Roche cobas b 221 system Service Manual
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Roche cobas b 221 system Service Manual

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Summary of Contents for Roche cobas b 221 system

  • Page 1 221 system Service Manual...
  • Page 2 COBAS, COBAS B and LIFE NEEDS ANSWERS are trademarks of Roche. ©2009 Roche Diagnostics Roche Diagnostics GmbH D-68298 Mannheim Germany www.roche.com...
  • Page 3 Service Manual on page G-6 Edition notice cobas b 221 system This manual is for the maintenance and repair of the cobas b 221 system. Service Manual cobas b 221 system In the course of 2006 the Roche OMNI S system was rebranded under the Roche Diagnostics professional IVD user brand cobas®.
  • Page 4 Roche replacement parts and Roche-approved materials to guarantee the full functionality of the cobas b 221 system. For the order numbers of replacement parts, refer to the cobas b 221 system Spare Part List. For an overview of possible revisions and available software versions, see:...
  • Page 5 221 system Table of contents Version History B-51 Edition notice tHb/SO module (cobas b 221<1/3/5> systems only) Intended use B-62 Copyrights Peristaltic pumps (PP) B-64 Trademarks Bottle compartment B-67 Contact address Vacuum system B-73 Preface Valves B-81 How to Use This Manual...
  • Page 6 221 system General information D-11 System stops D-13 Module stops D-37 System warnings D-51 Value flags D-58 USB troubleshooting D-91 Touch screen/PC unit troubleshooting D-91 Important test routines D-95 Sensor limits (Sensor report) D-135 Glossary Part Glossary Index...
  • Page 7 Roche replacement parts and Roche-approved materials to guarantee the full functionality of the cobas b 221 system. For the order numbers of replacement parts, refer to the cobas b 221 system Spare Part List. For an overview of possible revisions and available software versions, see:...
  • Page 8 Laser Class 3R according to EN 60825-1 P0 < 5 mW λ = 635 - 850 nm For more information about warning symbols, refer to the cobas b 221 system Intructions for Use. For more information about ESD protection measures, see ESD protection measures on page A-8.
  • Page 9 221 system Abbreviations The following abbreviations are used: Abbreviation Definition Analogue to digital converter ANSI American National Standards Institute AutoQC Blood Gases Charge coupled device CMOS Complementary Metal-Oxide Semiconductor EEPROM Electrically erasable programmable read-only memory e.g. exempli gratia – for example...
  • Page 10 221 system Abbreviation Definition Sample container detection Sample distributor Sample inlet path Software T&D Turn and Dock Transisitor-Transistor Logic Universal Serial Bus Valve 19 FMS Mixing Valve VPP (=VPS) Vacuum pump protector Roche Diagnostics May 2009 Service Manual · Version 9.0...
  • Page 11 System Description Safety information ........A-3 Fluid actions .

  • Page 13: Table Of Contents

    1 Safety information Table of contents Safety information Before the maintenance and repair of the cobas b 221 system, it is essential that the warnings, cautions, and safety requirements contained in this manual are read and understood by the user.
  • Page 14 1 Safety information cobas b 221 system Table of contents Roche Diagnostics May 2009 Service Manual · Version 9.0...

  • Page 15: Important Information

    Instrument repairs are only to be performed by the manufacturer or qualified service personnel. Only accessories and supplies either delivered by or approved by Roche are to be used with the instrument. This ensures the performance and measuring accuracy of the unit.

  • Page 16: Operating Safety Information

    The instrument is not suitable for operation with a direct current power supply. Use only the original mains plug delivered with the cobas b 221 system. The use of controls or adjustments or performance of procedures other than those specified herein may result in hazardous radiation exposure.

  • Page 17: Disinfectants

    Use only slightly moistened cloths or cotton sticks to clean the instrument. Disinfectants Use only liquid disinfectant such as protein remover (Roche deproteinizer) or an alcohol-based (about 70%) surface disinfectant. Do not spray disinfectant directly onto the instrument because this could cause malfunctions in the electronics.

  • Page 18: Esd Protection Measures

    1 Safety information cobas b 221 system ESD protection measures ESD protection measures ESD = Electrostatic Sensitive Device Explanation of the phenomenon The most frequent cause of electrostatic discharge is friction of various materials such as plastic, synthetic fiber, hard rubber or paper.

  • Page 19: Why Is Esd Protection So Important Today

    221 system 1 Safety information ESD protection measures Why is ESD protection so important today? Formerly, current controlling semiconductors were mostly used (TTL, normal transistors, etc.). Today the principle of current logic is virtually the only technology in use in MOS and CMOS components.
  • Page 20 1 Safety information cobas b 221 system ESD protection measures Roche Diagnostics May 2009 A-10 Service Manual · Version 9.0...
  • Page 21 221 system 2 Fluid actions Table of contents Fluid actions This chapter provides information about the fluidic actions of the cobas b 221 system. Chapter In this chapter Fluid actions overview ....................13 cobas b 221<1> system ................... 13 cobas b 221<2>...
  • Page 22 2 Fluid actions cobas b 221 system Table of contents CAL 2/CAL 3/CAL 4 Calibration ................42 COOX calibration ....................43 Roche Diagnostics May 2009 A-12 Service Manual · Version 9.0...

  • Page 23: Fluid Actions Overview

    221 system 2 Fluid actions Fluid actions overview Fluid actions overview cobas b 221<1> system Figure A-1 cobas b 221<1> system Roche Diagnostics May 2009 Service Manual · Version 9.0 A-13...

  • Page 24: Cobas B 221<2> System

    2 Fluid actions cobas b 221 system Fluid actions overview cobas b 221<2> system Figure A-2 cobas b 221<2> system Roche Diagnostics May 2009 A-14 Service Manual · Version 9.0...

  • Page 25: Cobas B 221<3> System

    221 system 2 Fluid actions Fluid actions overview cobas b 221<3> system Figure A-3 cobas b 221<3> system Roche Diagnostics May 2009 Service Manual · Version 9.0 A-15...

  • Page 26: Cobas B 221<4> System

    2 Fluid actions cobas b 221 system Fluid actions overview cobas b 221<4> system Figure A-4 cobas b 221<4> system Roche Diagnostics May 2009 A-16 Service Manual · Version 9.0...

  • Page 27: Cobas B 221<5> System

    221 system 2 Fluid actions Fluid actions overview cobas b 221<5> system Figure A-5 cobas b 221<5> system Roche Diagnostics May 2009 Service Manual · Version 9.0 A-17...

  • Page 28: Cobas B 221<6> System

    2 Fluid actions cobas b 221 system Fluid actions overview cobas b 221<6> system Figure A-6 cobas b 221<6> system Roche Diagnostics May 2009 A-18 Service Manual · Version 9.0...

  • Page 29: Pin Assignment Of S2 And S3 Fluid Packs

    221 system 2 Fluid actions Pin assignment of S2 and S3 Fluid Packs Pin assignment of S2 and S3 Fluid Packs S2 Fluid Pack zero point solution ISE reference solution CAL B (calibration solution) BG reference solution CAL A (calibration solution)

  • Page 30: T&D Positions

    2 Fluid actions cobas b 221 system T&D positions T&D positions 1: Releases the fill port for placing a sample 7: Na conditioning solution from S2 Fluid 2: S1 Rinse Solution Pack 3: Position for "aspiration from the syringe“ 8: CAL 3 from S3 Fluid Pack A 4: Dock position (cobas b 221<5/6>...

  • Page 31: Measurement

    221 system 2 Fluid actions Measurement Measurement Sample input Injecting sample Fill port Waste separator D SS3 Figure A-10 Injecting sample The sample container is detected by a light barrier on the T&D module. Sample path: fill port >...
  • Page 32 2 Fluid actions cobas b 221 system Measurement Excess sample material: V24 (open) > V23 (open) > Bypass > Waste separator Aspirate sample Main pump Fill port Figure A-11 Aspirate sample The sample container is detected by a light barrier on the T&D module. The sample is aspirated through the cross channel with the main pump.

  • Page 33: Sample Distribution

    221 system 2 Fluid actions Measurement Sample distribution Waste separator Separate BG Wash rail Position BG, separate ISE Main pump Separate tHb/SO or COOX D MSS output pump Position tHb/SO or COOX Position MSS S1 Rinse solution Position ISE...
  • Page 34 2 Fluid actions cobas b 221 system Measurement Positioning BG and This aspiration process assumes that the sample column tip is at SS1. It is aspirated separating ISE: via VBI and VBO with the main pump. The start of the sample movement is detected by the conductivity (breaking of the calibration solution column in the measuring chamber).

  • Page 35: Aspirating Mss Standby Solution And Starting Fms

    221 system 2 Fluid actions Measurement Aspirating MSS standby solution and starting FMS MSS output pump CAL A MSS input pump Starting FMS Aspirating MSS standby solution MSS standby solution D CAL B Figure A-13 Aspirating MSS standby solution and starting FMS...
  • Page 36 2 Fluid actions cobas b 221 system Measurement Aspirate sample The sample is aspirated by turning the MSS output pump and opening the VSI. For more information, see Sample distribution on page A-23. The tearing of the standby solution and the start of the sample is detected by the conductivity at the MSS input.

  • Page 37: Washing The Measuring Chamber Vicinity

    221 system 2 Fluid actions Measurement Washing the measuring chamber vicinity Vacuum pump Waste separator T&D module (position 2) D S1 Rinse solution Figure A-14 Washing the measuring chamber vicinity This section is used to clean sample residues from the aspiration path, the bypass and the sample distributor.

  • Page 38: Washing Thb/So Or Coox And Preparing Mix1

    2 Fluid actions cobas b 221 system Measurement Washing tHb/SO or COOX and preparing Mix1 Vacuum pump S1 Rinse solution Main pump Washing tHb/SO or COOX Preparing Mix1 D Waste separator Figure A-15 Washing tHb/SO or COOX and preparing Mix1 When the measuring chamber area is clean, the tHb/SO or COOX module is washed.

  • Page 39: Recalibrating Bg/Ise And Drying Thb/So Or Coox

    221 system 2 Fluid actions Measurement Recalibrating BG/ISE and drying tHb/SO or COOX Vacuum pump Main pump Drying tHb/SO or COOX Recalibrating BG/ISE D Waste separator Figure A-16 Recalibrating BG/ISE and drying tHb/SO or COOX To recalibrate BG and ISE the main pump first aspirates a mixture of air (from a reservoir between sample distributor and measuring chamber cartridge) and Mix1 through the measuring chambers.
  • Page 40 2 Fluid actions cobas b 221 system Measurement Finally the outlet and reference valves are closed and the conductivity is checked again. After each washing of the BG or ISE, the rail is washed and emptied to counteract electrical couplings to the pump elastomer.

  • Page 41: Calibration

    221 system 2 Fluid actions Calibration Calibration BG/ISE cleaning Main pump Waste separator T&D module (position 9) D Cleaning solution Figure A-17 BG/ISE cleaning This procedure removes deposits in the BG or ISE measuring chamber. The required cleaning solution is in the S2 Fluid Pack and is aspirated into the measuring chambers through the T&D disk (position 9), the aspiration channel and the sample distributor.

  • Page 42: Calibrating The Conductivity For Cal A Or Cal B

    2 Fluid actions cobas b 221 system Calibration Calibrating the conductivity for CAL A or CAL B Main pump CAL A CAL B D FMS Figure A-18 Calibrating the conductivity for CAL A or CAL B FMS adjustment: This procedure starts by aspirating the FMS through V19 (air) until it is empty. After...
  • Page 43 221 system 2 Fluid actions Calibration Calibrating the conductivity for In this section the conductivity of calibration solution CAL B is precisely measured in CAL B the BG and ISE measuring chamber. The precision of this measurement is very significant for Mix1 and Mix2, because they are based on this measurement.

  • Page 44: O 2 Zero Point Calibration

    2 Fluid actions cobas b 221 system Calibration zero point calibration Main pump D Waste separator electrode zero point solution T&D module (position 5) Figure A-19 zero point calibration This procedure determines the second calibration point of the O electrode. The O zero point solution is in the S2 Fluid Pack and is aspirated into the BG measuring chamber with the vacuum pump and the main pump through the T&D disk (position...

  • Page 45: Na Conditioning

    221 system 2 Fluid actions Calibration Na conditioning Vacuum pump D T&D module (position 7) Main pump Waste separator Na electrode Na conditioner Figure A-20 Na conditioning This procedure is necessary to retain the sensitivity of the Na electrode. The Na conditioner is in the S2 Fluid Pack and is aspirated into the ISE measuring chamber with the vacuum pump and the main pump through the T&D disk (position 7) and...

