Buchi B-290 Operation Manual
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Buchi B-290 Operation Manual

Mini spray dryer
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B-290 Mini Spray Dryer
Operation Manual
093001M en

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  • Page 1 B-290 Mini Spray Dryer Operation Manual 093001M en...
  • Page 2 E-Mail: quality@buchi.com BUCHI reserves the right to make changes to the manual as deemed necessary in the light of experience; espe- cially in respect to structure, illustrations and technical detail. This manual is copyright. Information from it may not be reproduced, distributed, or used for competitive purpos- es, nor made available to third parties.

  • Page 3: Table Of Contents

    Standard accessories ....... . . 18 3.1.3 Standard accessories with the B-290 Advanced ....18 3.1.4 Standard accessories with the B-290 Acid resistant.
  • Page 4 Operation with the Spray Chilling Accessory..... . 55 Mini Spray Dryer B-290 acid resistant ......56 Maintenance and repairs .
  • Page 5 Safety certificate........80 B-290 Operation Manual, Version M...

  • Page 6: About This Manual

    1 About this manual About this manual This manual describes the Mini Spray Dryer B-290 and its optional accessories and provides all infor- mation required for its safe operation and to maintain it in good working order. It is addressed to laboratory personnel and operators in particular.

  • Page 7: Safety

    Processing in “closed mode” requires N as an inert gas. The output particle size of the Mini Spray Dryer B-290 is between 2–25 µm. Thus, the instrument is suited to generate particles in the inhalable size range from a solution of suspension.

  • Page 8: Improper Use

    • Use of the instrument in rooms which require ex-protected instruments. • Spray drying of substances which might explode or ignite due to the processing and the selected parameters of the Mini Spray Dryer B-290 or installed sub systems. • Spray drying of toxic substances.
  • Page 9 Meaning General warning Electrical hazard Heavy weight, avoid over exertion Explosive gases, explosive environment Harmful to life-forms Hot item, hot surface Device damage Inhalation of substances Chemical burns by corrosives Fragile components Wear laboratory coat B-290 Operation Manual, Version M...

  • Page 10: Product Safety

    Directly withdraw released gases and gaeous substances by sufficient ventilation • Only operate the instrument in ventilated environments • Before opertation, check all parts, connections and sealings involved in the gasflow for proper sealing • Exchange worn out or defective parts immediately B-290 Operation Manual, Version M...
  • Page 11 Wear safety gloves • Wear a suitable protective mask • Wear a laboratory coat • Check for proper sealing before use • Do not inhale dried particles • Stop drying gas flow before opening the drying circuit B-290 Operation Manual, Version M...
  • Page 12 Do not operate the instrument in explosive environments • Do not operate the instrument with explosive gas mixtures • Before operation, check all gas connections for correct installation • Directly withdraw released gases and gaseous substances by sufficient ventilation B-290 Operation Manual, Version M...
  • Page 13 • Keep external vibrations away from the instrument NOTICE Risk of instrument damage by internal overpressure. • External supply pressure must meet the system specifications • Exchange clogged filters immediately • Dispose of filter immediately B-290 Operation Manual, Version M...

  • Page 14: Warning Labels On Housing And Assemblies

    Label, located at the spray cylinder, hot item, hot B-290 surface! See text Sticker at the rear side, B-290 See text Sticker/label, located on the B-295 2 .5 .3 Personal protective equipment Always wear personal protective equipment such as protective eye goggles, protective clothing and gloves.

  • Page 15: Safety Elements And Measures

    The system can be used in suction mode (standard) or in pressure mode. The suction procedure used in the Mini Spray Dryer B-290 produces a light negative pressure in the instrument and thus rules out, together with the inlet filter and outlet filter, a contamination of the environment through leaking from the instrumen.

  • Page 16: General Safety Rules

    Modifications to the instrument are only permitted after prior consultation and with the written approval of the manufacturer. Modifications and upgrades shall only be carried out by an authorized BUCHI technical engineer. The manufacturer will decline any claim resulting from unauthorized modifications.

