Hologic ThinPrep 5000 Instruction Manual page 21

The rate of agreement between the ThinPrep 5000 result and the ThinPrep 2000 result from the previous
table is presented below. PPA is the positive percent agreement, percent of specimens of ASC-H+
diagnosis with ThinPrep 5000 slides by a majority of laboratory CT/Pathologists among all specimens
of ASC-H+ diagnosis with ThinPrep 2000 slides by a majority of laboratory CT/Pathologists. NPA is
the negative percent agreement, percent of specimens of <ASC-H diagnosis with ThinPrep 5000 slides
by a majority of laboratory CT/Pathologists among all specimens of <ASC-H diagnosis with ThinPrep
2000 slides by a majority of laboratory CT/Pathologists.
Table 25: Rate of CT/Pathologist Agreement, ASC-H+
In Table 26 for ASCUS+, the number of specimens is shown for which various levels of agreement
among the CTs occurred. Either all three CTs rated the slide as positive (ASCUS+), two out of three
rated it positive, one out of three, or none of them.
Table 26: CT Agreement, All Results, ASCUS+
Three CTs had
ThinPrep
5000
Processor Two CTs had
ASCUS+ and one
Three lab
had <ASCUS
CTs have
read the One CT had
same ASCUS+ and two
ThinPrep
had <ASCUS
5000 slide
Three CTs had
from a vial
ThinPrep 5000
Processor Three
lab CTs have read
the same
ThinPrep 5000 slide
from a vial
ASC-H+
PPA 88.2%
NPA 96.7%
Three lab CTs have read the same ThinPrep 2000 slide from a vial
Three CTs
ASCUS+
had
ASCUS+
393
ASCUS+
31
11
3
<ASCUS
438
Totals
Three or two CTs
had ASCUS+
Three or two CTs
had <ASCUS
(194/220) (83.3% to 91.8%)
(1006/1040) (95.5% to 97.7%)
ThinPrep 2000 System
Two CTs had
ASCUS+ &
one had <ASCUS
36
24
8
13
81
ThinPrep 2000 System
Three lab CTs have read the same
ThinPrep 2000 slide from a vial
Three or two CTs
had ASCUS+
484
35
Totals
519
One CT had Three CTs
ASCUS+ &
two had <ASCUS <ASCUS
8
13
34
56
111
Three or two CTs
had <ASCUS
35
706
741
MAN-04008-001 Rev. 001
had Totals
4 441
10 78
53 106
563 635
630 1260
Totals
519
741
1260
Page 21 of 27