  • Page 46: Mix1/Mix2 Calibration, Aspirating Bg/Ise Reference Solution

    2 Fluid actions cobas b 221 system Calibration Mix1/Mix2 calibration, aspirating BG/ISE reference solution Main pump ISE Reference solution Aspirating BG reference solution CAL B Aspirating ISE reference solution CAL A D Mix1/Mix2 Calibration BG Reference solution Figure A-21 Mix1/Mix2 calibration, aspirating BG/ISE reference solution...
  • Page 47 221 system 2 Fluid actions Calibration Mix1 Calibration This section refers to the BG and ISE measuring chamber only. The Mix1 mixture is prepared similarly to a recalibration in the sample distributor after a measurement and is ready for entry to the measuring chamber at V21.

  • Page 48: O2-Air Calibration

    2 Fluid actions cobas b 221 system Calibration -air calibration Main pump T&D module (position 4) electrode Figure A-22 -air calibration This procedure determines the first calibration point of the O electrode. Ambient air is slowly aspirated from the T&D disk (position 4) into the BG measuring chamber over the aspiration channel and sample distributor.

  • Page 49: Aspirating Mss Reference Solution, Calibration With Standby Solution

    221 system 2 Fluid actions Calibration Aspirating MSS reference solution, calibration with standby solution MSS output pump D Aspirating MSS reference solution Calibration with standby solution MSS Reference solution Waste separator MSS Standby solution Figure A-23 Aspirating MSS reference solution, calibration with standby solution...
  • Page 50 2 Fluid actions cobas b 221 system Calibration The MSS cassette is calibrated in the following sequence: First a MSS standby solution packet is positioned through a metal pipe in the sample distributor and valves V10 and VSI into the MSS measuring chamber which is called "Ref.

  • Page 51: Cal 1 Calibration

    221 system 2 Fluid actions Calibration CAL 1 Calibration MSS output pump Waste separator D Calibration solution CAL 1 Figure A-24 This procedure determines the sensitivity of the sensors. CAL 1 is aspirated into the MSS measuring chamber from the S3 Fluid Pack A through a metal pipe in the sample distributor and valves V20 and VSI and measured.
  • Page 52 2 Fluid actions cobas b 221 system Calibration CAL 2/CAL 3/CAL 4 Calibration MSS output pump D CAL 2 T&D module (CAL 2=Pos.6, CAL 3=Pos.8, CAL 4= Pos.11) CAL 3 Waste separator CAL 4 Figure A-25 CAL 2/CAL 3/CAL 4 Calibration CAL 2 Calibration This procedure determines the linearity of the sensors.
  • Page 53 221 system 2 Fluid actions Calibration COOX calibration Main pump Separator COOX Aspirate excess out Waste separator Calibrator input D Position calibrator Fill port Figure A-26 COOX calibration Roche Diagnostics May 2009 Service Manual · Version 9.0 A-43...
  • Page 54 2 Fluid actions cobas b 221 system Calibration The calibration does not begin automatically but must be initiated by the user. The fill port of the T&D module is released for input from an external tHb calibrator. Once the SS2 sensor has detected the solution and the sample container has been removed, the positioning begins: a separation at the SS3 sensor is made, then the excess solution is aspirated out through the sample distributor.
  • Page 55 Servicing Protected software functions ......B-3 Components ........B-15 AutoQC module .
  • Page 57 221 system 3 Protected software functions Table of contents Protected software functions This chapter provides information about the protected software functions of the cobas b 221 system. Chapter In this chapter Protected setup ........................ 5 Sample counter ......................5 Baro settings ......................
  • Page 58 3 Protected software functions cobas b 221 system Table of contents Roche Diagnostics May 2009 Service Manual · Version 9.0...

  • Page 59: Protected Setup

    221 system 3 Protected software functions Protected setup Protected setup Sample counter This function allows manual editing of the internal sample counter. See Samples for the sum of all samples input (can be edited by the keyboard symbol), QC samples for...

  • Page 60: Miscellaneous Settings

    This key will switch instruments with serial number > 5000 to cobas b 221 system. [cobas b 221 auto.] [cobas b 221 This key switches the instrument to Roche OMNI S or to the cobas b 221 system. Roche OMNI S] Serial number This function assigns a serial number after pressing the keyboard symbol.
  • Page 61 221 system 3 Protected software functions Protected setup Instrument Setup Configuration cobas b 221<1> system BG + tHb cobas b 221<2> system BG + COOX cobas b 221<3> system BG + ISE + tHb cobas b 221<4> system BG + ISE + COOX cobas b 221<5>...
  • Page 62 3 Protected software functions cobas b 221 system Protected setup Setting Default Comment Economy mode: weekly: start day Friday Economy mode: weekly: start time 18:00 Economy mode: weekly: stop day Moday Economy mode: weekly: stop time 05:00 Aspirate from syringe...
  • Page 63 221 system 3 Protected software functions Protected setup Setting Default Comment AutoQC mat assignment all settings deleted Service mode PC Demo mode Table B-2 Default settings Default maintenance schedule: Maintenance Remind. Interval Samples BG cleaning Never ISE cleaning...

  • Page 64: Polarization Voltages

    3 Protected software functions cobas b 221 system Protected setup Polarization voltages Upol O The keyboard symbol under Upol O can be used to change the polarization voltage of the oxygen electrode (default value 750 mV). The [Adjust] key is used to confirm and import the newly defined value.

  • Page 65: Log Monitor

    The system data are being prepared and the instrument software will be restarted. 3 After restart of the software, press h [Save system data on USB device]. The system data will be saved into the folder "Roche\data\". This process may take several minutes.

  • Page 66: Aqc Adjustment

    USB instead of floppy disk. Export to and import from USB mass storage requires software version 5.00 or higher to be installed on instruments using touch screen/PC units version 4.X or higher and interface unit cobas b 221 system > SN 3000. Service log file export This function exports log files to USB mass storage or to a floppy disk.

  • Page 67: Protected Db Functions

    221 system 3 Protected software functions Protected DB functions Protected DB functions Delete all databases This function is used to delete all patient, measurement, QC measurement, calibration and instrument databases. The instrument will be restarted! Delete databases & archives This function deletes all databases and archives (corresponds to backups).
  • Page 68 3 Protected software functions cobas b 221 system Protected DB functions Roche Diagnostics May 2009 B-14 Service Manual · Version 9.0...
  • Page 69 In this chapter Important notes ......................19 Shutdown ........................19 The cobas b 221 system remains switched off for more than 24 hours ....19 Removing the rear panel ....................20 Folding up the central measuring unit ................. 20 T&D system (Turn & Dock) ..................21 Replacing the T&D module ..................
  • Page 70 4 Components cobas b 221 system Table of contents Replacing the sample distributor ................37 Replacing the SS1, SS2, SS3 and SS4 optical sensors ..........39 BG measuring chamber ....................40 Replacing the BG measuring chamber ..............40 Replacing the fan protector (BG module) ............. 41 Replacing the electrode locking lever (BG module) ..........
  • Page 71 221 system 4 Components Table of contents Replacing the waste docking mechanism ............... 69 Replacing the docking mechanism S1 (rinse solution) ......... 70 Replacing the docking mechanisms S2 and S3 (fluid packs) ........ 70 Replacing the clamp docking mechanism .............. 71 Replacing the micro switch module ...............
  • Page 72 4 Components cobas b 221 system Table of contents Connection of a second barcode scanner ............. 115 Testing the barcode scanner .................. 116 Roche Diagnostics May 2009 B-18 Service Manual · Version 9.0...

  • Page 73: Important Notes

    Important notes Important notes Various components of the cobas b 221 system, such as T&D module, tubes, waste container, waste separator etc., contain liquid biological residues after use that may cause infection. Handle these components with care and avoid skin contact. To avoid direct contact with biological materials, always wear appropriate protective equipment such as lab clothing, protective gloves, safety glasses and, if necessary, a face mask.

  • Page 74: Removing The Rear Panel

    Use the reverse order for assembly. Folding up the central measuring unit 1 Remove the top cover, printer cover and T&D cover of the cobas b 221 system. 2 Rotate the T&D lock on the T&D module 90 degrees to the right.

  • Page 75: T&D System (Turn & Dock)

    1 Switch off the cobas b 221 system. Please pay attention to Shutdown on page B-19. 2 Remove the top cover and T&D cover of the cobas b 221 system. 3 Rotate the T&D lock on the T&D module 90 degrees to the right (see below).
  • Page 76 4 Components cobas b 221 system T&D system (Turn & Dock) Three screws fastening the T&D module D Sample inlet path T&D lock Tubing strip AutoQC tube Figure B-4 T&D module 6 Unplug the AutoQC tube from the tube connection.

  • Page 77: Replacing The Fill Port

    221 system 4 Components T&D system (Turn & Dock) Actuator bus cable Figure B-6 T&D module - actuator bus cable 9 Remove T&D module. Use the reverse order for assembly. Replacing the fill port 1 Remove T&D cover.

  • Page 78: Replacing The Sample Inlet Path

    T&D system (Turn & Dock) Replacing the sample inlet path Various components of the cobas b 221 system, such as T&D module, tubes, waste bottle, waste separator etc., contain liquid biological residues after use that may cause infection. Handle these components with care and avoid skin contact. To avoid direct contact with biological materials, always wear appropriate protective equipment such as lab clothing, protective gloves, safety glasses and, if necessary, a face mask.

  • Page 79: Replacing The Optical Sensor Ss6

    221 system 4 Components T&D system (Turn & Dock) 3 Pull the bypass nipple up and disconnect it. For details, see Figure B-8 on page B-25. Bypass nipple Bypass holder Figure B-8 Replacing the bypass nipple Use the reverse order for assembly.

  • Page 80: Replacing The T&D Sensor Cover

    Use the reverse order for assembly. Replacing the T&D disk Various components of the cobas b 221 system, such as T&D module, tubes, waste bottle, waste separator etc., contain liquid biological residues after use that may cause infection. Handle these components with care and avoid skin contact. To avoid direct contact with biological materials, always wear appropriate protective equipment such as lab clothing, protective gloves, safety glasses and, if necessary, a face mask.

  • Page 81: Replacing The T&D Tubing Set

    221 system 4 Components T&D system (Turn & Dock) 3 Now use the fill port as a tool: Insert the fill port with the flat side into the slot in the T&D disk and turn it 90 degrees to the right or left. Hold the T&D disk in place during this process.

  • Page 82: Replacing The Plug Control

    T&D system (Turn & Dock) Replacing the plug control Various components of the cobas b 221 system, such as T&D module, tubes, waste bottle, waste separator etc., contain liquid biological residues after use that may cause infection. Handle these components with care and avoid skin contact. To avoid direct contact with biological materials, always wear appropriate protective equipment such as lab clothing, protective gloves, safety glasses and, if necessary, a face mask.
  • Page 83 221 system 4 Components T&D system (Turn & Dock) SCD cable Figure B-13 T&D module - SCD cable 5 Unscrew the three screws holding the housing cover at the bottom of the T&D module and remove the cover.

  • Page 84: Replacing The T&D Actuator Board

    4 Components cobas b 221 system T&D system (Turn & Dock) Plug control fixing screws Figure B-15 T&D module 7 Pull the plug control out to the front. Use the reverse order for assembly. Replacing the T&D actuator board Electrostatically sensitive components! 1 Disassemble T&D module.
  • Page 85 221 system 4 Components T&D system (Turn & Dock) Linear actuator connectors "POS" and "TURN" connectors Figure B-16 T&D module - Actuator board 3 Unscrew the screws (stainless steel) holding the stepper motor and remove the stepper motor (see below, B).

  • Page 86: Replacing The T&D Linear Actuators

    4 Components cobas b 221 system T&D system (Turn & Dock) Replacing the T&D linear actuators Electrostatically sensitive components! 1 Disassemble T&D module. For instructions, see Replacing the T&D module on page B-21. 2 Remove T&D disk. For instructions, see Replacing the T&D disk on page B-26.

  • Page 87: Fluid Mixing System (Fms)

    Do not remove the fastening screws completely, because they are secured against loss. 4 If an AutoQC module (optional) is installed in the cobas b 221 system, remove it to allow free access to the FMS (from the back of the instrument).
  • Page 88 4 Components cobas b 221 system Fluid mixing system (FMS) Cable connectors (red/greet/blue, yellow/red) Figure B-20 FMS control board-2 6 Disconnect the two FMS cable connectors on the board (see above). 7 Disconnect the two cable connectors (ground) from the FMS actuators.

  • Page 89: Replacing The Fms Control Board

    1 Remove the rear panel. For instructions, see Removing the rear panel on page B-20. 2 If an AutoQC module (optional) is installed in the cobas b 221 system, remove it to allow free access to the FMS (from the back of the instrument).
  • Page 90 4 Components cobas b 221 system Sample distributor (SD) Linear clamp D Bypass nipple Tubes to measuring chamber cartridge Sample distributor liquid connection Six screws holding the sample distributor cartridge Figure B-22 Sample distributor cartridge 5 Open the locking lever (Plexiglas cover) of the MSS input pump and slide the linear clip (white plastic piece) upwards.

