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UGO BASILE 37360 Instruction Manual

Tail-flick unit
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instruction manual
Tail-Flick Unit
Cat. No. 37360
UGO BASILE S.R.L.
sales@ugobasile.com / service@ugobasile.com www.
.com
ugobasile

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Summary of Contents for UGO BASILE 37360

  • Page 1 Tail-Flick Unit Cat. No. 37360 UGO BASILE S.R.L. sales@ugobasile.com / service@ugobasile.com www. .com ugobasile...
  • Page 2 THE INSTRUMENT IN SAFE CONDITIONS. SERVICE AND ADJUSTMENTS SHOULD BE CARRIED OUT BY QUALIFIED PERSON- NEL, AUTHORIZED BY UGO BASILE ORGANIZATION. ANY ADJUSTMENT, MAINTENANCE AND REPAIR OF THE OPENED INSTRUMENT UN- DER VOLTAGE SHOULD BE AVOIDED AS MUCH AS POSSIBLE AND, WHEN INEVITA- BLE, SHOULD BE CARRIED OUT BY A SKILLED PERSON WHO IS AWARE OF THE HAZARD INVOLVED.
  • Page 3 Automatic detection of the animal Comfortable, unobstructed working surface (no response protruding elements) Data portable to USB pen-drive Excellent reproducibility thanks to optics lodged stick or to PC (USB) in a rigid structure & electronically controlled I.R. flux Ugo Basile: more than 10,000 citations...
  • Page 4 CHECK-LIST Cat. No. 37360 Tail-Flick Unit CLIENTE / CUSTOMER______________________________________________ Ordine No. / Order No. ____________________ Data / Date____/_____/______ UB code  CAT.No. Q.ty DESCRIPTION DESCRIZIONE PEDAL SWITCH PEDALE 37215-303 EUROPE EUROPA E-WP 008 MAINS CABLE CAVO RETE E-WP 008-1 FUSES (2AF)

  • Page 5: Table Of Contents

    Page i 37360 Instruction Manual (Rev. 0) C O N T E N T S GENERAL ......................1     ..................1   RINCIPLE OF PERATION   INSTRUMENT DESCRIPTION ................1     ................2   OMMAND ISPLAY ODULE  ...
  • Page 6 Page ii 37360 Instruction Manual (Rev. 0) ..................13   ONFIGURATION   5.8.1  13  ROM THE EMORY EY TO THE NSTRUMENT 5.8.2  14  PLOADING 5.8.3  14  OWNLOADING 5.8.4  14  EMORY EY TO 5.8.5  14  NSTRUMENT OPERATING WITH MINI PRINTER AND PC ..........
  • Page 7 13.2 ..........27 APERS ENTIONING ASILE LICK     APPENDIX ......................1     FIGURE INDEX Figure 1 “Front Panel and USB slot” .................. 2 Figure 2 “Top Panel” ......................5 Figure 3 “Power Module” ....................6 Figure 4 “Back Panel” ......................7 Figure 4 “Back Panel”...

  • Page 8: General

    Page 1 37360 Instruction Manual (Rev. 0) Tail Flick Unit Cat. 3 7 3 6 0 GENERAL This new style Tail Flick Unit has been designed to perform rapid precise screening of analgesic drugs on the rat tail, according to D'Amour & Smith, see BIBLIOGRAPHY, par- agraph 13.1-Method Paper.

  • Page 9: The Command-Display Module

    Page 2 37360 Instruction Manual (Rev. 0) instrument compo- nents are neatly arranged in a box of new design, which contains the I.R. source, the sensor, the mi- crocontroller and the elec- tronic circuit. The instrument front panel encompasses the Com- mand-Display Module (2), see also paragraph 2.1...

  • Page 10: Keyboard

    Page 3 37360 Instruction Manual (Rev. 0) The four lines of the top area show: the actual date the actual time the instrument serial number the firmware version In all menus, the last two lines show the functions available by depressing the corre- sponding key on the right of the display.

  • Page 11: Data Acquisition & Data Print-Out

    Windows® based Data Acquisition Software Package, which ena- bles the research worker to route to the PC the data originated by all Ugo Basile instru- ments and store them into individual files, ready to be easily managed by most statistical analysis packages available on the market.

  • Page 12: Installation

    Check the contents of the shipment for completeness, packing list to hand, and visually inspect the instrument as soon you take it out of the packaging. Use the supplied Check List. The 37360 functional design which avoids protruding elements is the best defence against rough transport handling.

