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Holland Green Science Xiros Mikro User Manual

Freeze dryer
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User Manual
10107002
Xiros Mikro
Freeze Dryer
User Manual
Version 1.1
1

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Summary of Contents for Holland Green Science Xiros Mikro

  • Page 1 User Manual 10107002 Xiros Mikro Freeze Dryer User Manual Version 1.1...

  • Page 2: Table Of Contents

    User Manual Table of Contents Disclaimer & Warranty ..................... 3 LIMITED WARRANTY & DISCLAIMER ................3 LIMITATION OF LIABILITY ....................5 Safety ........................6 III. Introduction ......................7 After Sales Support ....................7 Proper Use ......................7 Warranty ........................ 7 Technical Specifications ..................

  • Page 3: Disclaimer & Warranty

    User Manual Disclaimer & Warranty • The intellectual property rights for this manual belongs to Holland Green Science Corporation (hereinafter referred to as “the Company”). • Products of the company are under the patent protection of China and other countries and regions (inclusive of obtained patents and patents currently under application).
  • Page 4 User Manual Notwithstanding the foregoing, Products supplied by the Company but not manufactured by the Company are not warranted by the Company, and the Company disclaims all warranties associated with the accuracy of any original manufacturer or third-party supplier Product information, but the Company agrees to assign to Buyer any warranty rights in such Product that the Company may have from the original manufacturer or third-party supplier, to the extent such assignment is allowed by such original manufacturer or third-party supplier.

  • Page 5: Limitation Of Liability

    User Manual PRODUCTS, USE WITH INAPPROPRIATE REAGENTS OR CONSUMABLES, DAMAGE CAUSED BY DISASTER, REPAIR OR MODIFICATIONS DONE BY ANYONE OTHER THAN THE COMPANY. THE COMPANY DOES NOT WARRANT THAT THE PRODUCT WILL NOT INFRINGE THE INTELLECTUAL PROPERTY RIGHTS OF A THIRD PARTY EITHER ALONE OR IN COMBINATION WITH OTHER PRODUCTS OR IN THE OPERATION OF ANY PROCESS.

  • Page 6: Safety

    User Manual Safety ! DANGER (may cause serious damage to property and or casualties) Please carefully read this User Manual prior to operating the instrument and observe and verify that all connections are properly secured. Utility requirements: Please ensure that the electrical connections meet the local standards and that the power supply is compatible with the Instrument nameplate.

  • Page 7: Introduction

    The instrument is designed for non-residential use and is to be used only in conjunction with accessories recommended within this manual and by the manufacturer. Warranty The warranty period for the Xiros Mikro freeze dryer is one (1) year from the date of shipping of the product. Version 1.1...

  • Page 8: Technical Specifications

    User Manual Technical Specifications Model 10107002 Product Name Xiros Mikro Product Weight 87 kg Rated Voltage 110 v +/-10% Rated Frequency 60 Hz Max Vacuum Pump Current Total Condenser Volume 11 L Ice Condenser Capacity 8 kg Ice Condenser Performance...

  • Page 9: Inspection

    User Manual V Inspection Packing List Unpack the equipment carefully and check for any damage which may have arisen during transport. In the event of identified damage, please contact ServiceUSA@hollandgreenscience.com The package includes the following items: Item Description Quantity Main Unit Vacuum Hose Clamps Sealing Ring...

  • Page 10: Precautions

    User Manual Precautions • The power supply should be connected to the electrical outlets safely. It is important that anyone using this equipment do so with dry hands and dry shoes to minimize the risk of electric shock. • A 120VAC 60Hz power supply is required for the freeze dryer operation. Any alternative supply voltage or frequency may damage the freeze dryer reduce its working lifespan.

  • Page 11: Components

    User Manual VII. Components Main Unit The USB port is used to update the Display and download log data. The RS232 is used to update the Logic Controller. When updating the instrument, often both the Logic and Display need to be updated. Version 1.1...

