SP Scientific VirTis BenchTop Pro Series Operator's Manual
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SP Scientific VirTis BenchTop Pro Series Operator's Manual

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FREEZE DRYER OPERATOR'S MANUAL
VIRTIS BENCHTOP PRO
FREEZE DRYERS

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Summary of Contents for SP Scientific VirTis BenchTop Pro Series

  • Page 1 FREEZE DRYER OPERATOR’S MANUAL VIRTIS BENCHTOP PRO FREEZE DRYERS...
  • Page 3 The information in this document is subject to change without prior notice. Always confirm with SP Scientific that you are using the most current version of this document. SP Scientific is free to modify any of its products and services, in any manner and at any time, notwithstanding the information contained in this document.

  • Page 4: Important Symbols

    Never use acrylic closures if they are cracked or crazed.  Never use with toxic, corrosive, flammable or organic materials unless special precautions are in place to prevent injury to personnel or damage to equipment. Rev 002, 01/14 © SP Scientific 2014...

  • Page 5: Warranty Information (Virtis Lyophilizers)

    Limited Warranty SP Scientific (the “Company”) shall warrant each of its products against defects in material or workmanship for a period of 12 months from the date of installation or 15 months from the date of shipment (whichever comes first) provided that the product is used in a reasonable manner under appropriate conditions and consistent with the applicable operating instructions.
  • Page 6 Rev 002, 01/14 © SP Scientific 2014...

  • Page 7: Table Of Contents

    Liquid Nitrogen Trap ............................19 Filter Trap ................................20 Degassing Filter Trap Cartridges ........................20 Stoppering-Tainer .............................. 21 Stoppering-Tainer Operation ......................... 21 General Maintenance ....................23 Vacuum System ..............................23 Vacuum Pump ............................... 23 Rev 002, 01/14 © SP Scientific 2014...
  • Page 8 Acrylic Parts ............................... 33 BenchTop Pro Bezel (ABS)..........................34 BenchTop Pro Front Panel (Kydex) ........................38 BenchTop Pro: Miscellaneous Parts ........................40 BenchTop Pro Top ............................. 53 Protective Cover for Omnitronics™ Controller ....................57 Rev 002, 01/14 © SP Scientific 2014...

  • Page 9: Introduction

    ¾-inch stainless steel port. For more information, refer to Chapter 4: Cold Trap Condenser. Note: A low condenser temperature is required when trying to trap organic solvents. Requires optional manifold. Rev 002, 01/14 © SP Scientific 2014...

  • Page 10: Available Configurations

    Available Configurations Freeze-drying in the Stainless Steel Vertical Acrylic Drum condenser (3L & 8L Only) Vertical Manifold Manifold with Shelf Rack Stainless Steel Stainless Steel Vertical Acrylic Drum Manifold Tree-Type Manifold Drum Manifold Rev 002, 01/14 © SP Scientific 2014...

  • Page 11: Installation And Startup

    Keep the contents, packing material and related paperwork intact until the written report is obtained. Note: SP Scientific will cooperate in the matter of collecting your claim, but shall not assume responsibility for the collection or free replacement of the material. When possible, replacement parts shall be shipped and invoiced to you, making them a part of your claim.

  • Page 12: Service Connections

    Four (4) feet of ¾-inch ID (Inside Diameter) rubber vacuum tubing. • One (1) 90° rubber elbow • One (1) plastic connector Consult SP Scientific and a qualified electrician if electrical configurations vary from standard, specified service requirements. Rev 002, 01/14 © SP Scientific 2014...

  • Page 13: Installing The Vacuum Pump

    Remove any material with the exception of the inlet filter screen and gasket. Place the adapter on the inlet port and secure with a fitting. If an adapter is not present, contact SP Scientific. Remove all objects from the vacuum pump outlet port, but retain for future use.

  • Page 14: Oil Mist Eliminators

    To reduce fumes from the vacuum pump and/or vent the vacuum exhaust externally, SP Scientific recommends the installation of an Oil Mist Eliminator (OME). An OME should be installed on the vacuum pump’s exhaust port (i.e., the OUT port located on the top of the vacuum pump).

  • Page 15: Benchtop Pro Setup

    Note: Quickseal valves are siliconized at the factory. Vacuum grease is not required. Plug the unit into an appropriate outlet and switch on the circuit breaker located on the left side of the unit. The Omnitronics™ controller will illuminate. Rev 002, 01/14 © SP Scientific 2014...

  • Page 16: Vacuum Baffle Plate

    Lower the baffle plate handle to raise the baffle plate when freeze-drying products directly on the baffle. This allows ice to build up on the condenser below and provides more room for the materials to be dried. Rev 002, 01/14 © SP Scientific 2014...