  • Page 91: Replacing The Sample Distributor

    The sample inlet path must be removed at this time, because otherwise it will be irreparably damaged by raising the central measuring unit. 5 Disassemble the cobas b 221 system fan unit. For instructions, see Replacing the main fan unit on page B-110.
  • Page 92 4 Components cobas b 221 system Sample distributor (SD) 14 Disconnect the sample sensor board from the mainboard. Sample sensor board Figure B-23 Sample sensor board 15 Pull the liquid connector of the sample distributor down. For details, see Figure B-22 on page B-36.

  • Page 93: Replacing The Ss1, Ss2, Ss3 And Ss4 Optical Sensors

    The sample inlet path must be removed at this time, otherwise it will be destroyed by folding the central measuring unit out. 7 Disassemble the cobas b 221 system fan unit. For instructions, see Replacing the main fan unit on page B-110.

  • Page 94: Bg Measuring Chamber

    4 Components cobas b 221 system BG measuring chamber b) Unscrew the two screws holding the VBI valve. For details, see Figure B-62 on page B-83. c) Remove the valve. Now slide the sensor out and remove it. Optical sensor SS2: a) Disassemble the mainboard unit.

  • Page 95: Replacing The Fan Protector (Bg Module)

    221 system 4 Components BG measuring chamber Three screws holding the ISE module Three screws holding the BG module Figure B-25 Screws holding the BG and ISE modules 4 Unscrew the three screws holding the ISE module (see above, A).

  • Page 96: Replacing The Electrode Locking Lever (Bg Module)

    Use the reverse order for assembly. Replacing the electrode locking lever (BG module) 1 Remove the cobas b 221 system top cover, open the BG measuring chamber and remove the electrodes. 2 Half open the electrode locking lever, hold it in place with both hands and pull it 3 Disconnect the tube and remove the electrode locking lever.

  • Page 97: Replacing The Fan Protector (Ise Module)

    Use the reverse order for assembly. Replacing the electrode locking lever (ISE module) 1 Remove the cobas b 221 system top cover and open the ISE measuring chamber. 2 Half open the electrode locking lever, hold it in place with both hands and pull it 3 Disconnect the tube and remove the electrode locking lever.

  • Page 98: Mss Measuring Chamber (Cobas B 221<5/6> Systems Only)

    4 Components cobas b 221 system MSS measuring chamber (cobas b 221<5/6> systems only) MSS measuring chamber (cobas b 221<5/6> systems only) Replacing the MSS measuring chamber Electrostatically sensitive components! 1 Disassemble the sample distributor cartridge. For instructions, see Replacing the sample distributor cartridge on page B-35.

  • Page 99: Replacing The Mss Mc Cover

    Make sure that there is no contamination between heating plate and sample distributor cartridge. Replacing the MSS MC cover 1 Remove the cobas b 221 system top cover and open the MSS measuring chamber. 2 Pull the MC cover upward.

  • Page 100: Replacing The Mss Clip

    Replacing the MSS clip Electrostatically sensitive components! 1 Remove the cobas b 221 system top cover and open the MSS measuring chamber. 2 Unscrew the screws marked A and B of the MSS module and open the module. For details, see Figure B-28 on page B-45.

  • Page 101: Replacing The Center Seal (Mss Module)

    MSS measuring chamber (cobas b 221<5/6> systems only) Replacing the center seal (MSS module) 1 Remove the cobas b 221 system top cover and open the MSS measuring chamber. 2 Open the electrode locking lever. 3 Remove electrodes and MSS-cartridge.

  • Page 102: Measuring Chamber Cartridge

    4 Components cobas b 221 system Measuring chamber cartridge Measuring chamber cartridge Replacing the measuring chamber cartridge Activate the function program [System] > [Utilities] > [Maintenance] > [Change MC cartridge] to position all valve actuators correctly. 1 Remove the top cover.
  • Page 103 221 system 4 Components Measuring chamber cartridge Tension lever Linear clamp Figure B-30 Measuring chamber cartridge - 2 3 Disconnect tube adapter to the bottle compartment, the connector tube to the waste separator and the connector tube to V4 on the T-piece (see below).

  • Page 104: Replacing The Mc Actor Control Board

    Replacing the MC Actor Control Board Electrostatically sensitive components! 1 Remove the top cover and the T&D cover of the cobas b 221 system. 2 Rotate the T&D lock on the T&D module 90 degrees to the right. For details, see Figure B-4 on page B-22.

  • Page 105: Coox Module (Cobas B 221<2/4/6> Systems Only)

    1 Remove the rear panel of the instrument. For instructions, see Removing the rear panel on page B-20. 2 Remove the T&D cover of the cobas b 221 system. 3 Unscrew the four screws holding the right side panel and remove the side panel.
  • Page 106 4 Components cobas b 221 system COOX module (cobas b 221<2/4/6> systems only) 4 Loosen the two cable clamp screws on the PolyOX-KX control board. Cable clamp Figure B-33 PolyOX-KX control board - cable clamp 5 Disconnect the power supply cable (identification: J7) and the two lamp plugs on the lamp unit (identification: J1, J2) on the board.

  • Page 107: Replacing The Polyox-Kx Control Board

    1 Remove the rear panel of the instrument. For instructions, see Removing the rear panel on page B-20. 2 Remove the T&D cover of the cobas b 221 system. 3 Unscrew the four screws holding the right side panel and remove the side panel.

  • Page 108: Replacing The Polychromator Bilirubin

    4 Components cobas b 221 system COOX module (cobas b 221<2/4/6> systems only) Replacing the Polychromator Bilirubin After replacing the polychromator bilirubin, a code must be entered in the protected setup. For this purpose, record the 16 digit code located on the polychromator bilirubin! For instructions, see COOX module (cobas b 221<2/4/6>...
  • Page 109 221 system 4 Components COOX module (cobas b 221<2/4/6> systems only) 10 Disconnect the light guide (gray) leading to the polychromator from the cuvette holder and slide it out to the back. 11 Pull the light guide leading to the polychromator out of the clamp beside the polychromator and slide it out to the right.

  • Page 110: Replacing The Primary Light Guide

    4 Components cobas b 221 system COOX module (cobas b 221<2/4/6> systems only) Screws Polychromator Bilirubin Figure B-38 Polychromator Bilirubin Use the reverse order for assembly. Light guide (black) Cable to HSIN board Light guide (grey) D Ground cable connection...
  • Page 111 221 system 4 Components COOX module (cobas b 221<2/4/6> systems only) 4 Unscrew the three screws holding the central measuring unit. For details, see Figure B-2 on page B-20. Do not remove the fastening screws completely, because they are secured against loss.

  • Page 112: Replacing The Cuvette Holder

    4 Components cobas b 221 system COOX module (cobas b 221<2/4/6> systems only) Replacing the cuvette holder 1 Remove the top cover, the printer cover and the T&D cover of the instrument. 2 Rotate the T&D lock on the T&D module 90 degrees to the right.

  • Page 113: Replacing The Cuvette

    4 Components COOX module (cobas b 221<2/4/6> systems only) Replacing the cuvette 1 Remove the cobas b 221 system top cover and open the cuvette holder. 2 Open the retainer and remove the cuvette. Use the reverse order for assembly.

  • Page 114: Replacing The Hemolyzer

    4 Components cobas b 221 system COOX module (cobas b 221<2/4/6> systems only) 1 Remove the top cover. 2 Disconnect the left tube from the cuvette holder. For details, see Figure B-41 on page B-58. 3 Disconnect the connector tube to V4 on the T-piece and remove tubing set tHb/ PolyOX..

  • Page 115: Replacing The Hemolyzer Tube

    Do not reverse the two tubes on the hemolyzer when reconnecting them! Replacing the Hemolyzer tube 1 Remove the cobas b 221 system top cover. 2 Disconnect the tube on the hemolyzer (out) and at the cuvette input and remove Use the reverse order for assembly.

  • Page 116: Thb/So 2 Module (Cobas B 221<1/3/5> Systems Only)

    These revisions are also compatible with software versions > 3.00! 1 Remove the top cover, T&D cover and printer cover of the cobas b 221 system. 2 Rotate the T&D lock on the T&D module 90 degrees to the right.

  • Page 117: Replacing The Tubing Set Thb/Polyox

    221 system 4 Components tHb/SO module (cobas b 221<1/3/5> systems only) The sample inlet path must be removed at this time, otherwise it will be destroyed by folding the central measuring unit out. 6 Disconnect the tube connector from the tHb/SO module.

  • Page 118: Peristaltic Pumps (Pp)

    221 system Peristaltic pumps (PP) 1 Remove the top cover and T&D cover of the cobas b 221 system. 2 Rotate the T&D lock on the T&D module 90 degrees to the right. For details, see Figure B-4 on page B-22.
  • Page 119 221 system 4 Components Peristaltic pumps (PP) Do not remove the fastening screws completely, because they are secured against loss. 6 Raise the central measuring unit forward until it clicks audibly into place. The sample inlet path must be removed at this time, otherwise it will be destroyed by folding the central measuring unit out.

  • Page 120: Replacing The Pump Head

    221 system Peristaltic pumps (PP) Replacing the pump head 1 Remove the cobas b 221 system top cover. 2 Open the locking lever (Plexiglas cover) of the peristaltic pump and slide the linear clamp (white plastic part) up.

  • Page 121: Replacing The Pump Tube

    4 Components Bottle compartment Replacing the pump tube 1 Remove the cobas b 221 system top cover. 2 Open the locking lever (Plexiglas cover) of the peristaltic pump and slide the linear clamp (white plastic part) up. For details, see Figure B-46 on page B-65.

  • Page 122: Replacing The Gas Dampers

    1 Open the bottle compartment cover. 2 Left gas damper: unscrew the five screws holding the left side panel of the cobas b 221 system and remove the side panel. Do not remove the fastening screws completely, because they are secured against loss.

  • Page 123: Replacing The Waste Docking Mechanism

    Use the reverse order for assembly. Replacing the waste docking mechanism Various components of the cobas b 221 system, such as T&D module, tubes, waste bottle, waste separator etc., contain liquid biological residues after use that may cause infection. Handle these components with care and avoid skin contact. To avoid direct contact with biological materials, always wear appropriate protective equipment such as lab clothing, protective gloves, safety glasses and, if necessary, a face mask.

  • Page 124: Replacing The Docking Mechanism S1 (Rinse Solution)

    Use the reverse order for assembly. Replacing the docking mechanisms S2 and S3 (fluid packs) 1 Remove the top cover and T&D cover of the cobas b 221 system. 2 Open bottle compartment cover and S2 (or S3) docking mechanism.

  • Page 125: Replacing The Clamp Docking Mechanism

    Assembly is done in reverse order. Check the tube connections after the assembly! Replacing the micro switch module 1 Remove the cobas b 221 system top cover. 2 Open the bottle compartment cover. 3 Unscrew the screw holding the micro switch module.

  • Page 126: Replacing The Bacteria Filter

    4 Components cobas b 221 system Bottle compartment Holding screw Micro switch Figure B-53 Micro switch 4 Pull micro switch module forward. 5 Disconnect the two plug connectors and remove the micro switch module. Use the reverse order for assembly.

  • Page 127: Vacuum System

    Vacuum system Replacing the vacuum pump completely Various components of the cobas b 221 system, such as T&D module, tubes, waste bottle, waste separator etc., contain liquid biological residues after use that may cause infection. Handle these components with care and avoid skin contact. To avoid direct contact with biological materials, always wear appropriate protective equipment such as lab clothing, protective gloves, safety glasses and, if necessary, a face mask.
  • Page 128 221 system Vacuum system 7 Unscrew the five screws holding the left side panel of the cobas b 221 system and remove the side panel. Do not remove the fastening screws completely, because they are secured against loss.
  • Page 129 221 system 4 Components Vacuum system Waste tube T-piece Cable clip Figure B-57 Waste tube 12 Unscrew the three screws holding the vacuum pump (see below, A) and remove the vacuum pump. Three screws holding the vacuum pump...

  • Page 130: Replacing The Vacuum Pump

    Vacuum system Replacing the vacuum pump Various components of the cobas b 221 system, such as T&D module, tubes, waste bottle, waste separator etc., contain liquid biological residues after use that may cause infection. Handle these components with care and avoid skin contact. To avoid direct contact with biological materials, always wear appropriate protective equipment such as lab clothing, protective gloves, safety glasses and, if necessary, a face mask.

  • Page 131: Replacing The Moisture Trap

    Always wear gloves when working with the instrument! The tubes may drip a little after being disconnected. Remove excess fluids with a clean, absorbent cloth. 1 Unscrew the five screws holding the left side panel of the cobas b 221 system and remove the side panel.