  • Page 17: Technical Data

    The scope of delivery can only be checked according to the individual delivery note and the listed order numbers. NOTE For additional information on the listed products, see www.buchi.com or contact your local dealer. 3 .1 .1 Standard instrument Table 3-1: Standard instrument...

  • Page 18: Standard Accessories

    Spray Dryer Application Support and 910040 Training (1 day training and application tests) 3 .1 .3 Standard accessories with the B-290 Advanced Table 3-3: Standard accessories with the B-290 Advanced Product Order number Lamella safety curtain 044783 Feed switch valve...

  • Page 19: Optional Accessories

    3 Technical data Table 3-4: Standard accessories with the B-290 Acid resistant (cont.) Temperature sensor support adapter 11056318 Clamp ring ID 8 mm 11056387 O-ring FPM 8×1 mm 004221 Connecting nipple PFA coated 11056328 Connecting piece PFA coated 11056334 Needle 0.7 mm titanium 11056415 Nozzle tip 0.7 mm titanium...

  • Page 20: Technical Data Overview

    3 Technical data 3 .2 Technical data overview Table 3-6: Technical data Mini Spray Dryer B-290 Power consumption max. 2900 W Connection voltage 200–230 V ± 10 % Frequency 50/60 Hz Environmental conditions for indoor use only Temperature 5–40 °C...

  • Page 21: Materials Used

    Product feed tube Silicone and tygon Molecular sieve bag of adsorption unit PEEK Acid resistant coated metal PFA (perfluoroalkoxy polymer) Acid resistant metal titanium, Alloy 600 Metal parts Mini Spray Dryer B-290 acid PFA-coated resistant B-290 Operation Manual, Version M...

  • Page 22: Description Of Function

    This chapter explains the basic working principle of the Mini Spray Dryer B-290 Basic (open mode only) and the Mini Spray Dryer B-290 Advanced (for closed mode operation). It also shows how the instruments are structured and provides a general functional description of the assemblies.

  • Page 23: Outlet Filter

    The inert gas is loaded with solvent from the spray drying process. After precooling in a preheat exchanger, the solvent is condensed in a refrigerator and collected in a closed bottle. The cleaned gas stream is preheated in the preheat exchanger and flows back to the Mini Spray Dryer B-290 Advanced.

  • Page 24: Dehumidifier B-296

    Condensed water h Feed Fig. 4.4: Open loop Mini Spray Dryer B-290 with Dehumidifier B-296 for inlet air conditioning Use as inlet air conditioning The Dehumidifier B-296 is an accessory to enable a drying under constant and reproducible humidity conditions cooling to a dew point of 3–5 °C.

  • Page 25: Spray Chilling Accessory

    Serial port RS-232 for data output to a PC b Connection for the remote control panel c Connection for Inert Loop B-295 d Connection for feed switch valve Fig. 4.6: Rear connections of the Mini Spray Dryer B-290 B-290 Operation Manual, Version M...

  • Page 26: Feed Switch Valve And Remote Control Panel

    4 .7 .2 Printer or PC for data output via RS-232 serial port The Mini Spray Dryer B-290 is supplied with a standard protocol for data readout. This is of special importance if the system is qualified and underlies special regulations.

  • Page 27: Putting Into Operation

    5 .2 Electrical connections The Mini Spray Dryer B-290 is aimed to be installed mobile and is and is shipped with a flexible power cord. After the installation, an electrical safety test is recommended to verify a safe system condition such as sufficient grounding.
  • Page 28 External power switches (e.g. emergency stop switches) must meet IEC 60947-1 and IEC 60947-3 requirements. Such devices must be clearly labeled and accessible at any tim. Heater connection Power supply connection B-290 Operation Manual, Version M...

  • Page 29: Installing The Compressed Air Maintenance Unit And Compressor (Optional)

    Installing the compressed air maintenance unit and compressor (optional) To ensure the Mini Spray Dryer B-290 achieves an optimal atomization performance, the supply of compressed air with a pressure of 5–8 bar is necessary. The compressed air must be dried and free of impurities (contamination of the product through impure air).