  • Page 17: Basic Operation

    Wide Mouth Flasks are the most popular glassware type, but other types of flasks, vials and ampoules are available. If you are not certain how to use glassware accessories, contact SP Scientific. Dry ice methods can freeze a product to approximately -78 °C, while liquid nitrogen (N...

  • Page 18: Product Preparation: Chamber Drying

    Note: Quickseal valves are an integral part of the freeze-drying process and must be maintained as such. For information regarding upkeep and service of Quickseal valves, see the General Maintenance section of this manual. Refer to Appendix B for a list of standard serum vial capacities. Rev 002, 01/14 © SP Scientific 2014...

  • Page 19: Basic Operation Instructions

    (i.e., approximately 90 to 95% of the moisture has been removed). Lower moisture content may be achieved by allowing the product to continue to dry for several hours. Rev 002, 01/14 © SP Scientific 2014...
  • Page 20 Appendix D, Chemical Resistance Charts for further information. The defrost system turns off automatically after one (1) hour or when the condenser reaches 60.0 °C (140.0 °F). To deactivate the defrost process manually, press the green DEFR button. Rev 002, 01/14 © SP Scientific 2014...

  • Page 21: Meltback

    99% of moisture has been removed from the product. You can assume drying is complete (i.e., <1% moisture content) when the exterior of the glassware is at room temperature. Rev 002, 01/14 © SP Scientific 2014...
  • Page 22 Basic Operation VirTis BenchTop Pro Rev 002, 01/14 © SP Scientific 2014...

  • Page 23: Cold Trap Condenser

    Freezing and condensing points of solvents. • Overall volume. • Solvent properties, such as toxicity. Note: This process is completely product dependent, so each application will vary in terms of temperature requirements and process time. Rev 002, 01/14 © SP Scientific 2014...

  • Page 24: Cold Trap Setup

    Connect the vacuum pump to your BenchTop Pro unit as described in Chapter 2, Installation and Setup. Rubber Elbow Quick Release Drain valve Connector (Body & Coupling) Hose Clamp Vacuum Tubing Hose Clamp PVC Tubing Vacuum Pump Rev 002, 01/14 © SP Scientific 2014...

  • Page 25: Accessories And Options

    Stainless steel drum manifold with 18 ports. • Vertical acrylic drum manifold with 8 or 12 ports. • Stainless steel tree-type manifold with 8 or 12 ports For more information about manifolds and product availability, contact SP Scientific. Rev 002, 01/14 © SP Scientific 2014...

  • Page 26: Shelf Racks

    Racks are available in both heated and unheated configurations. Available rack assemblies include: • Bulk processing 3-shelf rack with heated or non-heated shelves. For more information about shelf racks and product availability, contact SP Scientific. Rev 002, 01/14 © SP Scientific 2014...

  • Page 27: Liquid Nitrogen Trap

    Enable the vacuum and wait until vacuum pressure reaches 100 mT. The trap is now in operation. Over time, Liquid Nitrogen evaporates rapidly and solvent is condensed. Check center well often and refill with liquid nitrogen as needed. Rev 002, 01/14 © SP Scientific 2014...

  • Page 28: Filter Trap

    Depending on the usage and concentration, changing the charcoal cartridge every three to six months may suffice. WARNING! BE SURE TO PROPERLY HANDLE AND DISPOSE OF USED CARTRIDGES. Rev 002, 01/14 © SP Scientific 2014...

  • Page 29: Stoppering-Tainer

    Once stoppering and the system process is complete, disconnect the Stoppering-Tainer hose nipple, and remove the top plate by turning the Stoppering-Tainer handle in the opposite direction. Remove the vials from the Stoppering-Tainer stainless steel container. Rev 002, 01/14 © SP Scientific 2014...
  • Page 30 Accessories and Options VirTis BenchTop Pro Rev 002, 01/14 © SP Scientific 2014...

  • Page 31: General Maintenance

    Repeat steps 3 and 4 to complete the process. PROPERTY CAUTION! OIL MUST BE CHECKED AND CHANGED FREQUENTLY IF YOUR PRODUCT CONTAINS CORROSIVE MATERIALS OR ORGANIC SOLVENTS. IN ADDITION, A FILTER TRAP MAY BE INSTALLED TO PROTECT THE VACUUM PUMP. Rev 002, 01/14 © SP Scientific 2014...

  • Page 32: Clearing The Vacuum Pump Maintenance Alarm

    Inspect tubing and gaskets periodically for signs of wear. Check gaskets by removing and inspecting interior surfaces for potential problems. A light coating of vacuum grease on the exterior surfaces will protect gaskets and tubing. Reapply grease as needed. Rev 002, 01/14 © SP Scientific 2014...