  • Page 12: Other Components

    User Manual Other Components • Vacuum hose and KF 25 connectors • Clamps and sealing rings • Vacuum pump • Tray Version 1.1...

  • Page 13: Assembling The Freeze Dryer

    User Manual • Drain hose Assembling the Freeze Dryer 7.3.1 Connect the vacuum pump to the freeze dryer • The connector for the vacuum pump is located at the upper right corner at the back of the freeze dryer (Figure 1). Vacuum Pump Connector KF25 Figure 1...
  • Page 14 User Manual Wrap the clamp around the sealing ring and close the clamp (Figure 4). Tighten • the wing nut as shown in Figure 5. Please note that the clamp only needs to be done up finger tight – excessive tightening may cause damage to the fittings. Figure 4 Figure 5 •...

  • Page 15: Connect The Water Drain Hose To The Freeze Dryer

    User Manual 7.3.2 Connect the water drain hose to the freeze dryer • The connector for the drain hose is located to the left side of the freeze dryer (Figure 7). Figure 7 • Connect the drain hose to the connector and as shown in Figures 8, The other end should be placed in either a bucket or near a drain.

  • Page 16: Connect The Freeze Dryer To The Power Supply

    User Manual 7.3.3 Connect the freeze dryer to the power supply Main unit power Vacuum pump connector power connector Figure 9 • Locate the power connectors for the main unit and the vacuum pump at the right side of the freeze dryer (Figure 9). •...

  • Page 17: Operation

    User Manual VIII. Operation Before running the freeze dryer, please check and ensure that: • There is no residual water or foreign matter inside the chamber. • The drain valve is closed. • The vacuum pump is connected to the freeze dryer correctly. •...

  • Page 18: Manual Freeze-Drying Mode

    User Manual 8.1 Manual freeze-drying mode To enter the “Manual Control” page, click on the “Manual” button (Figure 12). Figure 12 Figure 13 The “Manual Control” page has the flowing functions: • Manual Control On/Off: click “On” to enter Manual Control Mode (Figure 13). •...
  • Page 19 User Manual Figure 14 • Temperature and pressure setpoints can be specified for the freeze dryer to maintain (if enabled). Note, for the freeze dryer to maintain the pressure setpoints, enable with the Vacuum Pump and Vacuum Valve (Figure 14). Note: •...

  • Page 20: Program Mode

    User Manual 8.2 Program Mode Click on “Program” on the home screen to enter the “Recipe Selector” page (Figure 15). Figure 15 The “Recipe Selector” page has 4 programs available for the users to enter and store self-defined parameters (Figure 16). Figure 16 Version 1.1...
  • Page 21 User Manual Program Explained: A Xiros Mirko program is broken down into 4 stages. Freezing, Evacuation, Drying, and Storage. Here are the stages in more detail: Freezing: This is the first stage of a program. This stage is used to cool the shelves and trays down enough to avoid risking product melting during evacuation and drying.
  • Page 22 User Manual Figure 18 • Click on individual parameter that you wish to change, enter the new value. • There are a total of 16 steps available. Even though not all steps need to have values, all steps are done in sequence. No blank step should be left between steps (A blank step would indicate the process is finished).
  • Page 23 User Manual Figure 19 Figure 20 Please note, it’s important to defrost the instrument before conducting another run. In addition, occasionally opening the ballast valve on the pump to release moisture build up is recommended. Version 1.1...
  • Page 24 User Manual Freezing Stage The freezing stage (Figure 21) is controlled by Freeze Temperature & Extra Freeze Time. For a successful run, the product must be frozen. It’s good practice to always allow additional freezing time after reaching the Freeze temperature. Specify the Freeze Temperature to around -20°C to -30°C and use 4-6 hours extra freezing time.
  • Page 25 User Manual Driving Stage In the drying stage (Figure 23), up to 16 drying steps can be specified. They run sequentially, composed of a temperature and pressure setpoint, time, and the option of ‘Including ramp time’. Including Ramp Time: This changes when the timer will start for the drying step. When the checkbox is checked, the timer will immediately start for the drying step.
  • Page 26 User Manual Figure 24 Verify the program is running by the sound of the compressor starting and the “Program Progress” screen appearing (Figure 25). Figure 25 The “Program Progress” screen displays real-time values of the operation of the current program (Figure 25). Some of the readings are as follows: •...
  • Page 27 User Manual The “Program Progress” screen also displays the current processing step. As mentioned in earlier sections, there are four stages in a Program, and they are “Freezing” (Figure 25), “Evacuating” (Figure 26), “Drying” (Figure 27) and “Storage” (Figure 28). Figure 26 Figure 27 Version 1.1...
  • Page 28 User Manual Figure 28 • When the “Stage / Drying step” displays “Storage” (Figure 28), the Program is finished, and it will maintain temps and pressure based on the storage parameters. Tap on “Complete” to stop the Program. A popup will appear to confirm the stoppage of the program (Figure 29).

