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Holland Green Science Xiros Mikro User Manual

Freeze dryer
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User Manual
50107002C
Xiros Mikro
Freeze Dryer
User Manual
Version 1.0
1

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Summary of Contents for Holland Green Science Xiros Mikro

  • Page 1 User Manual 50107002C Xiros Mikro Freeze Dryer User Manual Version 1.0...

  • Page 2: Table Of Contents

    User Manual Table of Contents Disclaimer & Warranty ..................... 4 LIMITED WARRANTY & DISCLAIMER ................4 LIMITATION OF LIABILITY ....................6 Safety ........................7 Panel Warning ......................9 Lifting and Moving ....................9 III. Sécurité ........................10 Avertissements du panneau .................. 12 Levage et déplacement ..................
  • Page 3 User Manual 8.5.1 Defrost Mode ..................... 46 System Settings ....................49 History Screen ...................... 51 8.7.1 History Export ....................52 Fault Diagnosis ....................... 53 Cleaning and Maintenance ..................54 10.1 Cleaning ......................54 10.2 Maintenance ...................... 54 Version 1.0...

  • Page 4: Disclaimer & Warranty

    User Manual Disclaimer & Warranty • The intellectual property rights for this manual belongs to Holland Green Science Corporation (hereinafter referred to as “the Company”). • Products of the company are under the patent protection of China and other countries and regions (inclusive of obtained patents and patents currently under application).
  • Page 5 User Manual & Conditions agreed to by the purchase of this product. Consumables are expressly excluded from this warranty. Notwithstanding the foregoing, Products supplied by the Company but not manufactured by the Company are not warranted by the Company, and the Company disclaims all warranties associated with the accuracy of any original manufacturer or third-party supplier Product information, but the Company agrees to assign to Buyer any warranty rights in such Product that the Company may have from the original manufacturer or third-party supplier, to the...

  • Page 6: Limitation Of Liability

    User Manual DEALING, OR USAGE OF TRADE). THIS WARRANTY IS NOT TRANSFERABLE FROM THE ORIGINAL PURCHASER TO A SUBSEQUENT OWNER. FURTHER, THE COMPANY IS NOT LIABLE IN CASES OF DELIBERATE, NEGLIGENT OR ACCIDENTAL MISUSE OF THE PRODUCTS, USE WITH INAPPROPRIATE REAGENTS OR CONSUMABLES, DAMAGE CAUSED BY DISASTER, REPAIR OR MODIFICATIONS DONE BY ANYONE OTHER THAN THE COMPANY.

  • Page 7: Safety

    User Manual Safety ! DANGER (may cause serious damage to property and or casualties) 1. No user serviceable parts inside. Service by authorized personnel only. 2. Read this manual prior to operating the freeze dryer and observe and verify that all connections are properly secured.
  • Page 8 User Manual 3. Timely maintenance of the freeze dryer MUST be conducted to ensure continued safe operation and to optimize the freeze dryer’s service life. 4. Only accredited and qualified professional repair technicians can open the freeze dryer or conduct required repairs. Persons performing repairs on the freeze dryer other than those selected or approved by the Company shall void any warranty for the product and are at risk of personal injury.

  • Page 9: Panel Warning

    User Manual Panel Warning CAUTION – RISK OF FIRE OR EXPLOSION due to puncture of REFRIGERANT TUBING. Follow Rear Panel Handling Instructions Carefully. FLAMMABLE REFRIGERANT used. WARNING – CRUSHING OF HANDS between the Door door and front panel, hinges, and door lock. Operate with caution.

  • Page 10: Sécurité

    User Manual III. Sécurité DANGER ! (peut causer de graves dommages aux biens ou faire des victimes) 1. Aucune pièce réparable par l’utilisateur ne se trouve à l’intérieur. L’entretien doit être effectué uniquement par du personnel autorisé. 2. Lisez ce manuel avant d’utiliser le lyophilisateur et vérifiez que toutes les connexions sont correctement fixées.
  • Page 11 User Manual ATTENTION ! (conséquences possibles sur les performances opérationnelles ou la durée de vie) 1. La sécurité générale du fonctionnement du lyophilisateur relève de la responsabilité du propriétaire du lyophilisateur et de son (ses) opérateur(s) attitré(s), qui doivent à leur tour s’assurer que les conseils du manuel de l’utilisateur sont appliqués, afin de garantir la sécurité...