  • Page 30: Installing The Glass Assembly

    • Screw the glass elbow i onto the top of the cyclone. • Connect the grounding cable l to the cover of the product collection vessel m and to the housing to minimize the electrostatic charge of the powder. B-290 Operation Manual, Version M...

  • Page 31: Installing The Spraying Nozzle

    The three fluid nozzle has two connections for two feeding tubes. An external peristaltic pump has to be mounted for the second feed supply. Fig. 5.4: Installing the spraying nozzle B-290 Operation Manual, Version M...

  • Page 32: Installing The Filters

    Fig. 5.6: Installing the outlet filter • Screw the support angle to the bottom side of the panel. • Mount the filter directly. • Install the connecting tubing between cyclone and filter with an SVL 42. B-290 Operation Manual, Version M...

  • Page 33: Inlet Filter Installation

    The flange screw coupling made of aluminum (order no. 048539) is recommended for the use of outlet temperatures higher than 80 °C for better sealing performance compared to the polymer (POM) flange (order no. 034139). B-290 Operation Manual, Version M...

  • Page 34: Ptfe Filter Membrane Installation

    ➡ Gently flush the PTFE filter membrane manually only. Use standard soap detergents for cleaning. It is recommended to exchange the filter membrane regularly. For installation proceed in reverse order. Wrap the end of the filter tube into the filter carrier and push in the end-cap (see Fig. 5.7). B-290 Operation Manual, Version M...
  • Page 35 Fig. 5.10: Housing with filter cartridge Installation as inlet cleaning filter Install the filter between the heater air inlet and the inlet filter. The filter cascade will ensure maximal particle free air in standard environment. B-290 Operation Manual, Version M...

  • Page 36: Cleaning Filter Installation

    Place the sample vessel onto the designated reservoir-plate on top of the instrument • Ensure a safe positioning of the sample vessel • Do not move the instrument when it is loaded with liquid • Keep external vibrations away from the instrument B-290 Operation Manual, Version M...
  • Page 37 Flow meter valve e Adjusting screw, pump bed Fig. 5.12: Pump bed adjustment Remove spraying nozzle from the Mini Sprayer B-290 and hold spraying nozzle into a suitable container. Insert tube a in to the pump bed. Put tube on the suction side into distilled water c.

  • Page 38: Tubing Installation

    Fig. 5.13: Quick coupling rear side The Mini Spray Dryer B-290 can be used in an open or closed mode. The open mode is set in the suction mode as a standard. However, if the exhaust gas is aggressive and could lead to a cor ro sion of the aspirator, the instrument can also be run in a pressure mode.

  • Page 39: Installing The Compressor

    • Place it in a dry, dust free and well tempered room with appropriate ventilation. • Follow the compressors manual to install the device. • Connect the outlet of the compressor to the compressed air inlet of the Mini Spry Dryer B-290. Fig. 5.16: Oil- and dust-free air compressor NOTE Set the compressor to 6 bar output pressure to achieve recommended standard spray conditions.

  • Page 40: Quick Hose Couplings

    – sensor immediately • Exchange O – sensor regularly within the specified maintenance intervals • Exchange clogged filters immediately • Exchange filters regularly within the specified maintenance intervals • Dispose of clogged or defective filters immediately B-290 Operation Manual, Version M...
  • Page 41 Connect the two instruments with the communica- tion cable to ensure their safe operation. The tubing is described below. Fig. 5.18: Inert Loop B-295 Fig. 5.19: Mini Spray Dryer B-290 Advanced with Inert Loop B-295 as trolley B-290 Operation Manual, Version M...
  • Page 42 Tubing between heater inlet and B-295 outlet d Tubing between aspirator outlet and B-295 inlet e Exhaust gas (nitrogen) outlet tube Fig. 5.20: Tubing installation for closed mode operation with Mini Spray Dryer B-290 Advanced and Inert Loop B-295 B-290 Operation Manual, Version M...

