Connection Of External Devices

    Tubing connection 750 – injection valve • Loosen rotary nipple 31 which is screwed onto the inner side of connection 3 of the 761 Compact IC (see Fig. 3 and Fig. 4). • Pull aspiration tubing 4 completely out from connection 3 and screw it off from connection "1"...

  • Page 60: Connection Of The 766 Ic Sample Processor

    761 Compact IC. Sample changing and filling the sample loop are started by a remote signal produced by the 761 Compact IC (761 Compact IC as "Master"). The 6.2141.110 Cable is required for connecting the 766 IC Sample Processor.
  • Page 61 2.10 Connection of external devices • Connect the end of the 6.2141.110 Cable marked with "732/1" to the remote interface 24 of the 761 Compact IC (see Fig. 2). Tubing connection 766 – injection valve • At the 761 Compact IC, loosen the rotary nipple 31 screwed onto the interior side of connection 3 (see Fig.

  • Page 62: Connection Of Other Devices

    Before an external device is connected to the remote interface 24, the 761 Compact IC must always be switched off using mains switch 19 ! The pin assignment of the remote interface, its functions and the elec- trical requirements and the conditions are described in section 6.1.

  • Page 63: Operating Tutorial

    3.1 Requirements Operating tutorial This section introduces you to the operation of the 761 Compact IC by means of a brief operating tutorial which describes the basic operat- ing steps needed for the recording of an ion chromatogram using one of the system files supplied.

  • Page 64: Preparations

    2. In what follows, the most important points for the installation are described once again (for details, see the sections mentioned). Install 761 Compact IC ⇒ Setting up instrument section 2.2 ⇒ Installing and connecting detector block section 2.3.1...

  • Page 65: Calibration

    In the description of the calibration procedure it is assumed that the PC and 761 Compact IC are not in operation and that the system must first be conditioned again. If this is not the case (e.g. if you start the tutorial immediately after conditioning) then you can skip steps 1 to 6.
  • Page 66 , beside Measure(Baseline) this running time, analysis time, absolute conductivity and number of measuring points per second are displayed. The messages Running [761 Compact IC] Waiting for INJECT appear in the window [Suppressed] SYSTEM STATE ⇒...
  • Page 67 10 Switch injection valve to "FILL" position ⇒ Click on the button of the 761 icon in the system window to switch the injection valve to the "FILL" position. At the same time, the suppressor module is switched to the next position. 761 Compact IC...
  • Page 68 Measure SYSTEM STATE sages Running [761 Compact IC] INJECT done [Suppressed] ⇒ When the analysis time of 24 min set in the method has expired the recorded chromatogram is automatically evalu- ated and stored. The chromatogram window then closes.
  • Page 69 This time is automatically shown in the Time chromatogram by the cursor. If the retention time is not lo- cated in the area of the middle of the peak then the value in column should be adapted accordingly. Time 761 Compact IC...
  • Page 70 Time The optimized table could, for example, then appear as follows: 16 Start calibration ⇒ Click the button in the component window. <Concentrations> ⇒ Click on . The window appears. <Add> Add level 761 Compact IC...
  • Page 71 ⇒ Enter the concentrations of all components of the standard solution used in this column: ⇒ Click on . The following window appears: <Calibrate> ⇒ Confirm with Level 1 <OK> ⇒ Click on in the window. <OK> Concentrations 761 Compact IC...
  • Page 72 ⇒ Save the method under the previously given name s-03.mtw If you want to store the method under a different name then this must be newly selected for the system under PC icon / Setup / Processing method 761 Compact IC...

  • Page 73: Sample Determination

    Switch injection valve to "FILL" position ⇒ Click on the button of the 761 icon in the system window to switch the injection valve to the "FILL" position. At the same time, the suppressor module is switched to the next position. 761 Compact IC...
  • Page 74 Measure SYSTEM STATE sages Running [761 Compact IC] INJECT done [Suppressed] ⇒ When the analysis time of 24 min set in the method has expired data recording is automatically stopped and the chromatogram is integrated and evaluated. In the chroma- togram window the peaks which have been found are num- bered and the baseline drawn.
  • Page 75 , switch on the desired target option Report destination for report output. ⇒ Under , click all desired Items to report More items to report elements for the report output. ⇒ Click on to start the report output to the selected <Report> target. 761 Compact IC...
  • Page 76 Print File window. The standard printing window is opened where printer, printing range and number of copies can be selected. After confirmation with the results including the chro- <OK> matogram are printed out. 761 Compact IC...

  • Page 77: Operation

    Operation This section describes the most important points concerning the operation of the 761 Compact IC. For further details please refer to the on-line help in the PC program which can provide you with the required information rapidly and conveniently from any place in the program.

  • Page 78: Glossary

    The calibration method which is mainly used in ion chromatography is the external standard calibration (absolute calibration); calibration with an internal standard (relative calibration) or tabulated calibra- tion are also possible. 761 Compact IC...

  • Page 79: Overview Of Program Windows

    4.1.3 Overview of program windows The «761 Compact IC» program consists of different windows whose functionality is linked together. The different windows are: Main program window for file administration, 761 COMPACT IC...

  • Page 80: Main Window Elements

    4 Operation 4.1.4 Main window elements The elements of the main window are the menu bar, 761 COMPACT IC the tool bar and the status bar, indicating prompts and logged-in user. Menu bar Tool bar Status bar Prompts, information Logged-in user 4.1.5...

  • Page 81: Overview Of File Types

    View whole chromatogram Help Lock system Connected system 4.1.6 Overview of file types The following file types are produced by the «761 Compact IC» soft- ware: Batch reprocessing file *.bar This binary file contains data of the batch reprocessing queue. The file is stored automatically in the *.bar...