  • Page 132: Replacing The Vacuum Pump Protector

    Always wear gloves when working with the instrument! The tubes may drip a little after being disconnected. Remove excess fluids with a clean, absorbent cloth. 1 Unscrew the five screws holding the left side panel of the cobas b 221 system and remove the side panel.
  • Page 133 The sample inlet path must be removed at this time, otherwise it will be destroyed by folding the central measuring unit out. 7 Unscrew the five screws holding the left side panel of the cobas b 221 system and remove the side panel.

  • Page 134: Replacing The Vacuum Control Board

    Replacing the vacuum control board Electrostatically sensitive components! 1 Remove the top cover and T&D cover of the cobas b 221 system. 2 Rotate the T&D lock on the T&D module 90 degrees to the right. For details, see Figure B-4 on page B-22.

  • Page 135: Valves

    221 system 4 Components Valves 6 Disconnect the connectors from the V4/V6 actuator board. 7 Unscrew the screw holding the V4/V6 actuator board and remove the board. Use the reverse order for assembly. Valves Replacing the valves of the measuring chamber cartridge...
  • Page 136 1 Switch off the cobas b 221 system. Please pay attention to Shutdown on page B-19. 2 Remove the top cover and T&D cover of the cobas b 221 system. 3 Rotate the T&D lock on the T&D module 90 degrees to the right For details, see Figure B-4 on page B-22.

  • Page 137: Replacing The Valves From Sample Distributor Cartridge And Hb Cartridge

    1 Switch off the cobas b 221 system. Please pay attention to Shutdown on page B-19. 2 Remove the cobas b 221 system top cover. 3 Rotate the T&D lock on the T&D module 90 degrees to the right. For details, see Figure B-4 on page B-22.
  • Page 138 4 Components cobas b 221 system Valves 5 Unscrew the three screws holding the central measuring unit. For details, see Figure B-2 on page B-20. Do not remove the fastening screws completely, because they are secured against loss. 6 Raise the central measuring unit forward until it clicks audibly into place.
  • Page 139 221 system 4 Components Valves Replacing the waste valves V13/V18 V13 and V18 are different parts: V13 = valve undamped V18 = VP waste valve V18 (VP waste valve) V13 (valve undamped) Figure B-63 Waste valves V13 and V18 1 Remove the vacuum pump completely.

  • Page 140: Replacing The Waste Valve V6

    The sample inlet path must be removed at this time, otherwise it will be destroyed by folding the central measuring unit out. 7 Unscrew the five screws holding the left side panel of the cobas b 221 system and remove the side panel.
  • Page 141 221 system 4 Components Valves Relief clamp Holding screw Actuator Board V4/V6 Figure B-64 Actuator board 10 Disconnect the waste tube from the waste docking mechanism and pull it out of the valve (see below). 11 Unscrew the two screws holding the V6 waste valve (see below, A).

  • Page 142: Replacing The Air Valve V4

    221 system Valves Replacing the air valve V4 V4 is a separate valve called "valve cobas b 221 system", do not use the valve called "valve unit", it is different! 1 Switch off the cobas b 221 system.

  • Page 143: Mainboard Unit

    1 Switch off the cobas b 221 system. Please pay attention to Shutdown on page B-19. 2 Remove the top cover and T&D cover of the cobas b 221 system. 3 Rotate the T&D lock on the T&D module 90 degrees to the right.
  • Page 144 4 Components cobas b 221 system Mainboard unit 10 Disconnect all cable connectors fixed to the mainboard with plugs on the modules. The BG and ISE module plug connectors on the mainboard are permanently attached: do not pull them off! 11 Press the mainboard unit to the left or right to release it from the retainer pins.

  • Page 145: Replacing The Sample Sensor Board

    221 system 4 Components Interface unit Replacing the sample sensor board Electrostatically sensitive components! 1 Follow section Replacing the Mainboard unit until step 8. For instructions, see steps 1 to 8 of Replacing the Mainboard unit on page B-89.

  • Page 146: Replacing The Interface Unit

    4 Components cobas b 221 system Interface unit Roche OMNI Roche OMNI cobas b 221 < TS-PC UNIT system SN < 1500 system system INTERFACE UNIT > (not upgraded) 1500 < SN < 3000 SN > 3000 TS-PC UNIT COMPLETE TS-PC UNIT 3.X >...
  • Page 147 221 system 4 Components Interface unit AutoQC module connector cable COOX module connector cable Figure B-70 Interface connections 7 Disconnect the screen cable on the left interior of the interface unit. For details, see Figure B-80 on page B-103.

  • Page 148: Replacing The Autoqc/Coox Cable

    4 Components cobas b 221 system Interface unit Grasp the interface unit while unscrewing the mounting screws to prevent it from sliding off! 11 Pull the interface unit to the back and remove it. Use the reverse order for assembly.

  • Page 149: Touch Screen/Pc Unit

    3 Backup all databases: [Data manager] > [Utilities] > [Backup / Restore] > [Backup now] For more information, refer to the cobas b 221 system Reference Manual, Section "Utilities". 4 Mark the last entry in the Backup/Restore list and copy it onto floppy disk For more information, refer to the cobas b 221 system Reference Manual, Section "Utilities".
  • Page 150 4 Components cobas b 221 system Touch screen/PC unit Read and record the 16 digit code located on the polychromator bilirubin (see below). 16 digit code Figure B-73 Polychromator bilirubin – code Reassemble the right side cover, the T&D cover and the printer cover. Close the bottle compartment.
  • Page 151 [SW upgrade]). For more information, refer to: Software update on page B-104 cobas b 221 system Reference Manual, chapter "Software modes", section "SW upgrade" Check date and time. Assign the instrument type and load the default setup. For instructions, see Instrument type on page B-6.
  • Page 152 221 system Touch screen/PC unit Enter the serial number of the cobas b 221 system – it is located on the rear panel of the cobas b 221 system. For more information, see Serial number on page B-6.

  • Page 153: Replacing The Hard Disk

    Perform a polychromator calibration (h [System] > [Calibrations]). Perform a COOX calibration (h [System] > [Calibrations]). Enter the serial number of the cobas b 221 system – it is located on the rear panel of the cobas b 221 system.
  • Page 154 4 Components cobas b 221 system Touch screen/PC unit 1 Disassemble the touch screen/PC unit. For instructions, see Replacing the touch screen/PC unit on page B-95. 2 Push the touch screen/PC unit joint to the vertical position. Touch screen/PC unit...

  • Page 155: Replacing The Floppy Disk Drive

    221 system 4 Components Touch screen/PC unit After replacing the hard disk, perform the same settings. For instructions, see Replacing the touch screen/PC unit on page B-95. Replacing the floppy disk drive Electrostatically sensitive components! 1 Disassemble the touch screen/PC unit.

  • Page 156: Replacing The Battery And Charger

    4 Components cobas b 221 system Touch screen/PC unit Replacing the battery and charger Electrostatically sensitive components! 1 Disassemble the touch screen/PC unit. For instructions, see Replacing the touch screen/PC unit on page B-95. 2 Push the touch screen/PC unit joint to the vertical position.

  • Page 157: Replacing The Screen Cable

    221 system 4 Components Touch screen/PC unit Peel off the foil on one side of the aluminum block only! Aluminium Block Figure B-79 Aluminium Block Replacing the screen cable 1 Remove the rear panel. For instructions, see Removing the rear panel on page B-20.

  • Page 158: Software Update

    Use the reverse order for assembly. Software update General The actual software version can be used for a software update of a cobas b 221 system currently running software version > 1.00 – 0316. Software packages The cobas b 221 system software is available in different formats for different purposes.
  • Page 159 USB software update requires software version 5.00 or higher to be installed on instruments using touch screen-PC units version 4.X or higher and interface unit cobas b 221 system > SN 3000. For details, see cobas b 221 system Spare Part List, section Touch Screen-PC Unit.
  • Page 160 1 Connect the computer and the cobas b 221 system using a crossover RJ45 network cable (available in specialized trade). Direct network connections between PC and cobas b 221 system are only possible by using a crossover network cable. Verify proper connection using the command PING on the computer.
  • Page 161 USB video sequences update 1 Perform a software update if necessary and restart the cobas b 221 system. 2 Prepare the PC and the cobas b 221 system same as Preparing the USB mass storage. For details, see Software update with USB mass storage on page B-105.

  • Page 162: Printer

    1 Perform a software update if necessary and restart the cobas b 221 system. 2 Prepare the PC and the cobas b 221 system same as for the software update with FTP until Connecting the FTP server and the cobas b 221 system.

  • Page 163: Replacing The Winder Unit

    221 system 4 Components Printer Figure B-82 Printer connector cable Use the reverse order for assembly. During assembly, observe the position of the printer connector cable (see above). Replacing the winder unit 1 Disassemble the printer unit. For instructions, see Replacing the Printer on page B-108.

  • Page 164: Fan Unit

    Fan unit Replacing the main fan unit 1 Remove the top cover, printer cover and T&D cover of the cobas b 221 system. 2 Rotate the T&D lock on the T&D module 90 degrees to the right. For details, see Figure B-4 on page B-22.
  • Page 165 221 system 4 Components Replacing the valve bus cable 6 Disassemble the fan shield. For instructions, see Replacing the main fan unit on page B-110. 7 Unscrew the two screws holding the mainboard retainer. For details, see Figure B-66 on page B-89.

  • Page 166: Replacing The Actuator Bus Main Controller Cable

    4 Components cobas b 221 system Replacing the actuator bus main controller cable Plug connector on the measuring chamber Plug connector on the V4/V6 actuator cartridge valve unit board Figure B-84 Valve bus cable 12 Release the valve bus connector cable on the V4/V6 actuator board and remove the cable (see above).

  • Page 167: Barcode Scanner

    221 system 4 Components Barcode scanner 7 Remove the two screws holding the actuator bus plug. 8 Release the controller cable connector on the hemolyzer. 9 Release the controller cable connector on the vacuum control board. 10 Release the controller cable connector on the FMS control board.
  • Page 168 4 Components cobas b 221 system Barcode scanner UPC-E More available barcode types can be programmed according to the enclosed manual of the PS2 hand-held scanner (included in delivery). Following barcode types are used for electrodes, QC materials and solutions:...
  • Page 169 221 system 4 Components Barcode scanner Connection of a second barcode scanner If it is necessary to use one of the two barcode types Code 39 or Interleaved 2 of 5 with "Check Digits", a second barcode scanner programmed specifically for the customer must be connected.
  • Page 170 4 Components cobas b 221 system Barcode scanner Testing the barcode scanner h At the ready screen, press [System] > [Component test] > [PC components] > [Barcode]. Read in a barcode. The displayed number on the screen must be identical with the number below the barcode.
  • Page 171 221 system 5 AutoQC module Table of contents AutoQC module This chapter provides servicing information about the AutoQC module. Chapter In this chapter AutoQC preparation for maintenance ............... 121 Initial installation of the AutoQC module ..............121 Replacing the AutoQC module ................... 122 Replacing the AQC snap lock ..................
  • Page 172 5 AutoQC module cobas b 221 system Table of contents Roche Diagnostics May 2009 B-118 Service Manual · Version 9.0...

  • Page 173: Autoqc Preparation For Maintenance

    5 Unscrew the two screws holding the AutoQC drawer cover on the bottom of the cobas b 221 system and fasten the drawer cover to the AutoQC module. 6 Remove the AutoQC snap lock from the module and plug it into the matching opening in the cobas b 221 system.

  • Page 174: Replacing The Autoqc Module

    7 Slide the AutoQC module into the opening and fasten it to the bottom of the cobas b 221 system with the two fixing screws. The AutoQC module rails must fit flush to the cobas b 221 system cover frame so the two fixing screws can grip.
  • Page 175 5 Disconnect the cable (at the board) and the wash tube (at the angled nipple) (see above). 6 Unscrew the two screws holding the AutoQC module on the bottom of the cobas b 221 system (see below, A). Two AutoQC fixing screws Figure B-91...

  • Page 176: Replacing The Aqc Snap Lock

    Replacing the AQC snap lock The snap lock of the cobas b 221 system AutoQC module consists of two parts. Part a is fixed to the AutoQC module; part b is fixed to the right frame of the cobas b 221 system.

  • Page 177: Replacing The Aqc Magnetic Valve

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Remove the back panel of the instrument. For instructions, see Removing the rear panel on page B-20.

  • Page 178: Replacing The Aqc Board

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Disassemble the AutoQC module. For instructions, see Replacing the AutoQC module on page B-120.

  • Page 179: Replacing The Yz Distributor Board

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Pull the AutoQC module out to the left.

  • Page 180: Replacing The Z Distributor Board

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Pull the AutoQC module out to the left.

  • Page 181: Replacing The Flex Cable (Short)

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Pull the AutoQC module out to the left.

  • Page 182: Replacing The Flex Cable (Long)

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Pull the AutoQC module out to the left.

