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Summary of Contents for UGO BASILE 47650
- Page 1 Rotarod Mouse Cat. No. 47650 E C T Unit Cat. No. 57800 UGO BASILE S.R.L. sales@ugobasile.com / service@ugobasile.com www. .com ugobasile...
- Page 3 RETAIN THE INSTRUMENT IN SAFE CONDITIONS. SERVICE AND ADJUSTMENTS SHOULD BE CARRIED OUT BY QUALIFIED PERSONNEL, AUTHORIZED BY UGO BASILE ORGANIZATION. ANY ADJUSTMENT, MAINTENANCE AND REPAIR OF THE OPENED INSTRUMENT UNDER VOLTAGE SHOULD BE AVOIDED AS MUCH AS POSSIBLE AND, WHEN INEVITABLE, SHOULD BE CARRIED OUT BY A SKILLED PERSON WHO IS AWARE OF THE HAZARD INVOLVED.
- Page 4 CHECK-LIST 47650 Mouse Rota-Rod CLIENTE / CUSTOMER______________________________________________ Ordine No. / Order No. ____________________ Data / Date____/_____/______ UB code CAT.No. Q.ty DESCRIPTION DESCRIZIONE E-WP 008 EUROPE EUROPA MAINS CABLE CAVO RETE E-WP 008-1 U.S.A. U.S.A. 47650-320 TRIP BOX VASCHETTA E-FT 013...
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Page 5: Table Of Contents
Page i 47650 Instruction Manual (Rev. 2.1) C O N T E N T S GENERAL ......................1 ..................1 RINCIPLE OF PERATION INSTRUMENT DESCRIPTION ................1 2.1.1 OTES ON ESISTIVE OUCH CREENS ..................... 3 EATURES ................4 XPERIMENTAL ONFIGURATION .............. - Page 6 Page ii 47650 Instruction Manual (Rev. 2.1) 5.4.2 TARTING A 5.4.3 TARTING A EVERSE OTATION ....................... 18 ESULTS USB S ...................... 18 TORAGE 5.6.1 5.6.2 ROTOCOL ....................... 19 TILITIES 5.7.1 OFTWARE PDATE 5.7.2 & T ETTING 5.7.3 IAGNOSTICS 5.7.4 ESET ....................
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Page 7: General
The Rota-Rod is the reference test to screen drugs potentially active, or having side effects, on motor coordination. The 47650 Rota-Rod NG (Next Generation), is an evolution of the original model and the result of many years of research in cooperation with the latest development in behavioral and pharmacological research. - Page 8 Page 2 47650 Instruction Manual (Rev. 2.1) The rotor, whose angular speed can be preset by the operator, turns on ball bearings. It is driven by a silent D.C. geared motor. Drive speed is unaffected by voltage variations, friction, or wear. This ensures that all trials can be repeated in constant operating conditions.
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Page 9: Notes On Resistive Touch-Screens
Page 3 47650 Instruction Manual (Rev. 2.1) See also paragraphs 2.3-Experimental Configuration and 2.4-Data Collection and Management. 2.1.1 Notes on Resistive Touch-Screens If you have in mind the sensitivity to touch of your tablet or smart-phone, you might think the Rota-Rod touch screen does not react promptly, and you have to press down harder. -
Page 10: Experimental Configuration
Page 4 47650 Instruction Manual (Rev. 2.1) Experimental Configuration Via the new X-PAD software, the operator can easily organize the experiment on her/his PC, and upload it to the Rota-Rod via the USB flash drive provided. Treatments, protocols, stages, animals, and various test features (speed, mode, revolution, etc.) can... -
Page 11: Notes On The Instruction Manual
Notes on the Instruction Manual The 47650 Instruction Manual included in the package (on the USB pen drive) is necessary for the correct installation and operation of the instrument. We recommend reading the manual with attention, as it is essential for the correct installation and operation of the instrument. -
Page 12: Mains Switch
(i.e. +10c° / +40c°, 95% max. relative humidity, non- condensing), see also paragraph 7-47650 SPECIFICATIONS. do not spray any liquid on the connectors and on the geared motor. UGO BASILE DOES NOT ACCEPT ANY RESPONSIBILITY FOR PROBLEMS OR HARM CAUSED TO THINGS OR PERSONS, ARISING FROM: ▪... -
Page 13: Connections
Error! Reference source not found.-Error! Reference source not found. ▪ this USB-B 2.0 allows communication to the PC (for Ugo Basile use, programming and debug) ▪ the Ethernet connector will be used for remote diagnosis and Internet access used for standard operation. - Page 14 Page 8 47650 Instruction Manual (Rev. 2.1) Flip them up by the tail, right-side up but dorsal side in first, and then drop them between the rotating discs onto the rotor. Figure 4 “Placing the Mice on the Rotor” IMPORTANT: The mice should not be lowered from above;...
