Lexus LS460 2011 Owner's Manual page 672

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If the coolant level drops within a short time after replenishing
Visually check the radiator, hoses, coolant reservoir cap, drain cock and
water pump.
If you cannot find a leak, have any authorized Lexus dealer or repairer, or
another duly qualified and equipped professional, test the cap and check for
leaks in the cooling systems.

Coolant selection
Only use "Toyota Super Long Life Coolant" or similar high quality ethylene
glycol based non-silicate, non-amine, non-nitrite, and non-borate coolant
with long-life hybrid organic acid technology.
"Toyota Super Long Life Coolant" is a mixture of 50% coolant and 50%
deionized water. (Enabled: -35C [-31F])
For more details about engine coolant, contact any authorized Lexus dealer
or repairer, or another duly qualified and equipped professional.
CAUTION

When the engine is hot
Do not remove the engine coolant reservoir cap.
The cooling system may be under pressure and may spray hot coolant if the
cap is removed, causing serious injuries, such as burns.
NOTICE

When adding engine coolant
Coolant is neither plain water nor straight antifreeze. The correct mixture of
water and antifreeze must be used to provide proper lubrication, corrosion
protection and cooling. Be sure to read the antifreeze or coolant label.

If you spill coolant
Be sure to wash it off with water to prevent damage to parts or paint.
LS460_EE
4-3. Do-it-yourself maintenance
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