  • Page 12: Avertissements Du Panneau

    User Manual Avertissements du panneau ATTENTION -RISQUE D’INCENDIE OU D’EXPLOSION dû à la perforation du TUBE RÉFRIGÉRANT. Suivez attentivement les Panneau arrière instructions de manipulation. RÉFRIGÉRANT INFLAMMABLE utilisé. AVERTISSEMENT -ÉCRASEMENT DES MAINS Porte entre la porte et le panneau avant, les charnières et la serrure de la porte.

  • Page 13: Introduction

    User Manual Introduction Users are advised to carefully read this manual prior to operating the freeze dryer so that they are aware of all precautions outlined and to ensure operation is in accordance with the instructions contained within this manual. After Sales Support If problems are encountered or technical support is required when installing or using the instrument, please contact ServiceUSA@hollandgreenscience.com...

  • Page 14: Warranty

    User Manual Warranty The warranty period for the Xiros Mikro freeze dryer is one (1) year from the date of shipping of the product. Return policy Holland Green Science will always do everything in our power to avoid a return + refund.

  • Page 15: Technical Specifications

    User Manual Technical Specifications Product Name Xiros Mikro Product SKU 50107002C Product Weight 87 kg AC120V, 50/60Hz, 2.8A Max Vacuum Pump Current AC220-240V, 50/60Hz, 1.6A (Not for UL- mark) Total Condenser Volume 11 liters Ice Condenser Capacity 8 kg Condenser Performance...

  • Page 16: Precautions

    User Manual Precautions • The freeze dryer should be connected to electrical outlets safely. Operate with dry hands to minimize the risk of electric shock. • A suitably fused power supply (according to the freeze dryer’s nameplate) is required. An alternative supply voltage or frequency may damage the freeze dryer or reduce its working lifespan.

  • Page 17: Components Overview

    User Manual VII. Components Overview Vacuum Pump Touchscreen Connector KF25 Chamber Door Seal Chamber Door Vent Door Lock Vacuum Pump Supply Output USB-A Port Power Switch Xiros Mikro Power Socket USB-B Port Fuse (250VAC F15AL) Vent Drain Valve Version 1.0...
  • Page 18 User Manual CD 8 Power Socket Fuse (250VAC F15AL) Vacuum Pump Supply Output Version 1.0...

  • Page 19: Software Operation

    User Manual VIII. Software Operation Immediately after powering on the freeze dryer, the home screen is shown (Figure 1). Figure 1 To go back to the home screen, tap the “Home” icon that is present on most screens (Figure 2). Figure 2 Version 1.0...

  • Page 20: Autodry

    User Manual AutoDry AutoDry automatically dries the product using an intelligent dryness detection algorithm. AutoDry cannot guarantee complete product dryness for each run performed. If the dried product is found to be too moist, proceed to “8.1.2 Editing AutoDry Parameters”. From the Home screen, tap on “AutoDry”...

  • Page 21: Autodry Process

    User Manual If in operation (i.e. Program or Defrost is running), Figure 5 shows an error message with the “Start” button blocked. Figure 5 To proceed, stop Defrosting or the Program by navigating onto the respective screen, and tap on “Stop” or “Cancel”. 8.1.1 AutoDry Process AutoDry is split into 4 stages.
  • Page 22 User Manual ”Estimated Running Time” is displayed at the bottom of the screen. This time is based on the average runtime of previous successful AutoDry runs. Therefore, the freeze dryer first needs to almost complete a run before the displayed time is self- corrected.

  • Page 23: Editing Autodry Parameters

    User Manual Figure 9 shows the Storage stage. Figure 9 8.1.2 Editing AutoDry Parameters To begin editing the parameters, tap on “Edit Parameters” from the AutoDry Start screen (Figure 10). Figure 10 Version 1.0...
  • Page 24 User Manual Figure 11 shows the Parameter Editor screen. This screen provides significant control over the behavior of the AutoDry algorithm. Only 3 of the 4 stages can be modified with AutoDry: Freezing, Drying, and Storage. Figure 11 “Freeze Timer Start” (Figure 12) specifies the temperature the shelves must reach before the timer begins.
  • Page 25 User Manual Figure 13 shows the Drying stage. You may increase the maximum drying temperature in conjunction with reducing sensitivity and adding more drying time. Higher temperatures and lower sensitivity will achieve shorter drying times but may have negative impacts on product quality. Reducing drying temperatures and increasing sensitivity will likely produce better quality results.