  • Page 82: Context Sensitive Menus

    Reduces a distance between channels of a chromatogram. [ 0 (Zero) ] Adjusts a zero on the last point of a chroma- togram (running chromatogram) or its lowest level (finished run). Only part of the chromatogram is on screen: 761 Compact IC...

  • Page 83: Help

    Green texts can be clicked to jump to a different Help topic. Violet texts identify the dialog item, parameter or button in the corresponding window. Blue texts identify important information. 761 Compact IC...

  • Page 84: Instrument And Software Settings

    Save fonts configuration 4.2.2 Security system The «761 Compact IC» program has a security system based on the list of users. Every user has his unique password and one of the following access levels: Restricted access to program functions. Allows...

  • Page 85: Global Settings

    This user name stamps all methods, chromatograms and reports. It is possible at any time to change the user with the menu item 761 COMPACT IC / Options / Lock sys- 4.2.3 Global settings 761 COMPACT IC / Options / Global preferences This window is used for global program settings.
  • Page 86 If this option is enabled, the button in <Apply> system settings windows is replaced by the button. The system settings can be <Save as> saved in a new file if the <Save as> <OK> button is clicked. 761 Compact IC...

  • Page 87: Com Port

    Default colors for chromatographic windows <Default colors> (details see section 4.5.3). 4.2.4 COM port 761 COMPACT IC / Options / 761 Compact IC:COM1 This menu item opens the window for COM port (serial RS232 in- Links terface) selection and settings.

  • Page 88: Systems

    4.3.1 System window A system window is opened with 761 COMPACT IC / File / Open / System and the selection of the desired system file. It contains icons for PC, Watch window (screen) and 761 Compact IC. 761 Compact IC Watch window 4.3.2...

  • Page 89: System Functions

    Start/stop hardware and record baseline SYSTEM / Control / Startup hardware (Measure Baseline) Starting the hardware at the 761 Compact IC includes sending of Sys- , starting of the high-pressure pump and (if present) tem startup values starting of the peristaltic pump.

  • Page 90: Start/Stop Determinations

    SYSTEM / Control / Start determination Start determination using the settings of the selected system. At this start command, the are set at the 761 Compact IC. System startup values The high-pressure pump and the peristaltic pump are started if they are not already running.
  • Page 91 Date and time of sample collection (the default Date/time when... values are equal to the date and time when the chromatogram starts). option is disabled if determinations are made with an Verify sample active sample queue. 761 Compact IC...

  • Page 92: System Settings

    The two objects available are: Data acquisition defined in the method. RECORDER Time program defined on the tab of 761 Compact IC Program the system control window. These two objects can be moved from one field to the other using the buttons.

  • Page 93: Print System Parameters

    The system report includes the name of the method linked to the system, the con- figuration settings for the 761 Compact IC, the system startup values and the time program (incl.

  • Page 94: Watch Window

    This window contains the following two fields: Connected data source. Connected Default setting: Cond[ 761 Compact IC] Available data sources of the 761 Compact IC: Available Conductivity # Cond Pressure # Press The data sources can be moved from one field to the other using the buttons (only one data source can be connected).

  • Page 95: Instrument Icon

    Injection valve in Injection valve in "INJECT" position "FILL" position The instrument icon for the 761 Compact IC is one of the three compo- nents of the window. If the system is connected, the 761 icon SYSTEM contains two buttons for manual control of the injection valve: Switch injection valve to "INJECT"...

  • Page 96: Instrument Control For Connected System

    For a connected system, the tab is displayed. It allows manual Control control of the 761 Compact IC functions and setting of startup values to be sent to the instrument. This tab shows the current measurement val- ues for conductivity and pressure.
  • Page 97 Stop peristaltic pump. <Off> The system startup values are sent and applied System startup values to the 761 Compact IC each time the system is connected, a determination is started, or the values are sent manually with <Send to unit>...

  • Page 98: Time Program

    Enable program start (a disabled program is ENABLED not started). Add new program instruction. <Add> Delete selected program instruction. <Delete> Test the time program (error messages are dis- <Verify> played if program is wrong). 761 Compact IC...
  • Page 99 Switch suppressor module to the next position. Peristaltic on, off Switch on or off the peristaltic pump. Remote configuration On the subtab user-defined remote commands can Remote configuration be defined, which can be inserted into a time program. 761 Compact IC...

  • Page 100: Configuration

    <Activate> sertion into the time program. Configuration tab in the system settings window contains configura- Configuration tion settings for the 761 Compact IC. Selection of instrument version: 761 unit version 761 Compact IC without suppressor 761.0010 761 Compact IC with suppressor 761.0020...

  • Page 101: Hardware Settings

    45 °C Thermostatting functions only if the ambient temperature is at least 5 °C lower than the operating temperature. It normally takes … ± 60 min after power on until a temperature stability of 0.01 °C is attained. 761 Compact IC...
  • Page 102 Valve Sup- pressor These values should only be changed after consulting the Metrohm Service. Outputs tab of the hardware settings window defines remote output Outputs signals to be set automatically if specific events occur. 761 Compact IC...
  • Page 103 Alarm stops for which the 761 Compact IC is stopped immediately. At an alarm stop, high-pressure pump and peristaltic pump are stopped immedi- ately, the running determination and the active sample queue are also stopped.

  • Page 104: Timer

    Leak struments interior. This information is also stored in the instrument itself, so that it is stopped automatically even without connection to the PC. Temporary power failure at the 761 Compact IC Power on hardware. 4.3.8 Timer the timer can be used to program system tasks which are started automatically daily or once at the desired time.

  • Page 105: System State Window

    SYSTEM STATE nected. It shows status and error messages for this system. Messages concerning the 761 Compact IC hardware are followed by [761 Compact , messages concerning the loaded system are followed by ["folder...

  • Page 106: Error Messages

    4 Operation Error messages Bad connection between PC and 761 Compact IC Detection of hard- or instrument switched off (check connecting ware failed cable or switch on instrument). The leak detector has detected a leak (check IC LEAK DETECTED system and connections).