  • Page 13: Environment

    Page 6 37360 Instruction Manual (Rev. 0) Environment Avoid direct illumination of the enclosure compartments, e.g., from a table lamp. This will definitely upset the animals which dislike full light, not to speak of the risk to raise their body temperature.

  • Page 14: Mains Cord

    Page 7 37360 Instruction Manual (Rev. 0) 4.5.3 Mains Cord It is a standard cable, Cat. # E-WP008, see paragraph 12-ORDERING INFORMATION. Make sure your power outtake is provided with a reliable ground connection. Connections Connect the mains cord to a power outtake, provided with a reliable earth connection, protected by a differential earth-leakage switch (CGFI) that breaks at the threshold of 0.03A, within a max.

  • Page 15: Installation Of Cub Software

    (i.e. +18C°/+24C°, 60% relative humidity, non-condensing); Do not spray any liquid on the connectors; g. Keep inflammables far from the heating source. UGO BASILE DOES NOT ACCEPT ANY RESPONSIBILITY FOR PROBLEMS OR HARM CAUSED TO THINGS OR PERSONS, ARISING FROM:  incorrect electrical supply;...

  • Page 16: Operation

    OPERATION Switching On Switch on the 37360; the software takes some seconds to perform a complete checking of the electronic circuit. During the checking, the display shows the mice logo. By de- pressing ESC, the display shows the software version which is actually installed, e.g., “V1.0”, see paragraph 2.1.1.

  • Page 17: Initial "Dry Run

    Page 10 37360 Instruction Manual (Rev. 0) Initial “Dry Run” We suggest to make an initial “dry run” to realize how the whole works, without the pres- ence of the animal which will inevitably catch all available attention, in particular before the operator masters how to position it.

  • Page 18: Note On Wet Surfaces

    Page 11 37360 Instruction Manual (Rev. 0) When the animal feels pain and flicks its tail, the I.R. source switches off and the reaction time counter stops. The withdrawal latency to the nearest 0.1 s is automatically deter- mined. The datum shown on the display can be printed on the MiniPrinter or routed to the PC, see paragraph 6-OPERATING WITH MINI PRINTER AND PC.

  • Page 19: Experiment Number

    Page 12 37360 Instruction Manual (Rev. 0) The sequence number will automatically increase by one figure at any subsequent measurement. It trips once a datum has been acquired and recorded, indicating the fresh sequence number ready for the next measurement.

  • Page 20: Configuration File

    Page 13 37360 Instruction Manual (Rev. 0) Select the cut-off time by depressing the F1 (OPR), F2 (SET) and F2 (CUT). Depress the F1 (UP ) or F2 (DWN) key un- til you reach the desired value and confirm it via the F4 (OK ) key.

  • Page 21: Uploading

    Page 14 37360 Instruction Manual (Rev. 0) 5.8.2 Uploading If the configuration is present, it can be uploaded and the instrument parameters can be changed, by depressing F1 (CHG). CHANGED” confirms the change. “CONFIGURATION The caption 5.8.3 Downloading If the configuration is present, the user can...

  • Page 22: How To Set The Data Output To Miniprinter

    Page 15 37360 Instruction Manual (Rev. 0) First of all, install the CUB Software, see paragraph 4.7. Then connect the cables as out- lined in paragraph 4.6-Connections. Open the CUB Program and select ‘FILE-CONFIGURATION’ and the type of connection, se- rial or USB (Help).

  • Page 23: Quick Setting Of The 37360 Tail Flick Unit

    = Animal gender = Sequence number = Test OK Quick setting of the 37360 Tail Flick Unit This Instruction Manual extensively explains how to take advantage of all the features of- fered by this microprocessor controlled unit. The following table summarizes them; however, we recommend you to browse the com- plete manual to go deep into details.

  • Page 24: Memory Management

    37360 memory to memory key Send DATA previously saved from CUB program: in the 37360 memory to PC Data/Mem Stick – send all data in mem Set DATE & TIME (FNC) - (CLK) - (UP)/(DWN) - ( > ) -...

  • Page 25: Memory Reset

    Page 18 37360 Instruction Manual (Rev. 0) MEMORY Menu, the F2 (OUT) key enables the researcher to export the data From the stored in the internal memory to the Memory Key or to print them on the MiniPrinter. You can now select the data output path, see paragraph 6, by depressing:...