  • Page 26: Program

    User Manual To restore to the default parameters for AutoDry, tap on “Reset”. The following popup will display (Figure 15): Figure 15 Tapping on “Confirm” will overwrite all previous changes to the AutoDry Parameters screen. Note: Adjusting any parameters or resetting the values will require AutoDry to re- learn the duration of the run, and therefore will not be able to provide the duration hint until it has nearly completed a run.
  • Page 27 User Manual To review the remaining 6 available programs, tap on the right arrow (Figure 17). Figure 17 Figure 18 shows the remaining 6 programs. To go back, tap on the left arrow. Figure 18 Version 1.0...

  • Page 28: Autodry/Program Stages

    User Manual To edit one of these programs, tap on one of the programs (Figure 19) to enter the program editor. This will be explored in the later chapters. Figure 19 8.2.1 AutoDry/Program Stages The freeze dryer Programs and AutoDry are broken down into 4 stages. Chronologically, they are as follows: Freezing, Evacuation, Drying, and Storage.

  • Page 29: Writing A Program & Parameters Explained

    User Manual 8.2.2 Writing a Program & Parameters Explained From the Program Selector screen discussed in chapter 8.2, tap on “Program 1” to enter the Program Editor screen, as shown in Figure 20. Figure 20 In Figure 20 the entries are only an example, as the parameters are dependent on the product.

  • Page 30: Evacuation Stage

    User Manual 8.2.2.2 Evacuation Stage The Evacuation stage (Figure 22) is controlled by Step 1’s pressure. Once the specified pressure is reached, the freeze dryer will proceed to the next stage. Figure 22 The Evacuation stage will only run for up to 15 minutes. If the run has exceeded that time and the pressure is more than 0.5 mbar above from the setpoint, the freeze dryer will abort the run and enable the compressor in the manual page.

  • Page 31: Drying Stage

    User Manual 8.2.2.3 Drying Stage In the Drying stage (Figure 24), up to 16 drying steps can be specified. They run sequentially, and are composed of a temperature and pressure setpoint, time, and the option of “Include Ramp Time”’. Incl. Ramp Time: This controls when the timer will start for the Drying stage. When the checkbox is checked, the timer will immediately start for the Drying stage.

  • Page 32: Storage Stage

    User Manual 8.2.2.4 Storage stage The freeze dryer will maintain a specified temperature and pressure that the product will be left at once the run has finished (Figure 26). Specify a pressure such as 1 mbar to avoid additional drying whilst in Storage and specify a temperature between 25-40C to prevent the product from absorbing moisture when it is reintroduced to the atmosphere.

  • Page 33: Renaming A Program

    User Manual 8.2.3 Renaming a Program The freeze dryer provides functionality to rename programs. On either the first or second Program Editor screen, tap on the program’s name to prompt the keyboard function (Figure 27). Figure 27 Type in a name, and then tap “Enter” to confirm the input. The name will update. The program name will be displayed on the Program Selection, Program Progress, and System Idle screens.

  • Page 34: Loading A Preset Program

    User Manual 8.2.4 Loading a Preset Program The freeze dryer comes with 4 preset programs as examples. To load a program, first select a program to load a preset program from the Program Selector screen. The button to load programs is located on the top-right of the Program Editor (Figure 28). Figure 28 To prompt the UI for selecting a loadable program, tap on “Load”...
  • Page 35 User Manual The following popup displays all the available programs to load (Figure 30). SafeDry, Liquid 2L, Candy, and Botanical example programs are available. Tapping on one of them will show a popup with product preparation instructions. Figure 30 Tap on “SafeDry”. Figure 31 is the popup that appears. Tapping on “Load” will close the popup and write the SafeDry program onto the selected program.

  • Page 36: Starting A Program

    User Manual 8.2.5 Starting a Program Before starting the program, ensure the following: • Product is evenly distributed between each tray for optimal drying. • The drain valve is closed. • The chamber is defrosted. • The chamber door contact surface is clear of ice, and the door is closed. It is important to defrost the freeze dryer before conducting a run.
  • Page 37 User Manual Figure 33 When you navigate to the Program Start page, it may take a few seconds to initialize. Wait until it initializes before attempting to start. If under an operation (e.g. Defrosting or AutoDry), you will get the following screen (Figure 34). Figure 34 You will need to stop the other mode (such as Defrost) to start a program.
  • Page 38 User Manual Figure 35 Verify the program is running by the sound of the compressor starting and the Program Progress screen appearing (Figure 36). Figure 36 The Program Progress screen displays real-time values of the operation of the current program (Figure 36). Some of the readings are as follows: Elapsed Time: The number of minutes that have passed since the program started.
  • Page 39 User Manual Note: Most timers don’t start unless the preconditions are met. For example, if the “Incl. Ramp Time” is unchecked, the drying step timer starts once the shelf temperatures are reached. This is indicated with a message under the “Cancel” button.

