Teledyne Hanson Research FLODEX Operation Manual
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Teledyne Hanson Research FLODEX Operation Manual

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F
™
LODEX
O
M
PERATION
ANUAL
21-101-000-Rev. E—18 June 2019

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Summary of Contents for Teledyne Hanson Research FLODEX

  • Page 1 ™ LODEX PERATION ANUAL 21-101-000-Rev. E—18 June 2019...
  • Page 2 About Teledyne Hanson Research Teledyne Hanson Research, a division of Teledyne Instruments, Inc., is a global technology company specializing in analytical test instruments for the pharmaceutical industry. Founded by the innovator of modern dissolution test technology, Teledyne Hanson Research (THR) helps ensure the world’s...
  • Page 3 Sales and Support Congratulations on your purchase of the Teledyne Hanson Research Flodex™. While we are certain you will enjoy this new product, we also understand from time to time you may have a question or technical issue requiring our assistance. Please feel free to contact us at any time by any of the methods below.
  • Page 4 25 Mar 2004 and Section Four: General Warranty. Updated bill of materials to correspond with 09 Mar 2010 figure 2 Stainless Cylinder Assembly (P/N 21-101-051). 18 June 2019 Updated to Teledyne format. Flodex Operation Manual—21-101-000 Rev. E—18 June 2019 3 of 17...

  • Page 5: Table Of Contents

    Table of Contents Table of Contents   SECTION 1 – ASSEMBLY INSTRUCTIONS  ...................  5   SECTION 2 – OPERATION  ....................... 11     .............................. 11 ENERAL    ............................... 12 HEORY     .............................. 13 ETUP    .......................... 14 UNNING THE    SECTION 3 – GENERAL WARRANTY  .................... 15   APPENDIX A – TECHNICAL BULLETIN ON INTRINSIC FLOWABILITY  .......... 16   Figures  ...

  • Page 6: Section 1 - Assembly Instructions

    Section 1 – Assembly Instructions Section 1 – Assembly Instructions (See Figure 1 – Flodex final assembly Insert the mounting post (2) into the base (1) while simultaneously inserting the shaft of the cylinder assembly (3) into the mounting post. Do not tighten the set screws.
  • Page 7 Section 1 – Assembly Instructions (See Figure 2 – Stainless cylinder assembly) Turn the release lever (9) until the lever arm drops. Insert a flow measurement disk (any size) with number side down by first removing the plastic ring retainer (3), inserting the disk and replacing the ring retainer with the disk in place.

  • Page 8: Figure 1 - Flodex Final Assembly (P/N 21-101-050)

    Section 1 – Assembly Instructions Description 21-100-003 Base 21-100-004 Post 21-101-051 Cylinder assembly 21-101-013 Loading funnel 21-100-002 Funnel ring 41-100-010 Cap screw 21-101-019 Disk stand 21-101-055 Disk kit ¼-20 x ¾” Mounting screw Figure 1 – Flodex final assembly (p/n 21-101-050) Flodex Operation Manual—21-101-000 Rev.

  • Page 9: Figure 2 - Stainless Cylinder Assembly (P/N 21-101-051)

    Section 1 – Assembly Instructions Figure 2 – Stainless cylinder assembly (p/n 21-101-051) Note: See the following page for part numbers and descriptions. This cylinder assembly is shipped completely assembled. It may be necessary to adjust dropping tension using adjusting screw (No.
  • Page 10 Section 1 – Assembly Instructions Part numbers/descriptions for Figure 2 on previous page. Description 21-101-006 Stainless cylinder 21-101-004 Cylinder mounting clamp 21-101-010 Disk retaining ring 21-101-007 Release bar 21-101-022 Closure plate 21-101-002 Bearing plate 21-101-017 Release lever 21-101-012 Mounting rod 21-101-014 10-24 bushing 21-101-018...