  • Page 33: Condenser Gasket

    If scratches or cracks are found, the selector part(s) should be replaced. Apply a thin film of high vacuum grease to an acceptable selector and reassemble the valve. Repeat for all remaining Quickseal valves. Rev 002, 01/14 © SP Scientific 2014...

  • Page 34: Refrigeration System

    Add baking soda or a mild buffering agent to the rinse water to help neutralize acidic residue. A siphon-type squeeze bottle can be used to direct the rinse spray into difficult to reach areas. Refer to Appendix C, Stainless Steel Cleaners for more information. Rev 002, 01/14 © SP Scientific 2014...

  • Page 35: Appendix A: Troubleshooting

    If you do not get a normal vacuum reading on the Omnitronics™ controller display or vacuum gauge within one (1) minute, start checking components individually. Rev 002, 01/14 © SP Scientific 2014...

  • Page 36: Product Melting

    Replace the vacuum probe and retest. Note: If this does not resolve your vacuum problem, contact SP Scientific for assistance. Product Melting The most common reason for product melting is poor vacuum. Adequate vacuum is required to keep products in a frozen state.

  • Page 37: Appendix B: Serum Vial Capacities

    Body OD (mm) Capacity (mL) 179077 179275 179101 179085 179143 179135 178855 178830 178897 178921 178954 178988 Add 8mm for partially inserted stopper. Thin Wall. Special Stoppering Ampoule (add 10mm for partially inserted stopper). Rev 002, 01/14 © SP Scientific 2014...
  • Page 38 Appendix B: Serum Vial Capacities VirTis BenchTop Pro Rev 002, 01/14 © SP Scientific 2014...

  • Page 39: Appendix C: Stainless Steel Cleaners

    Appendix Appendix C: Stainless Steel Cleaners The following table lists possible problem situations and suggests corrective actions. For additional information, contact SP Scientific. Cleaning Required Cleaning Agent Application Method Effect on Finish Penny-Brite or Copper-Brite Use in direction of polish lines May scratch No.
  • Page 40 Appendix C: Stainless Steel Cleaners VirTis BenchTop Pro Rev 002, 01/14 © SP Scientific 2014...

  • Page 41: Appendix D: Chemical Resistance Charts

    R = Resistant (withstands long periods of exposure at temperatures up to 50 °C). LR = Limited Resistance (withstands short periods of exposure at room temperature). NR = Not Resistant (immediate damage may occur upon exposure). PROPERTY CAUTION! DO NOT USE ORGANIC SOLVENTS OR ABRASIVE CLEANERS. Rev 002, 01/14 © SP Scientific 2014...

  • Page 42: Benchtop Pro Bezel (Abs)

    Benzoyl Peroxide Boric Acid Brines, Saturated Bromide (K) Solution Bromine Bromine Liquid, Tech. Bromine water, Saturated Aqueous Butyl Acetate Calcium Chloride CODES EX = Excellent Resistance SE = Severe Effect ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 43 Formic Acid FruitJuices Gelatine Glycerine Glycols Glycol, Ethylene Glycolic Acid Hexamethylene Diamine Hexamine Hydrazine Hydrobromic Acid Hydrochloric Acid Hydrochloric Acid conc. CODES EX = Excellent Resistance SE = Severe Effect ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 44 Oils, Diesel Oils, Essential Oils,Lubricating + Aromatic Additives Oils, Mineral Oils, Vegetable and Animal Oxalic Acid Ozone Paraffin Wax Perchloric Acid CODES EX = Excellent Resistance SE = Severe Effect ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 45 <50% Sulphuric Acid Sulphuric Acid Sulphuric Acid, Fuming Sulphur Chlorides Tallow Tannic Acid Tartaric Acid Trichlorethylene Urea Vinegar Water, Distilled. CODES EX = Excellent Resistance SE = Severe Effect ND = No Data Rev 002, 01/14 © SP Scientific 2014...

  • Page 46: Benchtop Pro Front Panel (Kydex)

    Motor Oil No Change Transmission Fluid No Change Brake Fluid No Change Ammonia No Change Coffee No Change Lestoil No Change Gasoline No Change Isopropyl Alcohol No Change 10% Hydrocloric Acid No Change Rev 002, 01/14 © SP Scientific 2014...
  • Page 47 None Mustard No Change Slight Grape Juice No Change Slight Clorox No Change None Rinso Blue No Change None Easy Monday Bluing No Change Medium Pepsi-Cola No Change None Water No Change None Rev 002, 01/14 © SP Scientific 2014...