  • Page 183: Aqc Sample Tube

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Pull the AutoQC module out to the left.

  • Page 184: Replacing The Aqc Sample Tube Short

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Pull the AutoQC module out to the left.

  • Page 185: Replacing The X Motor

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Disassemble the AutoQC module. For instructions, see Replacing the AutoQC module on page B-120.

  • Page 186: Replacing The Y Motor

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Pull the AutoQC module out to the left.

  • Page 187: Replacing The Autoqc Steel Tube

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Pull the AutoQC module out to the left.

  • Page 188: Replacing The Aqc Temperature Sensor

    > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. The cobas b 221 system must always be switched off, because the new AutoQC temperature sensor must be configured. This is done after the boot process.

  • Page 189: Replacing The Wash Port

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Pull the AutoQC module out to the left.

  • Page 190: Replacing The Toothed Belt (Short)

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Pull the AutoQC module out to the left.

  • Page 191: Replacing The Toothed Belt (Long)

    [System] > [Component test] > [Aggregates] > [AQC motors] > [AQC motors] > [Service Position] to bring the motors to the service position. 1 Switch off the cobas b 221 system. 2 Pull the AutoQC module out to the left.
  • Page 192 5 AutoQC module cobas b 221 system Replacing the toothed belt (long) Roche Diagnostics May 2009 B-138 Service Manual · Version 9.0...
  • Page 193 Maintenance Maintenance ........C-3 May 2009...
  • Page 195 221 system 6 Maintenance Table of contents Maintenance This chapter provides information about annual and three-year maintenance. Chapter In this chapter Decontamination ......................5 Surfaces ........................5 Screen ......................... 6 Barcode Scanner ......................6 Input unit ........................6 Modules and tubing paths ..................
  • Page 196 6 Maintenance cobas b 221 system Table of contents Roche Diagnostics May 2009 Service Manual · Version 9.0...

  • Page 197: Decontamination

    HIV) when replacing parts that were in contact with blood or other biological fluids. Various components of the cobas b 221 system, such as T&D module, tubes, waste bottle, waste separator etc., contain liquid biological residues after use that may cause infection.

  • Page 198: Screen

    6 Maintenance cobas b 221 system Decontamination Some surfaces require extended soaking to achieve cleaning. Important Never spray parts that cannot be removed or that are inside the instrument! For details, see section Decontamination on page C-5! Screen a Cleaning the screen 1 Press h [System] >...
  • Page 199 221 system 6 Maintenance Decontamination Measuring module Samples Cycle never never COOX und tHb/SO never never Table C-1 Standard settings for automatic internal cleaning Automatic BG cleaning If the automatic BG cleaning is activated, internal instrument data such as the measuring frequency and drift behavior of the sensors is used to automatically select an optimum cleaning interval.
  • Page 200 6 Maintenance cobas b 221 system Decontamination 3 Each external cleaning must be followed by a wetting using whole blood or serum, press: h System > Utilities > Fluid actions > Wetting routines 4 Press h [Start internal cleaning] to carry out a cleaning using the internal cleaning solution.

  • Page 201: Cleaning Of The Measuring Chambers Bg, Ise And Mss

    6 Maintenance Decontamination Cleaning of the measuring chambers BG, ISE and MSS 1 Remove the cobas b 221 system top cover. 2 Open the appropriate measuring chamber. 3 Open the electrode clamping lever in the measuring chamber and remove the electrodes.

  • Page 202: Cobas B 221<1/3/5> Systems (Thb/So 2 )

    221<1/3/5> systems (tHb/SO Yearly replacement Various components of the cobas b 221 system such as T&D module, tubes, waste container, etc., contain liquid biological residues after use that may cause infection. Handle these components with care and avoid skin contact. To avoid direct contact with biological materials, always wear appropriate protective equipment such as lab clothing, protective gloves, safety glasses and, if necessary, a face mask.

  • Page 203: Replace Every Three Years

    221<1/3/5> systems (tHb/SO Replace every three years Various components of the cobas b 221 system such as T&D module, tubes, waste container, etc., contain liquid biological residues after use that may cause infection. Handle these components with care and avoid skin contact. To avoid direct contact with biological materials, always wear appropriate protective equipment such as lab clothing, protective gloves, safety glasses and, if necessary, a face mask.

  • Page 204: Cobas B 221<2/4/6> Systems (Coox)

    221<2/4/6> systems (COOX) Yearly replacement Various components of the cobas b 221 system, such as T&D module, tubes, waste container, etc., contain liquid biological residues after use that may cause infection. Handle these components with care and avoid skin contact. To avoid direct contact with biological materials, always wear appropriate protective equipment such as lab clothing, protective gloves, safety glasses and, if necessary, a face mask.

  • Page 205: Replace Every Three Years

    221<2/4/6> systems (COOX) Replace every three years Various components of the cobas b 221 system, such as T&D module, tubes, waste container, etc., contain liquid biological residues after use that may cause infection. Handle these components with care and avoid skin contact. To avoid direct contact with biological materials, always wear appropriate protective equipment such as lab clothing, protective gloves, safety glasses and, if necessary, a face mask.

  • Page 206: Autoqc Module

    6 Maintenance cobas b 221 system AutoQC module The tubing paths must also be disinfected annually and the baro value must be checked. AutoQC module Yearly replacement AQC maintenance kit The AQC maintenance kit consists of the following components. Tube for magnetic valve Replacement: remove the tube at the angle nipples and replace it with a new one.
  • Page 207 Troubleshooting Troubleshooting ........D-3 May 2009...
  • Page 209 221 system 7 Troubleshooting Table of contents Troubleshooting This chapter provides information about the troubleshooting of the cobas b 221 system. The system stops and the error messages are listed (sorted by Info No.). Explanation of important test routines will assist in locating error sources.
  • Page 210 7 Troubleshooting cobas b 221 system Table of contents Error 10023 "Power fail" ..................16 Error 10024 "No wash-water container" ..............16 Error 10025 "Check date and time" ................ 17 Error 10026 "Bypass wash error 2" ................. 17 Error 10027 "SD wash error 2" ................17 Error 10028 "S1 on board time expired"...
  • Page 211 221 system 7 Troubleshooting Table of contents Error 10301 "Program error" .................. 29 Error 10302 "Program error" .................. 29 Errors 10303...10310 "Program error" ..............29 Errors 10318...10327 "Program error" ..............30 Error 10340 "Program error" .................. 30 Errors 10341, 10342 "Program error" ..............30 Error 10343 "Program error"...
  • Page 212 7 Troubleshooting cobas b 221 system Table of contents Error 20018 "Pack S2 empty" .................. 39 Error 20019 "Flap S2" ....................39 Error 20020 "No pack S2" ..................39 Error 20021 "ADC error cond BG/ISE" ..............40 Error 20022 "Transponder error S2" ..............40 Error 20023 "S2 on board time expired"...
  • Page 213 221 system 7 Troubleshooting Table of contents Warning 30009 "Pack S3 level is low" ..............51 Warning 30010 "Rinse level is low" ................ 52 Warning 30011 "Waste is nearly full" ..............52 Warning 30012 "Prep. of rinse not ok" ..............52 Warning 30013 "Prep.
  • Page 214 7 Troubleshooting cobas b 221 system Table of contents Flag no. 1027 "No sample detected (4)" ..............66 Flag no. 1028 "Insufficient sample (1)" ..............67 Flag no. 1029 "Insufficient sample (2)" ..............67 Flag no. 1030 "Insufficient sample (3)" ..............67 Flag no.
  • Page 215 221 system 7 Troubleshooting Table of contents Flags no. 5010...5012 "Calculation error (3...5)" ............ 82 Flag no. 6026 "ADC error" ..................82 Flag no. 6030 "COOX HW error" ................83 Flag no. 6031 "Neon lamp not OK" ................ 83 Flag no.
  • Page 216 7 Troubleshooting cobas b 221 system Table of contents Roche Diagnostics May 2009 D-10 Service Manual · Version 9.0...

  • Page 217: Important Notes

    Serious error messages are frequently the result of loose or incorrectly attached cable and tube connections. Various components of the cobas b 221 system, such as T&D module, tubes, waste bottle, waste separator etc., contain liquid biological residues after use that may cause infection.

  • Page 218: Fill Level Determination

    Starting from software version 6.00 and cobas bge link version 3.5 a new screen sharing feature is available and allows for on-screen control of the cobas b 221 system. This allows to operate the instrument on a PC using cobas bge link.

  • Page 219: System Stops

    Error 10002 "Out of operation" The instrument was taken out of operation. Perform installation procedures. For instructions, refer to the cobas b 221 system Instructions for Use, Chapter "Introduction", section "Installation". Error 10003 "Warmup" The instrument warms up after replacement of electrodes, power-on or power fail.

  • Page 220: Error 10005 "Comm. Error Pc-Μc

    7 Troubleshooting cobas b 221 system System stops Error 10005 "Comm. error PC-µC" Communications between PC and microcontroller is interrupted. Turn the instrument off and on again. After replacing the Screen/PC-unit or the hard disk, assign the valid instrument type and load the default settings.

  • Page 221: Error 10010 "Current Overload Valve Bus

    221 system 7 Troubleshooting System stops Error 10010 "Current overload valve bus" A component on the valve bus has a short circuit. Call up general hardware test. If the general hardware tests interrupts at beginning: Replace power supply.

  • Page 222: Error 10018 "Sd Wash Error 1

    7 Troubleshooting cobas b 221 system System stops Error 10018 "SD wash error 1" Sample sensor SS2 recognizes too less air during the wash procedure. Call up "Wash" again. h At the system stop screen, press [Wash]. Clean the moisture trap at the T&D tubing.

  • Page 223: Error 10025 "Check Date And Time

    221 system 7 Troubleshooting System stops Error 10025 "Check date and time" Date and time have to be verified. Input current date and time. Error 10026 "Bypass wash error 2" Sample sensor SS2 recognizes too less S1 Rinse Solution during the wash procedure.

  • Page 224: Error 10032 "Microcontroller Communications Error

    7 Troubleshooting cobas b 221 system System stops Error 10032 "Microcontroller communications error" A communications problem occurred at the microcontroller. Turn the instrument off, wait at least 3 minutes, and turn it back on. Check cabling between interface board and mainboard.

  • Page 225: Error 10041 "Waste Error 1

    221 system 7 Troubleshooting System stops Error 10041 "Waste error 1" The waste system is leaking. Insert new waste container. The waste docking mechanism is contaminated or damaged. It must be cleaned or replaced. For instructions, see Replacing the waste docking mechanism on page B-69.

  • Page 226: Error 10046 "Waste Line Blocked

    7 Troubleshooting cobas b 221 system System stops Error 10046 "Waste line blocked" The connection from separator into the waste container is not continuous. Insert new waste container. Waste separator empty: In the sensor test check the functioning of the waste sensor and if necessary replace the waste sensor.

  • Page 227: Error 10049 "Error Ss2

    221 system 7 Troubleshooting System stops Replace corresponding sample sensor. For instructions, see Replacing the SS1, SS2, SS3 and SS4 optical sensors on page B-39. Replace sample sensor board. For instructions, see Replacing the sample sensor board on page B-91.

  • Page 228: Error 10051 "Error Ss4

    7 Troubleshooting cobas b 221 system System stops Replace corresponding sample sensor. For instructions, see Replacing the SS1, SS2, SS3 and SS4 optical sensors on page B-39. Replace sample sensor board. For instructions, see Replacing the sample sensor board on page B-91.

  • Page 229: Error 10054 "Baro Sensor Error

    221 system 7 Troubleshooting System stops Replace the T&D actuator board. For instructions, see Replacing the T&D actuator board on page B-30. Error 10054 "Baro sensor error" The measured barometric pressure falls outside the specified range. Update Baro value.

  • Page 230: Errors 10095

    7 Troubleshooting cobas b 221 system System stops Replace the mainboard unit. For instructions, see Replacing the Mainboard unit on page B-89. Replace the interface unit. For instructions, see Replacing the Interface unit on page B-92. Errors 10095...10097 "Timing error"...

  • Page 231: Error 10106 "Timing Error

    221 system 7 Troubleshooting System stops Error 10106 "Timing error" An asynchronism occurred between processes and measuring (MSS). Check SD cartridge tubing. For instructions, see Sample distributor (SD) on page B-35. Call up the general fluidics test. h [System] > [Diagnostics] > [General fluidics test].

  • Page 232: Errors 10118

    7 Troubleshooting cobas b 221 system System stops Check connector cable between mainboard and interface unit. For details, see Figure Mainboard connectors on page B-90. Replace the mainboard unit. For instructions, see Replacing the Mainboard unit on page B-89. Replace the interface unit.

  • Page 233: Error 10127 "Timing Error Mss

    221 system 7 Troubleshooting System stops Error 10127 "Timing error MSS" A subprogram did not report back. Turn the instrument off, wait at least 3 minutes, and turn it back on. Check AQC/PolyOX cable for damage and replace if necessary.