  • Page 11: Figure 3 - Inside Hole Diameters Of Flow Disks

    Section 1 – Assembly Instructions Figure 3 – Inside hole diameters of flow disks MM marking on disk Inch; Tol. ± .003 .1575 .1969 .2362 .2756 .3150 .3543 .3937 .4724 .5512 .6299 .7087 .7874 .8661 .9449 1.0236 1.1023 1.1811 1.2598 1.3386 Flodex Operation Manual—21-101-000 Rev.

  • Page 12: Section 2 - Operation

    Section 2 – Operation Section 2 – Operation General The Flodex employs technology developed by Dr. Alberto Gioia of Dow/Gruppo-LePetit, S.P.A. Milan, Italy, to determine a repeatable flowability index over an arbitrary scale of 4 - 40. This reliable index of powder flowability is used as a specification for raw materials utilized in formulating oral pharmaceutical dosage forms.

  • Page 13: Theory

    Section 2 – Operation Theory A core of powder of the same diameter as a hole in the form of a cylinder surrounded by powder will fall through the hole if the weight of the core cylinder is greater than the friction of its side surface.

  • Page 14: Setup

    Section 2 – Operation Setup The Flodex should be carefully assembled as directed in Section 1 – Assembly Instructions, steps 1 through 7. The funnel should be adjusted to meet the approximate center of the stainless cylinder assembly. It should be as close as convenient to the top of the stainless cylinder and no more than 2 cm above it.

  • Page 15: Running The Test

    Section 2 – Operation Running the Test A 50 g sample is standard, but enough powder should be used to fill the cylinder to within 1 cm or so from the top. Loading Load carefully, tapping the bottom of the funnel lightly so that the powder is introduced into the receptacle cylinder without packing.

  • Page 16: Section 3 - General Warranty

    Section 3 – General Warranty Teledyne Hanson Research (THR) is a division of Teledyne Instruments, Inc. Teledyne Hanson products are warranted for one full year including parts and labor. Service contracts and preventive maintenance contracts are available for post- warranty support. International dealer warranties may vary. THR makes no warranty, expressed or implied, for glassware, consumables, or products not manufactured by THR, as evidenced by nameplate on the item or other designation.

  • Page 17: Appendix A - Technical Bulletin On Intrinsic Flowability

    Appendix A – Intrinsic Flowability Appendix A – Technical Bulletin on Intrinsic Flowability See attached Teledyne Hanson Research Document 99-380-001 Rev. 06-19 “Flodex Intrinsic Flowability Technical Bulletin” Flodex Operation Manual—21-101-000 Rev. E—18 June 2019 16 of 17...
  • Page 18 Teledyne Hanson Research 9810 Variel Avenue Chatsworth, CA 91311, USA Phone: +1 818.882.7266 www.teledynehanson.com Copyright © 2019 Teledyne Hanson Research, A division of Teledyne Instruments, Inc. Document 21-101-000 Rev. E Flodex Operation Manual—21-101-000 Rev. E—18 June 2019 17 of 17...
  • Page 19 Gold et al. obtained a weight/time-variation First, although many pharmacopeias indicate the weight- layout under standard vibration conditions by sacrificing variation limits acceptable in monodose forms, they do not the clarity of data on a single variable.5 Teledyne Hanson Research Document 99-380-001 Rev. 06-19...
  • Page 20 Very simply, the Dow-Lepetit device for testing intrinsic different diameters - in the bottom; the hole is closed b? powder flowability (Hanson Research Corp., Northridge, a tnobile shutter. Teledyne Hanson Research Document 99-380-001 Rev. 06-19...
  • Page 21 50%-120% of the diameter of the punch used. Figure 3: A veryflowable Figure 2: When loading is completed, 30 set should be powder will slowlyjlow through the small-diameter holes, leaving a cavity shaped like an upside-down, truncated cone. Teledyne Hanson Research Document 99-380-001 Rev. 06-19...
  • Page 22 47, 1958, Low bulk density has two consequences: low weight and Vol. Pharm. Sci., 55, No. Gold, G., et al., J. Vol. 11, 1966, p. 1291. low flowability. During wet or dry granulation, therefore, Teledyne Hanson Research Document 99-380-001 Rev. 06-19...

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