  • Page 107: Methods

    4.4.1 Method file handling The following menu items are used for opening and saving of methods: 761 COMPACT IC / File / Open / Method Load an existing method file ( ) from the directory and *.mtw Methods open an empty chromatogram window.

  • Page 108: General

    Name of the detector. It can be entered with Detector Method setup / Measure Number of the current run starting from the very first one. All runs are automatically numbered by the system. 761 Compact IC...

  • Page 109: Sample

    Amount Concentration of the internal standard compo- Internal standard amount nent for relative concentration calculations. Date and time of sample collection (the default Date/time when... values are equal to the date and time when the chromatogram starts). 761 Compact IC...

  • Page 110: Column

    . It is calculated by the system in accor- ear flow dance with the settings defined on Method setup / Math Precolumn Internal diameter of the precolumn in mm. Length of the precolumn in mm (set length to 0 Length if no precolumn is used). 761 Compact IC...

  • Page 111: Eluent

    Comment of passport for entry of free-text user comments into the Comment chromatogram description. Use this feature to enter any additional in- formation about the chromatogram not included in other sections of the method. 761 Compact IC...

  • Page 112: Method Log

    Clear all GLP messages in the GLP Log and <Clear> add a new GLP comment. Text can be entered in the window, date/time and New comment logged-in user are automatically added. 761 Compact IC...

  • Page 113: Data Log

    Add a new GLP comment to the Data Log. Text <Add new> can be entered in the window, New comment date/time and logged-in user are automatically added. 761 Compact IC...

  • Page 114: Method Setup

    4 Operation 4.4.3 Method setup 761 COMPACT IC / Method / Method setup This menu item opens the window which includes the Method setup most common parameters for data acquisition and evaluation of the method and consists of the following tabs: General information on determination.

  • Page 115: Filters

    Number of data points per chromatogram Raw data points (read-only). Number of data points per smallest peak on the Smallest peak has ... chromatogram (read-only). This information is valuable to perform the procedure Compress (data compression). 761 Compact IC...

  • Page 116: Processing

    <Browse> new directory. Name and path of the program to be started Program before automatically before the run is started. Name and path of the program to be started Program after automatically after the run is finished. 761 Compact IC...

  • Page 117: Math

    Selection of the method for void time calcula- Calculation method tion: Manual entry in the field. None Void time The peak corresponding to the first component 1st component is selected as a void time marker and its reten- 761 Compact IC...
  • Page 118 The index scale is constructed on the basis of Internal the current chromatogram. All components used for index scale calibration should be pre- sent in the current sample. The index scale is constructed on the basis of External another standard chromatogram. 761 Compact IC...

  • Page 119: Integration

    4.4 Methods 4.4.4 Integration 761 COMPACT IC / Method / Integration This menu item opens the window which contains Integration parameters parameters and events for peak integration and consists of the follow- ing two tabs: Integration parameters. Setup Integration events.

  • Page 120: Setup

    For an optimal evaluation, it is rec- ommended to enter the width of the narrowest peak on the chromatogram (normally 2…10 s). Entry range: 0.1…480 s 761 Compact IC...
  • Page 121 If this option is enabled, negative peaks are Negative peaks also detected. Interpolate baseline start/stop If this option is enabled, the baseline start and stop points are interpolated. This setting is rec- ommended for very sensitive determinations with high noise 761 Compact IC...

  • Page 122: Events

    Number of integration events (read-only). Number of events Add event to the list. <Add> Edit the selected event. <Modify> Delete the selected event. <Delete> Accept integration parameters and perform re- <Apply> integration. 761 Compact IC...
  • Page 123 (upslope) or terminated (downslope). Force peak end at the time of the event. Up- Set peak end slope peaks are rejected (except those born by event), downslope peaks are ter- Set peak start minated. 761 Compact IC...
  • Page 124 Set horizontal baseline for all peaks except the Set back horizontal base first one of adjacent peaks that are not sepa- rated. The baseline is drawn backwards from the peak end point. Set default baseline detection mode. Set normal baseline 761 Compact IC...
  • Page 125 The intersection of the baseline with the signal is defined as peak end point. Cancel horizontal baseline Clear mode. Force horizontal baseline Force horizontal Cancel horizontal base back base back 761 Compact IC...
  • Page 126 Set width Width fault linear growth of expected peak. Sets new value. Set slope Slope Sets new value. Set min height Minimum peak height Sets new value of parameter. Set rider ratio Rider ratio 761 Compact IC...

  • Page 127: Calibration And Quantification

    (standards). For each calibrated component a calibration curve is constructed as a result. With the 761 Compact IC three different procedures can be used for the construction of the calibration curve. By far the most important method for ion chromatography is the external standard calibration (absolute calibration) which is described in detail in this section.

  • Page 128: Notations

    Q vs. response R) and outputs the calibration func- tion W(R) used for prediction of the component quantity Q = W(R Subscript values used: Stands for j-th calibration level run. Stands for standard component. Stands for component number. 761 Compact IC...

  • Page 129: External Standard Calibration

    V': ) / V' Component table 761 COMPACT IC / Method / Calibration / Components If the component table is opened, the chromatogram window is split into two parts. The upper one shows the chromatogram, the compo- nent table appears in the bottom part of the screen. When moving into the component table, a special cursor in the upper part of the window jumps to the peak corresponding to the current component.
  • Page 130 (coefficient k of the calibration formula). Minimum (Maximum) concentration value for min C (max C) the component. Components whose concentration leaves the range are marked in the min C…max C peak table by the sign " ". 761 Compact IC...