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Page 15: Adjusting The Detection Sensitivity
Page 9 47650 Instruction Manual (Rev. 2.1) Adjusting the Detection Sensitivity A small stainless steel screw allows the gap magnet/keeper to be adjusted thereby enabling the plate release-sensitivity to be regulated. For juvenile (lighter) animals, it might be necessary to increase sensitivity a little. -
Page 16: Home Page
Page 10 47650 Instruction Manual (Rev. 2.1) Home Page The test is managed by the 4”3 touch-screen. This is how the Home Page looks like. From the Home Page, the logo button on the tool-bar, opens “screen-saver” window This window displays current date and time, and the version of the software on-board. -
Page 17: Experiment
Page 11 47650 Instruction Manual (Rev. 2.1) goes to START Page, see paragraph 5.4 goes to RESULTS Page, see paragraph 5.5 goes to USB STORAGE Page, see paragraph 5.6 goes to UTILITIES Page, see paragraph 5.7 Experiment In the EXPERIMENT page, it is possible to enter information about the test. -
Page 18: Set-Up
Page 12 47650 Instruction Manual (Rev. 2.1) NOTE: Whenever data are entered on the virtual keyboard, it is possible to use an external QWERTY keyboard instead, connected to the device’s upper USB port, see also paragraph Error! Reference source not found.. -
Page 19: Reverse Rotation
2RPM/s) 5.3.4 Custom Ramp The custom ramp option is a unique feature of the Ugo Basile RotaRod, enabling the creation of a custom defined speed curve, by putting together a sequence of speed elements, each with different speed, mode, etc. -
Page 20: Rocking
Page 14 47650 Instruction Manual (Rev. 2.1) This feature is not controlled on the touch-screen, and is to be set on the PC. The related button is not active. The custom ramp can be saved exported to the RotaRod via the USB flash drive. - Page 21 Page 15 47650 Instruction Manual (Rev. 2.1) 5.4.2 Starting a Ramp In the accelerating mode, when the button is depressed, the Rota-Rod will pass from the IDLE state (motor and counters disabled), to the initial speed. ALL Trip Boxes must...
- Page 22 Page 16 47650 Instruction Manual (Rev. 2.1) The experiment and the counters are started by the START button: the motor will accelerate from the INITIAL SPEED to the FINAL SPEED. When an animal falls off its rotor section, tilting the trip box to DOWN position, the related counter stops and the display shows the lane as green, indicating the completed revolutions;...
- Page 23 Page 17 47650 Instruction Manual (Rev. 2.1) All Trip Boxes must be in the UP position in order start experiment. -initial speed The experiment and the counters are started by the START button: the motor will accelerate from the INITIAL SPEED to the FINAL SPEED.
- Page 24 Page 18 47650 Instruction Manual (Rev. 2.1) Results Data are saved in the internal memory and they can be scrolled on the touch-screen. Reach the results section by depressing the “RESULTS” icon from the home page. The home page is reached from any menu, but depressing the...
- Page 25 Page 19 47650 Instruction Manual (Rev. 2.1) 5.6.1 Save Data By pressing this icon, it is possible to export the results on a USB-KEY. Insert in the upper USB port the USB flash drive provided with standard package. Correct insertion is confirmed by the icon on the toolbar.
- Page 26 The file is to be saved on a USB key (FAT32 file system formatted), for example the standard Ugo Basile USB key provided with the Rota-Rod. Proceed as follows: Copy the “RR_Update.hex” file on USB Key (file system FAT32);...
- Page 27 Page 21 47650 Instruction Manual (Rev. 2.1) Press the HOME button to check the new SW version. 5.7.2 Setting Date & Time Select the “DATE-TIME” icon ▲ Set date and time by using the the UP ▼ and DOWN arrows, then confirm by pressing _OK_.
- Page 28 Page 22 47650 Instruction Manual (Rev. 2.1) When the diagnostic sequence is completed, a report can be saved to USB 5.7.4 Reset HD This button resets the HD, which contains ALL THE EXPERIMENTAL DATA. A message box will ask to confirm the action.
- Page 29 Please note the TTL output is not real-time. Maximum delay: 200ms. MAINTENANCE While any service of the instrument ought to be carried out by Ugo Basile personnel or by qualified personnel authorized by UGO BASILE organization, this manual section describes normal maintenance procedures which can be carried out at your facility.
- Page 30 Page 24 47650 Instruction Manual (Rev. 2.1) Long Inactivity The instrument does not require any particular maintenance after long inactivity, except cleaning. Customer Support For any further information you may desire concerning the use and/or maintenance of the Rota-Rod, please do not hesitate to contact our service department (or our local distributor) either directly of via our support page http://www.ugobasile.com/support.html...
- Page 31 11Kg Shipping Weight 16Kg approx. Dimensions 46(w)x28(d)x33(h)cm Packing Dimensions 70x36x46cm Warranty 47650 is covered by a 24-month warranty ORDERING INFORMATION 47650 Mouse Rota-Rod NG , complete with standard accessories Stainless-Steel Trip-Box (5 are provided with standard package) 47650-320 E-AU 041...
- Page 32 ▪ Incoordination in Naive Mice Using an Accelerating Rotarod“ J. Pharm. Pharmac.: 20: 302-304, 1968 Papers Dealing With Ugo Basile Mouse Rota-Rod R.K. Sheean et alia: “Effect of Thymic Stimulation of CD4+ T Cell ▪ Expansion on Disease Onset and Progression in Mutant SOD1 Mice” J.
- Page 33 N o t e s _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _...
- Page 34 N o t e s _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _...
- Page 35 N o t e s _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _...
- Page 39 VALIDATION CERTIFICATE...
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