  • Page 234: Error 10153 "Measuring Chamber Cover Ise Open

    7 Troubleshooting cobas b 221 system System stops Error 10153 "Measuring chamber cover ISE open" The measuring chamber cover ISE is open. In case of closed measuring chamber cover with displayed "Changing of ISE electrodes" screen: Check all cable plug connectors on the ISE measuring chamber Replace ISE measuring chamber.

  • Page 235: Errors 10291

    221 system 7 Troubleshooting System stops Errors 10291...10294 "Program error" A communications error occurred as part of the programming of the module processors. Turn the instrument off, wait at least 3 minutes, and turn it back on. Replace the mainboard unit.

  • Page 236: Errors 10318

    7 Troubleshooting cobas b 221 system System stops Errors 10318...10327 "Program error" A communications error occurred as part of the programming of the module processors. Turn the instrument off, wait at least 3 minutes, and turn it back on. Replace the sample distributor.

  • Page 237: Error 10347 "Program Error

    221 system 7 Troubleshooting System stops Error 10347 "Program error" A communications error occurred as part of the programming of the module processors. Turn the instrument off, wait at least 3 minutes, and turn it back on. Replace the mainboard unit.

  • Page 238: Error 10352 "Program Error

    7 Troubleshooting cobas b 221 system System stops Error 10352 "Program error" A communications error occurred as part of the programming of the module processors. Turn the instrument off, wait at least 3 minutes, and turn it back on. Replace the FMS control board.

  • Page 239: Error 10427 "Hardware Error

    221 system 7 Troubleshooting System stops Error 10427 "Hardware error" A defective module was detected within the scope of the module communications. Replace the T&D actuator board. For instructions, see Replacing the T&D actuator board on page B-30.

  • Page 240: Error 10436 "Hardware Error

    7 Troubleshooting cobas b 221 system System stops Error 10436 "Hardware error" A defective module was detected within the scope of the module communications. Replace the ISE measuring chamber. For instructions, see Replacing the ISE measuring chamber on page B-42.

  • Page 241: Error 10444 "Hardware Error

    221 system 7 Troubleshooting System stops Error 10444 "Hardware error" A defective module was detected within the scope of the module communications. Replace the Actuator Board V4/V6. For instructions, see Replacing the Actuator Board V4/V6 on page B-80.

  • Page 242: Error 10470 "Transponder Error

    7 Troubleshooting cobas b 221 system System stops Error 10470 "Transponder error" An antenna of the transponder receiving circuit is defective. Remove and replace waste bottle, S1 rinse solution, S2 and S3 fluid pack. Check all cable plug connectors of the transponder antennas.

  • Page 243: Message 10489 "Remote Lock

    Message 10489 "Remote lock" Instrument locked by cobas bge link. To remove this lock press "Continue". Log on as a user with the privileg "Remote unlock". For more information on user management, refer to the cobas b 221 system Reference " " "...

  • Page 244: Error 20016 "Fms Volume Error

    7 Troubleshooting cobas b 221 system Module stops Error 20016 "FMS volume error" The calibration solution is not aspirated into the BG measuring chamber in the specified time. Aspirate CAL B. h [System] > [Utilities] > [Fluid actions] > [Fill routines].

  • Page 245: Error 20018 "Pack S2 Empty

    221 system 7 Troubleshooting Module stops Use fluid actions to aspirate CAL A and CAL B again. Evaluation ok: Replace FMS control board. For instructions, see Replacing the FMS control board on page B-35. Replace the fluid mixing system.

  • Page 246: Error 20021 "Adc Error Cond Bg/Ise

    7 Troubleshooting cobas b 221 system Module stops Error 20021 "ADC error cond BG/ISE" A hardware error occurred during mixture calibration Turn the instrument off, wait at least 3 minutes, and turn it back on. Replace the mainboard unit. For instructions, see Replacing the Mainboard unit on page B-89.

  • Page 247: Error 20035 "Bg Temperature Nok

    221 system 7 Troubleshooting Module stops Check cable press fit of the BG connector cable on the mainboard for damage. For details, see Figure Mainboard connectors on page B-90. Replace the mainboard unit. For instructions, see Replacing the Mainboard unit on page B-89.

  • Page 248: Errors 20048

    7 Troubleshooting cobas b 221 system Module stops Errors 20048...20050 "ISE temperature nOk" The temperature of the ISE measuring chamber falls outside the specified range. Turn the instrument off, wait at least 3 minutes, and turn it back on. Call up component test and check the ISE temperatures.

  • Page 249: Error 20054 "Hw Test Error Ise

    221 system 7 Troubleshooting Module stops Replace the mainboard unit. For instructions, see Replacing the Mainboard unit on page B-89. Error 20054 "HW test error ISE" A hardware error occurred during testing the ISE measuring chamber. Call up General hardware test and replace damaged parts.

  • Page 250: Error 20069 "Coox Hw Error

    7 Troubleshooting cobas b 221 system Module stops Replace the PolyOX-KX control board. For instructions, see Replacing the PolyOX-KX control board on page B-53. Error 20069 "COOX HW error" The supply voltage of the COOX module falls outside the specified range.

  • Page 251: Error 20080 "Pp Error

    221 system 7 Troubleshooting Module stops Call up General hardware test and replace damaged parts. h [System] > [Diagnostics] > [General hardware test]. Error 20080 "PP error" The pump performance of the MSS output pump falls outside the specified range.

  • Page 252: Error 20083 "Mss Pol. Not Ok

    7 Troubleshooting cobas b 221 system Module stops Error 20083 "MSS pol. not ok" The MSS polarization was canceled. Repeat MSS polarization. Error 20084 "HW test error MSS" An error was recognized in a hardware component of the MSS measuring chamber.

  • Page 253: Error 20091 "No Pack S3

    221 system 7 Troubleshooting Module stops Error 20091 "No pack S3" S3 Fluid Pack is missing. Check plug connectors of the transponder antenna cable. Replace transponder control S3. For instructions, see Replacing the Transponder Control (waste, S1, S2, S3) on page B-72.

  • Page 254: Error 20095 "S3 On Board Time Expired

    7 Troubleshooting cobas b 221 system Module stops If multiple "Transponder Errors" (Error 20022 "Transponder error S2" on page D-40, Error 20094 "Transponder error S3" on page D-47) occur simultaneously, replace mainboard unit. on page B-89 For instructions, see Replacing the Mainboard unit Error 20095 "S3 on board time expired"...

  • Page 255: Error 20112 "Ss5 Error

    221 system 7 Troubleshooting Module stops Error 20098 "tHb/SO module not ready" The tHb/SO module is not ready. Replace the tHb/SO module. For instructions, see Replacing the tHb/SO module on page B-62. Error 20112 "SS5 error" Call up "Wash AutoQC".

  • Page 256: Errors 20115

    7 Troubleshooting cobas b 221 system Module stops Errors 20115...20118 "module error AQC" The required position was not reached. Call up "Wash AutoQC". h [System] > [Wash & cleaning] > [Wash AutoQC]. Check all plug connectors on the AQC board.

  • Page 257: Error 20142 "Aqc Temperature Nok

    S2 Fluid Pack will be empty in the next 12 to 24 hours. If necessary, insert a new S2 Fluid Pack. For instructions, refer to the cobas b 221 system Instructions for Use, Chapter "Maintenance", section "Exchange of solutions and packs".

  • Page 258: Warning 30010 "Rinse Level Is Low

    S1 Rinse Solution will be empty in the next 12 to 24 hours. If necessary, insert a new S1 Rinse Solution. For instructions, refer to the cobas b 221 system Instructions for Use, Chapter "Maintenance", section "Exchange of solutions and packs".

  • Page 259: Warning 30014 "Prep. Of Cal A Not Ok

    221 system 7 Troubleshooting System warnings Perform general hardware test to test the valves. For instructions, see General hardware test on page D-127. Perform sample sensor test (SS1). h [System] > [Component test] > [Control sensors] > [Sample sensors].

  • Page 260: Warning 30017 "Prep. Of O2 Zero Not Ok

    7 Troubleshooting cobas b 221 system System warnings Check S2 docking mechanism. Insert new S2 Fluid Pack. Perform general hardware test to test the valves. For instructions, see General hardware test on page D-127. Warning 30017 "Prep. of O2 zero not ok"...

  • Page 261: Warning 30020 "Prep. Of Standby Not Ok

    221 system 7 Troubleshooting System warnings Perform sample sensor test (SS2). h [System] > [Component test] > [Control sensors] > [Sample sensors]. Warning 30020 "Prep. of standby not ok" The fill routine for MSS standby solution was not ok.

  • Page 262: Warnings 30023

    At least 1 mat in the AutoQC module contains only two (or less) full ampoules. If necessary, insert a new mat. For instructions, refer to the cobas b 221 system Instructions for Use, Chapter "Maintenance", section "Changing of AutoQC mats".

  • Page 263: Warning 30031 "Perform Maintenance

    One or more maintenance procedures must be carried out. Perform the maintenance preocedure. h [System] > [Utilities] > [Maintenance] > Maintenance procedure > [Do]. For instructions, refer to the cobas b 221 system Instructions for Use, Chapter "Maintenance". Warning 30032 "Printer - Lever open"...

  • Page 264: Warning 30037 "Screen Sharing Active

    7 Troubleshooting cobas b 221 system Value flags Warning 30037 "Screen sharing active" A service connection was established to the instrument. An indicator will be displayed in the status line. This warning will be removed after screen sharing was finished.

  • Page 265: Flag No. 1002 "Sample Sep. Error (1)

    221 system 7 Troubleshooting Value flags Difficult aspiration of CAL B due to FMS problems Remedy: Call up "General fluidics test" and check that tubing paths are open and without leaks. h [System] > [Diagnostics] > [General fluidics test].

  • Page 266: Flag No. 1005 "End Of Sample Detected

    7 Troubleshooting cobas b 221 system Value flags Remedy: Call up "Fill reference electrode" for the relevant module. h [System] > [Utilities] > [Fluid actions] > [Fill routines]. Replace S2/S3 fluid pack. Check plug connector of the reference tube. Call up "General fluidics test" and check that tubing paths are open and without leaks.

  • Page 267: Flag No. 1008 "Irregular Sample (2)

    221 system 7 Troubleshooting Value flags Light level too low Pump delivery volume too high Remedy: Call up internal cleaning of the COOX module. h [System] > [Wash & clean] > [Cleaning modules] > [COOX] > [Start internal cleaning].

  • Page 268: Flag No. 1010 "Sample Pos. Error (4)

    7 Troubleshooting cobas b 221 system Value flags Call up "Contact path test" and aspirate CAL B. For the details, see Contact path test on page D-95. Insert electrode simulator in the relevant module and act accordingly. Flag no. 1010 "Sample pos. error (4)"...

  • Page 269: Flag No. 1012 "Sample Pos. Error (6)

    221 system 7 Troubleshooting Value flags Flag no. 1012 "Sample pos. error (6)" Conductivity at sensor input was too low. Possible causes: Blockage MSS output pump tube is defective No fluid in the measuring chamber Remedy: Replace MSS output pump tube.

  • Page 270: Flag No. 1015 "Sample Pos. Error (8)

    7 Troubleshooting cobas b 221 system Value flags Remedy: Ensure that sample input is sufficient and homogenous. Perform "MSS polarization". Perform a wetting routine for MSS. h [System] > [Utilities] > [Fluid actions] > [Wetting routines]. Flag no. 1015 "Sample pos. error (8)"...

  • Page 271: Flag No. 1020 "Sample Distr. Error (1)

    [System] > [Diagnostics] > [General fluidics test]. Perform sample sensor test (SS1). Press [Measure] and [Calibrate]. h [System] > [Component test] > [Control sensors] > [Sample sensors]. For instructions, refer to the cobas b 221 system Reference Manual, section "Component test". Replace the SD cartridge.

  • Page 272: Flag No. 1023 "Sample Distr. Error (4)

    [System] > [Diagnostics] > [General fluidics test]. Perform sample sensor test (SS2). Press [Measure] and [Calibrate]. h [System] > [Component test] > [Control sensors] > [Sample sensors]. For instructions, refer to the cobas b 221 system Reference Manual, section "Component test". Replace sample sensor board.

  • Page 273: Flag No. 1028 "Insufficient Sample (1)

    221 system 7 Troubleshooting Value flags Possible causes: Sample path leaks or is blocked Cuvette fill leaks Main pump tube defective Remedy: Call up "Wash". Check/replace main pump tube. For the details, see Replacing the pump tube on page B-67.

  • Page 274: Flag No. 1032 "Sample Distr. Error (5)

    B-70. Call up "Component test > Control sensors > Sample sensors" and "Calibrate" (SS4). For instructions, refer to the cobas b 221 system Reference Manual, section "Component test". Flag no. 1036 "Insufficient sample (5)" Insufficient sample for MSS module was detected.