  • Page 131: Peak Identification

    Reject all changes and close the <Cancel> Component ta- The standard methods supplied with the «761 Compact IC» program all contain a component table with pre-defined components with entries for the names and retention times. If the output of all peaks is required in the result report then a so- called universal component can be defined in the component table for this purpose;...
  • Page 132 Information on the component with the worst Worst case... (largest) deviation of actual and expected reten- tion time. Deviation is given as a part of com- ponent’s identification window. Average relative deviation Relative deviation averaged for all components. 761 Compact IC...

  • Page 133: Concentration Table

    4.4 Methods Concentration table 761 COMPACT IC / Method / Calibration / Concentrations Selecting this menu item or clicking on in the compo- <Concentrations> nent table opens the window with the concentration table Concentrations containing concentrations of all components for all...
  • Page 134 Delete the current calibration level (where cur- <Delete> sor is situated) from the concentration table. Calibrate the current chromatogram with the se- <Calibrate> lected calibration level. The following window appears: Calibration level to be used for recalibration. Level 761 Compact IC...

  • Page 135: Calibration Curve

    4.4 Methods Calibration curve 761 COMPACT IC / Method / Calibration / Graphs Selecting this menu item or clicking on in the component ta- <Graphs> ble opens the window. Component In this window the results of the calibration are shown for each compo- nent together with the calibration curve.
  • Page 136 Tabulated calibration plified method of external standard calibration. If this checkbox is marked then the correspond- Local ing parameter is valid for the current compo- nent only. Otherwise this parameter is global (i.e. default for all other components). 761 Compact IC...

  • Page 137: Update Calibration

    Internal standard calibration Tabu- method (details see on-line lated calibration help). Update calibration 761 COMPACT IC / Method / Calibration / Update Selection of this menu item opens the window. Update Replace the expected retention times of the Retention time components with the retention times of the cor- responding peaks obtained in the current run.

  • Page 138: Load And Save Calibration Data

    This run Load and save calibration data 761 COMPACT IC / Method / Calibration / Load from method Load the calibration from the method. This option is used to update the calibration for the current run by the one taken from the method used for acquisition.

  • Page 139: Report Output

    4.4 Methods 4.4.6 Report output Report options 761 COMPACT IC / Method / Report options 761 COMPACT IC / Process / Make report window is divided into several regions that combine Report options parameters for report output on their functionality and includes several different areas.
  • Page 140 Retention Height Area Conc. Name uS/cm uS/cm*sec mg/L 2.83 0.09 0.803 0.04 fluoride 5.06 5.35 94.134 8.06 chloride 6.11 0.31 10.254 0.00 10.57 2.52 57.007 9.06 nitrate 16.87 1.43 53.565 6.40 sulfate _____________________________________________ 20.01 9.70 215.763 23.57 761 Compact IC...
  • Page 141 Spikes filter: Median filter: slit: Gauss filter: slit: Integration parameters and integration events. Integration INTEGRATION DEFAULTS Channel: Cond Delay: 2.60 min Width: 5.00 sec Broadening: 2.00 Slope: 5.00 Asymmetry: 1.50 MinArea: 0.00 MinHeight: 0.01 Rider ratio: 0.00 761 Compact IC...
  • Page 142 K1 = 0.0111539 K0 = 0.121632 Base: Area Ref.channel: ch1 ISTD: Formula: Y=K2·X^2+K1·X+K0 Weight: Level Height Area Conc. Volume Retention Used File 6.46 10.8 Yes g8140800.chw 10.8 Yes g8140823.chw 90.9 2.36e+03 10.8 Yes g8140858.chw 5.04e+03 10.8 Yes g8140929.chw 761 Compact IC...
  • Page 143 Coef µS/cm). Estimated baseline noise value of the channel Noise in ADC conversion units (bits). Not used for 761 Compact IC. Shift Report destination The following output devices can be selected simultaneously in any combination as targets for report output: Output report (without curves) to screen.
  • Page 144 Retention time Height Area Response factor Concentration Concentration% Name Relative concentration This quantification method uses the internal standard method to calculate the relative con- centrations of the components. For this proce- dure, a must be selected Standard component 761 Compact IC...
  • Page 145 Determines the order of the components in the Printing order peak table. Lists run results for all peaks detected. Uniden- By peaks tified peaks (corresponding to the universal component) are included, but missing compo- nents are not listed. 761 Compact IC...
  • Page 146 ANSI or ASCII format. So add an extension like to the file name. If the *.txt chromatogram plot checkbox is checked, the plot is saved in a separate file in the WMF *.wmf format under the same name. 761 Compact IC...
  • Page 147 ) to the void time of the system t (t - t = (t ) / t Total for this column is equal to the capacity factor of the last peak of the chromatogram. Resolution R for two neighboring peaks is cal- resolution culated as: 761 Compact IC...
  • Page 148 Peak asymmetry A is calculated at of the asymmetry peak height as a ratio of width after the top of the peak w to the width before the top w Coefficient k of the calibration curve. response factor 761 Compact IC...
  • Page 149 Σ Σ The types of components are designated by a type one-letter code: Reference component (used for peak identifica- tion). Standard component. Calibration standard in the case it is different from the quantification standard. 761 Compact IC...
  • Page 150 (horse) in this case. The complete component type may look like: BBD : !R Number of the group for the component. group Not used for 761 Compact IC. spectral ratio Name of the component. name File name of chromatogram. This column is...

  • Page 151: Chromatograms

    A chromatogram can be scaled with the help of keyboard or mouse functions or through the window opened with Chromatogram axes . Some of the win- COMPACT IC / View / Appearance / Chromatogram axes dow control functions are collected in the menu. Window 761 Compact IC...

  • Page 152: Chromatogram File Handling

    4 Operation 4.5.2 Chromatogram file handling Open chromatogram 761 COMPACT IC / File / Open / Chromatogram Load an existing chromatogram file ( ) from the directory and *.chw Data open the chromatogram window. The following window appears: Filename (common wildcards as Filename possible).