  • Page 43: Dehumidifier B-296 And Inert Loop B-295 Combination

    Inert Loop B-295 outlet tube Fig. 5.21: Tube connections B-290, B-296 and B-295 • Connect the Mini Spray Dryer B-290 outlet tube a with the inlet of the Dehumidifier B-296 • Connect the Dehumidifier B-296 outlet tube b to the Inert Loop B-295 inlet.
  • Page 44 Connect the tubing b from the outlet (labelled on the enclosure) of the Dehumidifier B-296 to the gas inlet of the Mini Spray Dryer B-290. Connect the tubing a from the Mini Spray Dryer B-290 outlet to the inlet of the Dehumidifier B-296 (labelled on the enclosure).

  • Page 45: Installing The Spray Chilling Accessory

    • Mount the complete bath b on the top of the Mini Spray Dryer B-290. • Use the knurled screws to fix the spray chilling accessory on the Mini Spray Dryer B-290 cover panel. Plug in the heater c of the spray chilling accessory instead of the standard heater of the Mini Spray Dryer B-290.

  • Page 46: Installation Check

    • Make sure that the cover of the product collection vessel is connected to the instrument by means of the cable for arresting electrostatic charges. • Make sure that the outlet temperature probe is inserted in the coupling. B-290 Operation Manual, Version M...

  • Page 47: Operation

    Exchange clogged filters immediately • Only operate the instrument in ventilated environments • Directly withdraw released gases and gaseous substances by sufficient ventilation • Perform a dry-run without sample material and check for gas leakages B-290 Operation Manual, Version M...

  • Page 48: Layout Of The Operating And Display Elements

    LED display pump output in % of max. pump rate l Regulating push-button aspirator f LED display for nozzle cleaning m Main switch aspirator g Feed switch valve button n Regulating push-button heating o Main switch heating Fig. 6.2: Operating and display elements B-290 Operation Manual, Version M...

  • Page 49: Conversion Tables For The Parameters

    With different tube diameters, the absolute flow is varying. The diagram shows the correlation for the standard silicone tube (2 mm ID, 4 mm OD) for water. Fig. 6.3: Pump settings versus throughput B-290 Operation Manual, Version M...

  • Page 50: Aspirator

    10. As soon as the desired operating conditions have been achieved and are stable, change the feed tube from pure solvent to the prepared feed solution. B-290 Operation Manual, Version M...

  • Page 51: Optimizing Parameters

    To give you an overview over the parameter settings best suited for your process, special training papers can be downloaded directly from the Internet. Please visit our homepage www.buchi.com. In the section Fields of Activities/Spray Drying, you will find the document to download. 6 .5 End of spray process •...

  • Page 52: Recovering Particles Of The Outlet Filter

    • With the nozzle cleaning set on level 1, a pressure blow is generated every 5 seconds on the inner side of the filter leading to a separation of the fines from the membrane. The particles fall into the glass and can be recovered. B-290 Operation Manual, Version M...

  • Page 53: Operation With The Inert Loop B-295

    Fig. 6.6: Display of the Inert Loop B-295 To operate the instruments, proceed as follows: Switch on the Mini Spray Dryer B-290 Advanced. The instrument automatically detects the connected periphery. Both signal lamps f and g at the Inert Loop B-295 are lit on. If the oxygen signal lamp f is off, there might still be enough inert gas in the loop.

  • Page 54: Status Messages

    This is indi cated by a lit signal lamp g and the message PR LO on the display of the Mini Spray Dryer B-290. The overpressure in the system due to the constant flow inlet is limited by the exhaust outlet at the Inert Loop B-295, which is permanently open.

  • Page 55: Operation With The Spray Chilling Accessory

    Close product vessel with the PTFE cover and close the spray chilling accessory with the cover comprising the heating coil. Switch on the Mini Spray Dryer B-290. The instrument is preset to the spray chilling mode, due to the connected long temperature probe.

  • Page 56: Mini Spray Dryer B-290 Acid Resistant

    6 Operation 6 .9 Mini Spray Dryer B-290 acid resistant For basic operations please see chapters 6.1–6.7. Nozzle cleaning instructions Clean the nozzle parts immediately after each spray drying run. Wash the nozzle parts with a mild detergent solution. Rinse the parts with hot water and let them dry.