  • Page 26: "Memory Full" Message

    Page 19 37360 Instruction Manual (Rev. 0) This command can be useful, for instance, before starting a new experimental session, if the operators prefers to cancel the data saved from previous experiments. The Memory menu automatically appears also when the memory is...

  • Page 27: Reproducibility Of The Test

    Page 20 37360 Instruction Manual (Rev. 0) REPRODUCIBILITY OF THE TEST Any repetitive test, in particular if carried out on experimental animals, challenges the ex- perimenter with a number of variables she/he tries to minimize, to obtain results as con- sistent as possible.

  • Page 28: Calibration Via The 37300 I.r. Radiometer

    Page 21 37360 Instruction Manual (Rev. 0) The knowledge of the I.R. power flux in quantitative terms enables the operator to: Check with the Radiometer (and adjust if necessary) the I.R. emission. In fact, the I.R. output of the Tail Flick Unit may undergo to a certain reduction, due to dust gathered on the optics, blackening of the I.R.

  • Page 29: Calibration Without I.r. Radiometer

    The default calibration value is thus recalled. MAINTENANCE While any service of the instrument ought to be carried out by Ugo Basile personnel or by qualified personnel authorized by UGO BASILE organization, this section of the instruc- tion manuals describes normal maintenance procedures which can be carried out at your facility.

  • Page 30: Battery Replacement

    Page 23 37360 Instruction Manual (Rev. 0) 10.1.1 Battery Replacement The Tail Flick Unit memory is supported by a battery snaphat type M4T32-BRI2SH1 of ST. The rated battery endurance is 10 years, therefore replacing the batteries is not a frequent task.

  • Page 31: Replacing The Bulb

    Page 24 37360 Instruction Manual (Rev. 0) At this point, set again date and time, see paragraph 7.2 and configuration, see para- graph 5.7. If a Radiometer 37300 is available, recalibrate, see paragraph 9.2. 10.2 Replacing the Bulb You will realize, in the course of an experiment that the bulb is burnt-out (glow lamps have unfortunately a finite life span) because the missing I.R.

  • Page 32: Customer Support

    Page 25 37360 Instruction Manual (Rev. 0) Calibration is recommended, if the Radiometer 37300 is available, see paragraph 9- CALIBRATION. 10.5 Customer Support For any further information you may desire concerning the use and/or maintenance of the Tail Flick Unit and accessories, please do not hesitate to contact our service department...

  • Page 33: Ordering Information

    Page 26 37360 Instruction Manual (Rev. 0) Sound Level negligible Physical Total Weight Shipping Weight 5.8Kg approx. Dimensions 43x22x10 cm (assembled) Packing Dimensions 45x34x26cm Warranty Warranty Tail Flick Unit is covered by a 24-month warranty. ORDERING INFORMATION 37360 Tail Flick Unit,...

  • Page 34: Thermal Miniprinter

    F.E. D’Amour & D.L. Smith: ”A Method for Determining Loss of Pain Sen-   sation” J. Pharmacol. Exp. Therap. 72: 74-79, 1941 13.2 Papers Mentioning Ugo Basile Tail Flick Unit  The Mineralocorticoid Receptor Antagonist Spironolactone  T.O. Lilius et alia: “...
  • Page 35 Page 28 37360 Instruction Manual (Rev. 0) J. Walsh et alia: “Disruption of Thermal Nociceptive Behaviour in Mice   Mutant for the Schizophrenia-Associated Genes NRG1, COMT and DISC1” Brain Res. 1348: 114-119, 2012 K. Guillemyn et alia: “In vivo Antinociception of Potent mu Opioid Agonist ...
  • Page 36 APPENDIX 37360 Instruction Manual (Rev. 0) APPENDIX Foot Withdrawal Response to Noxious Radiant Heat in the Rat In the living animal, the temperature at the target site, to which the infrared (IR) beam is applied, is definitely an elusive datum.
  • Page 37 N o t e s _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _...
  • Page 38 N o t e s _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _...
  • Page 39 N o t e s _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _...
  • Page 40 CE CONFORMITY STATEMENT Manufacturer UGO BASILE srl Address Via G. di Vittorio, 2 – 21036 Gemonio, VA, ITALY Phone n. +39 0332 744574 Fax n. +39 0332 745488 We hereby declare that Instrument. TAIL FLICK UNIT Catalog number 37360 It is manufactured in compliance with the following European Union Directives and relevant harmonized standards ...

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