  • Page 275: Flag No. 1038 "No Sample Detected (9)

    Perform sample sensor test (SS3). Press [Measure] and [Calibrate]. h [System] > [Component test] > [Control sensors] > [Sample sensors]. For instructions, refer to the cobas b 221 system Reference Manual, section "Component test". Flag no. 1050 "No sample in SIP"...

  • Page 276: Flag No. 1051 "No Aqc Sample Detected

    Remedy: Call up "Wash AutoQC". Check AutoQC material assignment (incorrect assignment of ampoules). For instructions, refer to the cobas b 221 system Instructions for Use, section "Material assignment – AutoQC materials". Check/replace AutoQC steel tube. For instructions, see Replacing the AutoQC steel tube on page B-133.

  • Page 277: Flag No. 2009 "Recal. Not Ok

    221 system 7 Troubleshooting Value flags Remedy: Perform "Calibration for Ready". h [System] > [Calibrations] > [Calibration for Ready]. Perform a wetting routine for the relevant module. h [System] > [Utilities] > [Fluid actions] > [Wetting routines]. Remove the electrode and tap the body of the electrode with a finger nail to detach any air bubbles from the electrode membrane.

  • Page 278: Flag No. 2012 "Sensor Signal Is Drifting

    7 Troubleshooting cobas b 221 system Value flags Remove the electrode and tap the body of the electrode with a finger nail to detach any air bubbles from the electrode membrane. Call up the stability monitor and check "Details" of the "Electrode slope". If the electrode/cartridge is defective, it is displayed.

  • Page 279: Flag No. 2021 "Drift Alarm

    221 system 7 Troubleshooting Value flags Possible causes: An air bubble has falsified the calibration Defective electrode Unhomogenous O zero point solution Remedy: Perform "Calibration for Ready". Call up "Wetting routine" for BG. h [System] > [Utilities] > [Fluid actions] > [Wetting routines].

  • Page 280: Flag No. 2023 "1 Point Sensitivity Drifts

    7 Troubleshooting cobas b 221 system Value flags S2 Fluid Pack docking mechanism contaminated Remedy: Call up "Fill reference electrode" for the relevant module. h [System] > [Utilities] > [Fluid actions] > [Fill routines]. Perform "Calibration for ready". Check S2 docking mechanism for contamination and if necessary clean it.

  • Page 281: Flag No. 2029 "Adc

    221 system 7 Troubleshooting Value flags Check Baro settings. For instructions, see Baro sensor on page D-101, Baro settings on page B-5. Insert electrode simulator and act accordingly. Flag no. 2029 "ADC >>>>>" Sensor signal is above the measuring range.

  • Page 282: Flag No. 2035 "Linearity Not Ok

    7 Troubleshooting cobas b 221 system Value flags Call up "General fluidics test" and check that tubing paths are open and without leaks, particularly the range VBI and BG measuring chamber. h [System] > [Diagnostics] > [General fluidics test]. For details, see diagrams in Chapter 2 Fluid actions.

  • Page 283: Flag No. 2042 "Wavelength Not Ok

    221 system 7 Troubleshooting Value flags Possible causes: Sample feeding clogged Remedy: Call up "Wash". Call up "General fluidics test" and check that tubing paths are open and without leaks. h [System] > [Diagnostics] > [General fluidics test].

  • Page 284: Flag No. 2070 "Sensor Signal Unstable

    7 Troubleshooting cobas b 221 system Value flags Flag no. 2070 "Sensor signal unstable" Sampling criterion for tHb measurement value calculation violated. Possible causes: Irregular sample Sample feed leaks or is blocked Remedy: Perform "Internal cleaning" for the tHb/SO module.

  • Page 285: Flag No. 3002 "Temperature Error

    221 system 7 Troubleshooting Value flags Flag no. 3002 "Temperature error" The module temperature is outside the permitted range. This flag corresponds to the temperature module stop for the relevant module. Possible causes and remedy: For instructions, see: Error 20000 "SD temp.

  • Page 286: Flag No. 3014 "Ref. Point Not Ok

    7 Troubleshooting cobas b 221 system Value flags Call up "Wetting routine" for MSS. h [System] > [Utilities] > [Fluid actions] > [Wetting routines]. Call up "Contact path test" for MSS and aspirate standby solution. For the details, see Contact path test on page D-95.

  • Page 287: Flag No. 3033 "0P Not Ok

    [Fluid actions] > [Fill routines] > [Aspirate solution O2 zero]. Check T&D disk and input unit for soiling. For instructions, refer to the cobas b 221 system Instructions for Use, Chapter "Maintenance". Call up "General fluidics test" and check that tubing paths are open and without leaks.

  • Page 288: Flag No. 5007 "Calculation Error (2)

    7 Troubleshooting cobas b 221 system Value flags Turn the instrument off, wait at least 3 minutes, and turn it back on. Check Baro settings. For instructions, see Baro sensor on page D-101, Baro settings on page B-5. Reinstall software.

  • Page 289: Flag No. 6030 "Coox Hw Error

    221 system 7 Troubleshooting Value flags If the conductivity is not OK, replace mainboard. For instructions, see Replacing the Mainboard unit on page B-89. Flag no. 6030 "COOX HW error" A hardware error occured at the COOX module.

  • Page 290: Flag No. 7034 "Solution Exhausted

    7 Troubleshooting cobas b 221 system Value flags Call up "Polychromator calibration". Replace cuvette. For instructions, see Replacing the cuvette on page B-59. Check/replace cuvette holder. For instructions, see Replacing the cuvette holder on page B-58. Check primary light guide for damage and if necessary replace it.

  • Page 291: Flag No. 8062 "Interferences (2)

    221 system 7 Troubleshooting Value flags Call up hemolyzer test and depending on the result replace hemolyzer unit or HSIN board. For instructions, see Hemolyzer (cobas b 221<2/4/6> systems only) on page D-100. Flag no. 8062 "Interferences (2)"...

  • Page 292: Flag No. 8071 "Ifs Calculation Error (1)

    7 Troubleshooting cobas b 221 system Value flags Perform "Calibration for Ready". Replace MSS cassette. Flag no. 8071 "IfS calculation error (1)" Microcontroller calculation error on interference sensor. Possible causes: An illegal calculation operation has occurred Remedy: Remove and replace MSS cassette.

  • Page 293: Flag No. 8074 "Ifs Ref. Point Not Ok

    221 system 7 Troubleshooting Value flags Flag no. 8074 "IfS ref. point not ok" Problem at reference point of MSS standby solution at interference sensor. Possible causes: Aspiration of MSS standby solution not ok Aspiration of MSS reference solution not ok Remedy: Call up "Aspirate standby solution".

  • Page 294: Flag No. 8077 "Ifs Adc

    7 Troubleshooting cobas b 221 system Value flags Flag no. 8077 "IfS ADC >>>>>" Interference sensor signal is above/below ADC range. Possible causes: Reference system not filled (reference electrode only for instruments with urea installed) Leaky/empty electrode Remedy: Call up "Fill ref. electrode MSS".

  • Page 295: Flag No. 8081 "Interferences (5)

    221 system 7 Troubleshooting Value flags Flag no. 8081 "Interferences (5)" The calculated COHb value is outside the permitted range. Possible causes: Unsuitable sample type Remedy: Check sample material: sample too old, partially hemolyzed, unhomogenous, incorrect anticoagulant. Flag no. 8082 "Interferences (6)"...

  • Page 296: Flag No. 9001 "Not Activated

    7 Troubleshooting cobas b 221 system Value flags Flag no. 9001 "Not activated" Parameter is not activated for measurement (gray). Flag no. 9002 "Not calibrated" Parameter is not calibrated (red cross). Remedy: Perform "Calibration for ready". Flag no. 9003 "Measurement running"...

  • Page 297: Usb Troubleshooting

    USB instead of floppy disk. Export to and import from USB mass storage requires software version 5.00 or higher to be installed on instruments using touch screen/PC units version 4.X or higher and interface unit cobas b 221 system > SN 3000. Error exporting data The export to USB mass storage failed.

  • Page 298: Troubleshooting List

    7 Troubleshooting cobas b 221 system Touch screen/PC unit troubleshooting Troubleshooting list Error picture Possible cause Corrective action PC looses Date and Time after start Defective main board battery. Replace the battery and control electronic. e For details, see Replacing the battery and charger on page B-102.
  • Page 299 In case the error persists, replace the touch srceen/PC unit. e For details, see Replacing the touch screen/PC unit on page B-95 (see also cobas b 221 system Service Bulletin 009). PC does not boot showing "Operating Short-circuit or interrupt of the hard Replace the hard disk bus cable.
  • Page 300 7 Troubleshooting cobas b 221 system Touch screen/PC unit troubleshooting Error picture Possible cause Corrective action PC does not boot showing "Kernel Physically destroyed sectors or Replace the hard disk and the hard disk bus cable. e For details, see Replacing the hard disk on panic".

  • Page 301: Important Test Routines

    221 system 7 Troubleshooting Important test routines Important test routines Contact path test BG/ISE h At the ready screen, press [System] > [Component test] > [Control Sensors] > [Contact paths] > [BG] or [System] > [Component test] > [Control Sensors] > [Contact paths] > [ISE].
  • Page 302 7 Troubleshooting cobas b 221 system Important test routines VO closed: MCO measurement value Status not ok – This error pattern corresponds to on page D-59 Flag no. 1003 "Ref. sol. asp. error" on page D-59 Flag no. 1004 "Ref. sol. pos. error"...
  • Page 303 221 system 7 Troubleshooting Important test routines Measurement value slightly lower: replace MSS cassette. Insert electrode simulator and act accordingly. Ref. aspiration: MCO measurement value Status not ok – Call up "Aspirate MSS reference solution" in the fill routines.

  • Page 304: Aggregates

    7 Troubleshooting cobas b 221 system Important test routines Aggregates T&D module h At the ready screen, press [System] > [Component test] > [Aggregates] > [T&D module]. Figure D-5 T&D module test Initialization: The T&D disc performs an automatic initialization.
  • Page 305 221 system 7 Troubleshooting Important test routines Place syringe: This function is used to check the needle position. It should be centered in the retainer. If the needle projects too far, it is more difficult to attach a sample container. If the needle is too far back, there is a danger that the sample container will fall off.
  • Page 306 7 Troubleshooting cobas b 221 system Important test routines Hemolyzer (cobas b 221<2/4/6> systems only) h At the ready screen, press [System] > [Component test] > [Aggregates] > [Hemolyzer]. Figure D-6 Hemolyzer (cobas b 221<2/4/6> systems only) Phase-angle adjustment voltage Status not ok –...

  • Page 307: Control Sensors

    221 system 7 Troubleshooting Important test routines The hemolyzer is damaged: replace unit. Current with sample and power Status not ok – The hemolyzer is damaged: replace unit. The HSIN board is defective: replace board. Voltage with sample and power Status not ok –...
  • Page 308 7 Troubleshooting cobas b 221 system Important test routines From approx. 3000 m above sea level or air pressure < 526 mmHg (70.13 kPa), the specifications for parameter PO are no longer fulfilled and the parameter must no longer be used for evaluation of the clinical decisions.

  • Page 309: Meas. Sensors

    221 system 7 Troubleshooting Important test routines Calibrate: The sample sensors are calibrated with the measuring medium located in the sample path (normally with air). The air calibration will set the sample sensor values to 100 %. High values for I-LED when injecting and measuring water indicate clogged sample sensors, bent or not corectly plugged light guides.
  • Page 310 7 Troubleshooting cobas b 221 system Important test routines h At the ready screen, press [System] > [Component test] > [Meas. sensors] > [ISE]. Use this function to monitor the ISE module. Figure D-9 Overview The current sensor values will be displayed in the column "Signal". Standard deviation in column "Std.
  • Page 311 221 system 7 Troubleshooting Important test routines h At the ready screen, press [System] > [Component test] > [Meas. sensors] > [MSS]. Use this function to monitor the MSS module. Figure D-10 Overview The current sensor values will be displayed in the column "Signal". Standard deviation in column "Std.
  • Page 312 7 Troubleshooting cobas b 221 system Important test routines tHb/SO (cobas b 221<1/3/5> systems only) h At the ready screen, press [System] > [Component test] > [Meas. sensors] > [tHb/SO Figure D-11 tHb/SO (cobas b 221<1/3/5> systems only) Overview Use this function to monitor the tHb/SO module.
  • Page 313 221 system 7 Troubleshooting Important test routines Figure D-12 Lamp test (Halogen lamp-green) Status not ok – If an error value is displayed on the halogen lamp x-peak, it indicates a grid shift (photodiode array movement). If necessary replace the polychromator bilirubin.