  • Page 57: Maintenance And Repairs

    Do not squeeze cables, tubes or other items at reassembling • Exchange defective cabling or tubing before reassembling Warning Death or serious injuries by compressed air and gases. • Depressurize air and gas circuit first • Wear safety goggles B-290 Operation Manual, Version M...

  • Page 58: Housing

    A special brush is supplied to clean the central tube of the nozzle body. Most efficient cleaning of all nozzle types is done in an ultrasonic bath. Clean the tubes and nozzles after each spray process. The tubes and nozzles can be cleaned with commercially available cleaning agents. B-290 Operation Manual, Version M...

  • Page 59: Aspirator Cleaning

    Remove the molecular sieve bag for the duration of cleaning if installed. • Check all sealings and tubes for good condition and proper sealing. • Raise the exhaust tube and fill the system through the inlet with cleaning medium (e.g. ethanol). B-290 Operation Manual, Version M...

  • Page 60: Outlet Filter

    Rinse out and dry the condensate vessel. • Reinstall the condensate vessel. • To dry the working circuit connect the Mini Spray Dryer B-290 and dry it by running the Aspirator with dry air. 7 .6 Outlet filter If the pressure drop of the outlet filter increases by more than 20 mbar relative to the clean filter, take the filter out and wash it manually or in a laboratory washing machine or replace it by a new filter.

  • Page 61: Replacing The Oxygen Sensor Of The Inert Loop B-295

    Addresses of official BUCHI customer service offices are given on the BUCHI website under: www.buchi.com. If malfunctions occur on your instrument or you have technical questions or applica- tion problems, contact one of these offices.

  • Page 62: Troubleshooting

    “Corrective measure”. The elimination of more complicated malfunctions or errors is usually performed by a BUCHI technical engineer who has access to the official service manuals. In this case, please refer to your local BUCHI customer service agent.

  • Page 63: Malfunctions And Their Remedy

    Encrustation on nozzle exit Cool nozzle with cooling water Nozzle is not clean Completely dismantle the nozzle (nozzle cap, tip, cleaning needle) and clean with water Nozzle is defective (bent nozzle Replace nozzle or defective element needle) B-290 Operation Manual, Version M...
  • Page 64 Hose not dipped into stock solution Dip hose into product Change of concentration in stock Agitate product (magnetic agitator) to solution obtain uniform concentration No feed of product Switch on peristaltic pump B-290 Operation Manual, Version M...

  • Page 65: Shutdown, Storage, Transport And Disposal

    3. This helps to ensure that the components are separated and recycled correctly. Please follow valid regional and local laws concerning disposal. You have to follow valid regional and local laws concerning disposal. NOTE For help, please contact your local authorities! B-290 Operation Manual, Version M...

  • Page 66: Spare Parts

    This section lists spare parts, accessories and options including their ordering information. Only order spare parts and consumables from BUCHI to maintain the warranty status and to assure best performance and reliability of the system and affected components. Any modifications to the spare parts used are only allowed with the prior written permission of the manufacturer.
  • Page 67 Nozzle Tip (2.0 mm) 046377 Needle (2.0 mm) 046373 Nozzle Cap (2.8 mm) 046375 Needle Table 10-5: Spray Nozzle ∅ 0.5 mm Description Order number Nozzle Tip (0.5 mm) 11056865 Needle (0.5 mm) 11056864 Nozzle Cap (1.4 mm) 044649 B-290 Operation Manual, Version M...
  • Page 68 (red), 2× 16.0×2.0 mm O-ring for needle and 004222 nozzle tip, FKM (green), 4× 6.0×1.5 mm 004222 O-ring for nozzle cleaner, 038348 002103 FKM (black), 2× 3.0×1.5 mm Set of standard O-rings, 044759 Set, complete complete B-290 Operation Manual, Version M...
  • Page 69 O-ring for nozzle cleaner, 044469 FKM (black), 2× 3.0×1.5 mm 046361 Set of FFKM O-rings, 046364 (002103) complete Set, complete 046363 NOTE O-rings in brackets are part of the standard O-ring set, order no. 044759! B-290 Operation Manual, Version M...