  • Page 153: Save Chromatogram

    Export the selected chromatogram in the AIA format (Analytical Instru- ment Association) as CDF file ( *.cdf 761 COMPACT IC / File / Export / Raw data to txt Export chromatographic raw data into an ASCII text file ( ). The fol- *.txt...

  • Page 154: Import Chromatogram

    761 COMPACT IC / File / Import / AIA file Import chromatogram in the AIA format (Analytical Instrument Associa- tion) from a CDF file ( *.cdf 761 COMPACT IC / File / Import / Raw data from txt Import chromatographic raw data from a text file (ASCII format). *.txt This is only possible if an appropriate method has been opened.

  • Page 155: Graphical Representation

    4.5 Chromatograms 4.5.3 Graphical representation Appearance 761 COMPACT IC / View / Appearance This menu item opens the window. It determines the ap- Appearance pearance of the chromatogram and consists of four tabs: Scaling of chromatogram axes. Chromatogram axes Settings for peak labels and baseline Labels drawing.
  • Page 156 Labels of the window with parameters for peak labeling Labels Appearance and baseline drawing. Peak labels No peak labels. None Peak number. Peak number Retention time. Retention time Name of the component. Component name 761 Compact IC...
  • Page 157 If is selected, total all chromatograms are added and the resulting addition curve is shown. Select all chromatograms in the selection win- <Show all> dow. Deselect all chromatograms in the selection <Hide all> window. 761 Compact IC...
  • Page 158 Set colors in the selected chromatogram win- <Load defaults> dow to the set defaults colors. Save color settings in the selected chroma- <Save defaults> togram window as default colors. 761 Compact IC...

  • Page 159: Other Graphical Functions

    4.5 Chromatograms Other graphical functions 761 COMPACT IC / View / X full scale By selecting this menu item or pressing [ Ctrl ] + [ Home ] the X axis is scaled so that the chromatogram perfectly fits the window horizontally.

  • Page 160: Peak Editor

    [ Delete ] 761 COMPACT IC / Peak / Delete peak Delete selected peak. 761 COMPACT IC / Peak / Select nearest point Move the cursor to the nearest start, top, end, or valley point and select the peak. 761 COMPACT IC / Peak / Select start point Move the cursor to the beginning of the nearest peak and select the peak.

  • Page 161: Moving The Cursor

    4.5 Chromatograms 761 COMPACT IC / Peak / Select end point Move the cursor to the end of the nearest peak and select the peak. 761 COMPACT IC / Peak / Select valley point Move the cursor to the valley of the two nearest peaks.

  • Page 162: Printing

    4 Operation 4.5.5 Printing Page layout for printing 761 COMPACT IC / File / Page layout The selection of this menu item or clicking on in the <Page...> Report op- window opens the window for page layout parameters. tions Page layout Selection of length units.

  • Page 163: Printer Settings

    4.5 Chromatograms Printer settings 761 COMPACT IC / File / Printer setup By selecting this menu item the window is opened where PRINT SETUP printer, paper size and format can be defined. Print preview 761 COMPACT IC / File / Preview...

  • Page 164: Subtraction Of A Chromatogram

    4 Operation Subtraction of a chromatogram 761 COMPACT IC / Process / More / Subtract This menu item opens the window allowing the Subtract chromatogram subtraction of any opened chromatogram from the active, selected chromatogram. Select the chromatogram that should be subtracted, click on <Sub-...

  • Page 165: Autodatabase Options

    4.5 Chromatograms Autodatabase options The «Autodatabase 1.0» PC program is a part of the 761 Compact IC standard accessories and is used to save and handle chromatograms and results produced with «761 Compact IC» in a database. You find a detailed description of this database program in the 8.110.8193 Instructions for Use supplied.

  • Page 166: Sample Queue

    Methods 4.6.1 Sample queue file handling Open sample queue 761 COMPACT IC / File / Open / Sample queue SYSTEM / System / Sample queue These two menu items open the window for opening an existing OPEN sample queue file or creation of a new sample queue file *.que...

  • Page 167: Sample Queue Control

    4.6 Sample queue 4.6.2 Sample queue control Sample queue overview table 761 COMPACT IC / File / Open / Sample queue SYSTEM / System / Sample queue These two menu items open the window for opening an existing OPEN sample queue file or creation of a new sample queue file *.que...

  • Page 168: Start Sample Queue

    Started row. If processing the sample queue is interrupted with then it can <Pause> be continued again with (with a running chromatogram only <Start> when data acquisition is finished). 761 Compact IC...

  • Page 169: Pause Sample Queue

    This function is only available if the sample queue has been interrupted by pressing the button. <Pause> 4.6.3 Sample queue editor Open queue editor window SAMPLE QUEUE OVERVIEW / Control / Edit This menu item opens the window for editing the sample Queue editor queue table. 761 Compact IC...
  • Page 170 Indication whether the sample determination Done has been done or not: determination not yet done determination or injection done 1…n First sample description. Sample Info 1 Second sample description. Sample Info 2 761 Compact IC...

  • Page 171: Sample Queue Editor Functions

    Save the modified sample queue table and close the sample queue editor window. QUEUE EDITOR / File / Exit Close the sample queue editor window. An inquiry appears asking whether or not the sample queue should be saved. 761 Compact IC...

  • Page 172: Batch Reprocessing

    *.bar Data 4.7.1 Batch reprocessing queue file handling Open batch reprocessing queue 761 COMPACT IC / File / Open / Batch reprocessing Load an existing batch reprocessing file ( ) from the directory *.bar Data and open the window.

  • Page 173: Perform Batch Reprocessing

    4.7 Batch reprocessing 4.7.2 Perform batch reprocessing Reprocess options window 761 COMPACT IC / File / Open / Batch reprocessing 761 COMPACT IC / File / Open / Last batch These two menu items are used to open the window, in...
  • Page 174 If this option is switched off, the calibra- tion curve stored in the first chromatogram re- mains active. Each further calibration chroma- togram in the batch reprocessing queue adds a new point to this calibration curve. 761 Compact IC...
  • Page 175 Report options of the report settings. Send chromatogram data to Autodatabase file Send to Autodatabase specified in the window Autodatabase options (see section 4.5.6). <Edit Autodatabase options> Open the window (see Autodatabase options section 4.5.6). 761 Compact IC...