  • Page 314: General Fluidics Test

    For instructions, see Vacuum System on page D-101. Overview The general fluidics test divides the cobas b 221 system into 11 ranges and performs fluid tests in these ranges. The test results are displayed on the screen. The possible test results are as follows: Ok –...
  • Page 315 221 system 7 Troubleshooting Important test routines Low pressure is built up between waste separator and main pump. To test for tightness, the tested section is kept closed and the vacuum is measured with the baro sensor. To test for blockages, the corresponding section is opened and the vacuum reduction is measured with the baro sensor.
  • Page 316 7 Troubleshooting cobas b 221 system Important test routines Sample distributor range Figure D-16 Sample distributor range Roche Diagnostics May 2009 D-110 Service Manual · Version 9.0...
  • Page 317 221 system 7 Troubleshooting Important test routines FMS range Figure D-17 FMS range Roche Diagnostics May 2009 Service Manual · Version 9.0 D-111...
  • Page 318 7 Troubleshooting cobas b 221 system Important test routines MSS measuring chamber range Figure D-18 MSS measuring chamber range Roche Diagnostics May 2009 D-112 Service Manual · Version 9.0...
  • Page 319 221 system 7 Troubleshooting Important test routines Sample input range Figure D-19 Sample input range Roche Diagnostics May 2009 Service Manual · Version 9.0 D-113...
  • Page 320 7 Troubleshooting cobas b 221 system Important test routines SS2 - SS3 range Figure D-20 SS2 - SS3 range Roche Diagnostics May 2009 D-114 Service Manual · Version 9.0...
  • Page 321 221 system 7 Troubleshooting Important test routines Converting line range Figure D-21 Converting line range Roche Diagnostics May 2009 Service Manual · Version 9.0 D-115...
  • Page 322 7 Troubleshooting cobas b 221 system Important test routines BG measuring chamber range Figure D-22 BG measuring chamber range Roche Diagnostics May 2009 D-116 Service Manual · Version 9.0...
  • Page 323 221 system 7 Troubleshooting Important test routines ISE measuring chamber range Figure D-23 ISE measuring chamber range Roche Diagnostics May 2009 Service Manual · Version 9.0 D-117...
  • Page 324 7 Troubleshooting cobas b 221 system Important test routines Hb module range Figure D-24 Hb module range Roche Diagnostics May 2009 D-118 Service Manual · Version 9.0...
  • Page 325 221 system 7 Troubleshooting Important test routines Bypass range Figure D-25 Bypass range Roche Diagnostics May 2009 Service Manual · Version 9.0 D-119...

  • Page 326: Stability Monitor

    Overview The stability monitor provides information about the instrument stability of the cobas b 221 system over a defined period based on the content of the log file. The default period for the stability monitor is two days. Figure D-26...
  • Page 327 221 system 7 Troubleshooting Important test routines Item Description description of the test Name sum of all entries for the test # found Appearance/ number of entries for the test too less information, use a longer time period/press [Start]...
  • Page 328 7 Troubleshooting cobas b 221 system Important test routines Aspiration status Evaluates the error probability of aspiration- and positioning procedures of calibration solutions. Possible error causes: leaky or blocked tubing paths, defective sample sensors or defective contact paths. Following items will be displayed in case of nOk –...
  • Page 329 221 system 7 Troubleshooting Important test routines Item Description affected parameters Parameters Each parameter may be listed more than once due to different electrode status messages. number of parameter messages Standard deviation If a parameter is listed more than once, each entry shows the totals for this parameter.
  • Page 330 7 Troubleshooting cobas b 221 system Important test routines Stability monitor limits The stability monitor uses smaller limits than the applied limits to the instrument in order to recognize problems at an early stage. Following items will be displayed in case of nOk –...
  • Page 331 221 system 7 Troubleshooting Important test routines Electrode slope Evaluates the sensitivity of the electrode/sensor to the sample medium. Possible error causes: old, defective or contaminated electrodes. With at least one error message, this test will result in nor ok –...
  • Page 332 7 Troubleshooting cobas b 221 system Important test routines Stability monitor limits The stability monitor uses smaller limits than the applied limits to the instrument in order to recognize problems at an early stage. Following items will be displayed in case of nOk –...

  • Page 333: General Hardware Test

    At the ready screen, press [System] > [Diagnostics] > [General hardware test]. Overview This test is used to check the hardware components of the cobas b 221 system. This test allows any faults in components to be detected and limited (status Ok –...
  • Page 334 7 Troubleshooting cobas b 221 system Important test routines Peltier BG output nOk – Remedy: Check cable plug from mainboard to BG module. Replace BG module. Error message: Peltier fan BG input nOk – Peltier fan BG output nOk –...
  • Page 335 221 system 7 Troubleshooting Important test routines Remedy: Check cable plug from mainboard to sample distributor. Replace sample distributor. Error message: Peltier fan SD 37°C at BG input nOk – Peltier fan SD 37°C at ISE input nOk –...
  • Page 336 7 Troubleshooting cobas b 221 system Important test routines Remedy: Check plug and cable of valve. Replace valve. Replace FMS control board. VMIX Error message: Valve MIX nOk – Remedy: Check plug and cable of valve. Replace valve. Replace FMS control board.
  • Page 337 221 system 7 Troubleshooting Important test routines Error message: Valve 18 nOk – Remedy: Check plug and cable of valve. Replace valve. Replace vacuum control board. Vacuum pump Error message: Power supply of the vacuum pump nOk –...

  • Page 338: Service Report

    7 Troubleshooting cobas b 221 system Important test routines Service report h At the ready screen, press [System] > [Diagnostics] > [Service report]. Overview The service report provides information about the sensor conditions as well as the FMX and COOX positioning times over a freely defined period or printed on-line over the printer.
  • Page 339 221 system 7 Troubleshooting Important test routines Cycle Description Measurement chamber conductivity CAL B BG, ISE conductivity CAL A BG, ISE Mix1 BG, ISE Mix2 BG, ISE air calibration zero point calibration NULL calibration with MSS standby solution...
  • Page 340 7 Troubleshooting cobas b 221 system Important test routines Mix1 "Mix 1" will be printed out after the "Status" as well as date and time and indicates the last value which the concerned parameter measured with Mix1. This enty can be compared with the last entry in the section Status in order to recognize the change in the signal characteristics.

  • Page 341: Sensor Limits (Sensor Report)

    221 system 7 Troubleshooting Sensor limits (Sensor report) Sensor limits (Sensor report) h At the ready screen, press > [Miscellaneous reports] > [Sensor report]. Conductivity BG A Pot. 55 mV 75 mV 105 mV B Pot. 1320 mV...
  • Page 342 7 Troubleshooting cobas b 221 system Sensor limits (Sensor report) Roche Diagnostics May 2009 D-136 Service Manual · Version 9.0...
  • Page 343 Glossary May 2009...
  • Page 345 221 system Glossary Acid base diagram -Dummy electrode Glossary necessary docking mechanisms for fluid transport into or out of the system. Acid base diagram Based on the log PCO /pH-graph Bottle tool To prevent spilling of the S1 solution. If the...
  • Page 346 Heparin salts Are the only clot inhibitors that may be individual issues affecting only a specific module of the used for analyses in the cobas b 221 system. analyzer and not the entire analyzer operation. MSS cassette The MSS cartridge is a multiparameter sensor, which contains the spots of the displayed parameters.
  • Page 347 221 system Glossary MSS polarisation -Touch screen/PC unit MSS polarisation A blood sample is inserted via fill QC material see AUTO-TROL PLUS B, AUTO-TROL port similar to a measurement. The MSS cassette is TS+, COMBITROL PLUS B, COMBITROL TS+ subsequently exposed to liquid and polarized.
  • Page 348 Glossary cobas b 221 system SIP -W Waste Container LCD that is covered with a touch-sensitive film ("touch to ± 0.03% absolute by the manufacturer. Expected and screen"). observed values for PCO and PO were corrected to 760 mmHg. SIP abbr. for sample inlet path S1 Rinse Solution To rinse the system.
  • Page 349 Index May 2009...
  • Page 351 221 system Index Index AutoQC Cable connectors – AutoQC preparation for maintenance, B-119 – Replacing the main controller cable, B-112 – Initial installation of the AutoQC module, B-119 – Replacing the valve bus cable, B-110 – Maintenance kit, C-14 Cal.
  • Page 352 Index cobas b 221 system – Tubing paths, C-8 Delete all databases, B-13 Delete databases & archives, B-13 Important information, A-5 Demo mode, B-6 Important notes, B-19 Diagnostics (test routines), D-95 Important notes and warnings, A-6 Disinfectant, A-7 Interface unit –...
  • Page 353 221 system Index – Symbols, 8 – Version, 3, G-6 Service mode, B-6 Operating safety information, A-6 Service report, D-132 Shutdown, B-19 Software – Version, 3, G-5 Software update PC unit, B-95 – video sequences (FTP), B-107 Peristaltic pumps –...
  • Page 354 Index cobas b 221 system – Replacing the VP waste water stop, B-78 – Replacing the waste valve V6, B-86 – Replacing the waste valves V13/V18, B-85 – Test, D-101 – VP tube set, B-78 – waste tube, B-77 Value flags, D-58 Valves, B-81 –...
  • Page 355 Versions Versions ......... . . G-3 May 2009...
  • Page 357 221 system 8 Versions Table of contents Versions This chapter provides information about the released software versions and the released service manuals. Chapter In this chapter Software ........................... 5 Service Manual ........................ 6 Version 1.0 ......................... 6 Version 2.0 ......................... 6 Version 3.0 .........................
  • Page 358 8 Versions cobas b 221 system Table of contents Roche Diagnostics May 2009 Service Manual · Version 9.0...
  • Page 359 221 system 8 Versions Software Software Version Nr. Release Date Remark 1.00 15.05.2003 First Release 1.02 29.09.2003 1.04 19.11.2003 2.00 12.03.2004 Mandatory upgrade 2.02 13.04.2004 2.03 29.04.2004 Mandatory upgrade 3.00 09.06.2004 Mandatory upgrade 3.01 29.06.2004 4.00 17.12.2004 4.02 15.04.2005...
  • Page 360 8 Versions cobas b 221 system Service Manual Service Manual Version 1.0 Version Nr. Date of Release Modified Chapters Applicable from Software Version May 2003 First edition Table G-2 Version 2.0 Version Nr. Date of Release Modified Chapters Applicable from Software Version...
  • Page 361 Sample counter Instrument type COOX module AVR-tools; Initialization; Shutdown PC Simulation mode; AQC adjustment; Logmonitor-connection information 8-36 Value flag 2024 deleted 8-53 COOX (Roche OMNI S 2, 4, 6 only) Table G-6 Roche Diagnostics May 2009 Service Manual · Version 9.0...
  • Page 362 8 Versions cobas b 221 system Service Manual Chapter–Page Modification / Addition 8-54 General fluidics test 8-68 General hardware test 9-1 to 9-4 Index Table G-6 Version 4.0 Version Nr. Date of Release Modified Chapters Applicable from Software Version December 2004 1, 2, 3, 6, 7, 8, 9 4.00...
  • Page 363 221 system 8 Versions Service Manual Version 4.1 Version Nr. Date of Release Modified Chapters Applicable from Software Version July 2005 All chapters 4.02 Table G-9 Chapter–Page Modification / Addition Cover page New: Edition notice Cover page New: Intended use...
  • Page 364 Table of contents Updated Version, Date Update: Version 6.0, March 2006 All parts and pages Roche OMNI S replaced by cobas b 221 system All parts "cover" corrected to "top cover" Instrument type: table and warning: new B-66 Replacing the docking mechanisms S2 and S3 (fluid packs): step 5 modified...
  • Page 365 221 system 8 Versions Service Manual Part–Page Modification / Addition D-16 Error 10032: modified D-38 Errors 20032...20034: sequence modified D-39 Error 20035: sequence modified D-39 Errors 20048...20050: sequence modified D-44 Errors 20087...20089: sequence modified D-45 Error 20096: sequence modified...
  • Page 366 8 Versions cobas b 221 system Service Manual Part–Page Modification / Addition Decontaminaten moved from part A; all sub sections updated Error 10045, 10155; Error 20000, 20019, 20032...20034, 20035, 20048...20050, 20051, 20072, 20086, 20087...20089, 20096, 20142; Warning 30032, 30033: software text modified D-19 Error 10046 "Waste line blocked": modified...
  • Page 367 221 system 8 Versions Service Manual Part–Page Modification / Addition D-25 Error 10106 "Timing error": modified D-37 Message 10489 "Remote lock": cobas bge link: updated Message 10491 "QC setup wizard active": new Message 10492 "Data transfer active": new D-58 Warning 30037 "Screen sharing active": new...
  • Page 368 8 Versions cobas b 221 system Service Manual Roche Diagnostics May 2009 G-14 Service Manual · Version 9.0...

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