  • Page 48: Benchtop Pro: Miscellaneous Parts

    Aluminum Potassium Sulfate (10%) Aluminum Potassium Sulfate (100%) Amines Ammonia (10%) Ammonia Nitrate Ammonia, Anhydrous Ammonia, Aqueous Ammonium Acetate CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 49 Barium Chloride Barium Cyanide Barium Hydroxide Barium Nitrate Barium Sulfate Barium Sulfide Battery Acid Bay Oil Benzaldehyde Benzene CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 50 Calcium Disulphide Calcium Hydroxide Calcium Hypochorite Calcium Nitrate Calcium Oxide Calcium Sulfate Carbolic Acid (Phenol) Carbon Bisulfide CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 51 Creosote Oil Cresol Cresylic Acids (50%) Cupric Acid Cyanic Acid Cycloheaxanol Cyclohexane Cyclohexanone Cyclohexene Decahydronaphthalene Detergents, Synthetic Dextrin CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 52 Ethyl Butyrate Ethyl Choride Ethyl Ether Ethyl Sulfate Ethylene Chloride Ethylene Chlorohydrin Ethylene Diamine Ethylene Dibromide Ethylene Dichloride CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 53 Hexamethylene Diamine Hexamine Hexane Hexyl Alcohol Hydraulic Oil Hydrazine Hydrobromic Acid (50%) Hydrochloric Acid (10%) Hydrochloric Acid (conc.) CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 54 Lead Sulfamate Lemon Oil Ligroin Lime (CaO) Linoleic Acid Linseed Oil Lubricants Lugal Solution Magnesium Carbonate Magnesium Chloride CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 55 Methyl Naphthalene Methyl Salicylate Methylamine Methylene Chloride Methylene DiChloride Methylsulfuric Acid Milk Mineral Oil Mineral Spirits Molasses Monobromonaphthalene CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 56 P3-Solution, Aqueous Paint Thinner Palmitic Acid Paraffin Oil Peanut Oil Pentane Perchlorethylene Perchloric Acid Petrolatum Petroleum Phosphorous Chlorides CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 57 Potassium Permanganate (1%) Potassium Persulfate Potassium Sulfate Potassium Sulfite Propane Propanol Propargyl Alcohol Propyl Alcohol Propylene Glycol Pyridene Pyridine CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 58 Sodium Hypochlorite (<20%) Sodium Hypochlorite (100%) Sodum Acetate Sodium Metaphosphate Sodium Metasilicate Sodium Nitrate (10%) Sodium Perborate Sodium Peroxide CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 59 Tannic Acid (10%) Tanning Oil Tantaric Acid Tartaric Acid Tetrachloroethane Tetrachloroethylene Tetrahydrofuran Tetrahydronaphthalene Thionyl Chloride Tincture of lodine (alc.) CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 60 Vegetable Oil Vinegar Wax, Molten Whey Wine, Brandy Xylene Yeast Zinc Chloride (10%) Zinc Hydrosulfite Zinc Sulfate CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...

  • Page 61: Benchtop Pro Top

    Carbon Tetrachloride Caustic Soda & Potash Cellulose Paint Chlorates of Na, K, Ba Chlorine, dry Chlorine, wet CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 62 Hydrocyanic Acid Hydrofluoric Acid Hydrofluoric Acid Hydrogen Peroxide Hydrogen Peroxide 30 - 90% Hydrogen Sulphide Hypochlorites CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 63 Oxalic Acid Ozone Paraffin Wax Perchloric Acid Petroleum Spirits Phenol Phosphoric Acid Phosphoric Acid Phosphoric Acid Phosphorous Chlorides CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...
  • Page 64 Tartaric Acid Trichlorethylene Urea Vinegar Water, Distilled. Water, Soft Water, Hard Wetting Agents <5% Yeast Zinc Chloride CODES R = Resistant LR = Limited Resistant NR = Not Recommended ND = No Data Rev 002, 01/14 © SP Scientific 2014...

  • Page 65: Protective Cover For Omnitronics™ Controller

    Tomato Juice Methylene Chloride Gasoline (Unleaded) Windex w/Ammonia D4 Lemon Juice Isopropyl Alcohol Butyl Cellosolve Wisk5 Grape Juice Cyclohexanone Mustard Downy1 Vinegar Ethyl Acetate Coffee Spray 'N Wash2 Milk Xylene Mr. Clean1 Clorox3 Vinegar Rev 002, 01/14 © SP Scientific 2014...
  • Page 66 SP Scientific 3538 Main Street Stone Ridge, NY 12484 USA (800) 251-1531 (845) 687-0071 935 Mearns Road Warminster, PA 18974 USA (800) 523-2327 (215) 672-7800 815 State Route 208 Gardiner, NY 12525 USA (800) 431-8232 (845) 255-5000 www.SPScientific.com...

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