  • Page 176: Merge Chromatograms

    [ Shift ] + [ ↑ ] and decreased by pressing [ Shift ] + [ ↓ ]. The chromatogram axes, labels and colors can be set in the Appearance window. The multi-channel chromatogram can be saved with File / Save / Chroma- togram 761 Compact IC...

  • Page 177: Batch Reprocessing Queue Editor

    Internal standard amount nent for relative concentration calculations. Will be placed into appropriate passport field. Calibration level (see section 4.4.5) for the Calibration level sample: Level stays for normal analysis, levels and greater for calibration runs. Correct filling 761 Compact IC...

  • Page 178: Batch Reprocessing Queue Editor Functions

    QUEUE EDITOR / File / Save & Exit Save the modified batch reprocessing queue and close the QUEUE EDI- window. QUEUE EDITOR / File / Exit Close the batch reprocessing window without saving the QUEUE EDITOR modified batch reprocessing table. 761 Compact IC...

  • Page 179: Notes - Maintenance - Faults

    To avoid contamination by abrasive particles arising from piston seals of the high-pressure pump, it is advantageous to install an in-line filter between the pump and the injection valve. In the 761 Compact IC a 6.2821.120 Filter unit PEEK is already mounted for this purpose (see section 2.6.2).

  • Page 180: High-Pressure Pump

    Pulsation dampener The MF 6.2620.150 Pulsation dampener belongs to the standard ac- cessories of the 761 Compact IC; its installation is described in sec- tion 2.6.2. It is used to reduce interfering pulsation in highly sensitive measurements and also protects the column material against pressure shocks caused by the injection.

  • Page 181: Eluents

    2.9.2. If the pump is to remain switched off for a lengthy period of time the tubing cartridges 48 should be raised completely by loosening the snap-action lever 51 on the right-hand side (the set contact pressure remains unchanged). 761 Compact IC...

  • Page 182: Suppressor Module

    (see section 2.8.2). Operation The Metrohm Suppressor Module MSM comprises a total of 3 sup- pressor units which are in turn used for suppression, regenerated with sulfuric acid and rinsed with water. To record every new chromatogram under comparable conditions, work is normally carried out with freshly regenerated suppressor.

  • Page 183: Maintenance And Servicing

    1.4.1. Maintenance by Metrohm service Maintenance of the 761 Compact IC is best done as part of an annual service performed by specialists from the Metrohm company. If work is frequently performed with caustic and corrosive chemicals, it may be necessary to shorten the interval between servicing.

  • Page 184: Recycling

    • with the 6.1010.000 IC Cation column METROSEP Cation 1-2. 5.2.4 Shutdown If the 761 Compact IC is shut down for a considerable length of time, the entire IC system (without column and suppressor) must be rinsed free from salt with methanol/water (1:4) to avoid crystallization of elu- ent salts with the corresponding subsequent damage.
  • Page 185 • Switch on high-pressure pump and rinse column with eluent for ca. 10 min, then switch off pump. Connect column to detector block • Screw outlet end of separating column 81 to inlet capillary 45 or suppressor inlet capillary 96. 761 Compact IC...

  • Page 186: Maintenance Work At The Pump Head

    When the special tool is screwed into the piston seal latter is completely destroyed! If you use only aqueous eluents the 6.2741.000 Piston seal can be replaced by the 6.2741.010 PE Piston seal available as an option. 761 Compact IC...

  • Page 187: Fig. 19: Components Of The Pump Head

    Screw holder for valve Spring (6.2824.060) for auxiliary piston Piston cartridge (4.709.0760) Special tool (6.2617.010) to remove the piston seal 112 Piston guide sleeve (4.709.4380) Special tool (6.2617.010) to install the piston seal 112 Sapphire supporting ring (6.2824.030) 761 Compact IC...
  • Page 188 If by mistake an inlet valve is installed instead of the outlet valve , an extreme pressure buildup occurs within the working cylinder, which is not detected by the pressure transducer and will destroy the piston seal 761 Compact IC...

  • Page 189: Fig. 21: Components Of Inlet Valve 113 And Outlet Valve 114

    Sapphire sphere Ceramic holder for sapphire sphere The large recess must point in the direction of the sapphire sphere Seal The larger opening must point outwards 113 and outlet valve 114 Fig. 21: Components of inlet valve 761 Compact IC...

  • Page 190: Regeneration Of The Suppressor Module

    • Disconnect suppressor from separating column and detector. Regenerate suppressor • Connect the inlet capillary 99 marked "H " to the inlet capillary 26 using coupling 33 (see Fig. 10 and Fig. 16). This connects the suppressor module directly to the high-pressure pump. 761 Compact IC...

  • Page 191: Cleaning The Suppressor

    • Disconnect input capillary 96 of the suppressor module 47 from the separating column 81 (see Fig. 16). • Disconnect output capillary 97 from inlet capillary 45. • Disconnect inlet capillaries 98 and 99 from the filter units 96 (supply from peristaltic pump). 761 Compact IC...
  • Page 192 (do not use tools). Connect and condition the suppressor • Reconnect the suppressor to the IC system. • Before switching the suppressor to the next position for the first time, rinse all 3 suppressor units with solution for 5 min. 761 Compact IC...

  • Page 193: Replacing The Suppressor

    • Unscrew nut 125 from suppressor holder 128. • Pull out connection piece 126 and suppressor rotor 127 from suppressor holder 128 (the connection piece and the rotor normally stick together). • Loosen connection piece 126 from suppressor rotor 127. 761 Compact IC...
  • Page 194 (do not use tools). Connect and condition the suppressor • Reconnect the suppressor to the IC system. • Before switching the suppressor to the next position for the first time, rinse all 3 suppressor units with solution for 5 min. 761 Compact IC...