  • Page 40: Program Vacuum Oven (Vo)

    User Manual Figure 39 When the Stage/Drying step displays “Storage” (Figure 39), the Program is finished and will maintain temperatures and pressure based on the storage parameters. Stopping a program is explored in “8.3 Extra Drying”. 8.2.6 Program Vacuum Oven (VO) Vacuum Oven (VO) provides the ability for the freeze dryer to serve as a vacuum oven.

  • Page 41: Extra Drying

    User Manual Once VO Mode is enabled, the Freezing stage is no longer editable and is skipped (Figure 41). Figure 41 Extra Drying Once a program or AutoDry run is in storage, the operator will have the ability to verify that their product is dry before ending the program. After tapping “Stop” on the Program Progress screen, a popup will appear (Figure 42).
  • Page 42 User Manual To start the extra drying, tap on “No”, and the following popup will appear (Figure 43): Figure 43 Figure 43 shows the Extra Drying Parameters popup. This popup will allow you to specify an extra drying step for your Program. Specifying pressure is not available in AutoDry (Figure 44).

  • Page 43: Power Recovery

    User Manual Figure 45 Power Recovery If a transient power outage occurs during a Program or AutoDry run, the freeze dryer will automatically recover back to the last state before the freeze dryer lost power. A popup will appear as soon as power is restored to the freeze dryer (Figure 46). Figure 46 This is designed to be completely autonomous.

  • Page 44: Manual Control

    User Manual Manual Control To enter the Manual Control screen, tap on the “Manual” button (Figure 47). Figure 47 Figure 48 shows the Manual Control screen. Figure 48 Version 1.0...
  • Page 45 User Manual On the right-hand side (Figure 49), temperature and pressure setpoints can be specified for the freeze dryer to maintain (if enabled). Figure 49 The left-hand side provides relay control of the freeze dryer. They are as follows: • Compressor •...

  • Page 46: Defrost Mode

    User Manual Note: For the freeze dryer to maintain the pressure setpoint, enable both the Vacuum Pump and Vacuum Valve. The Vacuum Valve will not open if the pump isn’t enabled, and a warning will display (Figure 51). This is to prevent suck-back contamination from the pump.
  • Page 47 User Manual Figure 53: The Defrost screen prior to starting. Figure 53 Before starting the Defrost process, confirm: • Product has been taken out. • Drain valve is open. • Chamber door is closed. Set the Defrost Temperature and Defrost Time as desired (Figure 54). A 50 C defrost temperature and 2 hours hold time are generally adequate.
  • Page 48 User Manual Tap on “Start” (Figure 55). Figure 55 The “Defrosting” icon will appear (Figure 56). Figure 56 The System Defrost screen will display the real-time values for the lower and upper shelf temperature and chamber temperature. Tap “Cancel” to stop the defrosting process (Figure 57). Version 1.0...

  • Page 49: System Settings

    User Manual Figure 57 System Settings Tap “Settings” on the home screen (Figure 58). Figure 58 Version 1.0...
  • Page 50 User Manual (Figure 59). Rebooting the display is not the same as power cycling the freeze dryer. After updating, perform a power cycle using the main power switch located under the display. Figure 59 The screen timeout specifies the time it takes to display the System State since the last touch interaction.

  • Page 51: History Screen

    User Manual History Screen The History screen shows data from the freeze dryer over time, in 15 second intervals. To access this screen, tap on “History” from the home screen (Figure 61). Figure 61 Figure 62 is the History screen. Tap on “Page Up” and “Page Down” to navigate through the history of the temperature/pressure sensors with the associated time stamps.

  • Page 52: History Export

    User Manual 8.7.1 History Export To export the History of the freeze dryer, insert a USB formatted as FAT32 into the USB-A port of the freeze dryer. After inserting the USB, navigate to the History screen and tap on “Export” (Figure 63). 17:02:51 2023/06/21 16.6...

  • Page 53: Fault Diagnosis

    User Manual Fault Diagnosis Before conducting a diagnosis, verify that the chamber is clean, dry, and empty of product. Error Solutions Check that the vacuum pump is correctly connected to the main unit with the clamp (tightly). Check that the drain valve is closed and is installed hand tight. Check that the vacuum hose and rings are installed correctly.

  • Page 54: Cleaning And Maintenance

    User Manual Cleaning and Maintenance 10.1 Cleaning • Water from the product will collect inside of the chamber during drying. Be sure to defrost after each run and clean the inside of the chamber periodically by wiping down the chamber walls with washing detergent. •...

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