  • Page 70: Glass Parts

    (protection for light sensitive substances) Description Order number Glass assembly, complete 044758 Spray cylinder, sideways outlet 044726 Spray cylinder, vertical outlet 044728 Separation flask 004343 Angle piece 046334 Standard cyclone 004348 Product collection vessel 044727 B-290 Operation Manual, Version M...
  • Page 71 046358 Large product collection vessel complete 11056899 (all above numbers) Table 10-13: High-performance cyclone in brown glass (protection for light sensitive substances) Description High-performance cyclone, brown glass 11056879 Small product collection vessel, brown 11056878 glass B-290 Operation Manual, Version M...

  • Page 72: Filters

    044407 004113 Polypress tube (3 m) 046341 Polypress tube (2 m) 046329 046341 (3 m) 046329 (2 m) Polypress tube (0.6 m) 046330 046330 (0.6 m) Filter tube, complete 046309 0.1 m flextube PFA 046310 B-290 Operation Manual, Version M...

  • Page 73: Trolley

    The appropriate instrument can be supplied by Testo (www.testo.com) type Test 435 with sensor No. 0635 1044. Table 10-18: Measurement tube Description Order number Measurement pipe for gas flow 044790 gas flow B-290 Operation Manual, Version M...

  • Page 74: Feed Switch Valve

    11056989 Description Order number Receiving vessel for solvent 040398 046348 PTFE tube to receiving vessel 004105 PTFE hose connection SVL 22 027338 Oxygen sensor 046348 Extension communication cable 11056989 004105 B-290/B-295 (3 m) 027338 040398 B-290 Operation Manual, Version M...

  • Page 75: Cylinder Insulation

    10 .10 Cylinder insulation With the cylinder insulation the process is carried out with less product loss, closer to scale-up condi- tions, and more energy-efficient. Table 10-23: Cylinder insulation Description Order number Cylinder insulation 040058 B-290 Operation Manual, Version M...

  • Page 76: 10 .11 Spray Chilling Accessory

    Silicone tubing D4/7 (pump tube) 004139 L-type connector D6 045519 Screw connection M5/M8 046557 Conversion kit for Spray Chilling accessory 040060 (necessary for Mini Spray Dryer B-290 instru- ments older than 2005) O-ring FKM 70, 6.0×1.5 004222 Cleaning brush 044782 Hose clip...

  • Page 77: 10 .12 Pre-Cleaning Glass-Set And Sterile Filter

    Small separator pre-cleaning 044424 Drain tubingfor pre-cleaning glass 044432 glass Sterile Filter for pre-cleaning 044435 Feed tubing for pre-cleaning glass 044433 glass Pre-cleaning glass set 044441 Ball valve 1” complete 044434 Support rod for sterile filter 048891 B-290 Operation Manual, Version M...

  • Page 78: 10 .13 Acid Resistant Accessories

    027900 Nozzle tip 1.4 mm titanium 11056419 O-ring set FFKM 046364 n.a. Nozzle cap 2.2 mm titanium 11057510 Needle 2.0 mm titanium 11056422 Nozzle tip 2.0 mm titanium 11056424 Nozzle cap 2.8 mm titanium 11057511 B-290 Operation Manual, Version M...

  • Page 79: Declarations And Requirements

    L’utilisation de cet appareil dans les zones résidentielles peut causer des interférences néfastes, auquel cas l’exploitant sera amené à prendre les dispositions utiles pour palier aux interférences à ses propres frais. B-290 Operation Manual, Version M...

  • Page 80: Safety Certificate

    10 Spare parts 11 .2 Safety certificate B-290 Operation Manual, Version M...
  • Page 81 11 Declarations and requirements B-290 Operation Manual, Version M...
  • Page 82 T +55 19 3849 1201 F +66 2 862 08 54 F +971 4 313 2861 F +55 19 3849 2907 bacc@buchi.com middleeast@buchi.com latinoamerica@buchi.com www.buchi.com/th-th www.buchi.com www.buchi.com/es-es We are represented by more than 100 distribution partners worldwide. Find your local representative at: www.buchi.com...

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