  • Page 195: Exchanging The Pump Tubing

    • Press contact pressure lever 49 upwards until the solution just starts to be drawn in. Then press contact pressure lever upwards until it clicks once more to obtain optimal contact pressure. • Switch off peristaltic pump. 761 Compact IC...

  • Page 196: Faults And Malfunctions

    4.3.8. 5.3.2 Malfunctions and their rectification If difficulties appear with the 761 Compact IC during analyses, their causes are best investigated in the order separating column → high- pressure pump → eluent → connections. Several of the malfunc- tions which may appear are listed in the following table with details of possible causes and countermeasures.
  • Page 197 • Replace the 6.2821.130 • Contamination of the Filter (see section 2.3.6) filter in the 6.2821.120 Filter unit PEEK • Clean or replace suppres- • Counterpressure at sor (see section … suppressor module too 5.2.6 5.2.8) high 761 Compact IC...

  • Page 198: Diagnostic Tests / Validation / Glp

    Under the title «Application Bulletin No. 277 – Validation of Metrohm ion chromatographs» an example of such a standard oper- ating procedure is available from Metrohm; it can be adapted and used with the 761 Compact IC. Further information on the subjects of QA, GLP and validation can also be found in the brochure «Quality management with Metrohm»,...

  • Page 199: Appendix

    Operating temperature Adjustable in steps of 5°C from 25…45°C ± 2.5°C Max. temperature deviation ≥ 30 min Heating time ≤ 0.01°C at constant ambient temperature Temperature stability Connection for detector block Dsub 15 pin (female) 761 Compact IC...

  • Page 200: 6.1.3 Injection Valve

    Response time: 5 pump cycles Pump head 40 µL Pump head volumes Main piston: 20 µL Priming piston: 28.5 µL Pump displacement Main piston: 14.25 µL volumes Priming piston: Length of stroke Main piston: 3.6 mm Priming piston: 1.8 mm 761 Compact IC...

  • Page 201: 6.1.5 Peristaltic Pump

    Resistance < 1 MΩ (for deion. water) 6.1.8 RS232 interface Connector Dsub 9 pin (male) Function TxD and RxD signal for connection with software handshake Default settings 9600 baud, 8 bit, 1 stop bit, no parity, XON/XOFF Pin assignment 761 Compact IC...

  • Page 202: Remote Interface

    5 mm dia., 20 mm length 100…120 V: 1.0 A (slow-blow) 220…240 V: 0.5 A (slow-blow) 6.1.12 Safety specifications Construction/testing According to IEC 1010 / EN 61010 / UL 3101-1, protection class 1, degree of protection IP20 761 Compact IC...

  • Page 203: Electromagnetic Compatibility (Emc)

    UL94VO, CFC-free Material of base Steel, enameled Width 259 mm Height 446 mm Depth 355 mm Weight 2.761.0010: 13.5 kg (without accessories) 15.7 kg (with accessories) 2.761.0020: 14.7 kg (without accessories) 21.7 kg (with accessories) 761 Compact IC...

  • Page 204: Standard Equipment

    Standard equipment Subject to changes ! All dimensions are given in mm. The 761 Compact IC is available in two versions: • 2.761.0010 Compact IC without suppressor module • 2.761.0020 Compact IC with suppressor module These instruments include the following parts: Quant.
  • Page 205 PTFE, with connector for 6.2821.090 aspirating filter Length = 2.5 m For the connection high-pressure pump – eluent bottle 6.2023.020 SGJ clip 6.2027.030 Column holder Diameter d = 8.5 mm 6.2027.040 Column holder Diameter d = 11.3 mm 761 Compact IC...
  • Page 206 6.2621.000 Adjustable spanner max. 6.2621.030 Hexagon key 4 mm For mounting the pump head of the high-pressure pump. 29.5 6.2744.010 PEEK compression fitting For the connection of 6.1831.010 PEEK capillaries or 6.1822.010 PTFE microcapillaries, set of 5 761 Compact IC...
  • Page 207 Coupling ⁄ – Luer Coupling for connection of a 6.1803.000 PTFE capillary to connection 2 of the 761 Compact IC when a 750 Autosam- pler or a 766 IC Sample Processor is used 6.2744.030 PEEK coupling Connection between 6.2744.010 PEEK compression fitting and 6.1826.060...

  • Page 208: Optional Accessories

    PEEK coupling " ⁄ For connection of capillaries 6.2744.070 PEEK compression fitting short Spare part for 6.2824.100 Pump head Set of 5 6.2821.130 Filter for filter unit PEEK Spare part for 6.2821.120 Filter unit PEEK. Set of 10 761 Compact IC...

  • Page 209: High-Pressure Pump

    65.5 6.2824.030 Sapphire supporting ring Spare part for 6.2824.100 Pump head ∅3.2 ∅6.3 6.2824.050 Spring for main piston Spare part for 6.2824.100 Pump head ∅11 6.2824.060 Spring for auxiliary piston Spare part for 6.2824.100 Pump head ∅11 761 Compact IC...

