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CombiFlash® Rf
User Manual
8.2 Preventive Maintenance
The system requires preventive maintenance for safe and
reliable operation. Refer to the schedule below for the
minimum periodic maintenance requirements.
As Needed – Perform these tasks as conditions require:
• Cleaning (section 8.3).
• Quick flow cell cleaning when recommended by a system
alert message (section 8.5.2).
• Wipe cone on PurIon system with wipe soaked with
methanol or water to remove visible residue near cone
inlet. (PurIon systems only).
Every Run – Perform these tasks at the end of each run:
• Allow the separation run to finish with a high
percentage of solvent B to flush residual compounds
from the column, internal tubing, and flow cell. Refer to
section 8.5.1.
• Allow Cone wash to run to completion (PurIon systems
only) to wash residual compounds from the fluid
interface, probe, and to clean the cone area.
Monthly – Perform these tasks at least monthly, more
frequently if conditions warrant:
• Tubing Inspection (section 8.4).
• Collection rack and tray cleaning (section 8.3.1).
• Monthly flow cell cleaning (section 8.5.3).
Annually - Perform these tasks at least annually, more
frequently if conditions warrant:
• Change roughing pump oil (PurIon systems only)
8.3 Cleaning
To clean the exterior surfaces, use a cleaning cloth dampened
with a mixture of distilled water and a mild detergent. Use
isopropyl alcohol for tougher stains.
On printed areas such as labels, avoid rubbing vigorously or
using aggressive solvents like acetone. Each will ruin the
printed text.
8-2
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