  • Page 29: Defrost Mode

    User Manual 8.3 Defrost Mode When the freeze-drying process is finished, the user can click “Defrost” on the home screen to enter “System Defrost” page (Figure 31). Note, the user can also use the “Defrost” function before any freeze-drying process to defrost the chamber if needed. Figure 31 Before starting the “Defrost”...
  • Page 30 User Manual Figure 32 Figure 33 Version 1.1...

  • Page 31: System Settings

    User Manual 8.4 System settings Figure 34 Click “Settings” on the home screen (Figure 34).The following settings can be defined by the user: password, time setting and, screen save (Figure 35). Figure 35 Version 1.1...

  • Page 32: History Data

    User Manual The screen save will display the following system state (Figure 36). Figure 36 8.5 History data To recover process history, insert a USB flash drive formatted with FAT32 and click “History” on the home screen (Figure 37). Figure 37 Then click “PAGE UP”...
  • Page 33 User Manual Figure 38 Version 1.1...

  • Page 34: Fault Diagnosis

    User Manual Fault Diagnosis Error Solutions Check that the vacuum pump is correctly connected to the main unit with the clamp (tightly). Check that the drain valve is closed. Check that the sealing ring is installed correctly. Ultimate vacuum can’t reach 0.5 mbar Check that the vacuum pump functions correctly and the vacuum pump oil is clear (if oil sealed vacuum pumps are...

  • Page 35: Cleaning And Maintenance

    User Manual X. Cleaning and Maintenance 10.1 Cleaning • Condensation from the product may collect inside of the chamber, please be sure to clean the inside of the chamber periodically by wiping off any the chamber walls. Clean the trays after every freeze-drying process with detergent. Wipe dry afterwards.

  • Page 36: Removing/Installing Shelf Stack

    User Manual XII. Removing/Installing Shelf Stack Step 1 • Open the chamber door and confirm there is no ice build-up that will prevent removing the shelf stack. Carefully pull out the shelf stack. • Place the stack on the table next to the freeze dryer (see Figure 40). Ensure the connecting cable is not strained.
  • Page 37 User Manual Step 2 • Locate the plug assembly and press the release tabs to unplug the shelf stack from the freeze dryer. (See Figure 42) Figure 42 Version 1.1...
  • Page 38 User Manual Step 3 • When installing the shelf stack, identify the top and bottom of the plug before attempting to plug it in. Make sure to remove any moisture from the connection points. • Figure 43 and Figure 44 demonstrate the male plug. Figure 43 Figure 44 •...
  • Page 39 User Manual Figure 45 • Figure 46 demonstrates the female plug. Figure 46 Step 4 Version 1.1...
  • Page 40 User Manual • When reinstalling the shelf stack, ensure the connecting cable is not coiled underneath as in Figure 47. Figure 47 Step 5 Version 1.1...
  • Page 41 User Manual • When reinstalling the shelf stack, gently push the shelving stacks halfway and ensure the connecting cable is behind the shelf stack, in a coiled format, so as to not affect the ice condensers efficiency (see Figure 48 and 49). Figure 48 Figure 49 Version 1.1...

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