  • Page 210: Separating Columns And Precolumns

    Column dimensions: 250 × 4.0 mm Precolumn: 6.1005.040 6.1005.040 IC precolumn cartridge PRP-X300 ∅6.4 To prolong the service life of the 6.1005.030 IC exclusion column PRP-X300. Column dimensions: 20 × 4.0 mm Installation using 6.2821.040 Cartridge head. 761 Compact IC...
  • Page 211 Column dimensions: 75 × 4.6 mm Precolumn: 6.1005.050 (installation with 6.2821.050 Twin cartridge holder) 6.1006.200 Preconcentration cartridge METROSEP Anion For anion preconcentration. Column dimensions: 30 × 3.0 mm Installation using 6.2828.010 Precolumn cartridge holder. 761 Compact IC...
  • Page 212 6.1012.100: set of 10 6.1012.X10 Sample pretreatment cartridge IC-H Cation exchanger in H orm. Removes interfering 15.5 2– – cations, CO , HCO or for alkaline samples. With Luer connection. 6.1012.010: set of 50 6.1012.110: set of 10 761 Compact IC...
  • Page 213 Spare part for 6.1005.000, 6.1005.010, 6.1005.030, 6.1007.000 and 6.1010.000 separating columns; set of 4. 6.2821.040 Cartridge head To hold precolumn cartridges; installed in the inlet capillary of the separating column. 6.2821.080 Steel spacer Spare part for 6.2821.040 Cartridge head. ∅0.25 ≈8.5 761 Compact IC...
  • Page 214 METROSEP Anion Dual 1. 6.2828.020 Glass cartridge holder To hold the 6.1006.0040 Column cartridge METROSEP Anion Dual 1. 6.2832.000 Suppressor rotor Replacement cartridge for Metrohm suppressor module 6.2832.010 Connection piece for suppressor rotor with input and output leads 761 Compact IC...

  • Page 215: Additional Devices And Cables

    11 mL; incl. accessories. Accessories: 6.2743.050 PP sample vessels, set of 2000 6.2743.060 Polyethylene stoppers, transparent, set of 1000 6.2125.010 Cable Connecting cable 761 Compact IC (RS232 interface) – PC 9 pol. neg. Adapter cable 25-pin to 9-pin. 25 pol. 0.3 m 6.2125.020...

  • Page 216: Warranty And Conformity

    Metrohm from any liability to pay compensation. If any instruments and parts have to be returned, the original packaging should be used if at all possible.

  • Page 217: Eu Declaration Of Conformity

    6.4 Warranty and conformity 6.4.2 EU Declaration of conformity EU Declaration of Conformity The METROHM AG company, Herisau, Switzerland hereby certifies, that the instrument: 761 Compact IC meets the requirements of EC Directives 89/336/EEC and 73/23/EEC. Source of the specifications: EN 50081-1 Electromagnetic compatibility, basic specification;...

  • Page 218: Certificate Of Conformity And System Validation

    The features of the system software are documented in the instruc- tion manual. Metrohm Ltd. is holder of the SQS-certificate of the quality system ISO 9001 for quality assurance in design/development, production, installation and servicing. Herisau, April 12, 1999 Dr.

  • Page 219: Index

    Ordering designation ......197 Editor ..........167 750 ......see Autosampler 750 File handling........162 Aspirating tubing 4 ......69,70,82 761 Compact IC File type..........72 Adjusting ...........16 ........90 761 unit version Functions in editor window..... 168 Aspirate sample ........64 766 ....
  • Page 220 Autosaving ........106 Connection 62 Component Batch reprocessing......162 Connect capillary 35 ......25 Information........126 Chromatogram window ....141 Figure..........26 Selection ......... 126 Close ..........143 Connection capillary 30 ........125,126 Component Color settings........148 Figure..........7,9 761 Compact IC...
  • Page 221 Ordering designation ...... 194 Figure ........7,9,37,40 Figure.......... 7,9,40 Ordering designation ......194 ..........101 Eluent C Installation......... 43 Detector name........98,104 Eluent change ........171 Passivation ........173 Determination Eluent vessel 67 Shutdown ........174 Automatic restart .......80 Recycling......... 174 Definition ...........68 761 Compact IC...
  • Page 222 Ordering designation ...... 197 IC precolumn cartridge ........... 120,140 Group ........... 105 Filters METROSEP Anion Dual 1 ..........136 Groups Filtration..........105 Ordering designation ..... 201 Filtration algorithms ......105 IC precolumn cartridge METROSEP Cation 1-2 ....202 ..........95,141 Finished 761 Compact IC...
  • Page 223 ......see Separating column ...........150 Insert peak ........ 100 Icons Logarithmic index Installation ........13,54 761 Compact IC ......78,85 Login ............. 67 of pump tubings........39 Main window........70 Loss of suppressor capacity ....183 Installing the PEEK Filter unit ....18 PC ..........78,83 Instructions for Use (8.110.8213) ..197...
  • Page 224 Technical data......... 190 Width..........110 ....... 76 Opening chromatograms Width at half height......137 ............ 137 Mode Opening the 761 Compact IC ....12 Peak asymmetry ......... 138 ..165 Modify chromatogram appearance Operating temperature ....91,189 Peak broadening ......170,187 Monograph Operating tutorial ........
  • Page 225 Program for 750 Autosampler..50 Program instructions....89,90 Program for Technical data......... 192 766 IC Sample Processor ....52 Values after power on ....... 91 Program icon ........22 Removing the Program instructions ....88,89,94 transport security screws....25 Program steps........88 761 Compact IC...
  • Page 226 ........... 146,147 Set all Screen icon........... 84 ..........95 ..... 114 Running Set back horizontal base Screw 104 ........95 ....... 115 Running program Set baseline point Figure..........177 Undo ..........176 ......114 Set horizontal baseline 761 Compact IC...
  • Page 227 Threaded stopper 65 ....... 114 Start single peak mode Program instruction......89 Figure ..........28 Protection ........172 Start time for event ......113 Installation ......... 27 Regeneration........180 ......82 Start with determination Threshold for peak recognition... 111 Replacement ........183 761 Compact IC...
  • Page 228 Validation..........188 ............ 113 Value ..........87,89 Valve Valve housing 118 Figure ..........179 ..........88 <Verify> ........63,80 Verify sample .........157,160,167 Vial ........81,99 Vial number .........146,149 View all ........108,118,137 Void time ......... 107 Void time/volume 761 Compact IC...

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